Reviewed, UniProtKB/Swiss-Prot P34548 (SQV3_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable galactosyltransferase sqv-3
    EC=2.4.1.-
Alternative name(s):
    Squashed vulva protein 3

Gene names

Name:	sqv-3
ORF Names:	R10E11.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the glycosyltransferase 7 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring glycosyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Probable galactosyltransferase sqv-3		PRO_0000080552
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 27	21	Signal-anchor for type II membrane protein Potential
	Topological domain	28 – 289	262	Lumenal Potential
Amino acid modifications
	Glycosylation	81	1	N-linked (GlcNAc...) Potential
	Glycosylation	90	1	N-linked (GlcNAc...) Potential
	Glycosylation	201	1	N-linked (GlcNAc...) Potential
Experimental info
	Mutagenesis	183	1	G → E in N2841. Ref.1
	Mutagenesis	275	1	V → F in N2823. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P34548-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 16C2C1F5AF35DC91	FASTA	289	33,807
	10 20 30 40 50 60 MKLKTRLILS GTILISLAAC YFLVLLVLDL EITRDLMTDY VDPRPLQTSY HKLCVIVPYR 70 80 90 100 110 120 DRLEELREFS PHMSKFLHNQ NVSHHILIIN QTDPLRFNRA SLINVGWNEA DRLGCDYMVM 130 140 150 160 170 180 NDVDLLPVNP EVPYDFPGIG VIRHITSPQY HPKYHYEKFI GGILMLTLKD YKKLNGMSNK 190 200 210 220 230 240 YWGWGLEDDE FYLRIIDSKL NLTRVSGLST DSSNTFRHIH GPKRKRDYTP KKNDKNQWEI 250 260 270 280 KRKRDHVSGL HDVRYLIDSR QLLDFSGTSV TIINVALHCD LNWTPYCKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway." Herman T., Horvitz H.R. Proc. Natl. Acad. Sci. U.S.A. 96:974-979(1999) [PubMed: 9927678] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF GLY-183 AND PHE-275. Strain: Bristol N2.
[2]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ005867 mRNA. Translation: CAA06744.1. Z29095 Genomic DNA. Translation: CAA82350.1.
PIR	S40716.
RefSeq	NP_499164.1.
UniGene	Cel.6955
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT7. Glycosyltransferase Family 7.
Genome annotation databases
Ensembl	R10E11.4. Caenorhabditis elegans. [Contig view]
GeneID	176382.
KEGG	cel:R10E11.4.
NMPDR	fig|6239.3.peg.11262.
Organism-specific databases
WormBase	WBGene00005021. sqv-3.
WormPep	R10E11.4. CE00306. [WorfDB]
Phylogenomic databases
OMA	P34548. FRFNRAS.
Gene expression databases
ArrayExpress	P34548.
Family and domain databases
InterPro	IPR003859. Galactosyl_T_2. [Graphical view]
PANTHER	PTHR19300. Galactosyl_T_2. 1 hit.
Pfam	PF02709. Galactosyl_T_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	892340.

Entry information

Entry name

SQV3_CAEEL

Accession

Primary (citable) accession number: P34548

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project