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Protein

Extracellular superoxide dismutase [Cu-Zn]

Gene

sod-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Copper; catalyticBy similarity1
Metal bindingi72Copper; catalyticBy similarity1
Metal bindingi87Copper; catalyticBy similarity1
Metal bindingi87Zinc; structuralBy similarity1
Metal bindingi95Zinc; structuralBy similarity1
Metal bindingi104Zinc; structuralBy similarity1
Metal bindingi107Zinc; structuralBy similarity1
Metal bindingi144Copper; catalyticBy similarity1

GO - Molecular functioni

  • copper ion binding Source: GO_Central
  • superoxide dismutase activity Source: WormBase
  • zinc ion binding Source: GO_Central

GO - Biological processi

  • superoxide metabolic process Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Short name:
EC-SOD
Gene namesi
Name:sod-4
ORF Names:F55H2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF55H2.1a; CE25009; WBGene00004933; sod-4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular space Source: WormBase
  • membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003286120 – 221Extracellular superoxide dismutase [Cu-Zn]Add BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...)2 Publications1
Disulfide bondi81 ↔ 170By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34461.
PeptideAtlasiP34461.
PRIDEiP34461.

Expressioni

Tissue specificityi

Isoform 2 is preferentially expressed in eggs.

Gene expression databases

BgeeiWBGene00004933.

Interactioni

Protein-protein interaction databases

STRINGi6239.F55H2.1b.

Structurei

3D structure databases

ProteinModelPortaliP34461.
SMRiP34461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
HOGENOMiHOG000263447.
InParanoidiP34461.
PhylomeDBiP34461.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P34461-2) [UniParc]FASTAAdd to basket
Also known as: Sod4-2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTRVVLILA LSVCIEAASE VIRARAYIFK AEAGKIPTEL IGTIDFDQSG
60 70 80 90 100
SFLKLNGSVS GLAAGKHGFH IHEKGDTGNG CLSAGGHYNP HKLSHGAPDD
110 120 130 140 150
SNRHIGDLGN IESPASGDTL ISVSDSLASL SGQYSIIGRS VVIHEKTDDL
160 170 180 190 200
GRGTSDQSKT TGNAGSRLAC GTIGTVEERI LETTTASLPP VTQSQPIGSS
210 220
SYYYSTFYLP IILYFLLSRI L
Length:221
Mass (Da):23,326
Last modified:August 4, 2003 - v2
Checksum:i0769AC65F17CC883
GO
Isoform 1 (identifier: P34461-1) [UniParc]FASTAAdd to basket
Also known as: Sod4-1

The sequence of this isoform differs from the canonical sequence as follows:
     177-221: Missing.

Show »
Length:176
Mass (Da):18,171
Checksum:i612E7737AA244EC9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007920177 – 221Missing in isoform 1. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003924 mRNA. Translation: BAA28262.1.
Z27080 Genomic DNA. Translation: CAB61015.1.
PIRiJE0097.
JE0098.
S40984.
RefSeqiNP_001255003.1. NM_001268074.1. [P34461-1]
UniGeneiCel.19659.

Genome annotation databases

GeneIDi176336.
UCSCiF55H2.1. c. elegans. [P34461-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003924 mRNA. Translation: BAA28262.1.
Z27080 Genomic DNA. Translation: CAB61015.1.
PIRiJE0097.
JE0098.
S40984.
RefSeqiNP_001255003.1. NM_001268074.1. [P34461-1]
UniGeneiCel.19659.

3D structure databases

ProteinModelPortaliP34461.
SMRiP34461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F55H2.1b.

Proteomic databases

PaxDbiP34461.
PeptideAtlasiP34461.
PRIDEiP34461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi176336.
UCSCiF55H2.1. c. elegans. [P34461-1]

Organism-specific databases

CTDi176336.
WormBaseiF55H2.1a; CE25009; WBGene00004933; sod-4.

Phylogenomic databases

eggNOGiKOG0441. Eukaryota.
COG2032. LUCA.
HOGENOMiHOG000263447.
InParanoidiP34461.
PhylomeDBiP34461.

Enzyme and pathway databases

ReactomeiR-CEL-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiP34461.

Gene expression databases

BgeeiWBGene00004933.

Family and domain databases

CDDicd00305. Cu-Zn_Superoxide_Dismutase. 1 hit.
Gene3Di2.60.40.200. 1 hit.
InterProiIPR024134. SOD_Cu/Zn_/chaperone.
IPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PANTHERiPTHR10003. PTHR10003. 1 hit.
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODE_CAEEL
AccessioniPrimary (citable) accession number: P34461
Secondary accession number(s): O61260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 4, 2003
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.