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Protein

Probable ubiquitin-conjugating enzyme E2 7

Gene

ubc-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 7 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 7
Ubiquitin carrier protein 7
Ubiquitin-protein ligase 7
Gene namesi
Name:ubc-7
ORF Names:F58A4.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF58A4.10; CE00216; WBGene00006704; ubc-7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825161 – 164Probable ubiquitin-conjugating enzyme E2 7Add BLAST164

Proteomic databases

EPDiP34477.
PaxDbiP34477.
PeptideAtlasiP34477.
PRIDEiP34477.

Expressioni

Gene expression databases

BgeeiWBGene00006704.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.F58A4.10.2.

Structurei

Secondary structure

1164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 17Combined sources13
Beta strandi23 – 29Combined sources7
Beta strandi35 – 41Combined sources7
Beta strandi52 – 58Combined sources7
Helixi63 – 65Combined sources3
Beta strandi69 – 72Combined sources4
Beta strandi85 – 87Combined sources3
Helixi90 – 92Combined sources3
Helixi115 – 127Combined sources13
Helixi137 – 144Combined sources8
Helixi147 – 161Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PZVX-ray2.52A1-164[»]
ProteinModelPortaliP34477.
SMRiP34477.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34477.

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0425. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00730000110436.
HOGENOMiHOG000233454.
InParanoidiP34477.
KOiK10575.
OMAiKEWREEY.
OrthoDBiEOG091G0O9F.
PhylomeDBiP34477.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSSLLLKK QLADMRRVPV DGFSAGLVDD NDIYKWEVLV IGPPDTLYEG
60 70 80 90 100
GFFKAILDFP RDYPQKPPKM KFISEIWHPN IDKEGNVCIS ILHDPGDDKW
110 120 130 140 150
GYERPEERWL PVHTVETILL SVISMLTDPN FESPANVDAA KMQRENYAEF
160
KKKVAQCVRR SQEE
Length:164
Mass (Da):18,939
Last modified:February 1, 1994 - v1
Checksum:i62580D9F3F8FD968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22179 Genomic DNA. Translation: CAA80166.1.
PIRiS40982.
RefSeqiNP_499133.1. NM_066732.4.
UniGeneiCel.18114.

Genome annotation databases

EnsemblMetazoaiF58A4.10; F58A4.10; WBGene00006704.
GeneIDi176363.
KEGGicel:CELE_F58A4.10.
UCSCiF58A4.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22179 Genomic DNA. Translation: CAA80166.1.
PIRiS40982.
RefSeqiNP_499133.1. NM_066732.4.
UniGeneiCel.18114.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PZVX-ray2.52A1-164[»]
ProteinModelPortaliP34477.
SMRiP34477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F58A4.10.2.

Proteomic databases

EPDiP34477.
PaxDbiP34477.
PeptideAtlasiP34477.
PRIDEiP34477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58A4.10; F58A4.10; WBGene00006704.
GeneIDi176363.
KEGGicel:CELE_F58A4.10.
UCSCiF58A4.10.1. c. elegans.

Organism-specific databases

CTDi176363.
WormBaseiF58A4.10; CE00216; WBGene00006704; ubc-7.

Phylogenomic databases

eggNOGiKOG0425. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00730000110436.
HOGENOMiHOG000233454.
InParanoidiP34477.
KOiK10575.
OMAiKEWREEY.
OrthoDBiEOG091G0O9F.
PhylomeDBiP34477.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-CEL-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.

Miscellaneous databases

EvolutionaryTraceiP34477.
PROiP34477.

Gene expression databases

BgeeiWBGene00006704.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBC7_CAEEL
AccessioniPrimary (citable) accession number: P34477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.