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P34579

- UNC47_CAEEL

UniProt

P34579 - UNC47_CAEEL

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Protein

Vesicular GABA transporter

Gene

unc-47

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the uptake of GABA into the synaptic vesicles.1 Publication

GO - Biological processi

  1. neurotransmitter transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiREACT_183019. GABA synthesis, release, reuptake and degradation.
REACT_260204. Transport of inorganic cations/anions and amino acids/oligopeptides.

Protein family/group databases

TCDBi2.A.18.5.1. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular GABA transporter
Alternative name(s):
Uncoordinated protein 47
Short name:
Protein unc-47
Gene namesi
Name:unc-47
ORF Names:T20G5.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiT20G5.6; CE25119; WBGene00006783; unc-47.

Subcellular locationi

Cytoplasmic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 1195Lumenal, vesicleSequence Analysis
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 16727CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 20315Lumenal, vesicleSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Topological domaini225 – 2284CytoplasmicSequence Analysis
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Topological domaini250 – 26314Lumenal, vesicleSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Topological domaini285 – 30521CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence AnalysisAdd
BLAST
Topological domaini327 – 34115Lumenal, vesicleSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 39836CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Topological domaini420 – 4212Lumenal, vesicleSequence Analysis
Transmembranei422 – 44221HelicalSequence AnalysisAdd
BLAST
Topological domaini443 – 45715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST
Topological domaini479 – 4868Lumenal, vesicleSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. synaptic vesicle Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi462 – 4621G → R in N2409; loss of GABA transport into synaptic vesicles. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Vesicular GABA transporterPRO_0000093824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP34579.

Structurei

3D structure databases

ProteinModelPortaliP34579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00490000043380.
HOGENOMiHOG000220837.
InParanoidiP34579.
KOiK15015.
OMAiSLREWAV.
OrthoDBiEOG7SR4M2.
PhylomeDBiP34579.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34579-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASNRFQNLQ NWTNKHVFSN SLDYWNQELN EVPSYQNQPQ TGESGSNPPP
60 70 80 90 100
HDRLEPIQES VVSEQPQKDD INKQEEAKDD GHGEASEPIS ALQAAWNVTN
110 120 130 140 150
AIQGMFIVGL PIAVKVGGWW SIGAMVGVAY VCYWTGVLLI ECLYENGVKK
160 170 180 190 200
RKTYREIADF YKPGFGKWVL AAQLTELLST CIIYLVLAAD LLQSCFPSVD
210 220 230 240 250
KAGWMMITSA SLLTCSFLDD LQIVSRLSFF NAISHLIVNL IMVLYCLSFV
260 270 280 290 300
SQWSFSTITF SLNINTLPTI VGMVVFGYTS HIFLPNLEGN MKNPAQFNVM
310 320 330 340 350
LKWSHIAAAV FKVVFGMLGF LTFGELTQEE ISNSLPNQSF KILVNLILVV
360 370 380 390 400
KALLSYPLPF YAAVQLLKNN LFLGYPQTPF TSCYSPDKSL REWAVTLRII
410 420 430 440 450
LVLFTLFVAL SVPYLVELMG LVGNITGTML SFIWPALFHL YIKEKTLNNF
460 470 480
EKRFDQGIII MGCSVCISGV YFSSMELLRA INSADS
Length:486
Mass (Da):54,439
Last modified:July 11, 2001 - v2
Checksum:i6435C3B338552925
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031935 mRNA. Translation: AAB87066.1.
Z30423 Genomic DNA. Translation: CAA83006.2.
PIRiS42372.
T42254.
RefSeqiNP_499255.1. NM_066854.5.
UniGeneiCel.19679.

Genome annotation databases

EnsemblMetazoaiT20G5.6.1; T20G5.6.1; WBGene00006783.
T20G5.6.2; T20G5.6.2; WBGene00006783.
GeneIDi176431.
KEGGicel:CELE_T20G5.6.
UCSCiT20G5.6.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031935 mRNA. Translation: AAB87066.1 .
Z30423 Genomic DNA. Translation: CAA83006.2 .
PIRi S42372.
T42254.
RefSeqi NP_499255.1. NM_066854.5.
UniGenei Cel.19679.

3D structure databases

ProteinModelPortali P34579.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.18.5.1. the amino acid/auxin permease (aaap) family.

Proteomic databases

PaxDbi P34579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T20G5.6.1 ; T20G5.6.1 ; WBGene00006783 .
T20G5.6.2 ; T20G5.6.2 ; WBGene00006783 .
GeneIDi 176431.
KEGGi cel:CELE_T20G5.6.
UCSCi T20G5.6.2. c. elegans.

Organism-specific databases

CTDi 176431.
WormBasei T20G5.6 ; CE25119 ; WBGene00006783 ; unc-47.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00490000043380.
HOGENOMi HOG000220837.
InParanoidi P34579.
KOi K15015.
OMAi SLREWAV.
OrthoDBi EOG7SR4M2.
PhylomeDBi P34579.

Enzyme and pathway databases

Reactomei REACT_183019. GABA synthesis, release, reuptake and degradation.
REACT_260204. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

NextBioi 892552.
PROi P34579.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the vesicular GABA transporter."
    McIntire S.L., Reimer R.J., Schuske K., Edwards R.H., Jorgensen E.M.
    Nature 389:870-876(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-462.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUNC47_CAEEL
AccessioniPrimary (citable) accession number: P34579
Secondary accession number(s): O17475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2001
Last modified: November 26, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3