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Protein

Probable tyrosine-protein phosphatase F54C8.4

Gene

F54C8.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei131Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein phosphatase F54C8.4 (EC:3.1.3.48)
Gene namesi
ORF Names:F54C8.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54C8.4a; CE00190; WBGene00010037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948851 – 359Probable tyrosine-protein phosphatase F54C8.4Add BLAST359

Proteomic databases

EPDiP34442.
PaxDbiP34442.
PeptideAtlasiP34442.

Expressioni

Gene expression databases

BgeeiWBGene00010037.
ExpressionAtlasiP34442. differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-6669542.
STRINGi6239.F54C8.4a.

Structurei

3D structure databases

ProteinModelPortaliP34442.
SMRiP34442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi292 – 310Asp/Glu-rich (highly acidic)Add BLAST19

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000115789.
InParanoidiP34442.
KOiK14165.
OMAiHMINAIL.
OrthoDBiEOG091G0HD0.
PhylomeDBiP34442.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVCRVVPK DWSKFQPVGN VIPRTRFIVF KTPINSQLST KIHKEQRFTT
60 70 80 90 100
NDLFRQLSER GQYLGLVVDL SDTDRYYDKK DITGMCVQYE KVNCPGRGFI
110 120 130 140 150
ERDDCVESFH QVIQDYTDKC DDPDALIGVH CTNGINRCGY LICRFLIDRL
160 170 180 190 200
GWSSHEAIDA FEQARGYSIE KGAYVMALHK AAKDKRDKQV DSDSDSSERQ
210 220 230 240 250
RKKKNKRKHR EIVEHENIVL INTIIGELGS QAASVSGTDY QNSPNGVSVD
260 270 280 290 300
PGQPQPHHWG FAIKRSKYAQ LNQPVANGAN TPPEPSEGTP QEEEEFEEDF
310 320 330 340 350
EEIEEETETE PGKGQSVSSK RRARRNRMQK YMQVMQRGRF HEIQAIREEV

ALSHGSARD
Length:359
Mass (Da):41,111
Last modified:February 1, 1994 - v1
Checksum:i55BB1D1E6DC45935
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80156.1.
PIRiS40746.
RefSeqiNP_001254988.1. NM_001268059.1.
UniGeneiCel.8899.

Genome annotation databases

EnsemblMetazoaiF54C8.4a; F54C8.4a; WBGene00010037.
GeneIDi176323.
KEGGicel:CELE_F54C8.4.
UCSCiF54C8.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80156.1.
PIRiS40746.
RefSeqiNP_001254988.1. NM_001268059.1.
UniGeneiCel.8899.

3D structure databases

ProteinModelPortaliP34442.
SMRiP34442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-6669542.
STRINGi6239.F54C8.4a.

Proteomic databases

EPDiP34442.
PaxDbiP34442.
PeptideAtlasiP34442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF54C8.4a; F54C8.4a; WBGene00010037.
GeneIDi176323.
KEGGicel:CELE_F54C8.4.
UCSCiF54C8.4. c. elegans.

Organism-specific databases

CTDi176323.
WormBaseiF54C8.4a; CE00190; WBGene00010037.

Phylogenomic databases

eggNOGiKOG2386. Eukaryota.
COG5226. LUCA.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000115789.
InParanoidiP34442.
KOiK14165.
OMAiHMINAIL.
OrthoDBiEOG091G0HD0.
PhylomeDBiP34442.

Miscellaneous databases

PROiP34442.

Gene expression databases

BgeeiWBGene00010037.
ExpressionAtlasiP34442. differential.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTP5_CAEEL
AccessioniPrimary (citable) accession number: P34442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.