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P34517

- GPDH2_CAEEL

UniProt

P34517 - GPDH2_CAEEL

Protein

Probable glycerol-3-phosphate dehydrogenase 2

Gene

gpdh-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (16 May 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301NADBy similarity
    Binding sitei153 – 1531NAD; via amide nitrogenBy similarity
    Binding sitei153 – 1531SubstrateBy similarity
    Binding sitei196 – 1961NAD; via amide nitrogenBy similarity
    Active sitei248 – 2481Proton acceptorBy similarity
    Binding sitei312 – 3121NADBy similarity
    Binding sitei341 – 3411NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi42 – 476NADBy similarity

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. glycerol-3-phosphate dehydrogenase activity Source: WormBase
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro
    3. hyperosmotic response Source: WormBase
    4. intracellular accumulation of glycerol Source: WormBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_184824. Synthesis of PA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycerol-3-phosphate dehydrogenase 2 (EC:1.1.1.8)
    Gene namesi
    Name:gpdh-2
    ORF Names:K11H3.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiK11H3.1b; CE31851; WBGene00010778; gpdh-2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Probable glycerol-3-phosphate dehydrogenase 2PRO_0000138070Add
    BLAST

    Proteomic databases

    PaxDbiP34517.
    PRIDEiP34517.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi41593. 2 interactions.
    IntActiP34517. 1 interaction.
    MINTiMINT-211360.

    Structurei

    3D structure databases

    ProteinModelPortaliP34517.
    SMRiP34517. Positions 33-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni312 – 3132Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0240.
    GeneTreeiENSGT00390000003114.
    HOGENOMiHOG000246855.
    InParanoidiP34517.
    KOiK00006.
    OMAiPVGEFIH.
    PhylomeDBiP34517.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
    PROSITEiPS00957. NAD_G3PDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34517-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSRIPQCE NSSRLSLSSI FRYFGTTSTI ATMSPKKVTI IGSGNWGSAI    50
    ARIVGSTTKS FPDEFDPTVR MWVFEEIVNG EKLSEVINNR HENIKYLPGK 100
    VLPNNVVAVT DLVESCEGSN VLVFVVPHQF VKGICEKLVG KIPADTQAIS 150
    LIKGISFDKT NQGVSTEKRG GLKLISEEIK EILKIEVSVL MGANLAPEVA 200
    NDNFCEATIG CKRKAEDGPL LKKLFHTDNF RINVVEDAHT VELCGALKNV 250
    VACAAGFTDG LGYGDNTKAA VIRLGLMETT KFVEHYYPGS NLQTFFESCG 300
    IADLITTCYG GRNRKVCEAF VKTGKSMAEV EKELLNGQSA QGPLTAEEVY 350
    LMMHKTGLDA KFPLFTAVHK ICAGEMKPAE LVDCLRNHPE HM 392
    Length:392
    Mass (Da):42,792
    Last modified:May 16, 2003 - v2
    Checksum:iE42BCCBE280B04A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22180 Genomic DNA. Translation: CAD54146.1.
    PIRiS40754.
    RefSeqiNP_871632.1. NM_181903.5.
    UniGeneiCel.10288.

    Genome annotation databases

    EnsemblMetazoaiK11H3.1b; K11H3.1b; WBGene00010778.
    GeneIDi176399.
    KEGGicel:CELE_K11H3.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22180 Genomic DNA. Translation: CAD54146.1 .
    PIRi S40754.
    RefSeqi NP_871632.1. NM_181903.5.
    UniGenei Cel.10288.

    3D structure databases

    ProteinModelPortali P34517.
    SMRi P34517. Positions 33-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41593. 2 interactions.
    IntActi P34517. 1 interaction.
    MINTi MINT-211360.

    Proteomic databases

    PaxDbi P34517.
    PRIDEi P34517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K11H3.1b ; K11H3.1b ; WBGene00010778 .
    GeneIDi 176399.
    KEGGi cel:CELE_K11H3.1.

    Organism-specific databases

    CTDi 176399.
    WormBasei K11H3.1b ; CE31851 ; WBGene00010778 ; gpdh-2.

    Phylogenomic databases

    eggNOGi COG0240.
    GeneTreei ENSGT00390000003114.
    HOGENOMi HOG000246855.
    InParanoidi P34517.
    KOi K00006.
    OMAi PVGEFIH.
    PhylomeDBi P34517.

    Enzyme and pathway databases

    Reactomei REACT_184824. Synthesis of PA.

    Miscellaneous databases

    NextBioi 892406.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
    PROSITEi PS00957. NAD_G3PDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGPDH2_CAEEL
    AccessioniPrimary (citable) accession number: P34517
    Secondary accession number(s): Q8I4H2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: May 16, 2003
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3