P34337 (YK13_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein phosphatase C15H7.3
EC=3.1.3.48

Gene names

ORF Names:

C15H7.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Putative tyrosine-protein phosphatase C15H7.3		PRO_0000094927
Regions
	Domain	125 – 376	252	Tyrosine-protein phosphatase

Sequences

	Sequence		Length	Mass (Da)
	P34337 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: CEEDE09FA0BC8F68	FASTA	398	44,926
	10 20 30 40 50 60 MERSQKSARK KKKTSKSGND RSIRSERKSK QKKPAGEKSQ KSRRTRKSRG PKGNGFTSRE 70 80 90 100 110 120 TIQPSSSGQS EGTTRMDDQK DEKKDDKKEE KKEERKEEKK EEVKEPWSEE EPAKRMVANG 130 140 150 160 170 180 FFTTTNVGGT FKQTDNFKTP MDSCPSFKNN MHKIRAPDCP IPEEKLVKLT NGPESFICAA 190 200 210 220 230 240 KITVPDFNRT MILTQVPDLS SAPDIADFWR MIHQESIASV VIAVMPLEVT LQQILPLLSG 250 260 270 280 290 300 TYSTYGKMFV NNKKVESAVG MTEYCLEIFP DGCSNSLLTT VYHLHNWRQK RGLEVVTDLV 310 320 330 340 350 360 ATMEKVMKVN DNTVLMSMNG TGRAGTMLTL FTAMLQVQKG KEVNAKETLA SLRAERCGIV 370 380 390 DNIDQFGTVH RSMACWFKNN STNEEVQRKV VEFAPSIQ

References

[1]

"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

[2]

"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z22173 Genomic DNA. Translation: CAA80125.1.
PIR	S40752.
RefSeq	NP_499135.1. NM_066734.5.
3D structure databases
ProteinModelPortal	P34337.
SMR	P34337. Positions 165-375.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.C15H7.3.
Proteomic databases
PaxDb	P34337.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C15H7.3; C15H7.3; C15H7.3.
GeneID	182639.
KEGG	cel:CELE_C15H7.3.
UCSC	C15H7.3. c. elegans.
Organism-specific databases
CTD	182639.
WormBase	C15H7.3; CE00081; WBGene00007610.
Phylogenomic databases
eggNOG	NOG327017.
GeneTree	ENSGT00530000064500.
HOGENOM	HOG000019963.
InParanoid	P34337.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00102. Y_phosphatase. 1 hit. [Graphical view]
SMART	SM00194. PTPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	918298.

Entry information

Entry name

YK13_CAEEL

Accession

Primary (citable) accession number: P34337

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project