P34496 (MTSS1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial single stranded DNA binding protein 1

Gene names

Name:	mtss-1
ORF Names:	PAR2.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a role in germline cell development and proliferation which affects the frequency of apoptosis. Required for mitochondrial DNA replication and transcription and fertility. Ref.3
Tissue specificity	Expressed in eggs. Ref.3
Developmental stage	Expressed at low levels in L1 larvae and increases at the L3 stage to the adult stage. Ref.3
Disruption phenotype	Reduced mitochondrial replication, transcriptional hypoxia response, sterility, arrest of germline cell proliferation, reduced frequency of apoptosis in the germline. Ref.3
Sequence similarities	Contains 1 SSB domain.

Ontologies

Keywords
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: InterPro
Molecular function	single-stranded DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
C06G3.6	Q17746	1	EBI-325500,EBI-313792
nhr-22	Q09587	1	EBI-325500,EBI-323124
T28C6.7	Q22847	1	EBI-325500,EBI-316760
W08G11.3	Q2XMY4	1	EBI-325500,EBI-325506

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Mitochondrial single stranded DNA binding protein 1		PRO_0000095993
Regions
	Domain	54 – 160	107	SSB

Sequences

	Sequence		Length	Mass (Da)
	P34496 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: D1FA3DEA8F94ABE1	FASTA	170	19,182
	10 20 30 40 50 60 MLRSLSTISK STVRCMSLTS KMAAEQPSKQ EVDDLFAEKP QHHNPEQRRH AYSVNKVELV 70 80 90 100 110 120 GGVALDPLYK TGRNGKPYLI FNIITNSYFK QQDGTTLDQT ERHAVSVFGK QAEILSKTIK 130 140 150 160 170 KGSRLMVQGR LHYSGGQKDE QGNRTQRNTY IIAQTVQPLA RAARENPDQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"Caenorhabditis elegans par2.1/mtssb-1 is essential for mitochondrial DNA replication and its defect causes comprehensive transcriptional alterations including a hypoxia response." Sugimoto T., Mori C., Takanami T., Sasagawa Y., Saito R., Ichiishi E., Higashitani A. Exp. Cell Res. 314:103-114(2008) [PubMed: 17900564] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081577 Genomic DNA. Translation: CCD72532.1.
PIR	S44857.
RefSeq	NP_498935.1. NM_066534.2.
UniGene	Cel.10245.
3D structure databases
ProteinModelPortal	P34496.
SMR	P34496. Positions 50-160.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-25867N.
IntAct	P34496. 4 interactions.
MINT	MINT-1058111.
STRING	P34496.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	PAR2.1.1; PAR2.1.1; PAR2.1. PAR2.1.2; PAR2.1.2; PAR2.1.
GeneID	187502.
KEGG	cel:PAR2.1.
Organism-specific databases
CTD	187502.
WormBase	PAR2.1; CE00768; WBGene00019800; mtss-1.
Phylogenomic databases
eggNOG	KOG1653.
GeneTree	EMGT00050000016910.
HOGENOM	HBG382015.
InParanoid	P34496.
OMA	CMSLTSK.
PhylomeDB	P34496.
Gene expression databases
ArrayExpress	P34496.
Family and domain databases
InterPro	IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR000424. Primosome_PriB/ssb. IPR011344. ssDNA-bd. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR10302. Single_strand_bd. 1 hit.
Pfam	PF00436. SSB. 1 hit. [Graphical view]
PIRSF	PIRSF002070. SSB. 1 hit.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00621. Ssb. 1 hit.
PROSITE	PS50935. SSB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	935490.

Entry information

Entry name

MTSS1_CAEEL

Accession

Primary (citable) accession number: P34496

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project