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P34477

- UBC7_CAEEL

UniProt

P34477 - UBC7_CAEEL

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Protein

Probable ubiquitin-conjugating enzyme E2 7

Gene

ubc-7

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 7 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 7
Ubiquitin-protein ligase 7
Gene namesi
Name:ubc-7
ORF Names:F58A4.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF58A4.10; CE00216; WBGene00006704; ubc-7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Probable ubiquitin-conjugating enzyme E2 7PRO_0000082516Add
BLAST

Proteomic databases

PaxDbiP34477.

Interactioni

Protein-protein interaction databases

STRINGi6239.F58A4.10.1.

Structurei

Secondary structure

1
164
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1713Combined sources
Beta strandi23 – 297Combined sources
Beta strandi35 – 417Combined sources
Beta strandi52 – 587Combined sources
Helixi63 – 653Combined sources
Beta strandi69 – 724Combined sources
Beta strandi85 – 873Combined sources
Helixi90 – 923Combined sources
Helixi115 – 12713Combined sources
Helixi137 – 1448Combined sources
Helixi147 – 16115Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZVX-ray2.52A1-164[»]
ProteinModelPortaliP34477.
SMRiP34477. Positions 4-164.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34477.

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110436.
HOGENOMiHOG000233454.
InParanoidiP34477.
KOiK10575.
OMAiFESPVFH.
PhylomeDBiP34477.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34477-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQSSLLLKK QLADMRRVPV DGFSAGLVDD NDIYKWEVLV IGPPDTLYEG
60 70 80 90 100
GFFKAILDFP RDYPQKPPKM KFISEIWHPN IDKEGNVCIS ILHDPGDDKW
110 120 130 140 150
GYERPEERWL PVHTVETILL SVISMLTDPN FESPANVDAA KMQRENYAEF
160
KKKVAQCVRR SQEE
Length:164
Mass (Da):18,939
Last modified:February 1, 1994 - v1
Checksum:i62580D9F3F8FD968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22179 Genomic DNA. Translation: CAA80166.1.
PIRiS40982.
RefSeqiNP_499133.1. NM_066732.4.
UniGeneiCel.18114.

Genome annotation databases

EnsemblMetazoaiF58A4.10; F58A4.10; WBGene00006704.
GeneIDi176363.
KEGGicel:CELE_F58A4.10.
UCSCiF58A4.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22179 Genomic DNA. Translation: CAA80166.1 .
PIRi S40982.
RefSeqi NP_499133.1. NM_066732.4.
UniGenei Cel.18114.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PZV X-ray 2.52 A 1-164 [» ]
ProteinModelPortali P34477.
SMRi P34477. Positions 4-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F58A4.10.1.

Proteomic databases

PaxDbi P34477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F58A4.10 ; F58A4.10 ; WBGene00006704 .
GeneIDi 176363.
KEGGi cel:CELE_F58A4.10.
UCSCi F58A4.10.1. c. elegans.

Organism-specific databases

CTDi 176363.
WormBasei F58A4.10 ; CE00216 ; WBGene00006704 ; ubc-7.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110436.
HOGENOMi HOG000233454.
InParanoidi P34477.
KOi K10575.
OMAi FESPVFH.
PhylomeDBi P34477.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

EvolutionaryTracei P34477.
NextBioi 892258.
PROi P34477.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBC7_CAEEL
AccessioniPrimary (citable) accession number: P34477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3