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Protein

GTP-binding protein Rheb homolog 1

Gene

rheb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds GTP and exhibits intrinsic GTPase activity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271MagnesiumBy similarity
Metal bindingi45 – 451MagnesiumBy similarity
Binding sitei70 – 701GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi23 – 286GTPBy similarity
Nucleotide bindingi39 – 457GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity
Nucleotide bindingi156 – 1572GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rheb homolog 1
Gene namesi
Name:rheb-1
ORF Names:F54C8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54C8.5; CE00191; WBGene00010038; rheb-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Inactivation promotes nuclear redistribution of dve-1, induction of ubl-5 and complex formation with dve-1.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204GTP-binding protein Rheb homolog 1PRO_0000082714Add
BLAST
Propeptidei205 – 2073Removed in mature formBy similarityPRO_0000281371

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Cysteine methyl esterBy similarity
Lipidationi204 – 2041S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP34443.
PaxDbiP34443.
PRIDEiP34443.

PTM databases

iPTMnetiP34443.

Interactioni

Protein-protein interaction databases

IntActiP34443. 1 interaction.
STRINGi6239.F54C8.5.

Structurei

3D structure databases

ProteinModelPortaliP34443.
SMRiP34443. Positions 10-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
InParanoidiP34443.
KOiK07208.
OMAiTILNSKH.
OrthoDBiEOG7Q2N6K.
PhylomeDBiP34443.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLQSNRQ SLNRKVAVMG YPHVGKSALV LRFTQNIFPE RYESTIEDQH
60 70 80 90 100
SKHIAAFHRD YHLRVTDTAG QQEYTVFPRS CSLDINGFIL VYAIDDRKSF
110 120 130 140 150
EMCSNIYEKI VRTYGDTSIP IVIVGNKTDL STQRVVRAEE GEELARQWDA
160 170 180 190 200
KFVEITARES NRVHEVFELL LREIEISRGN LSPTERPNGN SPKRNPFKDD

GKPCSIS
Length:207
Mass (Da):23,696
Last modified:February 1, 1994 - v1
Checksum:i720031575DE8E15F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80155.1.
PIRiS40747.
RefSeqiNP_499079.1. NM_066678.3.
UniGeneiCel.7479.

Genome annotation databases

EnsemblMetazoaiF54C8.5; F54C8.5; WBGene00010038.
GeneIDi176327.
KEGGicel:CELE_F54C8.5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80155.1.
PIRiS40747.
RefSeqiNP_499079.1. NM_066678.3.
UniGeneiCel.7479.

3D structure databases

ProteinModelPortaliP34443.
SMRiP34443. Positions 10-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP34443. 1 interaction.
STRINGi6239.F54C8.5.

PTM databases

iPTMnetiP34443.

Proteomic databases

EPDiP34443.
PaxDbiP34443.
PRIDEiP34443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF54C8.5; F54C8.5; WBGene00010038.
GeneIDi176327.
KEGGicel:CELE_F54C8.5.

Organism-specific databases

CTDi176327.
WormBaseiF54C8.5; CE00191; WBGene00010038; rheb-1.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121877.
HOGENOMiHOG000233973.
InParanoidiP34443.
KOiK07208.
OMAiTILNSKH.
OrthoDBiEOG7Q2N6K.
PhylomeDBiP34443.

Miscellaneous databases

NextBioi892108.
PROiP34443.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans."
    Haynes C.M., Petrova K., Benedetti C., Yang Y., Ron D.
    Dev. Cell 13:467-480(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiRHEB1_CAEEL
AccessioniPrimary (citable) accession number: P34443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.