Probable ubiquitin-conjugating enzyme E2 7

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Reviewed, UniProtKB/Swiss-Prot P34477 (UBC7_CAEEL)

Last modified June 16, 2009. Version 66. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Probable ubiquitin-conjugating enzyme E2 7
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase 7
    Ubiquitin carrier protein 7

Gene names

Name:	ubc-7
ORF Names:	F58A4.10

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

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Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

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Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW post-translational protein modification Inferred from electronic annotation. Source: InterPro regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 164

164

Probable ubiquitin-conjugating enzyme E2 7

PRO_0000082516

Sites

Active site

Glycyl thioester intermediate By similarity

Secondary structure

164

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P34477-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 62580D9F3F8FD968
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FASTA

164

18,939

        10         20         30         40         50         60 
MEQSSLLLKK QLADMRRVPV DGFSAGLVDD NDIYKWEVLV IGPPDTLYEG GFFKAILDFP 

        70         80         90        100        110        120 
RDYPQKPPKM KFISEIWHPN IDKEGNVCIS ILHDPGDDKW GYERPEERWL PVHTVETILL 

       130        140        150        160 
SVISMLTDPN FESPANVDAA KMQRENYAEF KKKVAQCVRR SQEE

« Hide

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References

[1]

"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L.

Wohldman P.
Nature 368:32-38(1994) [PubMed: 7906398] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

[2]

"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.

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Cross-references

Sequence databases

Z22179 Genomic DNA. Translation: CAA80166.1.

PIR

S40982.

RefSeq

NP_499133.1.

UniGene

Cel.18114

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1PZV	X-ray	2.52	A	1-164	[»]

ModBase

Search...

Genome annotation databases

Ensembl

F58A4.10. Caenorhabditis elegans. [Contig view]

GeneID

176363.

KEGG

cel:F58A4.10.

Organism-specific databases

WormBase

WBGene00006704. ubc-7.

WormPep

F58A4.10. CE00216. [WorfDB]

Phylogenomic databases

OMA

P34477. DIWHPNV.

Enzyme and pathway databases

BRENDA

6.3.2.19. 672.

Gene expression databases

ArrayExpress

P34477.

Family and domain databases

InterPro

IPR016135. UBQ-conjugat/RWD-like.
IPR000608. UBQ-conjugat_E2.
[Graphical view]

Gene3D

G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.

Pfam

PF00179. UQ_con. 1 hit.
[Graphical view]

ProDom

PD000461. UBQ_conjugat. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00212. UBCc. 1 hit.
[Graphical view]

PROSITE

PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

892258.

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Entry information

Entry name

UBC7_CAEEL

Accession

Primary (citable) accession number: P34477

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project

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