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P34442

- PTP5_CAEEL

UniProt

P34442 - PTP5_CAEEL

Protein

Probable tyrosine-protein phosphatase F54C8.4

Gene

F54C8.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable tyrosine-protein phosphatase F54C8.4 (EC:3.1.3.48)
    Gene namesi
    ORF Names:F54C8.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF54C8.4a; CE00190; WBGene00010037.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Probable tyrosine-protein phosphatase F54C8.4PRO_0000094885Add
    BLAST

    Proteomic databases

    PaxDbiP34442.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-6669542.
    STRINGi6239.F54C8.4.

    Structurei

    3D structure databases

    ProteinModelPortaliP34442.
    SMRiP34442. Positions 8-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi292 – 31019Asp/Glu-rich (highly acidic)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG252687.
    GeneTreeiENSGT00530000063473.
    HOGENOMiHOG000115789.
    InParanoidiP34442.
    KOiK01104.
    OMAiEIVEHEN.
    PhylomeDBiP34442.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34442-1 [UniParc]FASTAAdd to Basket

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    MVRVCRVVPK DWSKFQPVGN VIPRTRFIVF KTPINSQLST KIHKEQRFTT    50
    NDLFRQLSER GQYLGLVVDL SDTDRYYDKK DITGMCVQYE KVNCPGRGFI 100
    ERDDCVESFH QVIQDYTDKC DDPDALIGVH CTNGINRCGY LICRFLIDRL 150
    GWSSHEAIDA FEQARGYSIE KGAYVMALHK AAKDKRDKQV DSDSDSSERQ 200
    RKKKNKRKHR EIVEHENIVL INTIIGELGS QAASVSGTDY QNSPNGVSVD 250
    PGQPQPHHWG FAIKRSKYAQ LNQPVANGAN TPPEPSEGTP QEEEEFEEDF 300
    EEIEEETETE PGKGQSVSSK RRARRNRMQK YMQVMQRGRF HEIQAIREEV 350
    ALSHGSARD 359
    Length:359
    Mass (Da):41,111
    Last modified:February 1, 1994 - v1
    Checksum:i55BB1D1E6DC45935
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22178 Genomic DNA. Translation: CAA80156.1.
    PIRiS40746.
    RefSeqiNP_001254988.1. NM_001268059.1.
    UniGeneiCel.8899.

    Genome annotation databases

    EnsemblMetazoaiF54C8.4a; F54C8.4a; WBGene00010037.
    GeneIDi176323.
    KEGGicel:CELE_F54C8.4.
    UCSCiF54C8.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22178 Genomic DNA. Translation: CAA80156.1 .
    PIRi S40746.
    RefSeqi NP_001254988.1. NM_001268059.1.
    UniGenei Cel.8899.

    3D structure databases

    ProteinModelPortali P34442.
    SMRi P34442. Positions 8-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-6669542.
    STRINGi 6239.F54C8.4.

    Proteomic databases

    PaxDbi P34442.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F54C8.4a ; F54C8.4a ; WBGene00010037 .
    GeneIDi 176323.
    KEGGi cel:CELE_F54C8.4.
    UCSCi F54C8.4. c. elegans.

    Organism-specific databases

    CTDi 176323.
    WormBasei F54C8.4a ; CE00190 ; WBGene00010037 .

    Phylogenomic databases

    eggNOGi NOG252687.
    GeneTreei ENSGT00530000063473.
    HOGENOMi HOG000115789.
    InParanoidi P34442.
    KOi K01104.
    OMAi EIVEHEN.
    PhylomeDBi P34442.

    Miscellaneous databases

    NextBioi 892094.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPTP5_CAEEL
    AccessioniPrimary (citable) accession number: P34442
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3