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P34575

- CISY_CAEEL

UniProt

P34575 - CISY_CAEEL

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Protein

Probable citrate synthase, mitochondrial

Gene

cts-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei303 – 3031PROSITE-ProRule annotation
Active sitei349 – 3491PROSITE-ProRule annotation
Active sitei404 – 4041PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB
  2. cellular carbohydrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:cts-1
ORF Names:T20G5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiT20G5.2; CE00513; WBGene00000833; cts-1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB
  2. mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 468Probable citrate synthase, mitochondrialPRO_0000005470
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

PaxDbiP34575.

2D gel databases

World-2DPAGE0020:P34575.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.T20G5.2.2.

Structurei

3D structure databases

ProteinModelPortaliP34575.
SMRiP34575. Positions 32-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
GeneTreeiENSGT00390000006813.
HOGENOMiHOG000130831.
InParanoidiP34575.
KOiK01647.
OMAiELIYEDC.
PhylomeDBiP34575.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34575-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSGMAIRR LITKGVIPVC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV
60 70 80 90 100
KSFRTEHGST VVQNVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI
110 120 130 140 150
PECQKLLPKA KGGEEPLPEA IWWLLCTGDV PSEAQTAAIT KEWNARADLP
160 170 180 190 200
THVVRMLDNF PDNLHPMAQF IAAIAALNNE SKFAGAYARG VAKASYWEYA
210 220 230 240 250
YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA NFSSMLGYDD
260 270 280 290 300
PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMAGLAG
310 320 330 340 350
PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA
360 370 380 390 400
VLRKTDPRYE CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW
410 420 430 440 450
PNVDSHSGVL LQYFGMTEMS FYTVLFGVSR ALGCLSQLIW ARGMGLPLER
460
PKSHSTDGLI KLALAAKK
Length:468
Mass (Da):51,540
Last modified:February 1, 1994 - v1
Checksum:iCDE40CCA5729B9EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z30423 Genomic DNA. Translation: CAA83004.1.
PIRiS42370.
RefSeqiNP_499264.1. NM_066863.6.
UniGeneiCel.17843.

Genome annotation databases

EnsemblMetazoaiT20G5.2; T20G5.2; WBGene00000833.
GeneIDi176437.
KEGGicel:CELE_T20G5.2.
UCSCiT20G5.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z30423 Genomic DNA. Translation: CAA83004.1 .
PIRi S42370.
RefSeqi NP_499264.1. NM_066863.6.
UniGenei Cel.17843.

3D structure databases

ProteinModelPortali P34575.
SMRi P34575. Positions 32-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.T20G5.2.2.

2D gel databases

World-2DPAGE 0020:P34575.

Proteomic databases

PaxDbi P34575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T20G5.2 ; T20G5.2 ; WBGene00000833 .
GeneIDi 176437.
KEGGi cel:CELE_T20G5.2.
UCSCi T20G5.2.1. c. elegans.

Organism-specific databases

CTDi 176437.
WormBasei T20G5.2 ; CE00513 ; WBGene00000833 ; cts-1.

Phylogenomic databases

eggNOGi COG0372.
GeneTreei ENSGT00390000006813.
HOGENOMi HOG000130831.
InParanoidi P34575.
KOi K01647.
OMAi ELIYEDC.
PhylomeDBi P34575.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Miscellaneous databases

NextBioi 892576.
PROi P34575.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiCISY_CAEEL
AccessioniPrimary (citable) accession number: P34575
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 1, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3