P34616 (CADH3_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 109.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Cadherin-3 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Reference proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis![]() |
Protein attributes
| Sequence length | 3343 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Cell adhesion protein involved in the control of epithelial morphogenesis. Ref.3 |
| Subcellular location | Cell membrane; Single-pass type I membrane protein Potential. Cell junction By similarity. |
| Domain | Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity. |
| Sequence similarities | Contains 11 cadherin domains. Contains 1 laminin G-like domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 26 | 26 | Potential | ||||||||
| Chain | 27 – 3343 | 3317 | Cadherin-3 | PRO_0000004020 | |||||||
Regions | |||||||||||
| Topological domain | 27 – 3228 | 3202 | Extracellular Potential | ||||||||
| Transmembrane | 3229 – 3250 | 22 | Helical; Potential | ||||||||
| Topological domain | 3251 – 3343 | 93 | Cytoplasmic Potential | ||||||||
| Domain | 28 – 117 | 90 | Cadherin 1 | ||||||||
| Domain | 118 – 229 | 112 | Cadherin 2 | ||||||||
| Domain | 242 – 330 | 89 | Cadherin 3 | ||||||||
| Domain | 632 – 738 | 107 | Cadherin 4 | ||||||||
| Domain | 1279 – 1368 | 90 | Cadherin 5 | ||||||||
| Domain | 1545 – 1648 | 104 | Cadherin 6 | ||||||||
| Domain | 1676 – 1756 | 81 | Cadherin 7 | ||||||||
| Domain | 1757 – 1857 | 101 | Cadherin 8 | ||||||||
| Domain | 1954 – 2045 | 92 | Cadherin 9 | ||||||||
| Domain | 2046 – 2145 | 100 | Cadherin 10 | ||||||||
| Domain | 2146 – 2245 | 100 | Cadherin 11 | ||||||||
| Domain | 3040 – 3205 | 166 | Laminin G-like | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 22 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 149 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 250 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 288 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 369 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 467 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 612 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 752 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 806 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 941 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 966 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 970 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 985 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1042 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1335 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1425 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1429 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1557 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1563 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1597 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1624 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1695 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1702 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1895 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 1900 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2053 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2129 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2203 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2382 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2391 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2410 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2414 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2431 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2527 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2530 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2564 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2621 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2665 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2712 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2798 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2809 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2927 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 2976 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3045 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3222 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 3225 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 3172 ↔ 3205 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. Wohldman P.Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [2] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [3] | "cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans." Pettitt J., Wood W.B., Plasterk R.H. Development 122:4149-4157(1996) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | FO080308 Genomic DNA. Translation: CCD62768.1. |
| PIR | S44887. |
| RefSeq | NP_498687.1. NM_066286.3. |
3D structure databases | |
| ProteinModelPortal | P34616. |
| SMR | P34616. Positions 30-419, 627-831, 1564-1930, 1963-2324, 2960-3027. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 6239.ZK112.7. |
Proteomic databases | |
| PaxDb | P34616. |
| PRIDE | P34616. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | ZK112.7; ZK112.7; ZK112.7. |
| GeneID | 176085. |
| KEGG | cel:CELE_ZK112.7. |
| UCSC | ZK112.7. c. elegans. |
Organism-specific databases | |
| CTD | 176085. |
| WormBase | ZK112.7; CE00378; WBGene00000395; cdh-3. |
Phylogenomic databases | |
| eggNOG | NOG12793. |
| GeneTree | ENSGT00700000104170. |
| HOGENOM | HOG000015891. |
| InParanoid | P34616. |
| OMA | GWITVAG. |
Gene expression databases | |
| ArrayExpress | P34616. |
Family and domain databases | |
| Gene3D | 2.60.120.200. 1 hit. 2.60.40.60. 13 hits. |
| InterPro | IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR001791. Laminin_G. [Graphical view] |
| Pfam | PF00028. Cadherin. 7 hits. PF02210. Laminin_G_2. 1 hit. [Graphical view] |
| PRINTS | PR00205. CADHERIN. |
| SMART | SM00112. CA. 13 hits. SM00181. EGF. 1 hit. SM00282. LamG. 1 hit. [Graphical view] |
| SUPFAM | SSF49313. Cadherin. 14 hits. SSF49899. ConA_like_lec_gl. 1 hit. |
| PROSITE | PS00232. CADHERIN_1. 8 hits. PS50268. CADHERIN_2. 11 hits. PS50025. LAM_G_DOMAIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 891046. |
Entry information
| Entry name | CADH3_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P34616 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with
