Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicular GABA transporter

Gene

unc-47

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the uptake of GABA into the synaptic vesicles.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.
R-CEL-888590. GABA synthesis, release, reuptake and degradation.

Protein family/group databases

TCDBi2.A.18.5.1. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular GABA transporter
Alternative name(s):
Uncoordinated protein 47
Short name:
Protein unc-47
Gene namesi
Name:unc-47
ORF Names:T20G5.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT20G5.6; CE25119; WBGene00006783; unc-47.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 93CytoplasmicSequence analysisAdd BLAST93
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 119Lumenal, vesicleSequence analysis5
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Topological domaini141 – 167CytoplasmicSequence analysisAdd BLAST27
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 203Lumenal, vesicleSequence analysisAdd BLAST15
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 228CytoplasmicSequence analysis4
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 263Lumenal, vesicleSequence analysisAdd BLAST14
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 305CytoplasmicSequence analysisAdd BLAST21
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 341Lumenal, vesicleSequence analysisAdd BLAST15
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 398CytoplasmicSequence analysisAdd BLAST36
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 421Lumenal, vesicleSequence analysis2
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 457CytoplasmicSequence analysisAdd BLAST15
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Topological domaini479 – 486Lumenal, vesicleSequence analysis8

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • synaptic vesicle Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi462G → R in N2409; loss of GABA transport into synaptic vesicles. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938241 – 486Vesicular GABA transporterAdd BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi337N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP34579.

Expressioni

Gene expression databases

BgeeiWBGene00006783.

Interactioni

Protein-protein interaction databases

STRINGi6239.T20G5.6.2.

Structurei

3D structure databases

ProteinModelPortaliP34579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4303. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00490000043380.
HOGENOMiHOG000220837.
InParanoidiP34579.
KOiK15015.
OMAiPFTSCYS.
OrthoDBiEOG091G05MY.
PhylomeDBiP34579.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNRFQNLQ NWTNKHVFSN SLDYWNQELN EVPSYQNQPQ TGESGSNPPP
60 70 80 90 100
HDRLEPIQES VVSEQPQKDD INKQEEAKDD GHGEASEPIS ALQAAWNVTN
110 120 130 140 150
AIQGMFIVGL PIAVKVGGWW SIGAMVGVAY VCYWTGVLLI ECLYENGVKK
160 170 180 190 200
RKTYREIADF YKPGFGKWVL AAQLTELLST CIIYLVLAAD LLQSCFPSVD
210 220 230 240 250
KAGWMMITSA SLLTCSFLDD LQIVSRLSFF NAISHLIVNL IMVLYCLSFV
260 270 280 290 300
SQWSFSTITF SLNINTLPTI VGMVVFGYTS HIFLPNLEGN MKNPAQFNVM
310 320 330 340 350
LKWSHIAAAV FKVVFGMLGF LTFGELTQEE ISNSLPNQSF KILVNLILVV
360 370 380 390 400
KALLSYPLPF YAAVQLLKNN LFLGYPQTPF TSCYSPDKSL REWAVTLRII
410 420 430 440 450
LVLFTLFVAL SVPYLVELMG LVGNITGTML SFIWPALFHL YIKEKTLNNF
460 470 480
EKRFDQGIII MGCSVCISGV YFSSMELLRA INSADS
Length:486
Mass (Da):54,439
Last modified:July 11, 2001 - v2
Checksum:i6435C3B338552925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031935 mRNA. Translation: AAB87066.1.
Z30423 Genomic DNA. Translation: CAA83006.2.
PIRiS42372.
T42254.
RefSeqiNP_499255.1. NM_066854.5.
UniGeneiCel.19679.

Genome annotation databases

EnsemblMetazoaiT20G5.6.1; T20G5.6.1; WBGene00006783.
T20G5.6.2; T20G5.6.2; WBGene00006783.
GeneIDi176431.
KEGGicel:CELE_T20G5.6.
UCSCiT20G5.6.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031935 mRNA. Translation: AAB87066.1.
Z30423 Genomic DNA. Translation: CAA83006.2.
PIRiS42372.
T42254.
RefSeqiNP_499255.1. NM_066854.5.
UniGeneiCel.19679.

3D structure databases

ProteinModelPortaliP34579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T20G5.6.2.

Protein family/group databases

TCDBi2.A.18.5.1. the amino acid/auxin permease (aaap) family.

Proteomic databases

PaxDbiP34579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT20G5.6.1; T20G5.6.1; WBGene00006783.
T20G5.6.2; T20G5.6.2; WBGene00006783.
GeneIDi176431.
KEGGicel:CELE_T20G5.6.
UCSCiT20G5.6.2. c. elegans.

Organism-specific databases

CTDi176431.
WormBaseiT20G5.6; CE25119; WBGene00006783; unc-47.

Phylogenomic databases

eggNOGiKOG4303. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00490000043380.
HOGENOMiHOG000220837.
InParanoidiP34579.
KOiK15015.
OMAiPFTSCYS.
OrthoDBiEOG091G05MY.
PhylomeDBiP34579.

Enzyme and pathway databases

ReactomeiR-CEL-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.
R-CEL-888590. GABA synthesis, release, reuptake and degradation.

Miscellaneous databases

PROiP34579.

Gene expression databases

BgeeiWBGene00006783.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUNC47_CAEEL
AccessioniPrimary (citable) accession number: P34579
Secondary accession number(s): O17475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.