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Protein

Probable mannose-6-phosphate isomerase

Gene

ZK632.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991ZincBy similarity
Metal bindingi101 – 1011ZincBy similarity
Metal bindingi126 – 1261ZincBy similarity
Metal bindingi259 – 2591ZincBy similarity
Active sitei278 – 2781By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_284408. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
ORF Names:ZK632.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK632.4; CE36417; WBGene00014013.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Probable mannose-6-phosphate isomerasePRO_0000194233Add
BLAST

Proteomic databases

PaxDbiP34650.
PRIDEiP34650.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK632.4.

Structurei

3D structure databases

ProteinModelPortaliP34650.
SMRiP34650. Positions 2-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
GeneTreeiENSGT00390000016075.
HOGENOMiHOG000241277.
InParanoidiP34650.
KOiK01809.
OMAiKIFSRIW.
OrthoDBiEOG7GTT3M.
PhylomeDBiP34650.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKLKCTVN NYAWGPKGNS SMAGSLALDG GHIPNLDKDK PYAEFWVGTH
60 70 80 90 100
ANGPAHVIEK DIALKQLLAT SPELQGKHEK GNLSFLFKVL SVLGPLSIQI
110 120 130 140 150
HPTKEQGKLL HATDPKNYPD DNHKPEIAIA LTEFELLSGF RQHSQISEYL
160 170 180 190 200
KLYSEIQELL TEEEKSQIDS LGSYGESSAQ VLKKIFSRIW RTPKEKLQIV
210 220 230 240 250
VDKLARRIQG HENKTALDEI IVYLFTLYPG DVGVFAPIFL NYFKLQPGEA
260 270 280 290 300
TFLEPNMPHA YLKGDCVECM ADSDNTIRAG LTPKYIDVES LVEMLNYDET
310 320 330 340 350
LLPKYIPNEL DDGSLLFTPR GIDEFWVQEV KGPAGSIYQL PYSESCSVLT
360 370 380 390 400
VLYGTATVTL GDASQVLNRG EVVFIGATHD AERPKINISD DFLAFRAFTP
410
SPRALESLSN KRLIID
Length:416
Mass (Da):46,384
Last modified:August 16, 2004 - v3
Checksum:i1C7DEDEE85DB8459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22181 Genomic DNA. Translation: CAA80181.3.
PIRiS40936.
RefSeqiNP_499174.3. NM_066773.4.
UniGeneiCel.9546.

Genome annotation databases

EnsemblMetazoaiZK632.4; ZK632.4; WBGene00014013.
GeneIDi176388.
KEGGicel:CELE_ZK632.4.
UCSCiZK632.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22181 Genomic DNA. Translation: CAA80181.3.
PIRiS40936.
RefSeqiNP_499174.3. NM_066773.4.
UniGeneiCel.9546.

3D structure databases

ProteinModelPortaliP34650.
SMRiP34650. Positions 2-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.ZK632.4.

Proteomic databases

PaxDbiP34650.
PRIDEiP34650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK632.4; ZK632.4; WBGene00014013.
GeneIDi176388.
KEGGicel:CELE_ZK632.4.
UCSCiZK632.4. c. elegans.

Organism-specific databases

CTDi176388.
WormBaseiZK632.4; CE36417; WBGene00014013.

Phylogenomic databases

eggNOGiCOG1482.
GeneTreeiENSGT00390000016075.
HOGENOMiHOG000241277.
InParanoidiP34650.
KOiK01809.
OMAiKIFSRIW.
OrthoDBiEOG7GTT3M.
PhylomeDBiP34650.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00423.
ReactomeiREACT_284408. Synthesis of GDP-mannose.

Miscellaneous databases

NextBioi892362.
PROiP34650.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMPI_CAEEL
AccessioniPrimary (citable) accession number: P34650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 16, 2004
Last modified: April 1, 2015
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.