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Protein

Probable amino acid transporter skat-1

Gene

skat-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the accumulation of vital dyes and endogenous fluorescent compounds in lysosome related organelles. Has an effect on lysosome related organelle (LRO) function, in a pathway with serotonin.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi2.A.18.8.8. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable amino acid transporter skat-11 Publication
Alternative name(s):
Protein suppressor of kat-1Imported
Gene namesi
Name:skat-1Imported
ORF Names:F59B2.2Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF59B2.2; CE20899; WBGene00010307; skat-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence AnalysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence AnalysisAdd
BLAST
Transmembranei383 – 40321HelicalSequence AnalysisAdd
BLAST
Transmembranei426 – 44621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Probable amino acid transporter skat-1CuratedPRO_0000093831Add
BLAST

Proteomic databases

PaxDbiP34479.
PRIDEiP34479.

Expressioni

Tissue specificityi

Expressed in the head, tail, body and ventral nerve cord neurons, muscles of the vulva, and intestine.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6239.F59B2.2.

Structurei

3D structure databases

ProteinModelPortaliP34479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000018109.
InParanoidiP34479.
OrthoDBiEOG73FQRD.
PhylomeDBiP34479.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34479-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEEGRERA VTVEGDAESM NDGRALVQPP ARSGDVITPT RAVLTLSKSM
60 70 80 90 100
FNAGCFSLPY AWKLGGLWVS FVMSFVIAGL NWYGNHILVR ASQHLAKKSD
110 120 130 140 150
RSALDYGHFA KKVCDYSDIR FLRNNSKAVM YFVNVTILFY QLGMCSVAIL
160 170 180 190 200
FISDNLVNLV GDHLGGTRHQ QMILMATVSL FFILLTNMFT EMRIVSFFAL
210 220 230 240 250
VSSVFFVIGA AVIMQYTVQQ PNQWDKLPAA TNFTGTITMI GMSMYAFEGQ
260 270 280 290 300
TMILPIENKL DNPAAFLAPF GVLSTTMIIC TAFMTALGFF GYTGFGDSIA
310 320 330 340 350
PTITTNVPKE GLYSTVNVFL MLQSLLGNSI AMYVVYDMFF NGFRRKFGAR
360 370 380 390 400
FPNVPKWLSD KGFRVFWVLV TYLMAVLIPK LEIMIPLVGV TSGALCALIF
410 420 430 440 450
PPFFEMITFW TDWKGLLTYR QRMTKIFINL VVMAIGVFAI IAGVYTNIHA
460
IIQSFSQPDP
Length:460
Mass (Da):51,338
Last modified:December 1, 2000 - v2
Checksum:i0D78809A84EF15BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11505 Genomic DNA. Translation: CAA77582.1.
PIRiF88544.
S31123.
RefSeqiNP_498989.1. NM_066588.4.
UniGeneiCel.6066.

Genome annotation databases

EnsemblMetazoaiF59B2.2; F59B2.2; WBGene00010307.
GeneIDi176271.
KEGGicel:CELE_F59B2.2.
UCSCiF59B2.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11505 Genomic DNA. Translation: CAA77582.1.
PIRiF88544.
S31123.
RefSeqiNP_498989.1. NM_066588.4.
UniGeneiCel.6066.

3D structure databases

ProteinModelPortaliP34479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F59B2.2.

Protein family/group databases

TCDBi2.A.18.8.8. the amino acid/auxin permease (aaap) family.

Proteomic databases

PaxDbiP34479.
PRIDEiP34479.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59B2.2; F59B2.2; WBGene00010307.
GeneIDi176271.
KEGGicel:CELE_F59B2.2.
UCSCiF59B2.2. c. elegans.

Organism-specific databases

CTDi176271.
WormBaseiF59B2.2; CE20899; WBGene00010307; skat-1.

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00390000011245.
HOGENOMiHOG000018109.
InParanoidiP34479.
OrthoDBiEOG73FQRD.
PhylomeDBiP34479.

Miscellaneous databases

NextBioi891862.
PROiP34479.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genetic regulation of Caenorhabditis elegans lysosome related organelle function."
    Soukas A.A., Carr C.E., Ruvkun G.
    PLoS Genet. 9:E1003908-E1003908(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSKAT1_CAEEL
AccessioniPrimary (citable) accession number: P34479
Secondary accession number(s): Q9U3E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 1, 2000
Last modified: July 22, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.