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Protein

Kinesin heavy chain

Gene

unc-116

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Microtubule-dependent motor protein required for organelle transport (By similarity). Plays a role in endosome transport (PubMed:22634595). Involved in the nuclear migration of hyp7 hypodermal precursor cells (PubMed:19605495). Required for the formation of dendritic branches of PVD sensory neurons (PubMed:21205795).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 95ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: GO_Central
  • cytoskeleton-dependent intracellular transport Source: GO_Central
  • embryo development ending in birth or egg hatching Source: WormBase
  • establishment of meiotic spindle localization Source: WormBase
  • establishment of meiotic spindle orientation Source: WormBase
  • establishment or maintenance of microtubule cytoskeleton polarity Source: CACAO
  • locomotion Source: WormBase
  • meiotic cytokinesis Source: WormBase
  • microtubule-based movement Source: GO_Central
  • nuclear migration along microtubule Source: UniProtKB
  • polar body extrusion after meiotic divisions Source: WormBase
  • positive regulation of necrotic cell death Source: WormBase
  • protein localization Source: GO_Central
  • regulation of dendrite morphogenesis Source: WormBase
  • synaptic vesicle transport Source: WormBase

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain
Alternative name(s):
Uncoordinated protein 116
Short name:
Protein unc-116
Gene namesi
Name:unc-116Imported
Synonyms:khc-1Imported
ORF Names:R05D3.7Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiR05D3.7 ; CE26945 ; WBGene00006840 ; unc-116

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown results in an altered distribution of recycling and late endosomes (PubMed:22634595). RNAi-mediated knockdown results in reduced dendritic branch formation in PVD sensory neurons (PubMed:21205795).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253491 – 815Kinesin heavy chainAdd BLAST815

Proteomic databases

EPDiP34540
PaxDbiP34540
PeptideAtlasiP34540
PRIDEiP34540

PTM databases

iPTMnetiP34540

Expressioni

Gene expression databases

BgeeiWBGene00006840

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi41383, 4 interactors
IntActiP34540, 3 interactors
STRINGi6239.R05D3.7

Structurei

3D structure databases

ProteinModelPortaliP34540
SMRiP34540
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 329Kinesin motorPROSITE-ProRule annotationAdd BLAST319

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili335 – 374Sequence analysisAdd BLAST40
Coiled coili422 – 554Sequence analysisAdd BLAST133
Coiled coili695 – 785Sequence analysisAdd BLAST91

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000144010
HOGENOMiHOG000216718
InParanoidiP34540
KOiK10396
OMAiEEDFTMA
OrthoDBiEOG091G02A2
PhylomeDBiP34540

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 2 hits
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPRTDGAEC GVQVFCRIRP LNKTEEKNAD RFLPKFPSED SISLGGKVYV
60 70 80 90 100
FDKVFKPNTT QEQVYKGAAY HIVQDVLSGY NGTVFAYGQT SSGKTHTMEG
110 120 130 140 150
VIGDNGLSGI IPRIVADIFN HIYSMDENLQ FHIKVSYYEI YNEKIRDLLD
160 170 180 190 200
PEKVNLSIHE DKNRVPYVKG ATERFVGGPD EVLQAIEDGK SNRMVAVTNM
210 220 230 240 250
NEHSSRSHSV FLITVKQEHQ TTKKQLTGKL YLVDLAGSEK VSKTGAQGTV
260 270 280 290 300
LEEAKNINKS LTALGIVISA LAEGTKSHVP YRDSKLTRIL QESLGGNSRT
310 320 330 340 350
TVIICASPSH FNEAETKSTL LFGARAKTIK NVVQINEELT AEEWKRRYEK
360 370 380 390 400
EKEKNTRLAA LLQAAALELS RWRAGESVSE VEWVNLSDSA QMAVSEVSGG
410 420 430 440 450
STPLMERSIA PAPPMLTSTT GPITDEEKKK YEEERVKLYQ QLDEKDDEIQ
460 470 480 490 500
KVSQELEKLR QQVLLQEEAL GTMRENEELI REENNRFQKE AEDKQQEGKE
510 520 530 540 550
MMTALEEIAV NLDVRQAECE KLKRELEVVQ EDNQSLEDRM NQATSLLNAH
560 570 580 590 600
LDECGPKIRH FKEGIYNVIR EFNIADIASQ NDQLPDHDLL NHVRIGVSKL
610 620 630 640 650
FSEYSAAKES STAAEHDAEA KLAADVARVE SGQDAGRMKQ LLVKDQAAKE
660 670 680 690 700
IKPLTDRVNM ELTTLKNLKK EFMRVLVARC QANQDTEGED SLSGPAQKQR
710 720 730 740 750
IQFLENNLDK LTKVHKQLVR DNADLRVELP KMEARLRGRE DRIKILETAL
760 770 780 790 800
RDSKQRSQAE RKKYQQEVER IKEAVRQRNM RRMNAPQIVK PIRPGQVYTS
810
PSAGMSQGAP NGSNA
Length:815
Mass (Da):91,894
Last modified:November 1, 1995 - v2
Checksum:i1B32718C3A7C254C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017163 mRNA Translation: BAA32594.1
L19120 Genomic DNA Translation: AAA28155.1
FO081667 Genomic DNA Translation: CCD73193.1
PIRiS44868
RefSeqiNP_498842.1, NM_066441.6
UniGeneiCel.37531

Genome annotation databases

EnsemblMetazoaiR05D3.7; R05D3.7; WBGene00006840
GeneIDi176179
KEGGicel:CELE_R05D3.7
UCSCiR05D3.7 c. elegans

Similar proteinsi

Entry informationi

Entry nameiKINH_CAEEL
AccessioniPrimary (citable) accession number: P34540
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health