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Protein

Rap guanine nucleotide exchange factor 1

Gene

epac-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 140131cNMP 1Add
BLAST
Nucleotide bindingi375 – 492118cNMP 2Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_307545. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_315288. Rap1 signalling.
REACT_353541. Integrin alphaIIb beta3 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Rap guanine nucleotide exchange factor 1
Alternative name(s):
Exchange protein activated by cyclic AMP 1
Gene namesi
Name:epac-1
ORF Names:T20G5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT20G5.5; CE43630; WBGene00004255; epac-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10381038Rap guanine nucleotide exchange factor 1PRO_0000068900Add
BLAST

Proteomic databases

PRIDEiP34578.

Interactioni

Protein-protein interaction databases

STRINGi6239.T20G5.5.

Structurei

3D structure databases

ProteinModelPortaliP34578.
SMRiP34578. Positions 218-545, 695-784, 798-1028.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 31683DEPPROSITE-ProRule annotationAdd
BLAST
Domaini516 – 654139N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini795 – 1028234Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0664.
GeneTreeiENSGT00780000121847.
HOGENOMiHOG000230545.
InParanoidiP34578.
KOiK04351.
OMAiWYIVLKG.
OrthoDBiEOG7ZD1TF.
PhylomeDBiP34578.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00103. CAMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERIVSRVRR LSPLHTFSDA LLISLLSESD FQPDSIQQGV VLFEKDEPTE
60 70 80 90 100
YWYLLLSGEV QLYSKTYTGD FNHLKTLRCG ALFGDLSTLT HSCSCLVTRP
110 120 130 140 150
AQLIRIAQNH FLSVYNKHGD HLQPFIIIMH DILTDETPSD PIHPHSSGLF
160 170 180 190 200
NGQRSMDLIS TEINPSEIVS VSTNGMLSKM ILPSIPNQRE KPMNRVVVNQ
210 220 230 240 250
QKNEERNFIE FHNPTGIEKQ IRDSGGILHR KMLTDNHQVI RDITTEHTRV
260 270 280 290 300
QNCMIGAEMI DWLLTLFVST STTCSSLSRI QMSAIWQVLL NNGLISHIDG
310 320 330 340 350
EHQFLDKTNS YYRWVQQFRS RNKVAPSIEE VSKSITLLSS VAPETLFLMI
360 370 380 390 400
VSKPGFERSP EELEVVYEEL TFIKALSHLS TMVKRQLSNF VKVEQYVHAG
410 420 430 440 450
SVVFRQGEIG VYWYIVLKGA VEVNVNGKIV CLLREGDDFG KLALVNDLPR
460 470 480 490 500
AATIVTYEDD SMFLVVDKHH FNQILHQVEA NTVRLKDYGE DVLVLEKVDI
510 520 530 540 550
PRGAALENSN SCNFNCGYSV MAGKAEKILE YVLETRIDAL GDDISELDVF
560 570 580 590 600
VEDFILTHDA FMPDNTVCNF LKSYYFRTPY RATRDSITDS CTEEVRCKRR
610 620 630 640 650
VVQFVYVWCS LLRVNFFLNP VTNSFVEELF CHVIDDRKRL GGMEDILTRI
660 670 680 690 700
GSIRSTRENM QLVLARHPAI VLDCGVLSAH TPCPVLPSDV CNQIIYLADT
710 720 730 740 750
TCFVLPIRVD KTAEEICELS RRRMSFSAEP LNLVEVKSNG EKLIFSPNDR
760 770 780 790 800
AIPTVLSLNS KLYVVNREEI PLLVPMEDQN GPTPSSHSSI LHLIDSQELA
810 820 830 840 850
HQLFLFHLQL LRSTDSNELL YQVIGRESFP LSMPFNLDLL VRRFNEVQHW
860 870 880 890 900
STTEILLATE ENRMEILKKF ISIATIAREY RDLLTVFAIT LGLSHTSISR
910 920 930 940 950
LTLTWSKLPP ASLKTFSELE NLLDPTRNHR MYRLLVSKMS SPYIPFVPLI
960 970 980 990 1000
LKDLMFIHQG NKSFYNGLVN FEKMHMFAKI FRSFRQCKSQ MDNGAEHEFI
1010 1020 1030
EPQSLIRNLR VIDNQKKLMQ LSYEIEPKSA PKRNVIFH
Length:1,038
Mass (Da):118,871
Last modified:October 5, 2010 - v3
Checksum:iE8356D9D44E05819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30423 Genomic DNA. Translation: CAA83013.3.
PIRiS42368.
RefSeqiNP_499256.2. NM_066855.3.
UniGeneiCel.39285.

Genome annotation databases

EnsemblMetazoaiT20G5.5; T20G5.5; WBGene00004255.
GeneIDi176432.
KEGGicel:CELE_T20G5.5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30423 Genomic DNA. Translation: CAA83013.3.
PIRiS42368.
RefSeqiNP_499256.2. NM_066855.3.
UniGeneiCel.39285.

3D structure databases

ProteinModelPortaliP34578.
SMRiP34578. Positions 218-545, 695-784, 798-1028.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T20G5.5.

Proteomic databases

PRIDEiP34578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT20G5.5; T20G5.5; WBGene00004255.
GeneIDi176432.
KEGGicel:CELE_T20G5.5.

Organism-specific databases

CTDi176432.
WormBaseiT20G5.5; CE43630; WBGene00004255; epac-1.

Phylogenomic databases

eggNOGiCOG0664.
GeneTreeiENSGT00780000121847.
HOGENOMiHOG000230545.
InParanoidiP34578.
KOiK04351.
OMAiWYIVLKG.
OrthoDBiEOG7ZD1TF.
PhylomeDBiP34578.

Enzyme and pathway databases

ReactomeiREACT_307545. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_315288. Rap1 signalling.
REACT_353541. Integrin alphaIIb beta3 signaling.

Miscellaneous databases

NextBioi892556.
PROiP34578.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.840.10. 1 hit.
2.60.120.10. 2 hits.
InterProiIPR002373. cAMP/cGMP_kin.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR000591. DEP_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR014710. RmlC-like_jellyroll.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF00610. DEP. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
PRINTSiPR00103. CAMPKINASE.
SMARTiSM00100. cNMP. 2 hits.
SM00049. DEP. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF51206. SSF51206. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS50186. DEP. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiRPGF1_CAEEL
AccessioniPrimary (citable) accession number: P34578
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 5, 2010
Last modified: May 27, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.