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Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

F59B2.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi154Divalent metal cationBy similarity1
Metal bindingi223Divalent metal cation; via tele nitrogenBy similarity1
Metal bindingi244Divalent metal cation; via tele nitrogenBy similarity1
Binding sitei255SubstrateBy similarity1
Active sitei306Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-CEL-446210. Synthesis of UDP-N-acetyl-glucosamine.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseBy similarity (EC:3.5.1.25By similarity)
Short name:
GlcNAc 6-P deacetylaseBy similarity
Gene namesi
ORF Names:F59B2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF59B2.3; CE00231; WBGene00010308.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001709121 – 418N-acetylglucosamine-6-phosphate deacetylaseAdd BLAST418

Proteomic databases

EPDiP34480.
PaxDbiP34480.
PeptideAtlasiP34480.
PRIDEiP34480.

Expressioni

Gene expression databases

BgeeiWBGene00010308.

Interactioni

Protein-protein interaction databases

BioGridi41471. 2 interactors.
DIPiDIP-24730N.
IntActiP34480. 1 interactor.
MINTiMINT-1040237.
STRINGi6239.F59B2.3.1.

Structurei

3D structure databases

ProteinModelPortaliP34480.
SMRiP34480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 166Substrate bindingBy similarity2
Regioni247 – 248Substrate bindingBy similarity2
Regioni281 – 284Substrate bindingBy similarity4
Regioni340 – 342Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the NagA family.Curated

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
InParanoidiP34480.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
PhylomeDBiP34480.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.

Sequencei

Sequence statusi: Complete.

P34480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRKLKIDS TELAEITNEL VQFLNCLVLR SGGLKKEHIW VRNGRILDER
60 70 80 90 100
TVFFEEKTMA DVQIDCEGLI LSPGFIDLQL NGGFGIDFST YNSDDKEYQE
110 120 130 140 150
GLALVAKQLL AHGVTSFSPT VITSSPETYH KILPLLKPSN ASSEGAGNLG
160 170 180 190 200
AHLEGPFISA DKRGCHPEQL VITSLSPNPV EIIEHVYGST ENIAIVTMAP
210 220 230 240 250
ELEGAQEAIE YFVSTGTTVS VGHSSAKLGP GEMAVLSGAK MITHLFNAMQ
260 270 280 290 300
SYHHRDPGLI GLLTSSKLTP DHPLYYGIIS DGIHTHDSAL RIAYHTNSAG
310 320 330 340 350
LVLVTDAIAA LGMSDGVHKL GTQTIHVKGL EAKLDGTNTT AGSVASMPYC
360 370 380 390 400
IRHLMKATGC PIEFALQSAT HKPATLLGVS DEKGTLDVGR LADFVLIDKN
410
VTVKATFCSG KRVFLAQD
Length:418
Mass (Da):44,887
Last modified:February 1, 1994 - v1
Checksum:i4988EA416F5D1247
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11505 Genomic DNA. Translation: CAA77585.1.
PIRiS31124.
RefSeqiNP_498990.1. NM_066589.5.
UniGeneiCel.10376.

Genome annotation databases

EnsemblMetazoaiF59B2.3.1; F59B2.3.1; WBGene00010308.
F59B2.3.2; F59B2.3.2; WBGene00010308.
GeneIDi176272.
KEGGicel:CELE_F59B2.3.
UCSCiF59B2.3.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11505 Genomic DNA. Translation: CAA77585.1.
PIRiS31124.
RefSeqiNP_498990.1. NM_066589.5.
UniGeneiCel.10376.

3D structure databases

ProteinModelPortaliP34480.
SMRiP34480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41471. 2 interactors.
DIPiDIP-24730N.
IntActiP34480. 1 interactor.
MINTiMINT-1040237.
STRINGi6239.F59B2.3.1.

Proteomic databases

EPDiP34480.
PaxDbiP34480.
PeptideAtlasiP34480.
PRIDEiP34480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59B2.3.1; F59B2.3.1; WBGene00010308.
F59B2.3.2; F59B2.3.2; WBGene00010308.
GeneIDi176272.
KEGGicel:CELE_F59B2.3.
UCSCiF59B2.3.2. c. elegans.

Organism-specific databases

CTDi176272.
WormBaseiF59B2.3; CE00231; WBGene00010308.

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
InParanoidiP34480.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
PhylomeDBiP34480.

Enzyme and pathway databases

ReactomeiR-CEL-446210. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

PROiP34480.

Gene expression databases

BgeeiWBGene00010308.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAGA_CAEEL
AccessioniPrimary (citable) accession number: P34480
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.