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P34650 (MPI_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable mannose-6-phosphate isomerase
EC=5.3.1.8
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name=PMI
Gene names
ORF Names:ZK632.4
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the mannose-6-phosphate isomerase type 1 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmannose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Probable mannose-6-phosphate isomerase
PRO_0000194233

Sites

Active site2781 By similarity
Metal binding991Zinc By similarity
Metal binding1011Zinc By similarity
Metal binding1261Zinc By similarity
Metal binding2591Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P34650 [UniParc].

Last modified August 16, 2004. Version 3.
Checksum: 1C7DEDEE85DB8459

FASTA41646,384
        10         20         30         40         50         60 
MLLKLKCTVN NYAWGPKGNS SMAGSLALDG GHIPNLDKDK PYAEFWVGTH ANGPAHVIEK 

        70         80         90        100        110        120 
DIALKQLLAT SPELQGKHEK GNLSFLFKVL SVLGPLSIQI HPTKEQGKLL HATDPKNYPD 

       130        140        150        160        170        180 
DNHKPEIAIA LTEFELLSGF RQHSQISEYL KLYSEIQELL TEEEKSQIDS LGSYGESSAQ 

       190        200        210        220        230        240 
VLKKIFSRIW RTPKEKLQIV VDKLARRIQG HENKTALDEI IVYLFTLYPG DVGVFAPIFL 

       250        260        270        280        290        300 
NYFKLQPGEA TFLEPNMPHA YLKGDCVECM ADSDNTIRAG LTPKYIDVES LVEMLNYDET 

       310        320        330        340        350        360 
LLPKYIPNEL DDGSLLFTPR GIDEFWVQEV KGPAGSIYQL PYSESCSVLT VLYGTATVTL 

       370        380        390        400        410 
GDASQVLNRG EVVFIGATHD AERPKINISD DFLAFRAFTP SPRALESLSN KRLIID

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z22181 Genomic DNA. Translation: CAA80181.3.
PIRS40936.
RefSeqNP_499174.3. NM_066773.4.

3D structure databases

ProteinModelPortalP34650.
SMRP34650. Positions 2-398.
ModBaseSearch...

Protein-protein interaction databases

STRING6239.ZK632.4.

Proteomic databases

PaxDbP34650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK632.4; ZK632.4; ZK632.4.
GeneID176388.
KEGGcel:CELE_ZK632.4.
UCSCZK632.4. c. elegans.

Organism-specific databases

CTD176388.
WormBaseZK632.4; CE36417; WBGene00014013.

Phylogenomic databases

eggNOGCOG1482.
GeneTreeENSGT00390000016075.
HOGENOMHOG000241277.
InParanoidP34650.
KOK01809.
OMAGLPKAEM.

Enzyme and pathway databases

UniPathwayUPA00126; UER00423.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR10309. PTHR10309. 1 hit.
PfamPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSPR00714. MAN6PISMRASE.
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMsTIGR00218. manA. 1 hit.
PROSITEPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio892362.

Entry information

Entry nameMPI_CAEEL
AccessionPrimary (citable) accession number: P34650
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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