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Protein

Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1

Gene

mog-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi464 – 471ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • feminization of hermaphroditic germ-line Source: WormBase
  • mRNA splicing, via spliceosome Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-109688. Cleavage of Growing Transcript in the Termination Region.
R-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-CEL-72163. mRNA Splicing - Major Pathway.
R-CEL-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 (EC:3.6.4.13)
Alternative name(s):
Masculinization of germline protein 1
Sex determination protein mog-1
Gene namesi
Name:mog-1
ORF Names:K03H1.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiK03H1.2; CE01027; WBGene00003389; mog-1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551481 – 1131Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1Add BLAST1131

Proteomic databases

EPDiP34498.
PaxDbiP34498.
PeptideAtlasiP34498.
PRIDEiP34498.

PTM databases

iPTMnetiP34498.

Expressioni

Gene expression databases

BgeeiWBGene00003389.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi41603. 2 interactors.
IntActiP34498. 4 interactors.
STRINGi6239.K03H1.2.

Structurei

3D structure databases

ProteinModelPortaliP34498.
SMRiP34498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini451 – 614Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST164
Domaini629 – 812Helicase C-terminalPROSITE-ProRule annotationAdd BLAST184

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi561 – 564DEAH box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0925. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00880000137867.
HOGENOMiHOG000175261.
InParanoidiP34498.
KOiK12815.
OMAiPSRSTWE.
OrthoDBiEOG091G030Q.
PhylomeDBiP34498.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P34498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKRADGRL EGTSDTFGGL VIKKKKVEGD SKPTEPSGKS LLGLDRLAST
60 70 80 90 100
KREHARKRLE DDDDRGVTES VRKGIEKVHE KHRDRDDRGM KYKSRDDDRR
110 120 130 140 150
RDRDRSERRE PSSRRGWKDR SGDQTPRFKV PDTPSRMSWD QDDREGSSRK
160 170 180 190 200
RNSWDMPTPR GERDRKRYMD SERSISSAWR SERRNRDDEK RRRHRKPEDS
210 220 230 240 250
VRSVKEEKAE PTFHDDEERA QWEEEQKNLD REWYDNEGAF DDEYNPFNKV
260 270 280 290 300
SDEFVEKREK QWQEKTQKPR LTVKQQAIKR ENELWENNRL HRSGVVAMAD
310 320 330 340 350
ELSSIFEDET DENRVTILVQ NIVPPFLDGR IVFTKQAQPI IPVVDTTCDM
360 370 380 390 400
AVSAARGSVA VRKRREVEDR KKAQDKHWEL AGSKLGNLMG VKEKKDETAD
410 420 430 440 450
PEDDDSGNYK ESHQFASHMK DNEAVSDFAM EKSIKQQREY LPVFACRQKM
460 470 480 490 500
MNVIRENNVV IIVGETGSGK TTQLAQYLLE DGFGDSGLIG CTQPRRVAAM
510 520 530 540 550
SVARRVADEM GVDLGQDVGY AIRFEDCTSE KTIIKYMTDG ILLRECLGDG
560 570 580 590 600
SLDQYSAIIM DEAHERSLNT DVLFGLLREV IAKRADLKLI VTSATMDADK
610 620 630 640 650
FADFFGGNCP TFTIPGRTFP VELFHARTPV EDYVDAAVKQ AVTIHLGGMD
660 670 680 690 700
GDILIFMPGQ EDIECTCEMI KEKLGELDEA PPLAVLPIYS QLPSDLQAKI
710 720 730 740 750
FQRAPGGMRK AIVATNIAET SLTVDGILFV IDPGFCKMKV YNPRIGMDAL
760 770 780 790 800
SIFPVSQASA NQRTGRAGRT GPGQCYRLYT ERQFKDELLK STVPEIQRTN
810 820 830 840 850
LANVVLLLKS LGVDDLLKFH FMDAPPQDNM LNSMYQLWTL GALDNTGQLT
860 870 880 890 900
PMGRKMVEFP LDPTLSKMLI MSAEMGCSDE VLTIVSMLSV PAIFFRPKGR
910 920 930 940 950
EEEADAKKEK FQVPESDHLT FLNVYIQWRT HKYSAKWCAD NYLHVKALKK
960 970 980 990 1000
VREVRAQLKE IMQDLKLPLI SNGSEWDIVR KCICSAYFHN AARLKGIGEY
1010 1020 1030 1040 1050
VNVRTGIPCF LHPTSALFGM GFMPDYVVYH ELIMTAKEYM QCVTAVDAIW
1060 1070 1080 1090 1100
LAELGPMFYS IKESKQSRKE LKMESVRTVE TMEAEMREAQ KEMERRKEES
1110 1120 1130
DKAFKRPESS RRVVEVGSKS ARSERRKLWG L
Length:1,131
Mass (Da):129,424
Last modified:February 1, 1995 - v2
Checksum:i258C85D6584FAF3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120269 mRNA. Translation: AAD13795.1.
Z29560 Genomic DNA. Translation: CAA82662.1.
PIRiF88570.
S41025.
RefSeqiNP_499212.1. NM_066811.6.
UniGeneiCel.5743.

Genome annotation databases

EnsemblMetazoaiK03H1.2; K03H1.2; WBGene00003389.
GeneIDi176409.
KEGGicel:CELE_K03H1.2.
UCSCiK03H1.2.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiMOG1_CAEEL
AccessioniPrimary (citable) accession number: P34498
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families