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P34547 (UBPX_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase 46

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme
Ubiquitin thioesterase
Ubiquitin-specific-processing protease
Gene names
Name:usp-46
ORF Names:R10E11.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: P34547-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: P34547-2)

The sequence of this isoform differs from the canonical sequence as follows:
     32-43: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Potential
Chain2 – 426425Probable ubiquitin carboxyl-terminal hydrolase 46
PRO_0000080684

Regions

Domain27 – 406380USP

Sites

Active site361Nucleophile By similarity
Active site3421Proton acceptor By similarity

Amino acid modifications

Lipidation21N-myristoyl glycine Potential

Natural variations

Alternative sequence32 – 4312Missing in isoform b.
VSP_005268

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified December 4, 2007. Version 3.
Checksum: 1405021BDB5BA1AF

FASTA42648,277
        10         20         30         40         50         60 
MGATGSSQLE KEISTTESVN NANEHYYGLV NFGNTCYCNS VIQALFFCRP FREKVLNYKQ 

        70         80         90        100        110        120 
TLKKSGASKD NLVTCLADLF HSIASQKRRV GTIAPKRFIT KLKKENELFD NYMQQDAHEF 

       130        140        150        160        170        180 
FNYLINTISE TLIQEKIAER EKASRHGTLK KGNVTVNLAP ATAGLPRSDE KGTSERNGGI 

       190        200        210        220        230        240 
TVEGNEFLNK SDTTTWIHEI FQGILTNETR CLSCETVSSK DEDFLDLSID VEQNTSISHC 

       250        260        270        280        290        300 
LRVFSETETL CGDQKYFCET CSSKQEAQKR MRIKKPPQLL ALHLKRFKFV EPLNRHTKLS 

       310        320        330        340        350        360 
YRVVFPLELR LFNVSDDAEY GDRMYDLVAT VVHCGATPNR GHYITLVKSN SFWLVFDDDI 

       370        380        390        400        410        420 
VEKLEVSSME EFSGMSTDAN IQMPPGNQSA PQKNSESAYI LFYQARDYAA DDPNHNHKGK 


NSTHSV 

« Hide

Isoform b [UniParc].

Checksum: 7D7D0C014C061398
Show »

FASTA41446,947

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z29095 Genomic DNA. Translation: CAB54286.2.
Z29095 Genomic DNA. Translation: CAB54287.2.
PIRS40715.
RefSeqNP_499162.2. NM_066761.4. [P34547-1]
NP_499163.2. NM_066762.2. [P34547-2]
UniGeneCel.6955.

3D structure databases

ProteinModelPortalP34547.
SMRP34547. Positions 26-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41576. 2 interactions.
STRING6239.R10E11.3a.1.

Protein family/group databases

MEROPSC19.A37.

Proteomic databases

PaxDbP34547.
PRIDEP34547.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR10E11.3a.1; R10E11.3a.1; WBGene00011216. [P34547-1]
R10E11.3a.2; R10E11.3a.2; WBGene00011216. [P34547-1]
GeneID176381.
KEGGcel:CELE_R10E11.3.
UCSCR10E11.3a.1. c. elegans. [P34547-1]

Organism-specific databases

CTD176381.
WormBaseR10E11.3a; CE41150; WBGene00011216; usp-46.
R10E11.3b; CE41151; WBGene00011216; usp-46.

Phylogenomic databases

eggNOGCOG5077.
GeneTreeENSGT00650000093027.
HOGENOMHOG000231498.
InParanoidP34547.
KOK11842.
OMADANIQMP.
PhylomeDBP34547.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio892334.
PROP34547.

Entry information

Entry nameUBPX_CAEEL
AccessionPrimary (citable) accession number: P34547
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: June 11, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase