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P34517 (GPDH2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glycerol-3-phosphate dehydrogenase 2
EC=1.1.1.8
Gene names
Name:gpdh-2
ORF Names:K11H3.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Probable glycerol-3-phosphate dehydrogenase 2
PRO_0000138070

Regions

Nucleotide binding42 – 476NAD By similarity
Region312 – 3132Substrate binding By similarity

Sites

Active site2481Proton acceptor By similarity
Binding site1301NAD By similarity
Binding site1531NAD; via amide nitrogen By similarity
Binding site1531Substrate By similarity
Binding site1961NAD; via amide nitrogen By similarity
Binding site3121NAD By similarity
Binding site3411NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
P34517 [UniParc].

Last modified May 16, 2003. Version 2.
Checksum: E42BCCBE280B04A5

FASTA39242,792
        10         20         30         40         50         60 
MSSSRIPQCE NSSRLSLSSI FRYFGTTSTI ATMSPKKVTI IGSGNWGSAI ARIVGSTTKS 

        70         80         90        100        110        120 
FPDEFDPTVR MWVFEEIVNG EKLSEVINNR HENIKYLPGK VLPNNVVAVT DLVESCEGSN 

       130        140        150        160        170        180 
VLVFVVPHQF VKGICEKLVG KIPADTQAIS LIKGISFDKT NQGVSTEKRG GLKLISEEIK 

       190        200        210        220        230        240 
EILKIEVSVL MGANLAPEVA NDNFCEATIG CKRKAEDGPL LKKLFHTDNF RINVVEDAHT 

       250        260        270        280        290        300 
VELCGALKNV VACAAGFTDG LGYGDNTKAA VIRLGLMETT KFVEHYYPGS NLQTFFESCG 

       310        320        330        340        350        360 
IADLITTCYG GRNRKVCEAF VKTGKSMAEV EKELLNGQSA QGPLTAEEVY LMMHKTGLDA 

       370        380        390 
KFPLFTAVHK ICAGEMKPAE LVDCLRNHPE HM

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z22180 Genomic DNA. Translation: CAD54146.1.
PIRS40754.
RefSeqNP_871632.1. NM_181903.5.
UniGeneCel.10288.

3D structure databases

ProteinModelPortalP34517.
SMRP34517. Positions 33-392.
ModBaseSearch...

Protein-protein interaction databases

IntActP34517. 1 interaction.
MINTMINT-211360.

Proteomic databases

PaxDbP34517.
PRIDEP34517.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK11H3.1b; K11H3.1b; K11H3.1.
GeneID176399.
KEGGcel:CELE_K11H3.1.

Organism-specific databases

CTD176399.
WormBaseK11H3.1b; CE31851; WBGene00010778; gpdh-2.

Phylogenomic databases

eggNOGCOG0240.
GeneTreeENSGT00390000003114.
HOGENOMHOG000246855.
InParanoidP34517.
KOK00006.
OMAKELMQTS.

Gene expression databases

ArrayExpressP34517.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio892406.

Entry information

Entry nameGPDH2_CAEEL
AccessionPrimary (citable) accession number: P34517
Secondary accession number(s): Q8I4H2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 16, 2003
Last modified: May 29, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

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