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Protein

Probable glycerol-3-phosphate dehydrogenase 2

Gene

gpdh-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADBy similarity
Binding sitei153 – 1531NAD; via amide nitrogenBy similarity
Binding sitei153 – 1531SubstrateBy similarity
Binding sitei196 – 1961NAD; via amide nitrogenBy similarity
Active sitei248 – 2481Proton acceptorBy similarity
Binding sitei312 – 3121NADBy similarity
Binding sitei341 – 3411NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 476NADBy similarity

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • glycerol-3-phosphate catabolic process Source: InterPro
  • hyperosmotic response Source: WormBase
  • intracellular accumulation of glycerol Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_288331. Synthesis of PA.
REACT_351704. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase 2 (EC:1.1.1.8)
Gene namesi
Name:gpdh-2
ORF Names:K11H3.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK11H3.1b; CE31851; WBGene00010778; gpdh-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Probable glycerol-3-phosphate dehydrogenase 2PRO_0000138070Add
BLAST

Proteomic databases

PaxDbiP34517.
PRIDEiP34517.

Expressioni

Gene expression databases

ExpressionAtlasiP34517. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi41593. 2 interactions.
IntActiP34517. 1 interaction.
MINTiMINT-211360.
STRINGi6239.K11H3.1b.

Structurei

3D structure databases

ProteinModelPortaliP34517.
SMRiP34517. Positions 33-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni312 – 3132Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
InParanoidiP34517.
OMAiEVANDNF.
PhylomeDBiP34517.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSRIPQCE NSSRLSLSSI FRYFGTTSTI ATMSPKKVTI IGSGNWGSAI
60 70 80 90 100
ARIVGSTTKS FPDEFDPTVR MWVFEEIVNG EKLSEVINNR HENIKYLPGK
110 120 130 140 150
VLPNNVVAVT DLVESCEGSN VLVFVVPHQF VKGICEKLVG KIPADTQAIS
160 170 180 190 200
LIKGISFDKT NQGVSTEKRG GLKLISEEIK EILKIEVSVL MGANLAPEVA
210 220 230 240 250
NDNFCEATIG CKRKAEDGPL LKKLFHTDNF RINVVEDAHT VELCGALKNV
260 270 280 290 300
VACAAGFTDG LGYGDNTKAA VIRLGLMETT KFVEHYYPGS NLQTFFESCG
310 320 330 340 350
IADLITTCYG GRNRKVCEAF VKTGKSMAEV EKELLNGQSA QGPLTAEEVY
360 370 380 390
LMMHKTGLDA KFPLFTAVHK ICAGEMKPAE LVDCLRNHPE HM
Length:392
Mass (Da):42,792
Last modified:May 16, 2003 - v2
Checksum:iE42BCCBE280B04A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22180 Genomic DNA. Translation: CAD54146.1.
PIRiS40754.
RefSeqiNP_871632.1. NM_181903.5.
UniGeneiCel.10288.

Genome annotation databases

EnsemblMetazoaiK11H3.1b; K11H3.1b; WBGene00010778.
GeneIDi176399.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22180 Genomic DNA. Translation: CAD54146.1.
PIRiS40754.
RefSeqiNP_871632.1. NM_181903.5.
UniGeneiCel.10288.

3D structure databases

ProteinModelPortaliP34517.
SMRiP34517. Positions 33-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41593. 2 interactions.
IntActiP34517. 1 interaction.
MINTiMINT-211360.
STRINGi6239.K11H3.1b.

Proteomic databases

PaxDbiP34517.
PRIDEiP34517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK11H3.1b; K11H3.1b; WBGene00010778.
GeneIDi176399.

Organism-specific databases

CTDi176399.
WormBaseiK11H3.1b; CE31851; WBGene00010778; gpdh-2.

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
InParanoidiP34517.
OMAiEVANDNF.
PhylomeDBiP34517.

Enzyme and pathway databases

ReactomeiREACT_288331. Synthesis of PA.
REACT_351704. Triglyceride Biosynthesis.

Miscellaneous databases

NextBioi892406.
PROiP34517.

Gene expression databases

ExpressionAtlasiP34517. baseline.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGPDH2_CAEEL
AccessioniPrimary (citable) accession number: P34517
Secondary accession number(s): Q8I4H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 16, 2003
Last modified: July 22, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.