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P34400

- MIG10_CAEEL

UniProt

P34400 - MIG10_CAEEL

Protein

Abnormal cell migration protein 10

Gene

mig-10

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. May be involved in signal transduction during cell migration.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. SH3 domain binding Source: WormBase

    GO - Biological processi

    1. axon regeneration Source: WormBase
    2. cell projection morphogenesis Source: WormBase
    3. lamellipodium assembly Source: WormBase
    4. locomotion Source: WormBase
    5. mesodermal cell migration Source: WormBase
    6. neuron migration Source: WormBase
    7. oviposition Source: WormBase
    8. regulation of cell migration Source: WormBase
    9. signal transduction Source: InterPro
    10. vulval development Source: WormBase

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abnormal cell migration protein 10
    Gene namesi
    Name:mig-10
    ORF Names:F10E9.6/F09G8.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiF10E9.6a; CE29261; WBGene00003243; mig-10.
    F10E9.6b; CE00150; WBGene00003243; mig-10.
    F10E9.6c; CE36129; WBGene00003243; mig-10.

    Subcellular locationi

    GO - Cellular componenti

    1. growth cone membrane Source: WormBase
    2. lamellipodium Source: WormBase
    3. neuronal cell body membrane Source: WormBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 779779Abnormal cell migration protein 10PRO_0000181353Add
    BLAST

    Proteomic databases

    PaxDbiP34400.
    PRIDEiP34400.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    abi-1Q109296EBI-2315872,EBI-315750
    sorb-1O624826EBI-2315872,EBI-325337

    Protein-protein interaction databases

    BioGridi41372. 3 interactions.
    IntActiP34400. 7 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP34400.
    SMRiP34400. Positions 304-577.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini317 – 40791Ras-associatingPROSITE-ProRule annotationAdd
    BLAST
    Domaini456 – 566111PHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi48 – 10861Glu-richAdd
    BLAST
    Compositional biasi238 – 28245Ser-richAdd
    BLAST
    Compositional biasi589 – 66072Ser-richAdd
    BLAST
    Compositional biasi708 – 74235Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MRL family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 Ras-associating domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG279449.
    GeneTreeiENSGT00550000074537.
    HOGENOMiHOG000020872.
    InParanoidiP34400.
    OMAiHIALMED.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00314. RA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50200. RA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform c (identifier: P34400-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSCEEECDL EVDSDEEDQL FGEKCISLLS SLLPLSSSTL LSNAINLELD    50
    EVERPPPLLN VLEEQQFPKV CANIEEENEL EADTEEDIAE TADDEESKDP 100
    VEKTENFEPS VTMDTYDFPD PYPVQIRARP QVPPKPPIDT VRYSMNNIKE 150
    SADWQLDELL EELEALETQL NSSNGGDQLL LGVSGIPASS SRENVKSIST 200
    LPPPPPALSY HQTPQQPQLL HHHNNHLGYQ NGIHQITSIN SAASSCSSPD 250
    GDSAFGDSSS TESSNNRCRN SAFSSNDSCR DSLNTPSPTQ VSPRNGELNA 300
    EEAKAQKIRQ ALEKMKEAKV TKIFVKFFVE DGEALQLLID ERWTVADTLK 350
    QLAEKNHIAL MEDHCIVEEY PELYIKRVYE DHEKVVENIQ MWVQDSPNKL 400
    YFMRRPDKYA FISRPELYLL TPKTSDHMEI PSGDQWTIDV KQKFVSEYFH 450
    REPVVPPEME GFLYLKSDGR KSWKKHYFVL RPSGLYYAPK SKKPTTKDLT 500
    CLMNLHSNQV YTGIGWEKKY KSPTPWCISI KLTALQMKRS QFIKYICAED 550
    EMTFKKWLVA LRIAKNGAEL LENYERACQI RRETLGPASS MSAASSSTAI 600
    SEVPHSLSHH QRTPSVASSI QLSSHMMNNP THPLSVNVRN QSPASFSVNS 650
    CQQSHPSRTS AKLEIQYDEQ PTGTIKRAPL DVLRRVSRAS TSSPTIPQEE 700
    SDSDEEFPAP PPVASVMRMP PPVTPPKPCT PLTSKKAPPP PPKRSDTTKL 750
    QSASPMAPAK NDLEAALARR REKMATMEC 779

    Note: No experimental confirmation available.

    Length:779
    Mass (Da):87,502
    Last modified:June 7, 2005 - v3
    Checksum:iE5EAE25205EBFAC5
    GO
    Isoform a (identifier: P34400-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-112: Missing.

    Show »
    Length:667
    Mass (Da):74,985
    Checksum:i6B00AD9E18741811
    GO
    Isoform b (identifier: P34400-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-129: Missing.
         130-150: PQVPPKPPIDTVRYSMNNIKE → MYHDRRRTGFRQYETYMKQKQ

    Show »
    Length:650
    Mass (Da):73,318
    Checksum:iC3532BBF587D1335
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 129129Missing in isoform b. 1 PublicationVSP_008867Add
    BLAST
    Alternative sequencei1 – 112112Missing in isoform a. 1 PublicationVSP_014008Add
    BLAST
    Alternative sequencei130 – 15021PQVPP…NNIKE → MYHDRRRTGFRQYETYMKQK Q in isoform b. 1 PublicationVSP_014009Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081105 Genomic DNA. Translation: CCD69133.1.
    FO081105 Genomic DNA. Translation: CCD69132.1.
    FO081105 Genomic DNA. Translation: CCD69134.1.
    PIRiS44806.
    RefSeqiNP_001021248.1. NM_001026077.4. [P34400-3]
    NP_498821.2. NM_066420.4. [P34400-2]
    NP_498822.2. NM_066421.3. [P34400-1]
    UniGeneiCel.10613.

    Genome annotation databases

    EnsemblMetazoaiF10E9.6c; F10E9.6c; WBGene00003243. [P34400-3]
    GeneIDi176168.
    KEGGicel:CELE_F10E9.6.
    UCSCiF10E9.6c. c. elegans. [P34400-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081105 Genomic DNA. Translation: CCD69133.1 .
    FO081105 Genomic DNA. Translation: CCD69132.1 .
    FO081105 Genomic DNA. Translation: CCD69134.1 .
    PIRi S44806.
    RefSeqi NP_001021248.1. NM_001026077.4. [P34400-3 ]
    NP_498821.2. NM_066420.4. [P34400-2 ]
    NP_498822.2. NM_066421.3. [P34400-1 ]
    UniGenei Cel.10613.

    3D structure databases

    ProteinModelPortali P34400.
    SMRi P34400. Positions 304-577.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41372. 3 interactions.
    IntActi P34400. 7 interactions.

    Proteomic databases

    PaxDbi P34400.
    PRIDEi P34400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F10E9.6c ; F10E9.6c ; WBGene00003243 . [P34400-3 ]
    GeneIDi 176168.
    KEGGi cel:CELE_F10E9.6.
    UCSCi F10E9.6c. c. elegans. [P34400-1 ]

    Organism-specific databases

    CTDi 176168.
    WormBasei F10E9.6a ; CE29261 ; WBGene00003243 ; mig-10.
    F10E9.6b ; CE00150 ; WBGene00003243 ; mig-10.
    F10E9.6c ; CE36129 ; WBGene00003243 ; mig-10.

    Phylogenomic databases

    eggNOGi NOG279449.
    GeneTreei ENSGT00550000074537.
    HOGENOMi HOG000020872.
    InParanoidi P34400.
    OMAi HIALMED.

    Miscellaneous databases

    NextBioi 891414.
    PROi P34400.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00314. RA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50200. RA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development."
      Manser J., Roonprapunt C., Margolis B.
      Dev. Biol. 184:150-164(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMIG10_CAEEL
    AccessioniPrimary (citable) accession number: P34400
    Secondary accession number(s): P34386
    , P34403, Q7JQ80, Q8WT53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3