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Protein

Probable enoyl-CoA hydratase, mitochondrial

Gene

ech-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391Substrate; via amide nitrogenBy similarity
Sitei162 – 1621Important for catalytic activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
R-CEL-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
R-CEL-77348. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
R-CEL-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-CEL-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable enoyl-CoA hydratase, mitochondrial (EC:4.2.1.17)
Gene namesi
Name:ech-6
ORF Names:T05G5.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT05G5.6; CE00318; WBGene00001155; ech-6.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Probable enoyl-CoA hydratase, mitochondrialPRO_0000109262Add
BLAST

Proteomic databases

EPDiP34559.
PaxDbiP34559.
PRIDEiP34559.

2D gel databases

World-2DPAGE0011:P34559.
0020:P34559.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

BioGridi41571. 4 interactions.
DIPiDIP-26850N.
IntActiP34559. 4 interactions.
MINTiMINT-1058028.
STRINGi6239.T05G5.6.2.

Structurei

3D structure databases

ProteinModelPortaliP34559.
SMRiP34559. Positions 32-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni96 – 994Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1680. Eukaryota.
COG1024. LUCA.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000027939.
InParanoidiP34559.
KOiK07511.
OMAiSKAMEMV.
PhylomeDBiP34559.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRFSSMLVR NAKLCANVNQ MQVAAFSSKA PEMIKIEKVG EKQNVALIKL
60 70 80 90 100
NRPKALNALC AQLMTELADA LEVLDTDKSV GAIVITGSER AFAAGADIKE
110 120 130 140 150
MTNNEFATTF SGSFLSNWTA VSDVKKPVIA AVNGFALGGG NELAMMCDII
160 170 180 190 200
YAGEKARFGQ PEINIGTIPG AGGTQRWARA AGKSFAMEVC LTGNHVTAQE
210 220 230 240 250
AKEHGIVSKI FPADQVVGEA VKLGEKIADQ SPLIVQMAKE AVNKAYELTL
260 270 280
QEGLHFERRL FHATFATKDR KEGMTAFAEK RKPQWESK
Length:288
Mass (Da):31,172
Last modified:February 1, 1994 - v1
Checksum:iB7DFE711455CDCF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27079 Genomic DNA. Translation: CAA81594.1.
PIRiS41006.
RefSeqiNP_499156.1. NM_066755.5.
UniGeneiCel.4890.

Genome annotation databases

EnsemblMetazoaiT05G5.6.1; T05G5.6.1; WBGene00001155.
T05G5.6.2; T05G5.6.2; WBGene00001155.
GeneIDi176376.
KEGGicel:CELE_T05G5.6.
UCSCiT05G5.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27079 Genomic DNA. Translation: CAA81594.1.
PIRiS41006.
RefSeqiNP_499156.1. NM_066755.5.
UniGeneiCel.4890.

3D structure databases

ProteinModelPortaliP34559.
SMRiP34559. Positions 32-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41571. 4 interactions.
DIPiDIP-26850N.
IntActiP34559. 4 interactions.
MINTiMINT-1058028.
STRINGi6239.T05G5.6.2.

2D gel databases

World-2DPAGE0011:P34559.
0020:P34559.

Proteomic databases

EPDiP34559.
PaxDbiP34559.
PRIDEiP34559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT05G5.6.1; T05G5.6.1; WBGene00001155.
T05G5.6.2; T05G5.6.2; WBGene00001155.
GeneIDi176376.
KEGGicel:CELE_T05G5.6.
UCSCiT05G5.6.1. c. elegans.

Organism-specific databases

CTDi176376.
WormBaseiT05G5.6; CE00318; WBGene00001155; ech-6.

Phylogenomic databases

eggNOGiKOG1680. Eukaryota.
COG1024. LUCA.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000027939.
InParanoidiP34559.
KOiK07511.
OMAiSKAMEMV.
PhylomeDBiP34559.

Enzyme and pathway databases

UniPathwayiUPA00659.
ReactomeiR-CEL-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
R-CEL-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
R-CEL-77348. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
R-CEL-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-CEL-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.

Miscellaneous databases

NextBioi892310.
PROiP34559.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiECHM_CAEEL
AccessioniPrimary (citable) accession number: P34559
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.