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Protein

Abnormal cell migration protein 10

Gene

mig-10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN (PubMed:9142991). Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1. May regulate growth cone polarization by promoting asymmetric F-actin assembly (PubMed:18499456). May be involved in signal transduction during cell migration (PubMed:9142991).2 Publications

GO - Molecular functioni

  • SH3 domain binding Source: WormBase

GO - Biological processi

  • axon regeneration Source: WormBase
  • cell projection morphogenesis Source: WormBase
  • lamellipodium assembly Source: WormBase
  • locomotion Source: WormBase
  • mesodermal cell migration Source: WormBase
  • neuron migration Source: WormBase
  • oviposition Source: WormBase
  • regulation of cell migration Source: WormBase
  • signal transduction Source: InterPro
  • vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

ReactomeiR-CEL-354192. Integrin alphaIIb beta3 signaling.
R-CEL-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Abnormal cell migration protein 10
Gene namesi
Name:mig-10
ORF Names:F10E9.6/F09G8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiF10E9.6a; CE29261; WBGene00003243; mig-10.
F10E9.6b; CE00150; WBGene00003243; mig-10.
F10E9.6c; CE36129; WBGene00003243; mig-10.

Subcellular locationi

  • Perikaryon 1 Publication

  • Note: Enriched at the ventral edge of HSN cell bodies. This asymmetric distribution is regulated by ced-10/rac1.1 Publication

GO - Cellular componenti

  • growth cone membrane Source: WormBase
  • lamellipodium Source: WormBase
  • neuronal cell body membrane Source: WormBase
  • perikaryon Source: UniProtKB-SubCell
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Defects in axon guidance in HSN neurons although axons reach the ventral nerve cord in the end. In max-2 and mig-10 double mutants, the phenotype is more severe resulting in axons failing to reach the ventral nerve cord.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813531 – 779Abnormal cell migration protein 10Add BLAST779

Proteomic databases

PaxDbiP34400.
PeptideAtlasiP34400.

PTM databases

iPTMnetiP34400.

Expressioni

Gene expression databases

BgeeiWBGene00003243.

Interactioni

Subunit structurei

May interact (via Ras-associating and PH domains) with ced-10 (GTP-bound form).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
abi-1Q109296EBI-2315872,EBI-315750
sorb-1O624826EBI-2315872,EBI-325337

GO - Molecular functioni

  • SH3 domain binding Source: WormBase

Protein-protein interaction databases

BioGridi41372. 3 interactors.
IntActiP34400. 7 interactors.
STRINGi6239.F10E9.6c.

Structurei

3D structure databases

ProteinModelPortaliP34400.
SMRiP34400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini317 – 407Ras-associatingPROSITE-ProRule annotationAdd BLAST91
Domaini456 – 566PHPROSITE-ProRule annotationAdd BLAST111

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 108Glu-richAdd BLAST61
Compositional biasi238 – 282Ser-richAdd BLAST45
Compositional biasi589 – 660Ser-richAdd BLAST72
Compositional biasi708 – 742Pro-richAdd BLAST35

Sequence similaritiesi

Belongs to the MRL family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3751. Eukaryota.
ENOG410XXC8. LUCA.
GeneTreeiENSGT00550000074537.
HOGENOMiHOG000020872.
InParanoidiP34400.
OMAiHIALMED.
OrthoDBiEOG091G05PM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform c (identifier: P34400-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSCEEECDL EVDSDEEDQL FGEKCISLLS SLLPLSSSTL LSNAINLELD
60 70 80 90 100
EVERPPPLLN VLEEQQFPKV CANIEEENEL EADTEEDIAE TADDEESKDP
110 120 130 140 150
VEKTENFEPS VTMDTYDFPD PYPVQIRARP QVPPKPPIDT VRYSMNNIKE
160 170 180 190 200
SADWQLDELL EELEALETQL NSSNGGDQLL LGVSGIPASS SRENVKSIST
210 220 230 240 250
LPPPPPALSY HQTPQQPQLL HHHNNHLGYQ NGIHQITSIN SAASSCSSPD
260 270 280 290 300
GDSAFGDSSS TESSNNRCRN SAFSSNDSCR DSLNTPSPTQ VSPRNGELNA
310 320 330 340 350
EEAKAQKIRQ ALEKMKEAKV TKIFVKFFVE DGEALQLLID ERWTVADTLK
360 370 380 390 400
QLAEKNHIAL MEDHCIVEEY PELYIKRVYE DHEKVVENIQ MWVQDSPNKL
410 420 430 440 450
YFMRRPDKYA FISRPELYLL TPKTSDHMEI PSGDQWTIDV KQKFVSEYFH
460 470 480 490 500
REPVVPPEME GFLYLKSDGR KSWKKHYFVL RPSGLYYAPK SKKPTTKDLT
510 520 530 540 550
CLMNLHSNQV YTGIGWEKKY KSPTPWCISI KLTALQMKRS QFIKYICAED
560 570 580 590 600
EMTFKKWLVA LRIAKNGAEL LENYERACQI RRETLGPASS MSAASSSTAI
610 620 630 640 650
SEVPHSLSHH QRTPSVASSI QLSSHMMNNP THPLSVNVRN QSPASFSVNS
660 670 680 690 700
CQQSHPSRTS AKLEIQYDEQ PTGTIKRAPL DVLRRVSRAS TSSPTIPQEE
710 720 730 740 750
SDSDEEFPAP PPVASVMRMP PPVTPPKPCT PLTSKKAPPP PPKRSDTTKL
760 770
QSASPMAPAK NDLEAALARR REKMATMEC
Note: No experimental confirmation available.
Length:779
Mass (Da):87,502
Last modified:June 7, 2005 - v3
Checksum:iE5EAE25205EBFAC5
GO
Isoform a (identifier: P34400-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:667
Mass (Da):74,985
Checksum:i6B00AD9E18741811
GO
Isoform b (identifier: P34400-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-150: PQVPPKPPIDTVRYSMNNIKE → MYHDRRRTGFRQYETYMKQKQ

Show »
Length:650
Mass (Da):73,318
Checksum:iC3532BBF587D1335
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0088671 – 129Missing in isoform b. 1 PublicationAdd BLAST129
Alternative sequenceiVSP_0140081 – 112Missing in isoform a. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_014009130 – 150PQVPP…NNIKE → MYHDRRRTGFRQYETYMKQK Q in isoform b. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081105 Genomic DNA. Translation: CCD69133.1.
FO081105 Genomic DNA. Translation: CCD69132.1.
FO081105 Genomic DNA. Translation: CCD69134.1.
PIRiS44806.
RefSeqiNP_001021248.1. NM_001026077.4. [P34400-3]
NP_498821.2. NM_066420.4. [P34400-2]
NP_498822.2. NM_066421.3. [P34400-1]
UniGeneiCel.10613.

Genome annotation databases

EnsemblMetazoaiF10E9.6c; F10E9.6c; WBGene00003243. [P34400-3]
GeneIDi176168.
KEGGicel:CELE_F10E9.6.
UCSCiF10E9.6c. c. elegans. [P34400-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081105 Genomic DNA. Translation: CCD69133.1.
FO081105 Genomic DNA. Translation: CCD69132.1.
FO081105 Genomic DNA. Translation: CCD69134.1.
PIRiS44806.
RefSeqiNP_001021248.1. NM_001026077.4. [P34400-3]
NP_498821.2. NM_066420.4. [P34400-2]
NP_498822.2. NM_066421.3. [P34400-1]
UniGeneiCel.10613.

3D structure databases

ProteinModelPortaliP34400.
SMRiP34400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41372. 3 interactors.
IntActiP34400. 7 interactors.
STRINGi6239.F10E9.6c.

PTM databases

iPTMnetiP34400.

Proteomic databases

PaxDbiP34400.
PeptideAtlasiP34400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF10E9.6c; F10E9.6c; WBGene00003243. [P34400-3]
GeneIDi176168.
KEGGicel:CELE_F10E9.6.
UCSCiF10E9.6c. c. elegans. [P34400-1]

Organism-specific databases

CTDi176168.
WormBaseiF10E9.6a; CE29261; WBGene00003243; mig-10.
F10E9.6b; CE00150; WBGene00003243; mig-10.
F10E9.6c; CE36129; WBGene00003243; mig-10.

Phylogenomic databases

eggNOGiKOG3751. Eukaryota.
ENOG410XXC8. LUCA.
GeneTreeiENSGT00550000074537.
HOGENOMiHOG000020872.
InParanoidiP34400.
OMAiHIALMED.
OrthoDBiEOG091G05PM.

Enzyme and pathway databases

ReactomeiR-CEL-354192. Integrin alphaIIb beta3 signaling.
R-CEL-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.

Miscellaneous databases

PROiP34400.

Gene expression databases

BgeeiWBGene00003243.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000159. RA_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIG10_CAEEL
AccessioniPrimary (citable) accession number: P34400
Secondary accession number(s): P34386
, P34403, Q7JQ80, Q8WT53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.