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Protein

Probable glutamine synthetase

Gene

gln-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_254462. Amino acid synthesis and interconversion (transamination).
REACT_260243. Astrocytic Glutamate-Glutamine Uptake And Metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:gln-2
ORF Names:K03H1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiK03H1.1; CE00507; WBGene00001603; gln-2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Probable glutamine synthetasePRO_0000153147Add
BLAST

Proteomic databases

PaxDbiP34497.
PRIDEiP34497.

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

IntActiP34497. 2 interactions.
STRINGi6239.K03H1.1.

Structurei

3D structure databases

ProteinModelPortaliP34497.
SMRiP34497. Positions 25-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
GeneTreeiENSGT00390000010047.
HOGENOMiHOG000061500.
InParanoidiP34497.
KOiK01915.
OMAiAASSHTH.
OrthoDBiEOG7CZK5G.
PhylomeDBiP34497.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34497-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLNFETRM PLGTAVIDQF LGLRPHPTKI QATYVWIDGT GENLRSKTRT
60 70 80 90 100
FDKLPKRIED YPIWNYDGSS TGQAKGRDSD RYLRPVAAYP DPFLGGGNKL
110 120 130 140 150
VMCDTLDHQM QPTATSHRQA CAEIMHEIRD TRPWFGMEQE YLIVDRDEHP
160 170 180 190 200
LGWPKHGFPD PQGKYYCSVG ADRAFGREVV ETHYRACLHA GLNIFGTNAE
210 220 230 240 250
VTPGQWEFQI GTCEGIDMGD QLWMSRYILH RVAEQFGVCV SLDPKPKVTM
260 270 280 290 300
GDWNGAGCHT NFSTAEMRAP GGIAAIEAAM TGLKRTHLEA MKVYDPHGGE
310 320 330 340 350
DNLRRLTGRH ETSSADKFSW GVANRGCSIR IPRQVAAERK GYLEDRRPSS
360
NCDPYQVTAM IAQSILF
Length:367
Mass (Da):41,284
Last modified:February 1, 1994 - v1
Checksum:iA7E0A3351F6D32F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29560 Genomic DNA. Translation: CAA82655.1.
PIRiS41024.
RefSeqiNP_499208.1. NM_066807.3.
UniGeneiCel.10322.

Genome annotation databases

EnsemblMetazoaiK03H1.1; K03H1.1; WBGene00001603.
GeneIDi176407.
KEGGicel:CELE_K03H1.1.
UCSCiK03H1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29560 Genomic DNA. Translation: CAA82655.1.
PIRiS41024.
RefSeqiNP_499208.1. NM_066807.3.
UniGeneiCel.10322.

3D structure databases

ProteinModelPortaliP34497.
SMRiP34497. Positions 25-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP34497. 2 interactions.
STRINGi6239.K03H1.1.

Proteomic databases

PaxDbiP34497.
PRIDEiP34497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK03H1.1; K03H1.1; WBGene00001603.
GeneIDi176407.
KEGGicel:CELE_K03H1.1.
UCSCiK03H1.1. c. elegans.

Organism-specific databases

CTDi176407.
WormBaseiK03H1.1; CE00507; WBGene00001603; gln-2.

Phylogenomic databases

eggNOGiCOG0174.
GeneTreeiENSGT00390000010047.
HOGENOMiHOG000061500.
InParanoidiP34497.
KOiK01915.
OMAiAASSHTH.
OrthoDBiEOG7CZK5G.
PhylomeDBiP34497.

Enzyme and pathway databases

ReactomeiREACT_254462. Amino acid synthesis and interconversion (transamination).
REACT_260243. Astrocytic Glutamate-Glutamine Uptake And Metabolism.

Miscellaneous databases

NextBioi892444.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGLNA_CAEEL
AccessioniPrimary (citable) accession number: P34497
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.