P34420 (DGC14_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ES2 similar protein 2

Alternative name(s):
DiGeorge syndrome critical region 14 homolog

Gene names

Name:	ess-2
ORF Names:	F42H10.7

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the DGCR14 family.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase meiotic chromosome segregation Inferred from mutant phenotype. Source: WormBase
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform b (identifier: P34420-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform a (identifier: P34420-2)

The sequence of this isoform differs from the canonical sequence as follows:
     412-413: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	ES2 similar protein 2		PRO_0000079874
Natural variations
	Alternative sequence	412 – 413	2	Missing in isoform a.		VSP_015951

Sequences

	Sequence		Length	Mass (Da)
	Isoform b [UniParc]. Last modified October 25, 2005. Version 2. Checksum: 809E5BA29DC4173D	FASTA	531	58,519
	10 20 30 40 50 60 MSSFDKNDER AQLMVPKSIN EGKVVKLSQK TLVTKKIERQ VVPEEKYIAG LDKIIEKDYF 70 80 90 100 110 120 PHLKKMQAQK EYLEAVANKD INKIKELQMK FCSTGSVRTD RSFRTPITTR STTEAPDVSS 130 140 150 160 170 180 FDADTPGPSS ASTSSAHDWM QSPMPFANEE GDNEALNRKR KKKKEETLTS YLNKYTSEDN 190 200 210 220 230 240 ASFEELAKVM REREDARRPW VYKAEEEHNK NLVTRQAIAA EADVQLALKH AVDADDNRPL 250 260 270 280 290 300 NVDNWAYKAW NTVLFNPDGA ALTPAEIADA ARKQQTEINK RGTRFPDSGK LKPSDEAMTR 310 320 330 340 350 360 AAVSHALANA GKVDFLGNEV TPANSFKLLE TPNPNPDDMD SPLMTWGEID GTPFRLDAPD 370 380 390 400 410 420 VTEHSLPGAA PVFKIPEVPY REKIAQSMND SIAAKYRDKR KVAMRAAEGA HFSRTPGFGS 430 440 450 460 470 480 KRVSDKLAQL SPAAQKLATK KLGLKMLPAH KSPFASPKIM SNWSRPSSSK RSTTPGSAWS 490 500 510 520 530 RGSTTPGSSW SQGAQTPGTP GIESMIRRKG DNVGPSTSAG AADRANAGDF F
	Isoform a [UniParc]. Checksum: BBBBF2C479BFE253	FASTA	529	58,285
	10 20 30 40 50 60 MSSFDKNDER AQLMVPKSIN EGKVVKLSQK TLVTKKIERQ VVPEEKYIAG LDKIIEKDYF 70 80 90 100 110 120 PHLKKMQAQK EYLEAVANKD INKIKELQMK FCSTGSVRTD RSFRTPITTR STTEAPDVSS 130 140 150 160 170 180 FDADTPGPSS ASTSSAHDWM QSPMPFANEE GDNEALNRKR KKKKEETLTS YLNKYTSEDN 190 200 210 220 230 240 ASFEELAKVM REREDARRPW VYKAEEEHNK NLVTRQAIAA EADVQLALKH AVDADDNRPL 250 260 270 280 290 300 NVDNWAYKAW NTVLFNPDGA ALTPAEIADA ARKQQTEINK RGTRFPDSGK LKPSDEAMTR 310 320 330 340 350 360 AAVSHALANA GKVDFLGNEV TPANSFKLLE TPNPNPDDMD SPLMTWGEID GTPFRLDAPD 370 380 390 400 410 420 VTEHSLPGAA PVFKIPEVPY REKIAQSMND SIAAKYRDKR KVAMRAAEGA HRTPGFGSKR 430 440 450 460 470 480 VSDKLAQLSP AAQKLATKKL GLKMLPAHKS PFASPKIMSN WSRPSSSKRS TTPGSAWSRG 490 500 510 520 STTPGSSWSQ GAQTPGTPGI ESMIRRKGDN VGPSTSAGAA DRANAGDFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
[3]	"Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans." Rizzu P., Lindsay E.A., Taylor C., O'Donnell H., Levy A., Scambler P.J., Baldini A. Mamm. Genome 7:639-643(1996) [PubMed: 8703114] [Abstract] Cited for: SIMILARITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080327 Genomic DNA. Translation: CCD62885.1. FO080327 Genomic DNA. Translation: CCD62886.1.
PIR	S44649.
RefSeq	NP_001022580.1. NM_001027409.2. NP_001022581.1. NM_001027410.2.
UniGene	Cel.10487.
3D structure databases
ProteinModelPortal	P34420.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-25557N.
IntAct	P34420. 11 interactions.
MINT	MINT-115507.
STRING	P34420.
Proteomic databases
PRIDE	P34420.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F42H10.7b.1; F42H10.7b.1; F42H10.7. F42H10.7b.2; F42H10.7b.2; F42H10.7.
GeneID	176200.
KEGG	cel:F42H10.7.
UCSC	F42H10.7b. c. elegans.
Organism-specific databases
CTD	176200.
WormBase	F42H10.7a; CE00169; WBGene00018371; ess-2. F42H10.7b; CE37109; WBGene00018371; ess-2.
Phylogenomic databases
eggNOG	meNOG10948.
GeneTree	EMGT00050000016993.
HOGENOM	HBG381743.
InParanoid	P34420.
OMA	KVMRERE.
PhylomeDB	P34420.
Gene expression databases
ArrayExpress	P34420.
Family and domain databases
InterPro	IPR019148. Nuclear_protein_DGCR14. [Graphical view]
KO	K13118.
Pfam	PF09751. Es2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	891548.

Entry information

Entry name

DGC14_CAEEL

Accession

Primary (citable) accession number: P34420
Secondary accession number(s): Q6AHR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	October 25, 2005
Last modified:	December 14, 2011
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project