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P34477

- UBC7_CAEEL

UniProt

P34477 - UBC7_CAEEL

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Protein
Probable ubiquitin-conjugating enzyme E2 7
Gene
ubc-7, F58A4.10
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 7 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein 7
Ubiquitin-protein ligase 7
Gene namesi
Name:ubc-7
ORF Names:F58A4.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF58A4.10; CE00216; WBGene00006704; ubc-7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Probable ubiquitin-conjugating enzyme E2 7
PRO_0000082516Add
BLAST

Proteomic databases

PaxDbiP34477.

Interactioni

Protein-protein interaction databases

STRINGi6239.F58A4.10.1.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1713
Beta strandi23 – 297
Beta strandi35 – 417
Beta strandi52 – 587
Helixi63 – 653
Beta strandi69 – 724
Beta strandi85 – 873
Helixi90 – 923
Helixi115 – 12713
Helixi137 – 1448
Helixi147 – 16115

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PZVX-ray2.52A1-164[»]
ProteinModelPortaliP34477.
SMRiP34477. Positions 4-164.

Miscellaneous databases

EvolutionaryTraceiP34477.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110436.
HOGENOMiHOG000233454.
InParanoidiP34477.
KOiK10575.
OMAiFESPVFH.
PhylomeDBiP34477.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34477-1 [UniParc]FASTAAdd to Basket

« Hide

MEQSSLLLKK QLADMRRVPV DGFSAGLVDD NDIYKWEVLV IGPPDTLYEG    50
GFFKAILDFP RDYPQKPPKM KFISEIWHPN IDKEGNVCIS ILHDPGDDKW 100
GYERPEERWL PVHTVETILL SVISMLTDPN FESPANVDAA KMQRENYAEF 150
KKKVAQCVRR SQEE 164
Length:164
Mass (Da):18,939
Last modified:February 1, 1994 - v1
Checksum:i62580D9F3F8FD968
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22179 Genomic DNA. Translation: CAA80166.1.
PIRiS40982.
RefSeqiNP_499133.1. NM_066732.4.
UniGeneiCel.18114.

Genome annotation databases

EnsemblMetazoaiF58A4.10; F58A4.10; WBGene00006704.
GeneIDi176363.
KEGGicel:CELE_F58A4.10.
UCSCiF58A4.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22179 Genomic DNA. Translation: CAA80166.1 .
PIRi S40982.
RefSeqi NP_499133.1. NM_066732.4.
UniGenei Cel.18114.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1PZV X-ray 2.52 A 1-164 [» ]
ProteinModelPortali P34477.
SMRi P34477. Positions 4-164.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F58A4.10.1.

Proteomic databases

PaxDbi P34477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F58A4.10 ; F58A4.10 ; WBGene00006704 .
GeneIDi 176363.
KEGGi cel:CELE_F58A4.10.
UCSCi F58A4.10.1. c. elegans.

Organism-specific databases

CTDi 176363.
WormBasei F58A4.10 ; CE00216 ; WBGene00006704 ; ubc-7.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110436.
HOGENOMi HOG000233454.
InParanoidi P34477.
KOi K10575.
OMAi FESPVFH.
PhylomeDBi P34477.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

EvolutionaryTracei P34477.
NextBioi 892258.
PROi P34477.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBC7_CAEEL
AccessioniPrimary (citable) accession number: P34477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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