Reviewed, UniProtKB/Swiss-Prot P34420 (DGC14_CAEEL)

Names and origin

Protein names

Recommended name:
    Protein DGCR14 homolog
Alternative name(s):
    DiGeorge syndrome critical region 14 homolog

Gene names

ORF Names:

F42H10.7

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the DGCR14 family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q22174	1	EBI-321934,EBI-311938
atn-1	Q23158	1	EBI-321934,EBI-314014
rack-1	Q21215	1	EBI-321934,EBI-315497
tag-355	Q9N5M2	1	EBI-321934,EBI-321946
unc-57	O61843	1	EBI-321934,EBI-321745
uso-1	Q9XU77	1	EBI-321934,EBI-311986
zfp-3	Q8MPS9	1	EBI-321934,EBI-311975
ZK1098.4	P34604	1	EBI-321934,EBI-313831

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform b (identifier: P34420-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform a (identifier: P34420-2)

The sequence of this isoform differs from the canonical sequence as follows:
     412-413: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	Protein DGCR14 homolog		PRO_0000079874
Natural variations
	Alternative sequence	412 – 413	2	Missing in isoform a.		VSP_015951

Sequences

	Sequence		Length	Mass (Da)
	Isoform b [UniParc]. Last modified October 25, 2005. Version 2. Checksum: 809E5BA29DC4173D	FASTA	531	58,519
	10 20 30 40 50 60 MSSFDKNDER AQLMVPKSIN EGKVVKLSQK TLVTKKIERQ VVPEEKYIAG LDKIIEKDYF 70 80 90 100 110 120 PHLKKMQAQK EYLEAVANKD INKIKELQMK FCSTGSVRTD RSFRTPITTR STTEAPDVSS 130 140 150 160 170 180 FDADTPGPSS ASTSSAHDWM QSPMPFANEE GDNEALNRKR KKKKEETLTS YLNKYTSEDN 190 200 210 220 230 240 ASFEELAKVM REREDARRPW VYKAEEEHNK NLVTRQAIAA EADVQLALKH AVDADDNRPL 250 260 270 280 290 300 NVDNWAYKAW NTVLFNPDGA ALTPAEIADA ARKQQTEINK RGTRFPDSGK LKPSDEAMTR 310 320 330 340 350 360 AAVSHALANA GKVDFLGNEV TPANSFKLLE TPNPNPDDMD SPLMTWGEID GTPFRLDAPD 370 380 390 400 410 420 VTEHSLPGAA PVFKIPEVPY REKIAQSMND SIAAKYRDKR KVAMRAAEGA HFSRTPGFGS 430 440 450 460 470 480 KRVSDKLAQL SPAAQKLATK KLGLKMLPAH KSPFASPKIM SNWSRPSSSK RSTTPGSAWS 490 500 510 520 530 RGSTTPGSSW SQGAQTPGTP GIESMIRRKG DNVGPSTSAG AADRANAGDF F
	Isoform a. Checksum: BBBBF2C479BFE253	FASTA	529	58,285
	10 20 30 40 50 60 MSSFDKNDER AQLMVPKSIN EGKVVKLSQK TLVTKKIERQ VVPEEKYIAG LDKIIEKDYF 70 80 90 100 110 120 PHLKKMQAQK EYLEAVANKD INKIKELQMK FCSTGSVRTD RSFRTPITTR STTEAPDVSS 130 140 150 160 170 180 FDADTPGPSS ASTSSAHDWM QSPMPFANEE GDNEALNRKR KKKKEETLTS YLNKYTSEDN 190 200 210 220 230 240 ASFEELAKVM REREDARRPW VYKAEEEHNK NLVTRQAIAA EADVQLALKH AVDADDNRPL 250 260 270 280 290 300 NVDNWAYKAW NTVLFNPDGA ALTPAEIADA ARKQQTEINK RGTRFPDSGK LKPSDEAMTR 310 320 330 340 350 360 AAVSHALANA GKVDFLGNEV TPANSFKLLE TPNPNPDDMD SPLMTWGEID GTPFRLDAPD 370 380 390 400 410 420 VTEHSLPGAA PVFKIPEVPY REKIAQSMND SIAAKYRDKR KVAMRAAEGA HRTPGFGSKR 430 440 450 460 470 480 VSDKLAQLSP AAQKLATKKL GLKMLPAHKS PFASPKIMSN WSRPSSSKRS TTPGSAWSRG 490 500 510 520 STTPGSSWSQ GAQTPGTPGI ESMIRRKGDN VGPSTSAGAA DRANAGDFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
[3]	"Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans." Rizzu P., Lindsay E.A., Taylor C., O'Donnell H., Levy A., Scambler P.J., Baldini A. Mamm. Genome 7:639-643(1996) [PubMed: 8703114] [Abstract] Cited for: SIMILARITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L08403 Genomic DNA. Translation: AAA28021.1. L08403 Genomic DNA. Translation: AAT92077.1.
PIR	S44649.
RefSeq	NP_001022581.1.
UniGene	Cel.10487
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25557N.
IntAct	P34420. 12 interactions.
Proteomic databases
PRIDE	P34420.
Genome annotation databases
Ensembl	F42H10.7. Caenorhabditis elegans. [Contig view]
GeneID	176200.
Organism-specific databases
WormBase	WBGene00018371. F42H10.7.
WormPep	F42H10.7a. CE00169. [WorfDB] F42H10.7b. CE37109. [WorfDB]
Phylogenomic databases
OMA	P34420. KFVRNAI.
Gene expression databases
ArrayExpress	P34420.
Family and domain databases
InterPro	IPR019148. Nuclear_protein_DGCR14. [Graphical view]
Pfam	PF09751. Es2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	891548.

Entry information

Entry name

DGC14_CAEEL

Accession

Primary (citable) accession number: P34420
Secondary accession number(s): Q6AHR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	October 25, 2005
Last modified:	June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project