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P34400

- MIG10_CAEEL

UniProt

P34400 - MIG10_CAEEL

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Protein

Abnormal cell migration protein 10

Gene

mig-10

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. May be involved in signal transduction during cell migration.1 Publication

GO - Molecular functioni

  1. SH3 domain binding Source: WormBase

GO - Biological processi

  1. axon regeneration Source: WormBase
  2. cell projection morphogenesis Source: WormBase
  3. lamellipodium assembly Source: WormBase
  4. locomotion Source: WormBase
  5. mesodermal cell migration Source: WormBase
  6. neuron migration Source: WormBase
  7. oviposition Source: WormBase
  8. regulation of cell migration Source: WormBase
  9. signal transduction Source: InterPro
  10. vulval development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiREACT_255951. Integrin alphaIIb beta3 signaling.
REACT_271361. p130Cas linkage to MAPK signaling for integrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Abnormal cell migration protein 10
Gene namesi
Name:mig-10
ORF Names:F10E9.6/F09G8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiF10E9.6a; CE29261; WBGene00003243; mig-10.
F10E9.6b; CE00150; WBGene00003243; mig-10.
F10E9.6c; CE36129; WBGene00003243; mig-10.

Subcellular locationi

GO - Cellular componenti

  1. growth cone membrane Source: WormBase
  2. lamellipodium Source: WormBase
  3. neuronal cell body membrane Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Abnormal cell migration protein 10PRO_0000181353Add
BLAST

Proteomic databases

PaxDbiP34400.
PRIDEiP34400.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
abi-1Q109296EBI-2315872,EBI-315750
sorb-1O624826EBI-2315872,EBI-325337

Protein-protein interaction databases

BioGridi41372. 3 interactions.
IntActiP34400. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliP34400.
SMRiP34400. Positions 304-577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini317 – 40791Ras-associatingPROSITE-ProRule annotationAdd
BLAST
Domaini456 – 566111PHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi48 – 10861Glu-richAdd
BLAST
Compositional biasi238 – 28245Ser-richAdd
BLAST
Compositional biasi589 – 66072Ser-richAdd
BLAST
Compositional biasi708 – 74235Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the MRL family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG279449.
GeneTreeiENSGT00550000074537.
HOGENOMiHOG000020872.
InParanoidiP34400.
OMAiHIALMED.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform c (identifier: P34400-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSCEEECDL EVDSDEEDQL FGEKCISLLS SLLPLSSSTL LSNAINLELD
60 70 80 90 100
EVERPPPLLN VLEEQQFPKV CANIEEENEL EADTEEDIAE TADDEESKDP
110 120 130 140 150
VEKTENFEPS VTMDTYDFPD PYPVQIRARP QVPPKPPIDT VRYSMNNIKE
160 170 180 190 200
SADWQLDELL EELEALETQL NSSNGGDQLL LGVSGIPASS SRENVKSIST
210 220 230 240 250
LPPPPPALSY HQTPQQPQLL HHHNNHLGYQ NGIHQITSIN SAASSCSSPD
260 270 280 290 300
GDSAFGDSSS TESSNNRCRN SAFSSNDSCR DSLNTPSPTQ VSPRNGELNA
310 320 330 340 350
EEAKAQKIRQ ALEKMKEAKV TKIFVKFFVE DGEALQLLID ERWTVADTLK
360 370 380 390 400
QLAEKNHIAL MEDHCIVEEY PELYIKRVYE DHEKVVENIQ MWVQDSPNKL
410 420 430 440 450
YFMRRPDKYA FISRPELYLL TPKTSDHMEI PSGDQWTIDV KQKFVSEYFH
460 470 480 490 500
REPVVPPEME GFLYLKSDGR KSWKKHYFVL RPSGLYYAPK SKKPTTKDLT
510 520 530 540 550
CLMNLHSNQV YTGIGWEKKY KSPTPWCISI KLTALQMKRS QFIKYICAED
560 570 580 590 600
EMTFKKWLVA LRIAKNGAEL LENYERACQI RRETLGPASS MSAASSSTAI
610 620 630 640 650
SEVPHSLSHH QRTPSVASSI QLSSHMMNNP THPLSVNVRN QSPASFSVNS
660 670 680 690 700
CQQSHPSRTS AKLEIQYDEQ PTGTIKRAPL DVLRRVSRAS TSSPTIPQEE
710 720 730 740 750
SDSDEEFPAP PPVASVMRMP PPVTPPKPCT PLTSKKAPPP PPKRSDTTKL
760 770
QSASPMAPAK NDLEAALARR REKMATMEC

Note: No experimental confirmation available.

Length:779
Mass (Da):87,502
Last modified:June 7, 2005 - v3
Checksum:iE5EAE25205EBFAC5
GO
Isoform a (identifier: P34400-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:667
Mass (Da):74,985
Checksum:i6B00AD9E18741811
GO
Isoform b (identifier: P34400-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-150: PQVPPKPPIDTVRYSMNNIKE → MYHDRRRTGFRQYETYMKQKQ

Show »
Length:650
Mass (Da):73,318
Checksum:iC3532BBF587D1335
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 129129Missing in isoform b. 1 PublicationVSP_008867Add
BLAST
Alternative sequencei1 – 112112Missing in isoform a. 1 PublicationVSP_014008Add
BLAST
Alternative sequencei130 – 15021PQVPP…NNIKE → MYHDRRRTGFRQYETYMKQK Q in isoform b. 1 PublicationVSP_014009Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081105 Genomic DNA. Translation: CCD69133.1.
FO081105 Genomic DNA. Translation: CCD69132.1.
FO081105 Genomic DNA. Translation: CCD69134.1.
PIRiS44806.
RefSeqiNP_001021248.1. NM_001026077.4. [P34400-3]
NP_498821.2. NM_066420.4. [P34400-2]
NP_498822.2. NM_066421.3. [P34400-1]
UniGeneiCel.10613.

Genome annotation databases

EnsemblMetazoaiF10E9.6c; F10E9.6c; WBGene00003243. [P34400-3]
GeneIDi176168.
KEGGicel:CELE_F10E9.6.
UCSCiF10E9.6c. c. elegans. [P34400-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081105 Genomic DNA. Translation: CCD69133.1 .
FO081105 Genomic DNA. Translation: CCD69132.1 .
FO081105 Genomic DNA. Translation: CCD69134.1 .
PIRi S44806.
RefSeqi NP_001021248.1. NM_001026077.4. [P34400-3 ]
NP_498821.2. NM_066420.4. [P34400-2 ]
NP_498822.2. NM_066421.3. [P34400-1 ]
UniGenei Cel.10613.

3D structure databases

ProteinModelPortali P34400.
SMRi P34400. Positions 304-577.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41372. 3 interactions.
IntActi P34400. 7 interactions.

Proteomic databases

PaxDbi P34400.
PRIDEi P34400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F10E9.6c ; F10E9.6c ; WBGene00003243 . [P34400-3 ]
GeneIDi 176168.
KEGGi cel:CELE_F10E9.6.
UCSCi F10E9.6c. c. elegans. [P34400-1 ]

Organism-specific databases

CTDi 176168.
WormBasei F10E9.6a ; CE29261 ; WBGene00003243 ; mig-10.
F10E9.6b ; CE00150 ; WBGene00003243 ; mig-10.
F10E9.6c ; CE36129 ; WBGene00003243 ; mig-10.

Phylogenomic databases

eggNOGi NOG279449.
GeneTreei ENSGT00550000074537.
HOGENOMi HOG000020872.
InParanoidi P34400.
OMAi HIALMED.

Enzyme and pathway databases

Reactomei REACT_255951. Integrin alphaIIb beta3 signaling.
REACT_271361. p130Cas linkage to MAPK signaling for integrins.

Miscellaneous databases

NextBioi 891414.
PROi P34400.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development."
    Manser J., Roonprapunt C., Margolis B.
    Dev. Biol. 184:150-164(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiMIG10_CAEEL
AccessioniPrimary (citable) accession number: P34400
Secondary accession number(s): P34386
, P34403, Q7JQ80, Q8WT53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: November 26, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3