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P34616 (CADH3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cadherin-3
Gene names
Name:cdh-3
ORF Names:ZK112.7
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length3343 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cell adhesion protein involved in the control of epithelial morphogenesis. Ref.3

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential. Cell junction By similarity.

Sequence similarities

Contains 11 cadherin domains.

Contains 1 laminin G-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 33433317Cadherin-3
PRO_0000004020

Regions

Topological domain27 – 32283202Extracellular Potential
Transmembrane3229 – 325022Helical; Potential
Topological domain3251 – 334393Cytoplasmic Potential
Domain28 – 11790Cadherin 1
Domain118 – 229112Cadherin 2
Domain242 – 33089Cadherin 3
Domain632 – 738107Cadherin 4
Domain1279 – 136890Cadherin 5
Domain1545 – 1648104Cadherin 6
Domain1676 – 175681Cadherin 7
Domain1757 – 1857101Cadherin 8
Domain1954 – 204592Cadherin 9
Domain2046 – 2145100Cadherin 10
Domain2146 – 2245100Cadherin 11
Domain3040 – 3205166Laminin G-like

Amino acid modifications

Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation1491N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2881N-linked (GlcNAc...) Potential
Glycosylation3691N-linked (GlcNAc...) Potential
Glycosylation4671N-linked (GlcNAc...) Potential
Glycosylation6121N-linked (GlcNAc...) Potential
Glycosylation7521N-linked (GlcNAc...) Potential
Glycosylation8061N-linked (GlcNAc...) Potential
Glycosylation9411N-linked (GlcNAc...) Potential
Glycosylation9661N-linked (GlcNAc...) Potential
Glycosylation9701N-linked (GlcNAc...) Potential
Glycosylation9851N-linked (GlcNAc...) Potential
Glycosylation10421N-linked (GlcNAc...) Potential
Glycosylation13351N-linked (GlcNAc...) Potential
Glycosylation14251N-linked (GlcNAc...) Potential
Glycosylation14291N-linked (GlcNAc...) Potential
Glycosylation15571N-linked (GlcNAc...) Potential
Glycosylation15631N-linked (GlcNAc...) Potential
Glycosylation15971N-linked (GlcNAc...) Potential
Glycosylation16241N-linked (GlcNAc...) Potential
Glycosylation16951N-linked (GlcNAc...) Potential
Glycosylation17021N-linked (GlcNAc...) Potential
Glycosylation18951N-linked (GlcNAc...) Potential
Glycosylation19001N-linked (GlcNAc...) Potential
Glycosylation20531N-linked (GlcNAc...) Potential
Glycosylation21291N-linked (GlcNAc...) Potential
Glycosylation22031N-linked (GlcNAc...) Potential
Glycosylation23821N-linked (GlcNAc...) Potential
Glycosylation23911N-linked (GlcNAc...) Potential
Glycosylation24101N-linked (GlcNAc...) Potential
Glycosylation24141N-linked (GlcNAc...) Potential
Glycosylation24311N-linked (GlcNAc...) Potential
Glycosylation25271N-linked (GlcNAc...) Potential
Glycosylation25301N-linked (GlcNAc...) Potential
Glycosylation25641N-linked (GlcNAc...) Potential
Glycosylation26211N-linked (GlcNAc...) Potential
Glycosylation26651N-linked (GlcNAc...) Potential
Glycosylation27121N-linked (GlcNAc...) Potential
Glycosylation27981N-linked (GlcNAc...) Potential
Glycosylation28091N-linked (GlcNAc...) Potential
Glycosylation29271N-linked (GlcNAc...) Potential
Glycosylation29761N-linked (GlcNAc...) Potential
Glycosylation30451N-linked (GlcNAc...) Potential
Glycosylation32221N-linked (GlcNAc...) Potential
Glycosylation32251N-linked (GlcNAc...) Potential
Disulfide bond3172 ↔ 3205 By similarity

Sequences

Sequence LengthMass (Da)Tools
P34616 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 063E6F17FCC15D18

FASTA3,343375,752
        10         20         30         40         50         60 
MTIRIFFSIF LLNHLIFFHL FNFTHQFSEE TIKFSVSEDA KLNTIIGHLE AEIGYTYRLS 

        70         80         90        100        110        120 
RGNSKIKFDE QTLELSVSSP LDRESENAID MLIITSPPSI IHILIDVLDV NDNSPIFPID 

       130        140        150        160        170        180 
VQRVEIPETA PIGWRVQISG ATDPDEGKNG TIGKYELVDS LATVDTMSPF GIVQSDGFLF 

       190        200        210        220        230        240 
LEVTGKLDRE TRDLYSMRLT AIDQGVPELS SSCHLNILIL DINDNPPNFG IRSLTLNWNG 

       250        260        270        280        290        300 
LPNTKLFSLN ATDLDSNENS LLTYRILPSG PTSEMFSISD ENILVTQNNT ECLQRCEFVV 

       310        320        330        340        350        360 
EARDSGVPPL STTLNIVVNM EYGNEHEPNI NIRFYPSDYP FIIVQPEDVN GKTLAILSIT 

       370        380        390        400        410        420 
DSDGPLGANS TIWIENGNEQ SIFSLISRQS INILTVKHVE NANQEQYILE FRANDGQSPA 

       430        440        450        460        470        480 
DRITRKELKI FFKKYVKSTQ IHVERESHVT VEKDTVPGSF VAHVETNCTD MCSFELANSD 

       490        500        510        520        530        540 
VFKIDPFNGI IVTSSILPEG VTSYHLPIRI HLPPPSTQLV EADVFVKVIQ ESVPKNLIRS 

       550        560        570        580        590        600 
SESPIHLKRA YTFTTWQDVS LGTVIGRLPK AQIYSTIDTV SELGVFPDGS VFVGKTITSD 

       610        620        630        640        650        660 
FVTLPVTLVN RNTTQTSIIT LIVKPLNQHS PICQITEIHV LENAPIGTIF GRIQARDEDS 

       670        680        690        700        710        720 
GLSGVVSYKI LTKSDDYDGI FHLDSTSGSL RSLKAFDAEK KRSYTFEYEA KDLGTPSKTT 

       730        740        750        760        770        780 
NCPATIFIED VNDNVPKFGS RYYTATISGK SNETVAIVQA NDNDVDVKNQ KLQYHLLNYH 

       790        800        810        820        830        840 
DFFQLDKETG KVTTIQDVPM TWQRLNISIS AVNMDSERFL QSKTFLLVTV TSSSKLAVQL 

       850        860        870        880        890        900 
NSGNLIRIFK NDKIGEKVGH LDIASSETVY WSTLDPRLHV DSSGNIILIR RNAKQASTGF 

       910        920        930        940        950        960 
DIILTSENGE KTEKVNFEVE FVDSERSEDV EKVMDIVLNE NTTEVSNLMN DWKNWKISRV 

       970        980        990       1000       1010       1020 
ILENANNSGN NTFFLEHKKL WRTKNATVSN AYIILESEDQ EGSPKSFKLL HVTTSPSPSS 

      1030       1040       1050       1060       1070       1080 
ESSCISPAHL ISPPSTVPLP SNCSNVKLQN LKTSLQIHEN NLLIPTQSEL INHVDLVSTQ 

      1090       1100       1110       1120       1130       1140 
NSDMKPFMMT LIKDYLSEDV RFSTNNVLML LSSIHPIGTS FGRVTAESGY RIRYYIVGTD 

      1150       1160       1170       1180       1190       1200 
KISIDADTGE LILKERFYRN LNDILIVAVI PKGIAKAKIT IEVIEDRLIL PQSNFFIPSP 

      1210       1220       1230       1240       1250       1260 
PSFNSKSKIG KIPIDRDDVT IDVIDEHFYV RNFEIFVKRH FIPNSNFYDL KGTVKKGKLS 

      1270       1280       1290       1300       1310       1320 
APISVTLFFG EKMKSREIRE NELMFEIEEN SPIGTVVGVV PNSDTTKYRL VDPTCGLLID 

      1330       1340       1350       1360       1370       1380 
QEGIIRTTTV FDRENTSLLK TKMIEPSENR IWNLLIFIAD VNDNKPKILN APGRIIVYDD 

      1390       1400       1410       1420       1430       1440 
LNYKLEWEDL DAIASDVSFS IVDGDVFGNL EIEDSGVISL NSIPNESFNA TIRIYDNRPP 

      1450       1460       1470       1480       1490       1500 
FKVHFDDVTI EFQVTQKLRA VTCEDAEFWM FFGNEDVGML IASEIVTWRI VPQIGSDSFK 

      1510       1520       1530       1540       1550       1560 
IDPITGIIQS TPNTKPTSDI AKLKIQAISY DGERVGFCDV KIHIDKAAFV ENVVLSNGTF 

      1570       1580       1590       1600       1610       1620 
EFNISETADR FTEVGKIVIL GAGLEGSVFR IQDNDYNFTI SPFDGTIFTN SPLDFENIKT 

      1630       1640       1650       1660       1670       1680 
YRFNITAGKS TSQVIIHVTD ENDEAPRFIT GDVVNLKVLE ELDTVSYPLI IGSSIAEDLD 

      1690       1700       1710       1720       1730       1740 
EGQNGLVTYS ILSGNTSLFA VNSTTGDILS LIPLDREESS LHELLIEAKD AGIPSLSATS 

      1750       1760       1770       1780       1790       1800 
KILIHVGDIN DNTPEFELSS YFIKISENSK IGSKIIRILA TDKDKDAELQ YSLESNDEIT 

      1810       1820       1830       1840       1850       1860 
IPFRINVATG WITVAGKVNR EENEEFRFFV KVTDGEKSSK VIVEIHVEDF NDNHPMINDR 

      1870       1880       1890       1900       1910       1920 
NSDIFVPDPT RSVEIIHVIN VHDLDKSDHL KFSLNNSNLN LSENGEITLK SPLQTAVPVR 

      1930       1940       1950       1960       1970       1980 
VTVSDDAGHV AFMEYLFHPH SRKHFPVFVE KLDTVSVREH DEQELAVFKA NGDSIRYSIV 

      1990       2000       2010       2020       2030       2040 
SRCSDHLEME KSTGILKTKS SLDAEEYSEC LVFIIATTYF DNKPLSTITK ATIKIVDIND 

      2050       2060       2070       2080       2090       2100 
NSPRFDQQLY RFNVTENSGP KLIGHVIARD IDRSSRVFYE IVGGDANHEF MVTESGQIES 

      2110       2120       2130       2140       2150       2160 
VRDLDRETKS EYHLIVEAID DGKPRRRGNT TVIVTVLDED DNAPRFSRIF HVEVPEDVRI 

      2170       2180       2190       2200       2210       2220 
GEPVIQLSAS DADEHSNHRF ELDGGGEGIP FRVDENTGMV FVNDSLDFEK KQSYRIKVKL 

      2230       2240       2250       2260       2270       2280 
TDGAWLIETS LFVNVKDVND NAPIFEKPEY LFISEENSAE IGQFHASDMD SENNGKIRYS 

      2290       2300       2310       2320       2330       2340 
VTSPYFKIEP STGVLSRFRQ QLPQPLMSLK VTATDHGVPR LQKTVLAHLV DKSSFGKIKQ 

      2350       2360       2370       2380       2390       2400 
RRIRETTKVG DVIGKKIDSG ATIFPLDVAT VTRDGDVVLK KNATQFWILE NDTIYEFVKT 

      2410       2420       2430       2440       2450       2460 
DAMESTKNEN ITLNITSDIS MNSDNFKVLR NGSLIVFGFS GNQAHLKIQC DDGFWPKQDR 

      2470       2480       2490       2500       2510       2520 
KIINLVVNNL DADRNSFPLA RQPTIRKSMS LPKTMILNIP FDSPTGTIIW KNLENAVQYM 

      2530       2540       2550       2560       2570       2580 
ENQKNVNFSN GSKNLILKTP LEETMQIDIF GQNFERSALT ITPNRSLMAC PVFQKNFYFF 

      2590       2600       2610       2620       2630       2640 
ESVANLDSKH PTEIHNFGWS SDEIKGCQID IFDKTHLFYQ NGSSLIFLKP LLPGTYQFSL 

      2650       2660       2670       2680       2690       2700 
QIKSQSDSKI RSACHVVVTV IPPTNLTTWN IPSVIFATRN YNIPNLFHLP SGYSLSSDQR 

      2710       2720       2730       2740       2750       2760 
TFSLIGSGTG KNISKLSSGV YQVNVVGKDE KKEIVRILLD DVADDVTSKD IEYHVVSSTL 

      2770       2780       2790       2800       2810       2820 
SNLKIPTPID VECFPRTEEN LYEITKDCRL LFNSDVINTT IPVVTSPANS TWNLRIINES 

      2830       2840       2850       2860       2870       2880 
PETVKSLENN AVSLEIITQK SSIPRLITDL RVTYSDMKIY CLGTWQTSED IKYHITFVIV 

      2890       2900       2910       2920       2930       2940 
DRNGVVIEES EARQTLTSFL KKHRPGYLDF VDFDKDPCDG VTCIQKNSTC QPTLVGDSAS 

      2950       2960       2970       2980       2990       3000 
RLVSRSSSVI FDLPLKKLTA RCFCSSGIDC YDDTTNETIQ KTQKINVITT CDDIDCGPRG 

      3010       3020       3030       3040       3050       3060 
KCFMEESSQP ICRCGQGFES MYSCERADDV FSMSTGGSVE ISVRNGTSHL LKCSENCDGR 

      3070       3080       3090       3100       3110       3120 
DIQKIEFDFR TVQLEKSELF RVDFGKQVAL IELIGGSLTF SITDAYARPI ETRIEKRVND 

      3130       3140       3150       3160       3170       3180 
GRWHRLLFQM SEDGRRISIQ VNGRGKEVKS RVPLQMLFTA KKIQLMTPAA FCFRRLLAQN 

      3190       3200       3210       3220       3230       3240 
QFVHPILNRN KFFEISSTGT SRNECQFDSI QSGSGGFRLF SNFSNTTTLI LLITLALISL 

      3250       3260       3270       3280       3290       3300 
IGFSVCLLAI RRRWRQKSPG DQKQTERSNG WTGHVMPRRR GHINRSMVKS PDDDTYDVAT 

      3310       3320       3330       3340 
VYGMKSTSTD DITHIYTSSS SRRYQPPTAP SYRRDGHINM AYL

« Hide

References

« Hide 'large scale' references
[1]"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. expand/collapse author list , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.
Nature 368:32-38(1994) [PubMed: 7906398] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans."
Pettitt J., Wood W.B., Plasterk R.H.
Development 122:4149-4157(1996) [PubMed: 9012534] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO080308 Genomic DNA. Translation: CCD62768.1.
PIRS44887.
RefSeqNP_498687.1. NM_066286.2.
UniGeneCel.9582.

3D structure databases

ProteinModelPortalP34616.
SMRP34616. Positions 22-432, 623-830, 1270-1366, 1483-2467, 2959-3146.
ModBaseSearch...

Proteomic databases

PRIDEP34616.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaZK112.7; ZK112.7; ZK112.7.
GeneID176085.
KEGGcel:ZK112.7.
NMPDRfig|6239.3.peg.10611.
UCSCZK112.7. c. elegans.

Organism-specific databases

CTD176085.
WormBaseZK112.7; CE00378; WBGene00000395; cdh-3.

Phylogenomic databases

eggNOGKOG1219.
HOGENOMHBG382161.
InParanoidP34616.
OMADGHINMA.
PhylomeDBP34616.

Gene expression databases

ArrayExpressP34616.

Family and domain databases

InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl.
IPR013320. ConA-like_subgrp.
IPR006210. EGF-like.
IPR013032. EGF-like_reg_CS.
IPR001791. Laminin_G.
IPR012680. Laminin_G_2.
[Graphical view]
Gene3DG3DSA:2.60.40.60. Cadherin. 14 hits.
G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.
PfamPF00028. Cadherin. 7 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 13 hits.
SM00181. EGF. 1 hit.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMSSF49313. Cadherin. 14 hits.
SSF49899. ConA_like_lec_gl. 1 hit.
PROSITEPS00232. CADHERIN_1. 8 hits.
PS50268. CADHERIN_2. 11 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891046.

Entry information

Entry nameCADH3_CAEEL
AccessionPrimary (citable) accession number: P34616
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 14, 2011
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents