P34605 (TPPC3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable trafficking protein particle complex subunit 3

Gene names

ORF Names:

ZK1098.5

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in vesicular transport from endoplasmic reticulum to Golgi By similarity.
Subunit structure	Homodimer. Part of the multisubunit TRAPP (transport protein particle) complex By similarity.
Subcellular location	Golgi apparatus › cis-Golgi network By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the TRAPP small subunits family. BET3 subfamily.

Ontologies

Keywords
Biological process	ER-Golgi transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from mutant phenotype. Source: WormBase body morphogenesis Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase positive regulation of multicellular organism growth Inferred from mutant phenotype. Source: WormBase reproduction Inferred from mutant phenotype. Source: WormBase vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
F36D4.2	Q20100	6	EBI-312149,EBI-321262
R102.5B	Q9U389	2	EBI-312149,EBI-312154

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Probable trafficking protein particle complex subunit 3		PRO_0000211577
Amino acid modifications
	Lipidation	70	1	S-palmitoyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P34605 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 58340B5911AEDB3C	FASTA	181	19,699
	10 20 30 40 50 60 MSKAIKQNLA DSKKMSAELF CLTYGAMVTE MLKDYEDPKD VTIQLDKMGF NMGTRLADDF 70 80 90 100 110 120 LAKNANVPRC VDTRQIADVL CRNAIPCYLG ISATASSWTS GDREFTITLE ANPLTELVQV 130 140 150 160 170 180 PAHLVSAGLS YSQLIAGAIR GALEAVHFKV YASATDTGAN TEIRIRFDQV LKDSLPAGED D

References

[1]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z22176 Genomic DNA. Translation: CAA80133.1.
PIR	S40928.
RefSeq	NP_499100.1. NM_066699.3.
UniGene	Cel.34302.
3D structure databases
ProteinModelPortal	P34605.
SMR	P34605. Positions 10-172.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-25615N.
IntAct	P34605. 7 interactions.
MINT	MINT-1054072.
STRING	P34605.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK1098.5.1; ZK1098.5.1; ZK1098.5. ZK1098.5.2; ZK1098.5.2; ZK1098.5.
GeneID	176344.
KEGG	cel:ZK1098.5.
NMPDR	fig|6239.3.peg.11178.
UCSC	ZK1098.5. c. elegans.
Organism-specific databases
CTD	176344.
WormBase	ZK1098.5; CE00368; WBGene00014222.
Phylogenomic databases
eggNOG	meNOG10003.
GeneTree	EMGT00050000007312.
HOGENOM	HBG381378.
InParanoid	P34605.
OMA	EIRMKFI.
PhylomeDB	P34605.
Gene expression databases
ArrayExpress	P34605.
Family and domain databases
InterPro	IPR024096. NO_sig/Golgi_transp_ligand-bd. IPR007194. TRAPP_component. IPR016721. TRAPP_I_complex_Bet3. [Graphical view]
PANTHER	PTHR13048. PTHR13048. 1 hit.
Pfam	PF04051. TRAPP. 1 hit. [Graphical view]
PIRSF	PIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAM	SSF111126. Haem_NO-bd. 1 hit.
ProtoNet	Search...
Other
NextBio	892168.

Entry information

Entry name

TPPC3_CAEEL

Accession

Primary (citable) accession number: P34605

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project