Reviewed, UniProtKB/Swiss-Prot P34355 (ACOX_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable peroxisomal acyl-coenzyme A oxidase
      Short name=Acyl-CoA oxidase
      Short name=AOX
    EC=1.3.3.6

Gene names

ORF Names:

C48B4.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	659 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 659	659	Probable peroxisomal acyl-coenzyme A oxidase		PRO_0000204688
Regions
	Motif	657 – 659	3	Microbody targeting signal Potential

Sequences

	Sequence		Length	Mass (Da)
	P34355-1 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 5F0D6E92F8CAA5F8	FASTA	659	74,714
	10 20 30 40 50 60 MPLNKLIQDG DNQDLTDERF KATFDTDALA AVFHGGEDAL KRIRELRDEV TKRWHLFDAL 70 80 90 100 110 120 PGAHRTRAER MEDVSRKLKN LMESVGEFAD FTNNLDMLVI IRDVMGIEGF PLALHNLMFV 130 140 150 160 170 180 PTIQNQADDE QTEWWLMDAL QGKIIGTYAQ TELGHGTNLG AIETTATYDK LTEEFIIHTP 190 200 210 220 230 240 TTTATKWWPG GLGTSCTHVV LVANLIIDTK NYGLHPFFVP IRDRNSYSVM SGVRVGDIGT 250 260 270 280 290 300 KMGVNCVDNG FLAFDNYRIP RRNMLMKHSK VSKEGLYTAP SHPKVGYTTM LYMRSEMIYH 310 320 330 340 350 360 QAYYLAMAMA ISIRYSAVRR QGEIKPGTQE VQILDYQTQQ YRIFPGLARC FAFNTAAATV 370 380 390 400 410 420 RQMTENCIKQ LSHGNSDVLA DLHALSCGLK AVVTHQASQS IDQARQACGG HGYSDASYLP 430 440 450 460 470 480 TLYTCSVGAC TYEGENMVML LQLSKYLMKA AAKAEKGEEM APLVAYLVKP DITETNDKFA 490 500 510 520 530 540 KMLSHFEHIA RHRVMHAYRQ MIEEEKQGIE RDYAFANHSV DWTKAARAHT KLFIARGFVK 550 560 570 580 590 600 SVQEVSDEAV HDVLTTLAEL YLSYELIEMS ADLTANGYLS ESDVQQIRHQ IYDSMRKTRR 610 620 630 640 650 NAVSIVDSFD ICDRELRSVL GRRDGHVYEN LYKWAQMSPL NERNLPHVEK YLKPMTSKL

References

[1]

"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

[2]

"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z29117 Genomic DNA. Translation: CAA82376.1.
PIR	S40722.
RefSeq	NP_499119.1.
UniGene	Cel.10702
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBase	Search...
Genome annotation databases
Ensembl	C48B4.1. Caenorhabditis elegans. [Contig view]
GeneID	176353.
KEGG	cel:C48B4.1.
Organism-specific databases
WormBase	WBGene00008167. C48B4.1.
WormPep	C48B4.1. CE00491. [WorfDB]
Phylogenomic databases
OMA	P34355. MLMKHSK.
Enzyme and pathway databases
BRENDA	1.3.3.6. 672.
Gene expression databases
ArrayExpress	P34355.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	892210.

Entry information

Entry name

ACOX_CAEEL

Accession

Primary (citable) accession number: P34355

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project