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P34579

- UNC47_CAEEL

UniProt

P34579 - UNC47_CAEEL

Protein

Vesicular GABA transporter

Gene

unc-47

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (11 Jul 2001)
      Previous versions | rss
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    Functioni

    Involved in the uptake of GABA into the synaptic vesicles.1 Publication

    GO - Biological processi

    1. neurotransmitter transport Source: UniProtKB-KW

    Keywords - Biological processi

    Neurotransmitter transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_183019. GABA synthesis, release, reuptake and degradation.

    Protein family/group databases

    TCDBi2.A.18.5.1. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicular GABA transporter
    Alternative name(s):
    Uncoordinated protein 47
    Short name:
    Protein unc-47
    Gene namesi
    Name:unc-47
    ORF Names:T20G5.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiT20G5.6; CE25119; WBGene00006783; unc-47.

    Subcellular locationi

    Cytoplasmic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. synaptic vesicle Source: WormBase

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi462 – 4621G → R in N2409; loss of GABA transport into synaptic vesicles. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Vesicular GABA transporterPRO_0000093824Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP34579.

    Structurei

    3D structure databases

    ProteinModelPortaliP34579.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 1195Lumenal, vesicleSequence Analysis
    Topological domaini141 – 16727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini189 – 20315Lumenal, vesicleSequence AnalysisAdd
    BLAST
    Topological domaini225 – 2284CytoplasmicSequence Analysis
    Topological domaini250 – 26314Lumenal, vesicleSequence AnalysisAdd
    BLAST
    Topological domaini285 – 30521CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 34115Lumenal, vesicleSequence AnalysisAdd
    BLAST
    Topological domaini363 – 39836CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini420 – 4212Lumenal, vesicleSequence Analysis
    Topological domaini443 – 45715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini479 – 4868Lumenal, vesicleSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei306 – 32621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    GeneTreeiENSGT00490000043380.
    HOGENOMiHOG000220837.
    InParanoidiP34579.
    KOiK15015.
    OMAiSLREWAV.
    OrthoDBiEOG7SR4M2.
    PhylomeDBiP34579.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34579-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASNRFQNLQ NWTNKHVFSN SLDYWNQELN EVPSYQNQPQ TGESGSNPPP    50
    HDRLEPIQES VVSEQPQKDD INKQEEAKDD GHGEASEPIS ALQAAWNVTN 100
    AIQGMFIVGL PIAVKVGGWW SIGAMVGVAY VCYWTGVLLI ECLYENGVKK 150
    RKTYREIADF YKPGFGKWVL AAQLTELLST CIIYLVLAAD LLQSCFPSVD 200
    KAGWMMITSA SLLTCSFLDD LQIVSRLSFF NAISHLIVNL IMVLYCLSFV 250
    SQWSFSTITF SLNINTLPTI VGMVVFGYTS HIFLPNLEGN MKNPAQFNVM 300
    LKWSHIAAAV FKVVFGMLGF LTFGELTQEE ISNSLPNQSF KILVNLILVV 350
    KALLSYPLPF YAAVQLLKNN LFLGYPQTPF TSCYSPDKSL REWAVTLRII 400
    LVLFTLFVAL SVPYLVELMG LVGNITGTML SFIWPALFHL YIKEKTLNNF 450
    EKRFDQGIII MGCSVCISGV YFSSMELLRA INSADS 486
    Length:486
    Mass (Da):54,439
    Last modified:July 11, 2001 - v2
    Checksum:i6435C3B338552925
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031935 mRNA. Translation: AAB87066.1.
    Z30423 Genomic DNA. Translation: CAA83006.2.
    PIRiS42372.
    T42254.
    RefSeqiNP_499255.1. NM_066854.5.
    UniGeneiCel.19679.

    Genome annotation databases

    EnsemblMetazoaiT20G5.6.1; T20G5.6.1; WBGene00006783.
    T20G5.6.2; T20G5.6.2; WBGene00006783.
    GeneIDi176431.
    KEGGicel:CELE_T20G5.6.
    UCSCiT20G5.6.2. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031935 mRNA. Translation: AAB87066.1 .
    Z30423 Genomic DNA. Translation: CAA83006.2 .
    PIRi S42372.
    T42254.
    RefSeqi NP_499255.1. NM_066854.5.
    UniGenei Cel.19679.

    3D structure databases

    ProteinModelPortali P34579.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.18.5.1. the amino acid/auxin permease (aaap) family.

    Proteomic databases

    PaxDbi P34579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T20G5.6.1 ; T20G5.6.1 ; WBGene00006783 .
    T20G5.6.2 ; T20G5.6.2 ; WBGene00006783 .
    GeneIDi 176431.
    KEGGi cel:CELE_T20G5.6.
    UCSCi T20G5.6.2. c. elegans.

    Organism-specific databases

    CTDi 176431.
    WormBasei T20G5.6 ; CE25119 ; WBGene00006783 ; unc-47.

    Phylogenomic databases

    eggNOGi COG0814.
    GeneTreei ENSGT00490000043380.
    HOGENOMi HOG000220837.
    InParanoidi P34579.
    KOi K15015.
    OMAi SLREWAV.
    OrthoDBi EOG7SR4M2.
    PhylomeDBi P34579.

    Enzyme and pathway databases

    Reactomei REACT_183019. GABA synthesis, release, reuptake and degradation.

    Miscellaneous databases

    NextBioi 892552.
    PROi P34579.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the vesicular GABA transporter."
      McIntire S.L., Reimer R.J., Schuske K., Edwards R.H., Jorgensen E.M.
      Nature 389:870-876(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-462.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUNC47_CAEEL
    AccessioniPrimary (citable) accession number: P34579
    Secondary accession number(s): O17475
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: July 11, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3