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Protein

General transcription factor IIH subunit 2

Gene

T16H12.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri286 – 30318C4-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-113418. Formation of the Early Elongation Complex.
R-CEL-5696395. Formation of Incision Complex in GG-NER.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-674695. RNA Polymerase II Pre-transcription Events.
R-CEL-6781823. Formation of TC-NER Pre-Incision Complex.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-CEL-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-CEL-72086. mRNA Capping.
R-CEL-73776. RNA Polymerase II Promoter Escape.
R-CEL-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-CEL-75953. RNA Polymerase II Transcription Initiation.
R-CEL-75955. RNA Polymerase II Transcription Elongation.
R-CEL-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-CEL-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 2
Alternative name(s):
TFIIH basal transcription factor complex subunit 2
Gene namesi
ORF Names:T16H12.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT16H12.4; CE29053; WBGene00011814.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376General transcription factor IIH subunit 2PRO_0000119250Add
BLAST

Proteomic databases

EPDiP34567.
PaxDbiP34567.

Interactioni

Subunit structurei

One of the subunits forming the core-TFIIH basal transcription factor.By similarity

Protein-protein interaction databases

BioGridi41615. 1 interaction.
IntActiP34567. 1 interaction.
MINTiMINT-1042120.
STRINGi6239.T16H12.4.1.

Structurei

3D structure databases

ProteinModelPortaliP34567.
SMRiP34567. Positions 60-242, 323-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 206143VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GTF2H2 family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri286 – 30318C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2807. Eukaryota.
COG5151. LUCA.
GeneTreeiENSGT00490000043395.
HOGENOMiHOG000159415.
InParanoidiP34567.
KOiK03142.
OMAiIRMGFPH.
OrthoDBiEOG7WQ7SP.
PhylomeDBiP34567.

Family and domain databases

InterProiIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
IPR000433. Znf_ZZ.
[Graphical view]
PANTHERiPTHR12695:SF2. PTHR12695:SF2. 1 hit.
PfamiPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00622. ssl1. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDEQKGYT WEAGYAEGLN INDVLVEDEG GSIEKSIAKY VADSKRKARL
60 70 80 90 100
TKRPERIRLG IMRHVMIVID CSRFMTSKAM PPSRFVVVMK ALQTFLDRFF
110 120 130 140 150
EQNPIAQIGL ITCKDRKADR LTMMTGNIRV LKESLNTLTE AFCGGDFSLQ
160 170 180 190 200
NALQLACANL KGMPGHVSRE VVLVISALST IDPGNIYSTI ETMKRMNIRC
210 220 230 240 250
SAIGLSAEMF VCKEMAKATK GEYSVALDPD HLQLLFSKHT LPPSSAKSSE
260 270 280 290 300
CNAIHVGFPH HELITTRSFC VCHPDTKPIS SRGFICTQCG ARHCSIPAEC
310 320 330 340 350
PVCKLTLVAA PQLARAFRHL QPLSAFEQIE VTRGFCYACE TRLSGEGFRC
360 370
GSCQLVFCLD CDTLLHESLH VCPGCN
Length:376
Mass (Da):41,611
Last modified:January 27, 2003 - v3
Checksum:i03E8CF77EA00766F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30662 Genomic DNA. Translation: CAA83139.3.
PIRiS42385.
RefSeqiNP_499239.1. NM_066838.3.
UniGeneiCel.10041.

Genome annotation databases

EnsemblMetazoaiT16H12.4.1; T16H12.4.1; WBGene00011814.
T16H12.4.2; T16H12.4.2; WBGene00011814.
GeneIDi176421.
KEGGicel:CELE_T16H12.4.
UCSCiT16H12.4.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30662 Genomic DNA. Translation: CAA83139.3.
PIRiS42385.
RefSeqiNP_499239.1. NM_066838.3.
UniGeneiCel.10041.

3D structure databases

ProteinModelPortaliP34567.
SMRiP34567. Positions 60-242, 323-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41615. 1 interaction.
IntActiP34567. 1 interaction.
MINTiMINT-1042120.
STRINGi6239.T16H12.4.1.

Proteomic databases

EPDiP34567.
PaxDbiP34567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT16H12.4.1; T16H12.4.1; WBGene00011814.
T16H12.4.2; T16H12.4.2; WBGene00011814.
GeneIDi176421.
KEGGicel:CELE_T16H12.4.
UCSCiT16H12.4.1. c. elegans.

Organism-specific databases

CTDi176421.
WormBaseiT16H12.4; CE29053; WBGene00011814.

Phylogenomic databases

eggNOGiKOG2807. Eukaryota.
COG5151. LUCA.
GeneTreeiENSGT00490000043395.
HOGENOMiHOG000159415.
InParanoidiP34567.
KOiK03142.
OMAiIRMGFPH.
OrthoDBiEOG7WQ7SP.
PhylomeDBiP34567.

Enzyme and pathway databases

ReactomeiR-CEL-113418. Formation of the Early Elongation Complex.
R-CEL-5696395. Formation of Incision Complex in GG-NER.
R-CEL-5696400. Dual Incision in GG-NER.
R-CEL-674695. RNA Polymerase II Pre-transcription Events.
R-CEL-6781823. Formation of TC-NER Pre-Incision Complex.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-CEL-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-CEL-72086. mRNA Capping.
R-CEL-73776. RNA Polymerase II Promoter Escape.
R-CEL-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-CEL-75953. RNA Polymerase II Transcription Initiation.
R-CEL-75955. RNA Polymerase II Transcription Elongation.
R-CEL-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-CEL-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

PROiP34567.

Family and domain databases

InterProiIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
IPR000433. Znf_ZZ.
[Graphical view]
PANTHERiPTHR12695:SF2. PTHR12695:SF2. 1 hit.
PfamiPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00622. ssl1. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiTF2H2_CAEEL
AccessioniPrimary (citable) accession number: P34567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 27, 2003
Last modified: June 8, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.