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P34575 (CISY_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable citrate synthase, mitochondrial

EC=2.3.3.1
Gene names
Name:cts-1
ORF Names:T20G5.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 468Probable citrate synthase, mitochondrialPRO_0000005470

Sites

Active site3031 By similarity
Active site3491 By similarity
Active site4041 By similarity

Sequences

Sequence LengthMass (Da)Tools
P34575 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: CDE40CCA5729B9EA

FASTA46851,540
        10         20         30         40         50         60 
MSLSGMAIRR LITKGVIPVC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV KSFRTEHGST 

        70         80         90        100        110        120 
VVQNVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI PECQKLLPKA KGGEEPLPEA 

       130        140        150        160        170        180 
IWWLLCTGDV PSEAQTAAIT KEWNARADLP THVVRMLDNF PDNLHPMAQF IAAIAALNNE 

       190        200        210        220        230        240 
SKFAGAYARG VAKASYWEYA YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA 

       250        260        270        280        290        300 
NFSSMLGYDD PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMAGLAG 

       310        320        330        340        350        360 
PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA VLRKTDPRYE 

       370        380        390        400        410        420 
CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW PNVDSHSGVL LQYFGMTEMS 

       430        440        450        460 
FYTVLFGVSR ALGCLSQLIW ARGMGLPLER PKSHSTDGLI KLALAAKK 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z30423 Genomic DNA. Translation: CAA83004.1.
PIRS42370.
RefSeqNP_499264.1. NM_066863.6.
UniGeneCel.17843.

3D structure databases

ProteinModelPortalP34575.
SMRP34575. Positions 32-462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.T20G5.2.2.

2D gel databases

World-2DPAGE0020:P34575.

Proteomic databases

PaxDbP34575.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT20G5.2.1; T20G5.2.1; T20G5.2.
T20G5.2.2; T20G5.2.2; T20G5.2.
GeneID176437.
KEGGcel:CELE_T20G5.2.
UCSCT20G5.2.1. c. elegans.

Organism-specific databases

CTD176437.
WormBaseT20G5.2; CE00513; WBGene00000833; cts-1.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000130831.
InParanoidP34575.
KOK01647.
OMAELIYEDC.
PhylomeDBP34575.

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01793. cit_synth_euk. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio892576.
PROP34575.

Entry information

Entry nameCISY_CAEEL
AccessionPrimary (citable) accession number: P34575
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase