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Protein

Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1

Gene

F54C8.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

Pathway:ifatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei153 – 1531Important for catalytic activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_272147. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
REACT_310127. Beta oxidation of butanoyl-CoA to acetyl-CoA.
REACT_312874. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_334464. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_345702. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 (EC:1.1.1.35)
Gene namesi
ORF Names:F54C8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF54C8.1; CE00187; WBGene00010035.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1PRO_0000109253Add
BLAST

Proteomic databases

PaxDbiP34439.
PRIDEiP34439.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.F54C8.1.

Structurei

Secondary structure

1
298
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 54Combined sources
Beta strandi13 – 175Combined sources
Helixi21 – 3212Combined sources
Beta strandi36 – 405Combined sources
Helixi44 – 6421Combined sources
Helixi69 – 8012Combined sources
Beta strandi83 – 875Combined sources
Helixi89 – 935Combined sources
Beta strandi97 – 1015Combined sources
Helixi107 – 12014Combined sources
Beta strandi126 – 1294Combined sources
Beta strandi132 – 1343Combined sources
Helixi136 – 1394Combined sources
Turni140 – 1423Combined sources
Helixi146 – 1483Combined sources
Beta strandi149 – 1535Combined sources
Turni158 – 1603Combined sources
Beta strandi163 – 1686Combined sources
Helixi174 – 18613Combined sources
Beta strandi190 – 1967Combined sources
Turni198 – 2014Combined sources
Helixi202 – 21918Combined sources
Helixi224 – 23512Combined sources
Helixi241 – 2488Combined sources
Helixi250 – 26314Combined sources
Beta strandi264 – 2663Combined sources
Helixi268 – 2703Combined sources
Helixi274 – 2818Combined sources
Helixi287 – 2893Combined sources
Beta strandi291 – 2955Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J0EX-ray1.60A/B1-298[»]
4J0FX-ray2.20A/B1-298[»]
ProteinModelPortaliP34439.
SMRiP34439. Positions 1-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1250.
GeneTreeiENSGT00720000108673.
HOGENOMiHOG000141498.
InParanoidiP34439.
KOiK00022.
OMAiCEVIVES.
OrthoDBiEOG7K3TMS.
PhylomeDBiP34439.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTAKCAMQN IRNVAIVGSG QMGSGIAQVT ASSGFNVMLA DVNKKALDRA
60 70 80 90 100
MKAISQSVTH LSKKQKGTDK EKSDFVTLTM SRIKTCNNVS TAVADADLII
110 120 130 140 150
EAAIENIDLK RGIFAQIEQS CKKDSILTTN TSSFLLEDVA KGLQDKTRFG
160 170 180 190 200
GLHFFNPVPV MKLLEVIRSD DTSDETYATL IKFGTAVGKT TVACKDSPGF
210 220 230 240 250
IVNRLLIPYF FEAARMYERG DASMTDIDEA MKLGAGHPMG PFELADYIGL
260 270 280 290
DTVKFVMDGW AAKYPEVQLF EASPLVDKLV AEGKLGRKTG DGFYSYKK
Length:298
Mass (Da):32,492
Last modified:February 1, 1994 - v1
Checksum:iD8C2BE57823445B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80153.1.
PIRiS40743.
RefSeqiNP_499075.1. NM_066674.1.
UniGeneiCel.10436.

Genome annotation databases

EnsemblMetazoaiF54C8.1; F54C8.1; WBGene00010035.
GeneIDi186222.
KEGGicel:CELE_F54C8.1.
UCSCiF54C8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22178 Genomic DNA. Translation: CAA80153.1.
PIRiS40743.
RefSeqiNP_499075.1. NM_066674.1.
UniGeneiCel.10436.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4J0EX-ray1.60A/B1-298[»]
4J0FX-ray2.20A/B1-298[»]
ProteinModelPortaliP34439.
SMRiP34439. Positions 1-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F54C8.1.

Proteomic databases

PaxDbiP34439.
PRIDEiP34439.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF54C8.1; F54C8.1; WBGene00010035.
GeneIDi186222.
KEGGicel:CELE_F54C8.1.
UCSCiF54C8.1. c. elegans.

Organism-specific databases

CTDi186222.
WormBaseiF54C8.1; CE00187; WBGene00010035.

Phylogenomic databases

eggNOGiCOG1250.
GeneTreeiENSGT00720000108673.
HOGENOMiHOG000141498.
InParanoidiP34439.
KOiK00022.
OMAiCEVIVES.
OrthoDBiEOG7K3TMS.
PhylomeDBiP34439.

Enzyme and pathway databases

UniPathwayiUPA00659.
ReactomeiREACT_272147. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
REACT_310127. Beta oxidation of butanoyl-CoA to acetyl-CoA.
REACT_312874. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
REACT_334464. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
REACT_345702. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.

Miscellaneous databases

NextBioi931082.
PROiP34439.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHCDH1_CAEEL
AccessioniPrimary (citable) accession number: P34439
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 22, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.