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Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

F59B2.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi154Divalent metal cationBy similarity1
Metal bindingi223Divalent metal cation; via tele nitrogenBy similarity1
Metal bindingi244Divalent metal cation; via tele nitrogenBy similarity1
Binding sitei255SubstrateBy similarity1
Active sitei306Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMetal-binding

Enzyme and pathway databases

ReactomeiR-CEL-446210 Synthesis of UDP-N-acetyl-glucosamine

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseBy similarity (EC:3.5.1.25By similarity)
Short name:
GlcNAc 6-P deacetylaseBy similarity
Gene namesi
ORF Names:F59B2.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF59B2.3 ; CE00231 ; WBGene00010308

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001709121 – 418N-acetylglucosamine-6-phosphate deacetylaseAdd BLAST418

Proteomic databases

EPDiP34480
PaxDbiP34480
PeptideAtlasiP34480
PRIDEiP34480

Expressioni

Gene expression databases

BgeeiWBGene00010308

Interactioni

Protein-protein interaction databases

BioGridi41471, 2 interactors
DIPiDIP-24730N
IntActiP34480, 2 interactors
STRINGi6239.F59B2.3.1

Structurei

3D structure databases

ProteinModelPortaliP34480
SMRiP34480
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 166Substrate bindingBy similarity2
Regioni247 – 248Substrate bindingBy similarity2
Regioni281 – 284Substrate bindingBy similarity4
Regioni340 – 342Substrate bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3892 Eukaryota
COG1820 LUCA
GeneTreeiENSGT00390000012605
HOGENOMiHOG000275010
InParanoidiP34480
KOiK01443
OMAiHAFNAMP
OrthoDBiEOG091G08JG
PhylomeDBiP34480

Family and domain databases

CDDicd00854 NagA, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR003764 GlcNAc_6-P_deAcase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
PIRSFiPIRSF038994 NagA, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR00221 nagA, 1 hit

Sequencei

Sequence statusi: Complete.

P34480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRKLKIDS TELAEITNEL VQFLNCLVLR SGGLKKEHIW VRNGRILDER
60 70 80 90 100
TVFFEEKTMA DVQIDCEGLI LSPGFIDLQL NGGFGIDFST YNSDDKEYQE
110 120 130 140 150
GLALVAKQLL AHGVTSFSPT VITSSPETYH KILPLLKPSN ASSEGAGNLG
160 170 180 190 200
AHLEGPFISA DKRGCHPEQL VITSLSPNPV EIIEHVYGST ENIAIVTMAP
210 220 230 240 250
ELEGAQEAIE YFVSTGTTVS VGHSSAKLGP GEMAVLSGAK MITHLFNAMQ
260 270 280 290 300
SYHHRDPGLI GLLTSSKLTP DHPLYYGIIS DGIHTHDSAL RIAYHTNSAG
310 320 330 340 350
LVLVTDAIAA LGMSDGVHKL GTQTIHVKGL EAKLDGTNTT AGSVASMPYC
360 370 380 390 400
IRHLMKATGC PIEFALQSAT HKPATLLGVS DEKGTLDVGR LADFVLIDKN
410
VTVKATFCSG KRVFLAQD
Length:418
Mass (Da):44,887
Last modified:February 1, 1994 - v1
Checksum:i4988EA416F5D1247
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11505 Genomic DNA Translation: CAA77585.1
PIRiS31124
RefSeqiNP_498990.1, NM_066589.5
UniGeneiCel.10376

Genome annotation databases

EnsemblMetazoaiF59B2.3.1; F59B2.3.1; WBGene00010308
F59B2.3.2; F59B2.3.2; WBGene00010308
F59B2.3.3; F59B2.3.3; WBGene00010308
GeneIDi176272
KEGGicel:CELE_F59B2.3
UCSCiF59B2.3.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNAGA_CAEEL
AccessioniPrimary (citable) accession number: P34480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health