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P34578

- RPGF1_CAEEL

UniProt

P34578 - RPGF1_CAEEL

Protein

Rap guanine nucleotide exchange factor 1

Gene

epac-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 140131cNMP 1Add
    BLAST
    Nucleotide bindingi375 – 492118cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. cAMP-dependent protein kinase regulator activity Source: InterPro
    2. guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rap guanine nucleotide exchange factor 1
    Alternative name(s):
    Exchange protein activated by cyclic AMP 1
    Gene namesi
    Name:epac-1
    ORF Names:T20G5.5
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiT20G5.5; CE43630; WBGene00004255; epac-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cAMP-dependent protein kinase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10381038Rap guanine nucleotide exchange factor 1PRO_0000068900Add
    BLAST

    Proteomic databases

    PRIDEiP34578.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.T20G5.5.

    Structurei

    3D structure databases

    ProteinModelPortaliP34578.
    SMRiP34578. Positions 218-481, 695-784, 798-1028.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini234 – 31683DEPPROSITE-ProRule annotationAdd
    BLAST
    Domaini516 – 654139N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini795 – 1028234Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0664.
    GeneTreeiENSGT00750000117452.
    HOGENOMiHOG000230545.
    InParanoidiP34578.
    KOiK04351.
    OMAiVTSVTII.
    OrthoDBiEOG7ZD1TF.
    PhylomeDBiP34578.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.840.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProiIPR002373. cAMP/cGMP_kin.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR000591. DEP_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF00610. DEP. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    PRINTSiPR00103. CAMPKINASE.
    SMARTiSM00100. cNMP. 2 hits.
    SM00049. DEP. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 2 hits.
    SSF51206. SSF51206. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS50186. DEP. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34578-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERIVSRVRR LSPLHTFSDA LLISLLSESD FQPDSIQQGV VLFEKDEPTE     50
    YWYLLLSGEV QLYSKTYTGD FNHLKTLRCG ALFGDLSTLT HSCSCLVTRP 100
    AQLIRIAQNH FLSVYNKHGD HLQPFIIIMH DILTDETPSD PIHPHSSGLF 150
    NGQRSMDLIS TEINPSEIVS VSTNGMLSKM ILPSIPNQRE KPMNRVVVNQ 200
    QKNEERNFIE FHNPTGIEKQ IRDSGGILHR KMLTDNHQVI RDITTEHTRV 250
    QNCMIGAEMI DWLLTLFVST STTCSSLSRI QMSAIWQVLL NNGLISHIDG 300
    EHQFLDKTNS YYRWVQQFRS RNKVAPSIEE VSKSITLLSS VAPETLFLMI 350
    VSKPGFERSP EELEVVYEEL TFIKALSHLS TMVKRQLSNF VKVEQYVHAG 400
    SVVFRQGEIG VYWYIVLKGA VEVNVNGKIV CLLREGDDFG KLALVNDLPR 450
    AATIVTYEDD SMFLVVDKHH FNQILHQVEA NTVRLKDYGE DVLVLEKVDI 500
    PRGAALENSN SCNFNCGYSV MAGKAEKILE YVLETRIDAL GDDISELDVF 550
    VEDFILTHDA FMPDNTVCNF LKSYYFRTPY RATRDSITDS CTEEVRCKRR 600
    VVQFVYVWCS LLRVNFFLNP VTNSFVEELF CHVIDDRKRL GGMEDILTRI 650
    GSIRSTRENM QLVLARHPAI VLDCGVLSAH TPCPVLPSDV CNQIIYLADT 700
    TCFVLPIRVD KTAEEICELS RRRMSFSAEP LNLVEVKSNG EKLIFSPNDR 750
    AIPTVLSLNS KLYVVNREEI PLLVPMEDQN GPTPSSHSSI LHLIDSQELA 800
    HQLFLFHLQL LRSTDSNELL YQVIGRESFP LSMPFNLDLL VRRFNEVQHW 850
    STTEILLATE ENRMEILKKF ISIATIAREY RDLLTVFAIT LGLSHTSISR 900
    LTLTWSKLPP ASLKTFSELE NLLDPTRNHR MYRLLVSKMS SPYIPFVPLI 950
    LKDLMFIHQG NKSFYNGLVN FEKMHMFAKI FRSFRQCKSQ MDNGAEHEFI 1000
    EPQSLIRNLR VIDNQKKLMQ LSYEIEPKSA PKRNVIFH 1038
    Length:1,038
    Mass (Da):118,871
    Last modified:October 5, 2010 - v3
    Checksum:iE8356D9D44E05819
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z30423 Genomic DNA. Translation: CAA83013.3.
    PIRiS42368.
    RefSeqiNP_499256.2. NM_066855.3.
    UniGeneiCel.39285.

    Genome annotation databases

    EnsemblMetazoaiT20G5.5; T20G5.5; WBGene00004255.
    GeneIDi176432.
    KEGGicel:CELE_T20G5.5.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z30423 Genomic DNA. Translation: CAA83013.3 .
    PIRi S42368.
    RefSeqi NP_499256.2. NM_066855.3.
    UniGenei Cel.39285.

    3D structure databases

    ProteinModelPortali P34578.
    SMRi P34578. Positions 218-481, 695-784, 798-1028.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T20G5.5.

    Proteomic databases

    PRIDEi P34578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T20G5.5 ; T20G5.5 ; WBGene00004255 .
    GeneIDi 176432.
    KEGGi cel:CELE_T20G5.5.

    Organism-specific databases

    CTDi 176432.
    WormBasei T20G5.5 ; CE43630 ; WBGene00004255 ; epac-1.

    Phylogenomic databases

    eggNOGi COG0664.
    GeneTreei ENSGT00750000117452.
    HOGENOMi HOG000230545.
    InParanoidi P34578.
    KOi K04351.
    OMAi VTSVTII.
    OrthoDBi EOG7ZD1TF.
    PhylomeDBi P34578.

    Miscellaneous databases

    NextBioi 892556.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.840.10. 1 hit.
    2.60.120.10. 2 hits.
    InterProi IPR002373. cAMP/cGMP_kin.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR000591. DEP_dom.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR014710. RmlC-like_jellyroll.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF00610. DEP. 1 hit.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00103. CAMPKINASE.
    SMARTi SM00100. cNMP. 2 hits.
    SM00049. DEP. 1 hit.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 2 hits.
    SSF51206. SSF51206. 2 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS50186. DEP. 1 hit.
    PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiRPGF1_CAEEL
    AccessioniPrimary (citable) accession number: P34578
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3