ID   SKAT1_CAEEL             Reviewed;         460 AA.
AC   P34479; Q9U3E0;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   27-MAR-2024, entry version 137.
DE   RecName: Full=Probable amino acid transporter skat-1 {ECO:0000303|PubMed:24204312};
DE   AltName: Full=Protein suppressor of kat-1 {ECO:0000312|WormBase:F59B2.2};
GN   Name=skat-1 {ECO:0000312|WormBase:F59B2.2};
GN   ORFNames=F59B2.2 {ECO:0000312|WormBase:F59B2.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=24204312; DOI=10.1371/journal.pgen.1003908;
RA   Soukas A.A., Carr C.E., Ruvkun G.;
RT   "Genetic regulation of Caenorhabditis elegans lysosome related organelle
RT   function.";
RL   PLoS Genet. 9:E1003908-E1003908(2013).
CC   -!- FUNCTION: Plays a role in the accumulation of vital dyes and endogenous
CC       fluorescent compounds in lysosome related organelles. Has an effect on
CC       lysosome related organelle (LRO) function, in a pathway with serotonin.
CC       {ECO:0000269|PubMed:24204312}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}. Cytoplasmic granule
CC       {ECO:0000269|PubMed:24204312}.
CC   -!- TISSUE SPECIFICITY: Expressed in the head, tail, body and ventral nerve
CC       cord neurons, muscles of the vulva, and intestine.
CC       {ECO:0000269|PubMed:24204312}.
CC   -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC       {ECO:0000305}.
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DR   EMBL; Z11505; CAA77582.1; -; Genomic_DNA.
DR   PIR; F88544; F88544.
DR   PIR; S31123; S31123.
DR   RefSeq; NP_498989.1; NM_066588.4.
DR   AlphaFoldDB; P34479; -.
DR   STRING; 6239.F59B2.2.1; -.
DR   TCDB; 2.A.18.8.8; the amino acid/auxin permease (aaap) family.
DR   iPTMnet; P34479; -.
DR   EPD; P34479; -.
DR   PaxDb; 6239-F59B2-2; -.
DR   PeptideAtlas; P34479; -.
DR   EnsemblMetazoa; F59B2.2.1; F59B2.2.1; WBGene00010307.
DR   GeneID; 176271; -.
DR   KEGG; cel:CELE_F59B2.2; -.
DR   UCSC; F59B2.2; c. elegans.
DR   AGR; WB:WBGene00010307; -.
DR   WormBase; F59B2.2; CE20899; WBGene00010307; skat-1.
DR   eggNOG; KOG1304; Eukaryota.
DR   HOGENOM; CLU_009646_0_1_1; -.
DR   InParanoid; P34479; -.
DR   OMA; IAMYVVF; -.
DR   OrthoDB; 3601817at2759; -.
DR   PhylomeDB; P34479; -.
DR   Reactome; R-CEL-352230; Amino acid transport across the plasma membrane.
DR   Reactome; R-CEL-428559; Proton-coupled neutral amino acid transporters.
DR   Reactome; R-CEL-71240; Tryptophan catabolism.
DR   PRO; PR:P34479; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00010307; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR   GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR013057; AA_transpt_TM.
DR   PANTHER; PTHR22950; AMINO ACID TRANSPORTER; 1.
DR   PANTHER; PTHR22950:SF343; AMINO ACID TRANSPORTER SKAT-1-RELATED; 1.
DR   Pfam; PF01490; Aa_trans; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..460
FT                   /note="Probable amino acid transporter skat-1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000093831"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   460 AA;  51338 MW;  0D78809A84EF15BA CRC64;
     MSEEEGRERA VTVEGDAESM NDGRALVQPP ARSGDVITPT RAVLTLSKSM FNAGCFSLPY
     AWKLGGLWVS FVMSFVIAGL NWYGNHILVR ASQHLAKKSD RSALDYGHFA KKVCDYSDIR
     FLRNNSKAVM YFVNVTILFY QLGMCSVAIL FISDNLVNLV GDHLGGTRHQ QMILMATVSL
     FFILLTNMFT EMRIVSFFAL VSSVFFVIGA AVIMQYTVQQ PNQWDKLPAA TNFTGTITMI
     GMSMYAFEGQ TMILPIENKL DNPAAFLAPF GVLSTTMIIC TAFMTALGFF GYTGFGDSIA
     PTITTNVPKE GLYSTVNVFL MLQSLLGNSI AMYVVYDMFF NGFRRKFGAR FPNVPKWLSD
     KGFRVFWVLV TYLMAVLIPK LEIMIPLVGV TSGALCALIF PPFFEMITFW TDWKGLLTYR
     QRMTKIFINL VVMAIGVFAI IAGVYTNIHA IIQSFSQPDP
//