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P34575

- CISY_CAEEL

UniProt

P34575 - CISY_CAEEL

Protein

Probable citrate synthase, mitochondrial

Gene

cts-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei303 – 3031PROSITE-ProRule annotation
    Active sitei349 – 3491PROSITE-ProRule annotation
    Active sitei404 – 4041PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB
    2. cellular carbohydrate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable citrate synthase, mitochondrial (EC:2.3.3.16)
    Gene namesi
    Name:cts-1
    ORF Names:T20G5.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiT20G5.2; CE00513; WBGene00000833; cts-1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB
    2. mitochondrion Source: WormBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 468Probable citrate synthase, mitochondrialPRO_0000005470
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiP34575.

    2D gel databases

    World-2DPAGE0020:P34575.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi6239.T20G5.2.2.

    Structurei

    3D structure databases

    ProteinModelPortaliP34575.
    SMRiP34575. Positions 32-462.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    GeneTreeiENSGT00390000006813.
    HOGENOMiHOG000130831.
    InParanoidiP34575.
    KOiK01647.
    OMAiELIYEDC.
    PhylomeDBiP34575.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34575-1 [UniParc]FASTAAdd to Basket

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    MSLSGMAIRR LITKGVIPVC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV    50
    KSFRTEHGST VVQNVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI 100
    PECQKLLPKA KGGEEPLPEA IWWLLCTGDV PSEAQTAAIT KEWNARADLP 150
    THVVRMLDNF PDNLHPMAQF IAAIAALNNE SKFAGAYARG VAKASYWEYA 200
    YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA NFSSMLGYDD 250
    PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMAGLAG 300
    PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA 350
    VLRKTDPRYE CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW 400
    PNVDSHSGVL LQYFGMTEMS FYTVLFGVSR ALGCLSQLIW ARGMGLPLER 450
    PKSHSTDGLI KLALAAKK 468
    Length:468
    Mass (Da):51,540
    Last modified:February 1, 1994 - v1
    Checksum:iCDE40CCA5729B9EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z30423 Genomic DNA. Translation: CAA83004.1.
    PIRiS42370.
    RefSeqiNP_499264.1. NM_066863.6.
    UniGeneiCel.17843.

    Genome annotation databases

    EnsemblMetazoaiT20G5.2; T20G5.2; WBGene00000833.
    GeneIDi176437.
    KEGGicel:CELE_T20G5.2.
    UCSCiT20G5.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z30423 Genomic DNA. Translation: CAA83004.1 .
    PIRi S42370.
    RefSeqi NP_499264.1. NM_066863.6.
    UniGenei Cel.17843.

    3D structure databases

    ProteinModelPortali P34575.
    SMRi P34575. Positions 32-462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.T20G5.2.2.

    2D gel databases

    World-2DPAGE 0020:P34575.

    Proteomic databases

    PaxDbi P34575.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T20G5.2 ; T20G5.2 ; WBGene00000833 .
    GeneIDi 176437.
    KEGGi cel:CELE_T20G5.2.
    UCSCi T20G5.2.1. c. elegans.

    Organism-specific databases

    CTDi 176437.
    WormBasei T20G5.2 ; CE00513 ; WBGene00000833 ; cts-1.

    Phylogenomic databases

    eggNOGi COG0372.
    GeneTreei ENSGT00390000006813.
    HOGENOMi HOG000130831.
    InParanoidi P34575.
    KOi K01647.
    OMAi ELIYEDC.
    PhylomeDBi P34575.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Miscellaneous databases

    NextBioi 892576.
    PROi P34575.

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiCISY_CAEEL
    AccessioniPrimary (citable) accession number: P34575
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3