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Protein

Probable tyrosine-protein phosphatase F54C8.4

Gene

F54C8.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein phosphatase F54C8.4 (EC:3.1.3.48)
Gene namesi
ORF Names:F54C8.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54C8.4a; CE00190; WBGene00010037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Probable tyrosine-protein phosphatase F54C8.4PRO_0000094885Add
BLAST

Proteomic databases

PaxDbiP34442.

Expressioni

Gene expression databases

ExpressionAtlasiP34442. baseline.

Interactioni

Protein-protein interaction databases

MINTiMINT-6669542.
STRINGi6239.F54C8.4a.

Structurei

3D structure databases

ProteinModelPortaliP34442.
SMRiP34442. Positions 8-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 31019Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG252687.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000115789.
InParanoidiP34442.
OMAiHMINAIL.
PhylomeDBiP34442.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVCRVVPK DWSKFQPVGN VIPRTRFIVF KTPINSQLST KIHKEQRFTT
60 70 80 90 100
NDLFRQLSER GQYLGLVVDL SDTDRYYDKK DITGMCVQYE KVNCPGRGFI
110 120 130 140 150
ERDDCVESFH QVIQDYTDKC DDPDALIGVH CTNGINRCGY LICRFLIDRL
160 170 180 190 200
GWSSHEAIDA FEQARGYSIE KGAYVMALHK AAKDKRDKQV DSDSDSSERQ
210 220 230 240 250
RKKKNKRKHR EIVEHENIVL INTIIGELGS QAASVSGTDY QNSPNGVSVD
260 270 280 290 300
PGQPQPHHWG FAIKRSKYAQ LNQPVANGAN TPPEPSEGTP QEEEEFEEDF
310 320 330 340 350
EEIEEETETE PGKGQSVSSK RRARRNRMQK YMQVMQRGRF HEIQAIREEV

ALSHGSARD
Length:359
Mass (Da):41,111
Last modified:February 1, 1994 - v1
Checksum:i55BB1D1E6DC45935
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80156.1.
PIRiS40746.
RefSeqiNP_001254988.1. NM_001268059.1.
UniGeneiCel.8899.

Genome annotation databases

EnsemblMetazoaiF54C8.4a; F54C8.4a; WBGene00010037.
GeneIDi176323.
UCSCiF54C8.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80156.1.
PIRiS40746.
RefSeqiNP_001254988.1. NM_001268059.1.
UniGeneiCel.8899.

3D structure databases

ProteinModelPortaliP34442.
SMRiP34442. Positions 8-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-6669542.
STRINGi6239.F54C8.4a.

Proteomic databases

PaxDbiP34442.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF54C8.4a; F54C8.4a; WBGene00010037.
GeneIDi176323.
UCSCiF54C8.4. c. elegans.

Organism-specific databases

CTDi176323.
WormBaseiF54C8.4a; CE00190; WBGene00010037.

Phylogenomic databases

eggNOGiNOG252687.
GeneTreeiENSGT00530000063473.
HOGENOMiHOG000115789.
InParanoidiP34442.
OMAiHMINAIL.
PhylomeDBiP34442.

Miscellaneous databases

NextBioi892094.
PROiP34442.

Gene expression databases

ExpressionAtlasiP34442. baseline.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPTP5_CAEEL
AccessioniPrimary (citable) accession number: P34442
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 22, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.