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Protein

Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1

Gene

F54C8.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei153Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
R-CEL-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
R-CEL-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA
R-CEL-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA
R-CEL-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA
UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 (EC:1.1.1.35)
Gene namesi
ORF Names:F54C8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54C8.1 ; CE00187 ; WBGene00010035

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001092531 – 298Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1Add BLAST298

Proteomic databases

EPDiP34439
PaxDbiP34439
PeptideAtlasiP34439
PRIDEiP34439

Expressioni

Gene expression databases

BgeeiWBGene00010035

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.F54C8.1

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 5Combined sources4
Beta strandi13 – 17Combined sources5
Helixi21 – 32Combined sources12
Beta strandi36 – 40Combined sources5
Helixi44 – 64Combined sources21
Helixi69 – 80Combined sources12
Beta strandi83 – 87Combined sources5
Helixi89 – 93Combined sources5
Beta strandi97 – 101Combined sources5
Helixi107 – 120Combined sources14
Beta strandi126 – 129Combined sources4
Beta strandi132 – 134Combined sources3
Helixi136 – 139Combined sources4
Turni140 – 142Combined sources3
Helixi146 – 148Combined sources3
Beta strandi149 – 153Combined sources5
Turni158 – 160Combined sources3
Beta strandi163 – 168Combined sources6
Helixi174 – 186Combined sources13
Beta strandi190 – 196Combined sources7
Turni198 – 201Combined sources4
Helixi202 – 219Combined sources18
Helixi224 – 235Combined sources12
Helixi241 – 248Combined sources8
Helixi250 – 263Combined sources14
Beta strandi264 – 266Combined sources3
Helixi268 – 270Combined sources3
Helixi274 – 281Combined sources8
Helixi287 – 289Combined sources3
Beta strandi291 – 295Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4J0EX-ray1.60A/B1-298[»]
4J0FX-ray2.20A/B1-298[»]
ProteinModelPortaliP34439
SMRiP34439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2304 Eukaryota
COG1250 LUCA
GeneTreeiENSGT00880000137923
HOGENOMiHOG000141498
InParanoidiP34439
KOiK00022
OMAiYPMGPLT
OrthoDBiEOG091G089P
PhylomeDBiP34439

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR022694 3-OHacyl-CoA_DH
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PIRSFiPIRSF000105 HCDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit

Sequencei

Sequence statusi: Complete.

P34439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTAKCAMQN IRNVAIVGSG QMGSGIAQVT ASSGFNVMLA DVNKKALDRA
60 70 80 90 100
MKAISQSVTH LSKKQKGTDK EKSDFVTLTM SRIKTCNNVS TAVADADLII
110 120 130 140 150
EAAIENIDLK RGIFAQIEQS CKKDSILTTN TSSFLLEDVA KGLQDKTRFG
160 170 180 190 200
GLHFFNPVPV MKLLEVIRSD DTSDETYATL IKFGTAVGKT TVACKDSPGF
210 220 230 240 250
IVNRLLIPYF FEAARMYERG DASMTDIDEA MKLGAGHPMG PFELADYIGL
260 270 280 290
DTVKFVMDGW AAKYPEVQLF EASPLVDKLV AEGKLGRKTG DGFYSYKK
Length:298
Mass (Da):32,492
Last modified:February 1, 1994 - v1
Checksum:iD8C2BE57823445B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA Translation: CAA80153.1
PIRiS40743
RefSeqiNP_499075.1, NM_066674.1
UniGeneiCel.10436

Genome annotation databases

EnsemblMetazoaiF54C8.1; F54C8.1; WBGene00010035
GeneIDi186222
KEGGicel:CELE_F54C8.1
UCSCiF54C8.1 c. elegans

Entry informationi

Entry nameiHCDH1_CAEEL
AccessioniPrimary (citable) accession number: P34439
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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