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P34650

- MPI_CAEEL

UniProt

P34650 - MPI_CAEEL

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Protein

Probable mannose-6-phosphate isomerase

Gene

ZK632.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi99 – 991ZincBy similarity
Metal bindingi101 – 1011ZincBy similarity
Metal bindingi126 – 1261ZincBy similarity
Metal bindingi259 – 2591ZincBy similarity
Active sitei278 – 2781By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_183021. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
ORF Names:ZK632.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiZK632.4; CE36417; WBGene00014013.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Probable mannose-6-phosphate isomerasePRO_0000194233Add
BLAST

Proteomic databases

PaxDbiP34650.
PRIDEiP34650.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK632.4.

Structurei

3D structure databases

ProteinModelPortaliP34650.
SMRiP34650. Positions 2-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
GeneTreeiENSGT00390000016075.
HOGENOMiHOG000241277.
InParanoidiP34650.
KOiK01809.
OMAiPYAEFWV.
OrthoDBiEOG7GTT3M.
PhylomeDBiP34650.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34650-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLKLKCTVN NYAWGPKGNS SMAGSLALDG GHIPNLDKDK PYAEFWVGTH
60 70 80 90 100
ANGPAHVIEK DIALKQLLAT SPELQGKHEK GNLSFLFKVL SVLGPLSIQI
110 120 130 140 150
HPTKEQGKLL HATDPKNYPD DNHKPEIAIA LTEFELLSGF RQHSQISEYL
160 170 180 190 200
KLYSEIQELL TEEEKSQIDS LGSYGESSAQ VLKKIFSRIW RTPKEKLQIV
210 220 230 240 250
VDKLARRIQG HENKTALDEI IVYLFTLYPG DVGVFAPIFL NYFKLQPGEA
260 270 280 290 300
TFLEPNMPHA YLKGDCVECM ADSDNTIRAG LTPKYIDVES LVEMLNYDET
310 320 330 340 350
LLPKYIPNEL DDGSLLFTPR GIDEFWVQEV KGPAGSIYQL PYSESCSVLT
360 370 380 390 400
VLYGTATVTL GDASQVLNRG EVVFIGATHD AERPKINISD DFLAFRAFTP
410
SPRALESLSN KRLIID
Length:416
Mass (Da):46,384
Last modified:August 16, 2004 - v3
Checksum:i1C7DEDEE85DB8459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22181 Genomic DNA. Translation: CAA80181.3.
PIRiS40936.
RefSeqiNP_499174.3. NM_066773.4.
UniGeneiCel.9546.

Genome annotation databases

EnsemblMetazoaiZK632.4; ZK632.4; WBGene00014013.
GeneIDi176388.
KEGGicel:CELE_ZK632.4.
UCSCiZK632.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22181 Genomic DNA. Translation: CAA80181.3 .
PIRi S40936.
RefSeqi NP_499174.3. NM_066773.4.
UniGenei Cel.9546.

3D structure databases

ProteinModelPortali P34650.
SMRi P34650. Positions 2-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.ZK632.4.

Proteomic databases

PaxDbi P34650.
PRIDEi P34650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai ZK632.4 ; ZK632.4 ; WBGene00014013 .
GeneIDi 176388.
KEGGi cel:CELE_ZK632.4.
UCSCi ZK632.4. c. elegans.

Organism-specific databases

CTDi 176388.
WormBasei ZK632.4 ; CE36417 ; WBGene00014013 .

Phylogenomic databases

eggNOGi COG1482.
GeneTreei ENSGT00390000016075.
HOGENOMi HOG000241277.
InParanoidi P34650.
KOi K01809.
OMAi PYAEFWV.
OrthoDBi EOG7GTT3M.
PhylomeDBi P34650.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .
Reactomei REACT_183021. Synthesis of GDP-mannose.

Miscellaneous databases

NextBioi 892362.
PROi P34650.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMPI_CAEEL
AccessioniPrimary (citable) accession number: P34650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3