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P34442

- PTP5_CAEEL

UniProt

P34442 - PTP5_CAEEL

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Protein

Probable tyrosine-protein phosphatase F54C8.4

Gene
F54C8.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein phosphatase F54C8.4 (EC:3.1.3.48)
Gene namesi
ORF Names:F54C8.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF54C8.4a; CE00190; WBGene00010037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Probable tyrosine-protein phosphatase F54C8.4PRO_0000094885Add
BLAST

Proteomic databases

PaxDbiP34442.

Interactioni

Protein-protein interaction databases

MINTiMINT-6669542.
STRINGi6239.F54C8.4.

Structurei

3D structure databases

ProteinModelPortaliP34442.
SMRiP34442. Positions 8-179.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 31019Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG252687.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000115789.
InParanoidiP34442.
KOiK01104.
OMAiEIVEHEN.
PhylomeDBiP34442.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34442-1 [UniParc]FASTAAdd to Basket

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MVRVCRVVPK DWSKFQPVGN VIPRTRFIVF KTPINSQLST KIHKEQRFTT    50
NDLFRQLSER GQYLGLVVDL SDTDRYYDKK DITGMCVQYE KVNCPGRGFI 100
ERDDCVESFH QVIQDYTDKC DDPDALIGVH CTNGINRCGY LICRFLIDRL 150
GWSSHEAIDA FEQARGYSIE KGAYVMALHK AAKDKRDKQV DSDSDSSERQ 200
RKKKNKRKHR EIVEHENIVL INTIIGELGS QAASVSGTDY QNSPNGVSVD 250
PGQPQPHHWG FAIKRSKYAQ LNQPVANGAN TPPEPSEGTP QEEEEFEEDF 300
EEIEEETETE PGKGQSVSSK RRARRNRMQK YMQVMQRGRF HEIQAIREEV 350
ALSHGSARD 359
Length:359
Mass (Da):41,111
Last modified:February 1, 1994 - v1
Checksum:i55BB1D1E6DC45935
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22178 Genomic DNA. Translation: CAA80156.1.
PIRiS40746.
RefSeqiNP_001254988.1. NM_001268059.1.
UniGeneiCel.8899.

Genome annotation databases

EnsemblMetazoaiF54C8.4a; F54C8.4a; WBGene00010037.
GeneIDi176323.
KEGGicel:CELE_F54C8.4.
UCSCiF54C8.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22178 Genomic DNA. Translation: CAA80156.1 .
PIRi S40746.
RefSeqi NP_001254988.1. NM_001268059.1.
UniGenei Cel.8899.

3D structure databases

ProteinModelPortali P34442.
SMRi P34442. Positions 8-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-6669542.
STRINGi 6239.F54C8.4.

Proteomic databases

PaxDbi P34442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F54C8.4a ; F54C8.4a ; WBGene00010037 .
GeneIDi 176323.
KEGGi cel:CELE_F54C8.4.
UCSCi F54C8.4. c. elegans.

Organism-specific databases

CTDi 176323.
WormBasei F54C8.4a ; CE00190 ; WBGene00010037 .

Phylogenomic databases

eggNOGi NOG252687.
GeneTreei ENSGT00530000063473.
HOGENOMi HOG000115789.
InParanoidi P34442.
KOi K01104.
OMAi EIVEHEN.
PhylomeDBi P34442.

Miscellaneous databases

NextBioi 892094.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPTP5_CAEEL
AccessioniPrimary (citable) accession number: P34442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 11, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi