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P34477

- UBC7_CAEEL

UniProt

P34477 - UBC7_CAEEL

Protein

Probable ubiquitin-conjugating enzyme E2 7

Gene

ubc-7

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin-conjugating enzyme E2 7 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein 7
    Ubiquitin-protein ligase 7
    Gene namesi
    Name:ubc-7
    ORF Names:F58A4.10
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF58A4.10; CE00216; WBGene00006704; ubc-7.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Probable ubiquitin-conjugating enzyme E2 7PRO_0000082516Add
    BLAST

    Proteomic databases

    PaxDbiP34477.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F58A4.10.1.

    Structurei

    Secondary structure

    1
    164
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1713
    Beta strandi23 – 297
    Beta strandi35 – 417
    Beta strandi52 – 587
    Helixi63 – 653
    Beta strandi69 – 724
    Beta strandi85 – 873
    Helixi90 – 923
    Helixi115 – 12713
    Helixi137 – 1448
    Helixi147 – 16115

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PZVX-ray2.52A1-164[»]
    ProteinModelPortaliP34477.
    SMRiP34477. Positions 4-164.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP34477.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00730000110436.
    HOGENOMiHOG000233454.
    InParanoidiP34477.
    KOiK10575.
    OMAiFESPVFH.
    PhylomeDBiP34477.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34477-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQSSLLLKK QLADMRRVPV DGFSAGLVDD NDIYKWEVLV IGPPDTLYEG    50
    GFFKAILDFP RDYPQKPPKM KFISEIWHPN IDKEGNVCIS ILHDPGDDKW 100
    GYERPEERWL PVHTVETILL SVISMLTDPN FESPANVDAA KMQRENYAEF 150
    KKKVAQCVRR SQEE 164
    Length:164
    Mass (Da):18,939
    Last modified:February 1, 1994 - v1
    Checksum:i62580D9F3F8FD968
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22179 Genomic DNA. Translation: CAA80166.1.
    PIRiS40982.
    RefSeqiNP_499133.1. NM_066732.4.
    UniGeneiCel.18114.

    Genome annotation databases

    EnsemblMetazoaiF58A4.10; F58A4.10; WBGene00006704.
    GeneIDi176363.
    KEGGicel:CELE_F58A4.10.
    UCSCiF58A4.10.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22179 Genomic DNA. Translation: CAA80166.1 .
    PIRi S40982.
    RefSeqi NP_499133.1. NM_066732.4.
    UniGenei Cel.18114.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PZV X-ray 2.52 A 1-164 [» ]
    ProteinModelPortali P34477.
    SMRi P34477. Positions 4-164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F58A4.10.1.

    Proteomic databases

    PaxDbi P34477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F58A4.10 ; F58A4.10 ; WBGene00006704 .
    GeneIDi 176363.
    KEGGi cel:CELE_F58A4.10.
    UCSCi F58A4.10.1. c. elegans.

    Organism-specific databases

    CTDi 176363.
    WormBasei F58A4.10 ; CE00216 ; WBGene00006704 ; ubc-7.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00730000110436.
    HOGENOMi HOG000233454.
    InParanoidi P34477.
    KOi K10575.
    OMAi FESPVFH.
    PhylomeDBi P34477.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    EvolutionaryTracei P34477.
    NextBioi 892258.
    PROi P34477.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUBC7_CAEEL
    AccessioniPrimary (citable) accession number: P34477
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3