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P34400 (MIG10_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abnormal cell migration protein 10
Gene names
Name:mig-10
ORF Names:F10E9.6/F09G8.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length779 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. May be involved in signal transduction during cell migration. Ref.1

Sequence similarities

Belongs to the MRL family.

Contains 1 PH domain.

Contains 1 Ras-associating domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

abi-1Q109296EBI-2315872,EBI-315750
sorb-1O624826EBI-2315872,EBI-325337

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform c (identifier: P34400-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform a (identifier: P34400-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
Isoform b (identifier: P34400-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-129: Missing.
     130-150: PQVPPKPPIDTVRYSMNNIKE → MYHDRRRTGFRQYETYMKQKQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 779779Abnormal cell migration protein 10
PRO_0000181353

Regions

Domain317 – 40791Ras-associating
Domain456 – 566111PH
Compositional bias48 – 10861Glu-rich
Compositional bias238 – 28245Ser-rich
Compositional bias589 – 66072Ser-rich
Compositional bias708 – 74235Pro-rich

Natural variations

Alternative sequence1 – 129129Missing in isoform b.
VSP_008867
Alternative sequence1 – 112112Missing in isoform a.
VSP_014008
Alternative sequence130 – 15021PQVPP…NNIKE → MYHDRRRTGFRQYETYMKQK Q in isoform b.
VSP_014009

Sequences

Sequence LengthMass (Da)Tools
Isoform c [UniParc].

Last modified June 7, 2005. Version 3.
Checksum: E5EAE25205EBFAC5

FASTA77987,502
        10         20         30         40         50         60 
MDSCEEECDL EVDSDEEDQL FGEKCISLLS SLLPLSSSTL LSNAINLELD EVERPPPLLN 

        70         80         90        100        110        120 
VLEEQQFPKV CANIEEENEL EADTEEDIAE TADDEESKDP VEKTENFEPS VTMDTYDFPD 

       130        140        150        160        170        180 
PYPVQIRARP QVPPKPPIDT VRYSMNNIKE SADWQLDELL EELEALETQL NSSNGGDQLL 

       190        200        210        220        230        240 
LGVSGIPASS SRENVKSIST LPPPPPALSY HQTPQQPQLL HHHNNHLGYQ NGIHQITSIN 

       250        260        270        280        290        300 
SAASSCSSPD GDSAFGDSSS TESSNNRCRN SAFSSNDSCR DSLNTPSPTQ VSPRNGELNA 

       310        320        330        340        350        360 
EEAKAQKIRQ ALEKMKEAKV TKIFVKFFVE DGEALQLLID ERWTVADTLK QLAEKNHIAL 

       370        380        390        400        410        420 
MEDHCIVEEY PELYIKRVYE DHEKVVENIQ MWVQDSPNKL YFMRRPDKYA FISRPELYLL 

       430        440        450        460        470        480 
TPKTSDHMEI PSGDQWTIDV KQKFVSEYFH REPVVPPEME GFLYLKSDGR KSWKKHYFVL 

       490        500        510        520        530        540 
RPSGLYYAPK SKKPTTKDLT CLMNLHSNQV YTGIGWEKKY KSPTPWCISI KLTALQMKRS 

       550        560        570        580        590        600 
QFIKYICAED EMTFKKWLVA LRIAKNGAEL LENYERACQI RRETLGPASS MSAASSSTAI 

       610        620        630        640        650        660 
SEVPHSLSHH QRTPSVASSI QLSSHMMNNP THPLSVNVRN QSPASFSVNS CQQSHPSRTS 

       670        680        690        700        710        720 
AKLEIQYDEQ PTGTIKRAPL DVLRRVSRAS TSSPTIPQEE SDSDEEFPAP PPVASVMRMP 

       730        740        750        760        770 
PPVTPPKPCT PLTSKKAPPP PPKRSDTTKL QSASPMAPAK NDLEAALARR REKMATMEC 

« Hide

Isoform a [UniParc].

Checksum: 6B00AD9E18741811
Show »

FASTA66774,985
Isoform b [UniParc].

Checksum: C3532BBF587D1335
Show »

FASTA65073,318

References

« Hide 'large scale' references
[1]"C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development."
Manser J., Roonprapunt C., Margolis B.
Dev. Biol. 184:150-164(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION.
[2]"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. expand/collapse author list , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.
Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081105 Genomic DNA. Translation: CCD69133.1.
FO081105 Genomic DNA. Translation: CCD69132.1.
FO081105 Genomic DNA. Translation: CCD69134.1.
PIRS44806.
RefSeqNP_001021248.1. NM_001026077.4.
NP_498821.2. NM_066420.4.
NP_498822.2. NM_066421.3.
UniGeneCel.10613.

3D structure databases

ProteinModelPortalP34400.
SMRP34400. Positions 304-577.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41372. 2 interactions.
IntActP34400. 7 interactions.

Proteomic databases

PaxDbP34400.
PRIDEP34400.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF10E9.6c; F10E9.6c; F10E9.6. [P34400-3]
GeneID176168.
KEGGcel:CELE_F10E9.6.
UCSCF10E9.6c. c. elegans. [P34400-1]

Organism-specific databases

CTD176168.
WormBaseF10E9.6a; CE29261; WBGene00003243; mig-10.
F10E9.6b; CE00150; WBGene00003243; mig-10.
F10E9.6c; CE36129; WBGene00003243; mig-10.

Phylogenomic databases

eggNOGNOG279449.
HOGENOMHOG000020872.
InParanoidP34400.
OMAHIALMED.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR000159. Ras-assoc.
[Graphical view]
PfamPF00169. PH. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891414.
PROP34400.

Entry information

Entry nameMIG10_CAEEL
AccessionPrimary (citable) accession number: P34400
Secondary accession number(s): P34386 expand/collapse secondary AC list , P34403, Q7JQ80, Q8WT53
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase