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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

coq-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation1 Publication

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061S-adenosyl-L-methionineUniRule annotation
Binding sitei126 – 1261S-adenosyl-L-methionineUniRule annotation
Binding sitei173 – 1731S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • ubiquinone biosynthetic process Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
Gene namesi
Name:coq-5UniRule annotation
ORF Names:ZK652.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK652.9; CE29014; WBGene00000765; coq-5.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionSequence analysisAdd
BLAST
Chaini31 – 2852552-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialPRO_0000193362Add
BLAST

Proteomic databases

EPDiP34666.
PaxDbiP34666.
PRIDEiP34666.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex.UniRule annotation

Protein-protein interaction databases

BioGridi41307. 1 interaction.
IntActiP34666. 1 interaction.
MINTiMINT-117184.
STRINGi6239.ZK652.9.

Structurei

3D structure databases

ProteinModelPortaliP34666.
SMRiP34666. Positions 63-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni156 – 1572S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
InParanoidiP34666.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG712TXJ.
PhylomeDBiP34666.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34666-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGATNLFKS MRKPTNVGNF RQFSVNQVNS DNKRSEPGKK THFGFTDVDE
60 70 80 90 100
AEKEQKVHHV FANVAKKYDL MNDAMSMGVH RLWKDYYVGG LQVPYNAKCL
110 120 130 140 150
DMAGGTGDIA FRILRHSPTA KVTVSDINQP MLDVGKKRAE KERDIQPSRA
160 170 180 190 200
EWVCANAEQM PFESNTYDLF TMSFGIRNCT HPEKVVREAF RVLKPGGQLA
210 220 230 240 250
ILEFSEVNSA LKPIYDAYSF NVIPVLGEIL ASDRASYQYL VESIRKFPNQ
260 270 280
DEFARIIREE GFSNVRYENL TFGVCSIHKG MKPRK
Length:285
Mass (Da):32,435
Last modified:June 6, 2002 - v2
Checksum:i2FEBD79A79D6990D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080278 Genomic DNA. Translation: CCD62554.1.
PIRiS44904.
RefSeqiNP_498704.1. NM_066303.6.
UniGeneiCel.9527.

Genome annotation databases

EnsemblMetazoaiZK652.9; ZK652.9; WBGene00000765.
GeneIDi176099.
KEGGicel:CELE_ZK652.9.
UCSCiZK652.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080278 Genomic DNA. Translation: CCD62554.1.
PIRiS44904.
RefSeqiNP_498704.1. NM_066303.6.
UniGeneiCel.9527.

3D structure databases

ProteinModelPortaliP34666.
SMRiP34666. Positions 63-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41307. 1 interaction.
IntActiP34666. 1 interaction.
MINTiMINT-117184.
STRINGi6239.ZK652.9.

Proteomic databases

EPDiP34666.
PaxDbiP34666.
PRIDEiP34666.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK652.9; ZK652.9; WBGene00000765.
GeneIDi176099.
KEGGicel:CELE_ZK652.9.
UCSCiZK652.9. c. elegans.

Organism-specific databases

CTDi176099.
WormBaseiZK652.9; CE29014; WBGene00000765; coq-5.

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
InParanoidiP34666.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG712TXJ.
PhylomeDBiP34666.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

NextBioi891112.
PROiP34666.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. Cited for: FUNCTION.

Entry informationi

Entry nameiCOQ5_CAEEL
AccessioniPrimary (citable) accession number: P34666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 6, 2002
Last modified: May 11, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.