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P34578 (RPGF1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rap guanine nucleotide exchange factor 1
Alternative name(s):
Exchange protein activated by cyclic AMP 1
Gene names
Name:epac-1
ORF Names:T20G5.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1038 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Sequence similarities

Contains 2 cyclic nucleotide-binding domains.

Contains 1 DEP domain.

Contains 1 N-terminal Ras-GEF domain.

Contains 1 Ras-GEF domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10381038Rap guanine nucleotide exchange factor 1
PRO_0000068900

Regions

Domain234 – 31683DEP
Domain516 – 654139N-terminal Ras-GEF
Domain795 – 1028234Ras-GEF
Nucleotide binding10 – 140131cNMP 1
Nucleotide binding375 – 492118cNMP 2

Sequences

Sequence LengthMass (Da)Tools
P34578 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: E8356D9D44E05819

FASTA1,038118,871
        10         20         30         40         50         60 
MERIVSRVRR LSPLHTFSDA LLISLLSESD FQPDSIQQGV VLFEKDEPTE YWYLLLSGEV 

        70         80         90        100        110        120 
QLYSKTYTGD FNHLKTLRCG ALFGDLSTLT HSCSCLVTRP AQLIRIAQNH FLSVYNKHGD 

       130        140        150        160        170        180 
HLQPFIIIMH DILTDETPSD PIHPHSSGLF NGQRSMDLIS TEINPSEIVS VSTNGMLSKM 

       190        200        210        220        230        240 
ILPSIPNQRE KPMNRVVVNQ QKNEERNFIE FHNPTGIEKQ IRDSGGILHR KMLTDNHQVI 

       250        260        270        280        290        300 
RDITTEHTRV QNCMIGAEMI DWLLTLFVST STTCSSLSRI QMSAIWQVLL NNGLISHIDG 

       310        320        330        340        350        360 
EHQFLDKTNS YYRWVQQFRS RNKVAPSIEE VSKSITLLSS VAPETLFLMI VSKPGFERSP 

       370        380        390        400        410        420 
EELEVVYEEL TFIKALSHLS TMVKRQLSNF VKVEQYVHAG SVVFRQGEIG VYWYIVLKGA 

       430        440        450        460        470        480 
VEVNVNGKIV CLLREGDDFG KLALVNDLPR AATIVTYEDD SMFLVVDKHH FNQILHQVEA 

       490        500        510        520        530        540 
NTVRLKDYGE DVLVLEKVDI PRGAALENSN SCNFNCGYSV MAGKAEKILE YVLETRIDAL 

       550        560        570        580        590        600 
GDDISELDVF VEDFILTHDA FMPDNTVCNF LKSYYFRTPY RATRDSITDS CTEEVRCKRR 

       610        620        630        640        650        660 
VVQFVYVWCS LLRVNFFLNP VTNSFVEELF CHVIDDRKRL GGMEDILTRI GSIRSTRENM 

       670        680        690        700        710        720 
QLVLARHPAI VLDCGVLSAH TPCPVLPSDV CNQIIYLADT TCFVLPIRVD KTAEEICELS 

       730        740        750        760        770        780 
RRRMSFSAEP LNLVEVKSNG EKLIFSPNDR AIPTVLSLNS KLYVVNREEI PLLVPMEDQN 

       790        800        810        820        830        840 
GPTPSSHSSI LHLIDSQELA HQLFLFHLQL LRSTDSNELL YQVIGRESFP LSMPFNLDLL 

       850        860        870        880        890        900 
VRRFNEVQHW STTEILLATE ENRMEILKKF ISIATIAREY RDLLTVFAIT LGLSHTSISR 

       910        920        930        940        950        960 
LTLTWSKLPP ASLKTFSELE NLLDPTRNHR MYRLLVSKMS SPYIPFVPLI LKDLMFIHQG 

       970        980        990       1000       1010       1020 
NKSFYNGLVN FEKMHMFAKI FRSFRQCKSQ MDNGAEHEFI EPQSLIRNLR VIDNQKKLMQ 

      1030 
LSYEIEPKSA PKRNVIFH 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z30423 Genomic DNA. Translation: CAA83013.3.
PIRS42368.
RefSeqNP_499256.2. NM_066855.3.
UniGeneCel.39285.

3D structure databases

ProteinModelPortalP34578.
SMRP34578. Positions 1-1028.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.T20G5.5.

Proteomic databases

PRIDEP34578.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT20G5.5; T20G5.5; T20G5.5.
GeneID176432.
KEGGcel:CELE_T20G5.5.

Organism-specific databases

CTD176432.
WormBaseT20G5.5; CE43630; WBGene00004255; epac-1.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000230545.
InParanoidP34578.
KOK04351.
OMAVTSVTII.
OrthoDBEOG7ZD1TF.
PhylomeDBP34578.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProIPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR008937. Ras_GEF.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR014710. RmlC-like_jellyroll.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR23113. PTHR23113. 1 hit.
PfamPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSPR00103. CAMPKINASE.
SMARTSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio892556.

Entry information

Entry nameRPGF1_CAEEL
AccessionPrimary (citable) accession number: P34578
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase