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P34439 (HCDH1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1

EC=1.1.1.35
Gene names
ORF Names:F54C8.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentMitochondrion
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid beta-oxidation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NAD+ binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1
PRO_0000109253

Sites

Site1531Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
P34439 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: D8C2BE57823445B4

FASTA29832,492
        10         20         30         40         50         60 
MFTAKCAMQN IRNVAIVGSG QMGSGIAQVT ASSGFNVMLA DVNKKALDRA MKAISQSVTH 

        70         80         90        100        110        120 
LSKKQKGTDK EKSDFVTLTM SRIKTCNNVS TAVADADLII EAAIENIDLK RGIFAQIEQS 

       130        140        150        160        170        180 
CKKDSILTTN TSSFLLEDVA KGLQDKTRFG GLHFFNPVPV MKLLEVIRSD DTSDETYATL 

       190        200        210        220        230        240 
IKFGTAVGKT TVACKDSPGF IVNRLLIPYF FEAARMYERG DASMTDIDEA MKLGAGHPMG 

       250        260        270        280        290 
PFELADYIGL DTVKFVMDGW AAKYPEVQLF EASPLVDKLV AEGKLGRKTG DGFYSYKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z22178 Genomic DNA. Translation: CAA80153.1.
PIRS40743.
RefSeqNP_499075.1. NM_066674.1.
UniGeneCel.10436.

3D structure databases

ProteinModelPortalP34439.
SMRP34439. Positions 11-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F54C8.1.

Proteomic databases

PaxDbP34439.
PRIDEP34439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF54C8.1; F54C8.1; F54C8.1.
GeneID186222.
KEGGcel:CELE_F54C8.1.
UCSCF54C8.1. c. elegans.

Organism-specific databases

CTD186222.
WormBaseF54C8.1; CE00187; WBGene00010035.

Phylogenomic databases

eggNOGCOG1250.
HOGENOMHOG000141498.
InParanoidP34439.
KOK00022.
OMALIDISWD.
OrthoDBEOG7K3TMS.
PhylomeDBP34439.

Enzyme and pathway databases

UniPathwayUPA00659.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFPIRSF000105. HCDH. 1 hit.
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio931082.

Entry information

Entry nameHCDH1_CAEEL
AccessionPrimary (citable) accession number: P34439
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase