Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycerol-3-phosphate dehydrogenase 2

Gene

gpdh-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130NADBy similarity1
Binding sitei153NAD; via amide nitrogenBy similarity1
Binding sitei153SubstrateBy similarity1
Binding sitei196NAD; via amide nitrogenBy similarity1
Active sitei248Proton acceptorBy similarity1
Binding sitei312NADBy similarity1
Binding sitei341NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi42 – 47NADBy similarity6

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • glycerol-3-phosphate catabolic process Source: InterPro
  • hyperosmotic response Source: WormBase
  • intracellular accumulation of glycerol Source: WormBase

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase 2 (EC:1.1.1.8)
Gene namesi
Name:gpdh-2
ORF Names:K11H3.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK11H3.1b ; CE31851 ; WBGene00010778 ; gpdh-2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380701 – 392Probable glycerol-3-phosphate dehydrogenase 2Add BLAST392

Proteomic databases

EPDiP34517
PaxDbiP34517
PeptideAtlasiP34517
PRIDEiP34517

Expressioni

Gene expression databases

BgeeiWBGene00010778
ExpressionAtlasiP34517 baseline and differential

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi41593, 2 interactors
IntActiP34517, 1 interactor
STRINGi6239.K11H3.1b

Structurei

3D structure databases

ProteinModelPortaliP34517
SMRiP34517
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 313Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2711 Eukaryota
COG0240 LUCA
GeneTreeiENSGT00390000003114
HOGENOMiHOG000246855
InParanoidiP34517
OMAiWLCKGFE
OrthoDBiEOG091G0DO6
PhylomeDBiP34517

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

P34517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSRIPQCE NSSRLSLSSI FRYFGTTSTI ATMSPKKVTI IGSGNWGSAI
60 70 80 90 100
ARIVGSTTKS FPDEFDPTVR MWVFEEIVNG EKLSEVINNR HENIKYLPGK
110 120 130 140 150
VLPNNVVAVT DLVESCEGSN VLVFVVPHQF VKGICEKLVG KIPADTQAIS
160 170 180 190 200
LIKGISFDKT NQGVSTEKRG GLKLISEEIK EILKIEVSVL MGANLAPEVA
210 220 230 240 250
NDNFCEATIG CKRKAEDGPL LKKLFHTDNF RINVVEDAHT VELCGALKNV
260 270 280 290 300
VACAAGFTDG LGYGDNTKAA VIRLGLMETT KFVEHYYPGS NLQTFFESCG
310 320 330 340 350
IADLITTCYG GRNRKVCEAF VKTGKSMAEV EKELLNGQSA QGPLTAEEVY
360 370 380 390
LMMHKTGLDA KFPLFTAVHK ICAGEMKPAE LVDCLRNHPE HM
Length:392
Mass (Da):42,792
Last modified:May 16, 2003 - v2
Checksum:iE42BCCBE280B04A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22180 Genomic DNA Translation: CAD54146.1
PIRiS40754
RefSeqiNP_871632.1, NM_181903.5
UniGeneiCel.10288

Genome annotation databases

EnsemblMetazoaiK11H3.1b; K11H3.1b; WBGene00010778
GeneIDi176399

Similar proteinsi

Entry informationi

Entry nameiGPDH2_CAEEL
AccessioniPrimary (citable) accession number: P34517
Secondary accession number(s): Q8I4H2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 16, 2003
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health