SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P34400

- MIG10_CAEEL

UniProt

P34400 - MIG10_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Abnormal cell migration protein 10

Gene
mig-10, F10E9.6/F09G8.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. May be involved in signal transduction during cell migration.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. SH3 domain binding Source: WormBase

GO - Biological processi

  1. axon regeneration Source: WormBase
  2. cell projection morphogenesis Source: WormBase
  3. lamellipodium assembly Source: WormBase
  4. locomotion Source: WormBase
  5. mesodermal cell migration Source: WormBase
  6. neuron migration Source: WormBase
  7. oviposition Source: WormBase
  8. regulation of cell migration Source: WormBase
  9. signal transduction Source: InterPro
  10. vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Abnormal cell migration protein 10
Gene namesi
Name:mig-10
ORF Names:F10E9.6/F09G8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF10E9.6a; CE29261; WBGene00003243; mig-10.
F10E9.6b; CE00150; WBGene00003243; mig-10.
F10E9.6c; CE36129; WBGene00003243; mig-10.

Subcellular locationi

GO - Cellular componenti

  1. growth cone membrane Source: WormBase
  2. lamellipodium Source: WormBase
  3. neuronal cell body membrane Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Abnormal cell migration protein 10PRO_0000181353Add
BLAST

Proteomic databases

PaxDbiP34400.
PRIDEiP34400.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
abi-1Q109296EBI-2315872,EBI-315750
sorb-1O624826EBI-2315872,EBI-325337

Protein-protein interaction databases

BioGridi41372. 2 interactions.
IntActiP34400. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliP34400.
SMRiP34400. Positions 304-577.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini317 – 40791Ras-associatingAdd
BLAST
Domaini456 – 566111PHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi48 – 10861Glu-richAdd
BLAST
Compositional biasi238 – 28245Ser-richAdd
BLAST
Compositional biasi589 – 66072Ser-richAdd
BLAST
Compositional biasi708 – 74235Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the MRL family.
Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG279449.
GeneTreeiENSGT00550000074537.
HOGENOMiHOG000020872.
InParanoidiP34400.
OMAiHIALMED.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform c (identifier: P34400-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSCEEECDL EVDSDEEDQL FGEKCISLLS SLLPLSSSTL LSNAINLELD    50
EVERPPPLLN VLEEQQFPKV CANIEEENEL EADTEEDIAE TADDEESKDP 100
VEKTENFEPS VTMDTYDFPD PYPVQIRARP QVPPKPPIDT VRYSMNNIKE 150
SADWQLDELL EELEALETQL NSSNGGDQLL LGVSGIPASS SRENVKSIST 200
LPPPPPALSY HQTPQQPQLL HHHNNHLGYQ NGIHQITSIN SAASSCSSPD 250
GDSAFGDSSS TESSNNRCRN SAFSSNDSCR DSLNTPSPTQ VSPRNGELNA 300
EEAKAQKIRQ ALEKMKEAKV TKIFVKFFVE DGEALQLLID ERWTVADTLK 350
QLAEKNHIAL MEDHCIVEEY PELYIKRVYE DHEKVVENIQ MWVQDSPNKL 400
YFMRRPDKYA FISRPELYLL TPKTSDHMEI PSGDQWTIDV KQKFVSEYFH 450
REPVVPPEME GFLYLKSDGR KSWKKHYFVL RPSGLYYAPK SKKPTTKDLT 500
CLMNLHSNQV YTGIGWEKKY KSPTPWCISI KLTALQMKRS QFIKYICAED 550
EMTFKKWLVA LRIAKNGAEL LENYERACQI RRETLGPASS MSAASSSTAI 600
SEVPHSLSHH QRTPSVASSI QLSSHMMNNP THPLSVNVRN QSPASFSVNS 650
CQQSHPSRTS AKLEIQYDEQ PTGTIKRAPL DVLRRVSRAS TSSPTIPQEE 700
SDSDEEFPAP PPVASVMRMP PPVTPPKPCT PLTSKKAPPP PPKRSDTTKL 750
QSASPMAPAK NDLEAALARR REKMATMEC 779

Note: No experimental confirmation available.

Length:779
Mass (Da):87,502
Last modified:June 7, 2005 - v3
Checksum:iE5EAE25205EBFAC5
GO
Isoform a (identifier: P34400-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:667
Mass (Da):74,985
Checksum:i6B00AD9E18741811
GO
Isoform b (identifier: P34400-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-150: PQVPPKPPIDTVRYSMNNIKE → MYHDRRRTGFRQYETYMKQKQ

Show »
Length:650
Mass (Da):73,318
Checksum:iC3532BBF587D1335
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 129129Missing in isoform b. VSP_008867Add
BLAST
Alternative sequencei1 – 112112Missing in isoform a. VSP_014008Add
BLAST
Alternative sequencei130 – 15021PQVPP…NNIKE → MYHDRRRTGFRQYETYMKQK Q in isoform b. VSP_014009Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081105 Genomic DNA. Translation: CCD69133.1.
FO081105 Genomic DNA. Translation: CCD69132.1.
FO081105 Genomic DNA. Translation: CCD69134.1.
PIRiS44806.
RefSeqiNP_001021248.1. NM_001026077.4. [P34400-3]
NP_498821.2. NM_066420.4. [P34400-2]
NP_498822.2. NM_066421.3. [P34400-1]
UniGeneiCel.10613.

Genome annotation databases

EnsemblMetazoaiF10E9.6c; F10E9.6c; WBGene00003243. [P34400-3]
GeneIDi176168.
KEGGicel:CELE_F10E9.6.
UCSCiF10E9.6c. c. elegans. [P34400-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081105 Genomic DNA. Translation: CCD69133.1 .
FO081105 Genomic DNA. Translation: CCD69132.1 .
FO081105 Genomic DNA. Translation: CCD69134.1 .
PIRi S44806.
RefSeqi NP_001021248.1. NM_001026077.4. [P34400-3 ]
NP_498821.2. NM_066420.4. [P34400-2 ]
NP_498822.2. NM_066421.3. [P34400-1 ]
UniGenei Cel.10613.

3D structure databases

ProteinModelPortali P34400.
SMRi P34400. Positions 304-577.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41372. 2 interactions.
IntActi P34400. 7 interactions.

Proteomic databases

PaxDbi P34400.
PRIDEi P34400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F10E9.6c ; F10E9.6c ; WBGene00003243 . [P34400-3 ]
GeneIDi 176168.
KEGGi cel:CELE_F10E9.6.
UCSCi F10E9.6c. c. elegans. [P34400-1 ]

Organism-specific databases

CTDi 176168.
WormBasei F10E9.6a ; CE29261 ; WBGene00003243 ; mig-10.
F10E9.6b ; CE00150 ; WBGene00003243 ; mig-10.
F10E9.6c ; CE36129 ; WBGene00003243 ; mig-10.

Phylogenomic databases

eggNOGi NOG279449.
GeneTreei ENSGT00550000074537.
HOGENOMi HOG000020872.
InParanoidi P34400.
OMAi HIALMED.

Miscellaneous databases

NextBioi 891414.
PROi P34400.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development."
    Manser J., Roonprapunt C., Margolis B.
    Dev. Biol. 184:150-164(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiMIG10_CAEEL
AccessioniPrimary (citable) accession number: P34400
Secondary accession number(s): P34386
, P34403, Q7JQ80, Q8WT53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: September 3, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi