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Protein

GTP-binding protein Rheb homolog 1

Gene

rheb-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds GTP and exhibits intrinsic GTPase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27MagnesiumBy similarity1
Metal bindingi45MagnesiumBy similarity1
Binding sitei70GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi23 – 28GTPBy similarity6
Nucleotide bindingi39 – 45GTPBy similarity7
Nucleotide bindingi126 – 129GTPBy similarity4
Nucleotide bindingi156 – 157GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rheb homolog 1
Gene namesi
Name:rheb-1
ORF Names:F54C8.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54C8.5 ; CE00191 ; WBGene00010038 ; rheb-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Inactivation promotes nuclear redistribution of dve-1, induction of ubl-5 and complex formation with dve-1.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827141 – 204GTP-binding protein Rheb homolog 1Add BLAST204
PropeptideiPRO_0000281371205 – 207Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204Cysteine methyl esterBy similarity1
Lipidationi204S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP34443
PaxDbiP34443
PeptideAtlasiP34443
PRIDEiP34443

PTM databases

iPTMnetiP34443

Expressioni

Gene expression databases

BgeeiWBGene00010038

Interactioni

Protein-protein interaction databases

IntActiP34443, 1 interactor
STRINGi6239.F54C8.5

Structurei

3D structure databases

ProteinModelPortaliP34443
SMRiP34443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133696
HOGENOMiHOG000233973
InParanoidiP34443
KOiK07208
OMAiFIENHFV
OrthoDBiEOG091G0ONO
PhylomeDBiP34443

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSLQSNRQ SLNRKVAVMG YPHVGKSALV LRFTQNIFPE RYESTIEDQH
60 70 80 90 100
SKHIAAFHRD YHLRVTDTAG QQEYTVFPRS CSLDINGFIL VYAIDDRKSF
110 120 130 140 150
EMCSNIYEKI VRTYGDTSIP IVIVGNKTDL STQRVVRAEE GEELARQWDA
160 170 180 190 200
KFVEITARES NRVHEVFELL LREIEISRGN LSPTERPNGN SPKRNPFKDD

GKPCSIS
Length:207
Mass (Da):23,696
Last modified:February 1, 1994 - v1
Checksum:i720031575DE8E15F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA Translation: CAA80155.1
PIRiS40747
RefSeqiNP_499079.1, NM_066678.3
UniGeneiCel.7479

Genome annotation databases

EnsemblMetazoaiF54C8.5; F54C8.5; WBGene00010038
GeneIDi176327
KEGGicel:CELE_F54C8.5

Similar proteinsi

Entry informationi

Entry nameiRHEB1_CAEEL
AccessioniPrimary (citable) accession number: P34443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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