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Protein

Tubulin gamma chain

Gene

tbg-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi144 – 150GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: WormBase

GO - Biological processi

  • cytoplasmic microtubule organization Source: InterPro
  • detection of temperature stimulus Source: UniProtKB
  • maintenance of centrosome location Source: UniProtKB
  • microtubule nucleation Source: WormBase
  • mitotic sister chromatid segregation Source: WormBase
  • mitotic spindle organization Source: WormBase
  • regulation of mitotic cell cycle, embryonic Source: UniProtKB
  • regulation of mitotic cytokinetic process Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma chain
Alternative name(s):
Gamma-tubulin
Gene namesi
Name:tbg-1
ORF Names:F58A4.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF58A4.8 ; CE00224 ; WBGene00006540 ; tbg-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484481 – 444Tubulin gamma chainAdd BLAST444

Proteomic databases

EPDiP34475
PaxDbiP34475
PeptideAtlasiP34475
PRIDEiP34475

Expressioni

Developmental stagei

Expressed in between seam cells at the lima-bean, 1.5-fold and 3-fold stages of embryonic development.1 Publication

Gene expression databases

BgeeiWBGene00006540

Interactioni

Protein-protein interaction databases

BioGridi41556, 12 interactors
DIPiDIP-26367N
IntActiP34475, 4 interactors
STRINGi6239.F58A4.8.2

Structurei

3D structure databases

ProteinModelPortaliP34475
SMRiP34475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00910000144217
HOGENOMiHOG000165714
InParanoidiP34475
KOiK10389
OMAiEGFMLMH
OrthoDBiEOG091G08A9
PhylomeDBiP34475

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

P34475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTGALMTV HVGQCGNQLA QAFWKSMVDE HGINERGQTT HEDDMNDKKD
60 70 80 90 100
LLFYQADDDH YVPRAVLVDL EPRVINGMMQ SPNFSNLFNT DNIFMSDHGG
110 120 130 140 150
GAGNNWASGY CQGQEVQEKI MDIIIREAEN TNNLDGILFT HSVSGGTGSG
160 170 180 190 200
TGSLLLERLR EAFPKKVIQT YSVFANSDTS TDVVVHPYNW VLSMQRLIEN
210 220 230 240 250
PDHVVVLDNA ALHRLAAGKF KTDTPTFDHI NSLVARIMST STAPYRFNSA
260 270 280 290 300
MCPSIRYLDL APFPPMHFIQ SAISPVVDPN ENFTRKTSVA DVTRFLLKPT
310 320 330 340 350
SMMVSTASRV RPNDCMLSAY MFLQGQIEAH TIMTAEQNVD FAIRRPPFYM
360 370 380 390 400
LKPLRMMHAP LSPYVRPQYK VSGLLLNNST SVAPLFESLL SKYDKLRSKR
410 420 430 440
AFIDKFEKID NFSLDMMDDA MHIVQDLLDE YKAVVQKDYL TRGL
Length:444
Mass (Da):49,929
Last modified:February 1, 1994 - v1
Checksum:iF96CB905B014D6A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287259 mRNA Translation: AAG24513.1
Z22179 Genomic DNA Translation: CAA80164.1
PIRiS40980
RefSeqiNP_499131.1, NM_066730.6
UniGeneiCel.19457

Genome annotation databases

EnsemblMetazoaiF58A4.8; F58A4.8; WBGene00006540
GeneIDi176361
KEGGicel:CELE_F58A4.8
UCSCiF58A4.8.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTBG_CAEEL
AccessioniPrimary (citable) accession number: P34475
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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