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Protein

Putative tyrosine-protein phosphatase C15H7.3

Gene

C15H7.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase C15H7.3 (EC:3.1.3.48)
Gene namesi
ORF Names:C15H7.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC15H7.3; CE00081; WBGene00007610.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Putative tyrosine-protein phosphatase C15H7.3PRO_0000094927Add
BLAST

Proteomic databases

PaxDbiP34337.

Interactioni

Protein-protein interaction databases

STRINGi6239.C15H7.3.

Structurei

3D structure databases

ProteinModelPortaliP34337.
SMRiP34337. Positions 165-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 376252Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG327017.
GeneTreeiENSGT00530000064500.
HOGENOMiHOG000019963.
InParanoidiP34337.
OMAiHLHNWRQ.
PhylomeDBiP34337.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSQKSARK KKKTSKSGND RSIRSERKSK QKKPAGEKSQ KSRRTRKSRG
60 70 80 90 100
PKGNGFTSRE TIQPSSSGQS EGTTRMDDQK DEKKDDKKEE KKEERKEEKK
110 120 130 140 150
EEVKEPWSEE EPAKRMVANG FFTTTNVGGT FKQTDNFKTP MDSCPSFKNN
160 170 180 190 200
MHKIRAPDCP IPEEKLVKLT NGPESFICAA KITVPDFNRT MILTQVPDLS
210 220 230 240 250
SAPDIADFWR MIHQESIASV VIAVMPLEVT LQQILPLLSG TYSTYGKMFV
260 270 280 290 300
NNKKVESAVG MTEYCLEIFP DGCSNSLLTT VYHLHNWRQK RGLEVVTDLV
310 320 330 340 350
ATMEKVMKVN DNTVLMSMNG TGRAGTMLTL FTAMLQVQKG KEVNAKETLA
360 370 380 390
SLRAERCGIV DNIDQFGTVH RSMACWFKNN STNEEVQRKV VEFAPSIQ
Length:398
Mass (Da):44,926
Last modified:February 1, 1994 - v1
Checksum:iCEEDE09FA0BC8F68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22173 Genomic DNA. Translation: CAA80125.1.
PIRiS40752.
RefSeqiNP_499135.1. NM_066734.5.
UniGeneiCel.10838.

Genome annotation databases

EnsemblMetazoaiC15H7.3; C15H7.3; WBGene00007610.
GeneIDi182639.
KEGGicel:CELE_C15H7.3.
UCSCiC15H7.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22173 Genomic DNA. Translation: CAA80125.1.
PIRiS40752.
RefSeqiNP_499135.1. NM_066734.5.
UniGeneiCel.10838.

3D structure databases

ProteinModelPortaliP34337.
SMRiP34337. Positions 165-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C15H7.3.

Proteomic databases

PaxDbiP34337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC15H7.3; C15H7.3; WBGene00007610.
GeneIDi182639.
KEGGicel:CELE_C15H7.3.
UCSCiC15H7.3. c. elegans.

Organism-specific databases

CTDi182639.
WormBaseiC15H7.3; CE00081; WBGene00007610.

Phylogenomic databases

eggNOGiNOG327017.
GeneTreeiENSGT00530000064500.
HOGENOMiHOG000019963.
InParanoidiP34337.
OMAiHLHNWRQ.
PhylomeDBiP34337.

Miscellaneous databases

NextBioi918298.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiYK13_CAEEL
AccessioniPrimary (citable) accession number: P34337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.