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P34650

- MPI_CAEEL

UniProt

P34650 - MPI_CAEEL

Protein

Probable mannose-6-phosphate isomerase

Gene

ZK632.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi99 – 991ZincBy similarity
    Metal bindingi101 – 1011ZincBy similarity
    Metal bindingi126 – 1261ZincBy similarity
    Metal bindingi259 – 2591ZincBy similarity
    Active sitei278 – 2781By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_183021. Synthesis of GDP-mannose.
    UniPathwayiUPA00126; UER00423.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    ORF Names:ZK632.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiZK632.4; CE36417; WBGene00014013.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Probable mannose-6-phosphate isomerasePRO_0000194233Add
    BLAST

    Proteomic databases

    PaxDbiP34650.
    PRIDEiP34650.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.ZK632.4.

    Structurei

    3D structure databases

    ProteinModelPortaliP34650.
    SMRiP34650. Positions 2-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    GeneTreeiENSGT00390000016075.
    HOGENOMiHOG000241277.
    InParanoidiP34650.
    KOiK01809.
    OMAiPYAEFWV.
    OrthoDBiEOG7GTT3M.
    PhylomeDBiP34650.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR10309. PTHR10309. 1 hit.
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSiPR00714. MAN6PISMRASE.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 1 hit.
    PROSITEiPS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34650-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLKLKCTVN NYAWGPKGNS SMAGSLALDG GHIPNLDKDK PYAEFWVGTH    50
    ANGPAHVIEK DIALKQLLAT SPELQGKHEK GNLSFLFKVL SVLGPLSIQI 100
    HPTKEQGKLL HATDPKNYPD DNHKPEIAIA LTEFELLSGF RQHSQISEYL 150
    KLYSEIQELL TEEEKSQIDS LGSYGESSAQ VLKKIFSRIW RTPKEKLQIV 200
    VDKLARRIQG HENKTALDEI IVYLFTLYPG DVGVFAPIFL NYFKLQPGEA 250
    TFLEPNMPHA YLKGDCVECM ADSDNTIRAG LTPKYIDVES LVEMLNYDET 300
    LLPKYIPNEL DDGSLLFTPR GIDEFWVQEV KGPAGSIYQL PYSESCSVLT 350
    VLYGTATVTL GDASQVLNRG EVVFIGATHD AERPKINISD DFLAFRAFTP 400
    SPRALESLSN KRLIID 416
    Length:416
    Mass (Da):46,384
    Last modified:August 16, 2004 - v3
    Checksum:i1C7DEDEE85DB8459
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22181 Genomic DNA. Translation: CAA80181.3.
    PIRiS40936.
    RefSeqiNP_499174.3. NM_066773.4.
    UniGeneiCel.9546.

    Genome annotation databases

    EnsemblMetazoaiZK632.4; ZK632.4; WBGene00014013.
    GeneIDi176388.
    KEGGicel:CELE_ZK632.4.
    UCSCiZK632.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22181 Genomic DNA. Translation: CAA80181.3 .
    PIRi S40936.
    RefSeqi NP_499174.3. NM_066773.4.
    UniGenei Cel.9546.

    3D structure databases

    ProteinModelPortali P34650.
    SMRi P34650. Positions 2-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.ZK632.4.

    Proteomic databases

    PaxDbi P34650.
    PRIDEi P34650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai ZK632.4 ; ZK632.4 ; WBGene00014013 .
    GeneIDi 176388.
    KEGGi cel:CELE_ZK632.4.
    UCSCi ZK632.4. c. elegans.

    Organism-specific databases

    CTDi 176388.
    WormBasei ZK632.4 ; CE36417 ; WBGene00014013 .

    Phylogenomic databases

    eggNOGi COG1482.
    GeneTreei ENSGT00390000016075.
    HOGENOMi HOG000241277.
    InParanoidi P34650.
    KOi K01809.
    OMAi PYAEFWV.
    OrthoDBi EOG7GTT3M.
    PhylomeDBi P34650.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00423 .
    Reactomei REACT_183021. Synthesis of GDP-mannose.

    Miscellaneous databases

    NextBioi 892362.
    PROi P34650.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR10309. PTHR10309. 1 hit.
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSi PR00714. MAN6PISMRASE.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 1 hit.
    PROSITEi PS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMPI_CAEEL
    AccessioniPrimary (citable) accession number: P34650
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3