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P34439

- HCDH1_CAEEL

UniProt

P34439 - HCDH1_CAEEL

Protein

Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1

Gene

F54C8.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei153 – 1531Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
    2. NAD+ binding Source: InterPro

    GO - Biological processi

    1. fatty acid beta-oxidation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00659.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 (EC:1.1.1.35)
    Gene namesi
    ORF Names:F54C8.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF54C8.1; CE00187; WBGene00010035.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1PRO_0000109253Add
    BLAST

    Proteomic databases

    PaxDbiP34439.
    PRIDEiP34439.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi6239.F54C8.1.

    Structurei

    Secondary structure

    1
    298
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 54
    Beta strandi13 – 175
    Helixi21 – 3212
    Beta strandi36 – 405
    Helixi44 – 6421
    Helixi69 – 8012
    Beta strandi83 – 875
    Helixi89 – 935
    Beta strandi97 – 1015
    Helixi107 – 12014
    Beta strandi126 – 1294
    Beta strandi132 – 1343
    Helixi136 – 1394
    Turni140 – 1423
    Helixi146 – 1483
    Beta strandi149 – 1535
    Turni158 – 1603
    Beta strandi163 – 1686
    Helixi174 – 18613
    Beta strandi190 – 1967
    Turni198 – 2014
    Helixi202 – 21918
    Helixi224 – 23512
    Helixi241 – 2488
    Helixi250 – 26314
    Beta strandi264 – 2663
    Helixi268 – 2703
    Helixi274 – 2818
    Helixi287 – 2893
    Beta strandi291 – 2955

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4J0EX-ray1.60A/B1-298[»]
    4J0FX-ray2.20A/B1-298[»]
    ProteinModelPortaliP34439.
    SMRiP34439. Positions 1-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1250.
    GeneTreeiENSGT00720000108673.
    HOGENOMiHOG000141498.
    InParanoidiP34439.
    KOiK00022.
    OMAiGNEAMWM.
    OrthoDBiEOG7K3TMS.
    PhylomeDBiP34439.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR022694. 3-OHacyl-CoA_DH.
    IPR006180. 3-OHacyl-CoA_DH_CS.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000105. HCDH. 1 hit.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS00067. 3HCDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34439-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTAKCAMQN IRNVAIVGSG QMGSGIAQVT ASSGFNVMLA DVNKKALDRA    50
    MKAISQSVTH LSKKQKGTDK EKSDFVTLTM SRIKTCNNVS TAVADADLII 100
    EAAIENIDLK RGIFAQIEQS CKKDSILTTN TSSFLLEDVA KGLQDKTRFG 150
    GLHFFNPVPV MKLLEVIRSD DTSDETYATL IKFGTAVGKT TVACKDSPGF 200
    IVNRLLIPYF FEAARMYERG DASMTDIDEA MKLGAGHPMG PFELADYIGL 250
    DTVKFVMDGW AAKYPEVQLF EASPLVDKLV AEGKLGRKTG DGFYSYKK 298
    Length:298
    Mass (Da):32,492
    Last modified:February 1, 1994 - v1
    Checksum:iD8C2BE57823445B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22178 Genomic DNA. Translation: CAA80153.1.
    PIRiS40743.
    RefSeqiNP_499075.1. NM_066674.1.
    UniGeneiCel.10436.

    Genome annotation databases

    EnsemblMetazoaiF54C8.1; F54C8.1; WBGene00010035.
    GeneIDi186222.
    KEGGicel:CELE_F54C8.1.
    UCSCiF54C8.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22178 Genomic DNA. Translation: CAA80153.1 .
    PIRi S40743.
    RefSeqi NP_499075.1. NM_066674.1.
    UniGenei Cel.10436.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4J0E X-ray 1.60 A/B 1-298 [» ]
    4J0F X-ray 2.20 A/B 1-298 [» ]
    ProteinModelPortali P34439.
    SMRi P34439. Positions 1-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F54C8.1.

    Proteomic databases

    PaxDbi P34439.
    PRIDEi P34439.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F54C8.1 ; F54C8.1 ; WBGene00010035 .
    GeneIDi 186222.
    KEGGi cel:CELE_F54C8.1.
    UCSCi F54C8.1. c. elegans.

    Organism-specific databases

    CTDi 186222.
    WormBasei F54C8.1 ; CE00187 ; WBGene00010035 .

    Phylogenomic databases

    eggNOGi COG1250.
    GeneTreei ENSGT00720000108673.
    HOGENOMi HOG000141498.
    InParanoidi P34439.
    KOi K00022.
    OMAi GNEAMWM.
    OrthoDBi EOG7K3TMS.
    PhylomeDBi P34439.

    Enzyme and pathway databases

    UniPathwayi UPA00659 .

    Miscellaneous databases

    NextBioi 931082.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR022694. 3-OHacyl-CoA_DH.
    IPR006180. 3-OHacyl-CoA_DH_CS.
    IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000105. HCDH. 1 hit.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS00067. 3HCDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiHCDH1_CAEEL
    AccessioniPrimary (citable) accession number: P34439
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3