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Protein

Tubulin gamma chain

Gene

tbg-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi144 – 150GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: WormBase

GO - Biological processi

  • cytoplasmic microtubule organization Source: InterPro
  • detection of temperature stimulus Source: UniProtKB
  • maintenance of centrosome location Source: UniProtKB
  • microtubule nucleation Source: WormBase
  • mitotic sister chromatid segregation Source: WormBase
  • mitotic spindle organization Source: WormBase
  • regulation of mitotic cell cycle, embryonic Source: UniProtKB
  • regulation of mitotic cytokinetic process Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma chain
Alternative name(s):
Gamma-tubulin
Gene namesi
Name:tbg-1
ORF Names:F58A4.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF58A4.8; CE00224; WBGene00006540; tbg-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484481 – 444Tubulin gamma chainAdd BLAST444

Proteomic databases

EPDiP34475.
PaxDbiP34475.
PeptideAtlasiP34475.
PRIDEiP34475.

Expressioni

Developmental stagei

Expressed in between seam cells at the lima-bean, 1.5-fold and 3-fold stages of embryonic development.1 Publication

Gene expression databases

BgeeiWBGene00006540.

Interactioni

Protein-protein interaction databases

BioGridi41556. 12 interactors.
DIPiDIP-26367N.
IntActiP34475. 12 interactors.
MINTiMINT-1047366.
STRINGi6239.F58A4.8.2.

Structurei

3D structure databases

ProteinModelPortaliP34475.
SMRiP34475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000165714.
InParanoidiP34475.
KOiK10389.
OMAiEGFMLMH.
OrthoDBiEOG091G08A9.
PhylomeDBiP34475.

Family and domain databases

CDDicd02188. gamma_tubulin. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiView protein in InterPro
IPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiView protein in Pfam
PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiView protein in PROSITE
PS00227. TUBULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P34475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTGALMTV HVGQCGNQLA QAFWKSMVDE HGINERGQTT HEDDMNDKKD
60 70 80 90 100
LLFYQADDDH YVPRAVLVDL EPRVINGMMQ SPNFSNLFNT DNIFMSDHGG
110 120 130 140 150
GAGNNWASGY CQGQEVQEKI MDIIIREAEN TNNLDGILFT HSVSGGTGSG
160 170 180 190 200
TGSLLLERLR EAFPKKVIQT YSVFANSDTS TDVVVHPYNW VLSMQRLIEN
210 220 230 240 250
PDHVVVLDNA ALHRLAAGKF KTDTPTFDHI NSLVARIMST STAPYRFNSA
260 270 280 290 300
MCPSIRYLDL APFPPMHFIQ SAISPVVDPN ENFTRKTSVA DVTRFLLKPT
310 320 330 340 350
SMMVSTASRV RPNDCMLSAY MFLQGQIEAH TIMTAEQNVD FAIRRPPFYM
360 370 380 390 400
LKPLRMMHAP LSPYVRPQYK VSGLLLNNST SVAPLFESLL SKYDKLRSKR
410 420 430 440
AFIDKFEKID NFSLDMMDDA MHIVQDLLDE YKAVVQKDYL TRGL
Length:444
Mass (Da):49,929
Last modified:February 1, 1994 - v1
Checksum:iF96CB905B014D6A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287259 mRNA. Translation: AAG24513.1.
Z22179 Genomic DNA. Translation: CAA80164.1.
PIRiS40980.
RefSeqiNP_499131.1. NM_066730.6.
UniGeneiCel.19457.

Genome annotation databases

EnsemblMetazoaiF58A4.8; F58A4.8; WBGene00006540.
GeneIDi176361.
KEGGicel:CELE_F58A4.8.
UCSCiF58A4.8.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiTBG_CAEEL
AccessioniPrimary (citable) accession number: P34475
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 27, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families