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Protein

Probable citrate synthase, mitochondrial

Gene

cts-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable citrate synthase, mitochondrial (cts-1)
  2. Probable aconitate hydratase, mitochondrial (aco-2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei303PROSITE-ProRule annotation1
Active sitei349PROSITE-ProRule annotation1
Active sitei404PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

ReactomeiR-CEL-71403. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable citrate synthase, mitochondrial (EC:2.3.3.16)
Gene namesi
Name:cts-1
ORF Names:T20G5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT20G5.2; CE00513; WBGene00000833; cts-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005470? – 468Probable citrate synthase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiP34575.
PaxDbiP34575.
PeptideAtlasiP34575.
PRIDEiP34575.

2D gel databases

World-2DPAGEi0020:P34575.

Expressioni

Gene expression databases

BgeeiWBGene00000833.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.T20G5.2.2.

Structurei

3D structure databases

ProteinModelPortaliP34575.
SMRiP34575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2617. Eukaryota.
COG0372. LUCA.
GeneTreeiENSGT00890000140548.
HOGENOMiHOG000130831.
InParanoidiP34575.
KOiK01647.
OMAiTVGWCAQ.
OrthoDBiEOG091G068F.
PhylomeDBiP34575.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiView protein in InterPro
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR010109. Citrate_synthase_euk.
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiView protein in Pfam
PF00285. Citrate_synt. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00480. CITRATE_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34575-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSGMAIRR LITKGVIPVC QVAPLSTSAE GSTNLKEVLS KKIPAHNAKV
60 70 80 90 100
KSFRTEHGST VVQNVNIDMI YGGMRSMKGM VTETSVLDPE EGIRFRGYSI
110 120 130 140 150
PECQKLLPKA KGGEEPLPEA IWWLLCTGDV PSEAQTAAIT KEWNARADLP
160 170 180 190 200
THVVRMLDNF PDNLHPMAQF IAAIAALNNE SKFAGAYARG VAKASYWEYA
210 220 230 240 250
YEDSMDLLAK LPTVAAIIYR NLYRDGSAVS VIDPKKDWSA NFSSMLGYDD
260 270 280 290 300
PLFAELMRLY LVIHSDHEGG NVSAHTSHLV GSALSDPYLS FSAAMAGLAG
310 320 330 340 350
PLHGLANQEV LVFLNKIVGE IGFNYTEEQL KEWVWKHLKS GQVVPGYGHA
360 370 380 390 400
VLRKTDPRYE CQREFALKHL PNDDLFKLVS TLYKITPGIL LEQGKAKNPW
410 420 430 440 450
PNVDSHSGVL LQYFGMTEMS FYTVLFGVSR ALGCLSQLIW ARGMGLPLER
460
PKSHSTDGLI KLALAAKK
Length:468
Mass (Da):51,540
Last modified:February 1, 1994 - v1
Checksum:iCDE40CCA5729B9EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30423 Genomic DNA. Translation: CAA83004.1.
PIRiS42370.
RefSeqiNP_499264.1. NM_066863.6.
UniGeneiCel.17843.

Genome annotation databases

EnsemblMetazoaiT20G5.2; T20G5.2; WBGene00000833.
GeneIDi176437.
KEGGicel:CELE_T20G5.2.
UCSCiT20G5.2.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiCISY_CAEEL
AccessioniPrimary (citable) accession number: P34575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 30, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families