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Protein

Protein cbp-1

Gene

cbp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1 (PubMed:19521535).1 PublicationBy similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1284 – 12841Acetyl-CoA; via carbonyl oxygenBy similarity
Binding sitei1289 – 12891Acetyl-CoABy similarity
Binding sitei1293 – 12931Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri399 – 505107TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1493 – 153442ZZ-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1550 – 163182TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • histone acetyltransferase activity Source: WormBase
  • lysine N-acetyltransferase activity, acting on acetyl phosphate as donor Source: WormBase
  • RNA polymerase II sequence-specific DNA binding transcription factor binding Source: WormBase
  • transcription cofactor activity Source: WormBase
  • transcription factor binding Source: WormBase
  • zinc ion binding Source: InterPro

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • embryo development ending in birth or egg hatching Source: WormBase
  • histone acetylation Source: WormBase
  • internal peptidyl-lysine acetylation Source: WormBase
  • positive regulation of apoptotic process Source: WormBase
  • positive regulation of transcription from RNA polymerase II promoter Source: WormBase
  • regulation of neuron projection development Source: WormBase
  • regulation of transcription, DNA-templated Source: WormBase
  • spermatogenesis Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-CEL-3371568. Attenuation phase.
R-CEL-6781823. Formation of TC-NER Pre-Incision Complex.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
SignaLinkiP34545.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cbp-1 (EC:2.3.1.48By similarity)
Gene namesi
Name:cbp-1
ORF Names:R10E11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR10E11.1a; CE47039; WBGene00000366; cbp-1.
R10E11.1b; CE46860; WBGene00000366; cbp-1.
R10E11.1c; CE46909; WBGene00000366; cbp-1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi234 – 2341R → A: Loss of methylation by prmt-5. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20172017Protein cbp-1PRO_0000211189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341Symmetric dimethylarginine; by PRMT5; in vitro1 Publication

Post-translational modificationi

Methylation by prmt-5 may repress the capacity of cbp-1 to enhance cep-1-dependent transcription of egl-1.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

EPDiP34545.
PaxDbiP34545.
PRIDEiP34545.

PTM databases

iPTMnetiP34545.

Expressioni

Gene expression databases

ExpressionAtlasiP34545. baseline and differential.

Interactioni

Subunit structurei

Interacts (via N-terminus domain and HAT domain) with prmt-5; the interaction results in methylation of cbp-1 (PubMed:19521535). Interacts (via HAT domain) with cep-1; cep-1 transcriptional activity may be inhibited by interaction with methylated cbp-1 (PubMed:19521535). Component of a complex that contains prmt-5 and cbp-1 (PubMed:19521535).1 Publication1 Publication

GO - Molecular functioni

  • RNA polymerase II sequence-specific DNA binding transcription factor binding Source: WormBase
  • transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi41575. 5 interactions.
STRINGi6239.R10E11.1b.

Structurei

3D structure databases

ProteinModelPortaliP34545.
SMRiP34545. Positions 399-510, 596-679, 822-1488, 1552-1634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini593 – 67280KIXPROSITE-ProRule annotationAdd
BLAST
Domaini881 – 95373BromoPROSITE-ProRule annotationAdd
BLAST
Domaini1112 – 1492381CBP/p300-type HATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni902 – 94847Interaction with histoneBy similarityAdd
BLAST
Regioni1224 – 12263Interaction with histoneBy similarity
Regioni1225 – 12273Acetyl-CoA bindingBy similarity
Regioni1237 – 12382Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1687 – 2008322Gln/Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation
Contains 1 KIX domain.PROSITE-ProRule annotation
Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri399 – 505107TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1493 – 153442ZZ-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1550 – 163182TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Bromodomain, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1778. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000019113.
InParanoidiP34545.
KOiK04498.
OMAiMFESAND.
OrthoDBiEOG75B84F.

Family and domain databases

Gene3Di1.10.246.20. 1 hit.
1.20.1020.10. 2 hits.
1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR031162. CBP_P300_HAT.
IPR010303. DUF902_CREBbp.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR003101. KIX_dom.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. HAT_KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51727. CBP_P300_HAT. 1 hit.
PS50952. KIX. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: P34545-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDEPPSKKSR ADSDYDSGLD ALSALESLEA FPTSSKDTDV DNNPSTSAGG
60 70 80 90 100
SGGPSGSTPH PQGTPQPAPS NNGGFNLQPG QSQPQQPPQN MGGGVNGSVL
110 120 130 140 150
QELLMNPSQT SNNSPRPQAY PPGQQNAFNR SPMMPNGTPN MMSPPSMGRV
160 170 180 190 200
PGPSPGGPQP PGPGQPQMRP GQPGMFQGDQ QQQMMMGAQG QQFPGMMHRY
210 220 230 240 250
PYAQGGPPPG AQGMPQGYPG VSRGGPTPGQ PMGRGAMMNG AMPRSGPMPT
260 270 280 290 300
QGRPGIPPNQ QAMMQPMMTD RQFMQHGQYG QQRPEFMQQY GRPGGYPMMH
310 320 330 340 350
QGMMMDSNGQ PIRGPNQMMM MSNGHPGMSH GPPNGQPGPQ AAAAQHAAQQ
360 370 380 390 400
QAAAQAQAQA AAQQQQQQQR EQEAAAAAQR NGAGRATTPG SSMLATHQDP
410 420 430 440 450
EKRKLIQQQL VLLLHAHKCS QREKENRDFA AKNQPPPHAA CTLPHCSTMK
460 470 480 490 500
EVLTHMTSCN VGRLCHSDTT QTTKKCSVAH CASSRQIIAH WKNCSREDCP
510 520 530 540 550
VCKPLKRIQD TPLQFSLPDL ANLIGVNGNS NGSAEGDGLH QFGSPAMRTG
560 570 580 590 600
NITNSLFEGF NGNPFQNGPN RGGPRPPGGN GEIPNLPPPD MPDCTKEWHH
610 620 630 640 650
QVTKDLRNHL VGKLVKAIFP EPNQEAMNDN RLKDLIAYAR KVEKEMFESA
660 670 680 690 700
NDREEYYHLL AEKIYKIQKE LQEKKNSRLN QGAAAHDQYA IPPSNELAQM
710 720 730 740 750
LGVEGGRSDV HSEGSSMAVA PSQQNQPWGG APNSNMHQQI PPNGQVPQVN
760 770 780 790 800
NSSTFPSSGN STPNIGASST VSAMLQPKTE PMDDQNTDSL SSRPPTAIGF
810 820 830 840 850
GGSSSSTPAP IMNGIVKKEE DPEESSNQAP PSVKDTKDGV AESKPKEQQA
860 870 880 890 900
KREPTPPPTE DTVFSQEDLI KFLLPVWEKL DKSEDAAPFR VPVDAKLLNI
910 920 930 940 950
PDYHEIIKRP MDLETVHKKL YAGQYQNAGQ FCDDIWLMLD NAWLYNRKNS
960 970 980 990 1000
KVYKYGLKLS EMFVSEMDPV MKSMGYCCAK KLAFTPLSLF CYGAAMCTIA
1010 1020 1030 1040 1050
REQQYWVFEQ SSTQYNVTVT ERYTYCQKCF DALPPEGISL SENPNDRNNM
1060 1070 1080 1090 1100
APKTSFTEQK NSVIDYEPFE RCKYCMRKWH RICALHDKKV YPEGFICECC
1110 1120 1130 1140 1150
RTAKKYQKPD NKYLASKLPH NKLSTFLEDR VNGFIKKQLQ AEAHKYPVII
1160 1170 1180 1190 1200
RTLCVQDKEA EVKAQMKQKY VESNQFPEKF PYRTKAVFAF EIIDGVEVCF
1210 1220 1230 1240 1250
FGLHVQEYGS ACPAPNARRV YIAYLDSVHF FQPRELRTDV YHELLLGYLD
1260 1270 1280 1290 1300
YAKMLGYTMA HIWACPPSEG DDYIFHCHPP EQKIPKPKRL QDWYKKMLEK
1310 1320 1330 1340 1350
GVQEGSVVEF KDIYKQARDD NLTTPTQLPY FEGDFWPNVI EDCIREASNE
1360 1370 1380 1390 1400
EAQRKVKEDD DDGEDADGGL GGGDSGKKKS SKNKKNNLKK NAKMNKKKAG
1410 1420 1430 1440 1450
SITGNEVADK LYSQFEKHKE VFFTIRLVSL QNEPAVLAKP ISDPDGLMQS
1460 1470 1480 1490 1500
DMMDGRDTFL TKAREEHWEF SSLRRAKYST LCLAYSLHET DSKGMEYTCN
1510 1520 1530 1540 1550
KCSSPAVWHC QSCDDFDLCD GCKPTTQHPH EMEKIKSLIG GGEAGDSAAG
1560 1570 1580 1590 1600
GTRYESIQRC IASLVHACQC RDANCRRMSC HKMKRVVQHT KMCKKRINGT
1610 1620 1630 1640 1650
CPVCKQLIAL CCYHAKHCTR DACTVPFCMN IRQKLAEQKR SQQRRADMMM
1660 1670 1680 1690 1700
RRRMEGLQSH VGGAAPTPST VSNGTPSNAP TPPVSAGPGP AVKGGGVGQV
1710 1720 1730 1740 1750
QMQQHQGSHV GGSGPAGMGQ PMNSFGGMPG MGLGPNAQNG PGLPGMNPQM
1760 1770 1780 1790 1800
NANQSRYMPN GPGLGQSGAP GQQQQPMYSS GMPMQRPGGL GGMNPQQQPQ
1810 1820 1830 1840 1850
QQQGHPGLQN PGGRPGGVHG MGQNQPVRNN QDMVMNMQMQ NQHQQPPPFD
1860 1870 1880 1890 1900
STLQPQIMKI NSRLKAAKTE EERETVFSDL KKTPHLFHAW LRMRENQNLV
1910 1920 1930 1940 1950
PNRMQGYSQM SMGSSNLQNL QQQQLQQQQA GAMRGGGGFA PGQNNSQPRA
1960 1970 1980 1990 2000
PSGQFASMNP SMQQQYPQQQ QGWPQQRQQN PGGMQQNANP YNQFQNRQNM
2010
MMMPQQQQPH PSNAGGQ
Length:2,017
Mass (Da):222,415
Last modified:October 3, 2012 - v6
Checksum:iAAA0D2A7962DF163
GO
Isoform a (identifier: P34545-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-478: SDTTQTTKKCSV → F

Note: No experimental confirmation available.
Show »
Length:2,006
Mass (Da):221,281
Checksum:i86C92757AE478BFE
GO
Isoform c (identifier: P34545-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     467-478: SDTTQTTKKCSV → F
     1893-1921: Missing.

Note: No experimental confirmation available.
Show »
Length:1,977
Mass (Da):217,943
Checksum:i6483CE231C65A663
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei467 – 47812SDTTQ…KKCSV → F in isoform a and isoform c. CuratedVSP_000557Add
BLAST
Alternative sequencei1893 – 192129Missing in isoform c. CuratedVSP_044149Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29095 Genomic DNA. Translation: CAA82353.3.
Z29095 Genomic DNA. Translation: CAD18875.2.
Z29095 Genomic DNA. Translation: CAP72377.2.
PIRiG88564.
S60123.
RefSeqiNP_001122711.2. NM_001129239.2. [P34545-3]
NP_499160.2. NM_066759.3. [P34545-1]
NP_499161.2. NM_066760.5. [P34545-2]
UniGeneiCel.22950.

Genome annotation databases

EnsemblMetazoaiR10E11.1b; R10E11.1b; WBGene00000366. [P34545-1]
GeneIDi176380.
KEGGicel:CELE_R10E11.1.
UCSCiR10E11.1c. c. elegans. [P34545-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29095 Genomic DNA. Translation: CAA82353.3.
Z29095 Genomic DNA. Translation: CAD18875.2.
Z29095 Genomic DNA. Translation: CAP72377.2.
PIRiG88564.
S60123.
RefSeqiNP_001122711.2. NM_001129239.2. [P34545-3]
NP_499160.2. NM_066759.3. [P34545-1]
NP_499161.2. NM_066760.5. [P34545-2]
UniGeneiCel.22950.

3D structure databases

ProteinModelPortaliP34545.
SMRiP34545. Positions 399-510, 596-679, 822-1488, 1552-1634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41575. 5 interactions.
STRINGi6239.R10E11.1b.

PTM databases

iPTMnetiP34545.

Proteomic databases

EPDiP34545.
PaxDbiP34545.
PRIDEiP34545.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR10E11.1b; R10E11.1b; WBGene00000366. [P34545-1]
GeneIDi176380.
KEGGicel:CELE_R10E11.1.
UCSCiR10E11.1c. c. elegans. [P34545-1]

Organism-specific databases

CTDi176380.
WormBaseiR10E11.1a; CE47039; WBGene00000366; cbp-1.
R10E11.1b; CE46860; WBGene00000366; cbp-1.
R10E11.1c; CE46909; WBGene00000366; cbp-1.

Phylogenomic databases

eggNOGiKOG1778. Eukaryota.
COG5076. LUCA.
GeneTreeiENSGT00760000119206.
HOGENOMiHOG000019113.
InParanoidiP34545.
KOiK04498.
OMAiMFESAND.
OrthoDBiEOG75B84F.

Enzyme and pathway databases

ReactomeiR-CEL-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-CEL-3371568. Attenuation phase.
R-CEL-6781823. Formation of TC-NER Pre-Incision Complex.
R-CEL-6782135. Dual incision in TC-NER.
R-CEL-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
SignaLinkiP34545.

Miscellaneous databases

NextBioi892328.
PROiP34545.

Gene expression databases

ExpressionAtlasiP34545. baseline and differential.

Family and domain databases

Gene3Di1.10.246.20. 1 hit.
1.20.1020.10. 2 hits.
1.20.920.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR031162. CBP_P300_HAT.
IPR010303. DUF902_CREBbp.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR003101. KIX_dom.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF06001. DUF902. 1 hit.
PF08214. HAT_KAT11. 1 hit.
PF02172. KIX. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47040. SSF47040. 1 hit.
SSF47370. SSF47370. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51727. CBP_P300_HAT. 1 hit.
PS50952. KIX. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  3. "Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis."
    Yang M., Sun J., Sun X., Shen Q., Gao Z., Yang C.
    PLoS Genet. 5:E1000514-E1000514(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PRMT-5 AND CEP-1, MUTAGENESIS OF ARG-234, METHYLATION AT ARG-234.

Entry informationi

Entry nameiCBP1_CAEEL
AccessioniPrimary (citable) accession number: P34545
Secondary accession number(s): B0M0M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 3, 2012
Last modified: May 11, 2016
This is version 131 of the entry and version 6 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.