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P34329 (PDIA4_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein disulfide-isomerase A4

EC=5.3.4.1
Alternative name(s):
ERp-72 homolog
Gene names
ORF Names:C14B9.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length618 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 3 thioredoxin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 618597Probable protein disulfide-isomerase A4
PRO_0000034232

Regions

Domain22 – 139118Thioredoxin 1
Domain138 – 254117Thioredoxin 2
Domain480 – 609130Thioredoxin 3
Motif615 – 6184Prevents secretion from ER

Amino acid modifications

Disulfide bond65 ↔ 68Redox-active By similarity
Disulfide bond176 ↔ 179Redox-active By similarity
Disulfide bond529 ↔ 532Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P34329 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 1DC0207A71444220

FASTA61869,797
        10         20         30         40         50         60 
MMFDRRFFAL VVLLCVSAVR STEDASDDEL NYEMDEGVVV LTDKNFDAFL KKNPSVLVKF 

        70         80         90        100        110        120 
YAPWCGHCKH LAPEYEKASS KVSIPLAKVD ATVETELGKR FEIQGYPTLK FWKDGKGPND 

       130        140        150        160        170        180 
YDGGRDEAGI VEWVESRVDP NYKPPPEEVV TLTTENFDDF ISNNELVLVE FYAPWCGHCK 

       190        200        210        220        230        240 
KLAPEYEKAA QKLKAQGSKV KLGKVDATIE KDLGTKYGVS GYPTMKIIRN GRRFDYNGPR 

       250        260        270        280        290        300 
EAAGIIKYMT DQSKPAAKKL PKLKDVERFM SKDDVTIIGF FATEDSTAFE AFSDSAEMLR 

       310        320        330        340        350        360 
EEFKTMGHTS DPAAFKKWDA KPNDIIIFYP SLFHSKFEPK SRTYNKAAAT SEDLLAFFRE 

       370        380        390        400        410        420 
HSAPLVGKMT KKNAATRYTK KPLVVVYYNA DFSVQYREGS EYWRSKVLNI AQKYQKDKYK 

       430        440        450        460        470        480 
FAVADEEEFA KELEELGLGD SGLEHNVVVF GYDGKKYPMN PDEFDGELDE NLEAFMKQIS 

       490        500        510        520        530        540 
SGKAKAHVKS APAPKDDKGP VKTVVGSNFD KIVNDESKDV LIEFYAPWCG HCKSFESKYV 

       550        560        570        580        590        600 
ELAQALKKTQ PNVVLAKMDA TINDAPSQFA VEGFPTIYFA PAGKKSEPIK YSGNRDLEDL 

       610 
KKFMTKHGVK SFQKKDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080531 Genomic DNA. Translation: CCD64436.1.
PIRS44756.
RefSeqNP_498775.2. NM_066374.7.
UniGeneCel.17287.

3D structure databases

ProteinModelPortalP34329.
SMRP34329. Positions 2-618.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41353. 1 interaction.
MINTMINT-1112011.
STRING6239.C14B9.2.1.

Proteomic databases

PaxDbP34329.
PRIDEP34329.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC14B9.2; C14B9.2; WBGene00015752.
GeneID176147.
KEGGcel:CELE_C14B9.2.
UCSCC14B9.2.1. c. elegans.

Organism-specific databases

CTD176147.
WormBaseC14B9.2; CE30601; WBGene00015752.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00740000115037.
HOGENOMHOG000162459.
InParanoidP34329.
KOK09582.
OMAIIGVFKG.
OrthoDBEOG7VHSX1.
PhylomeDBP34329.

Family and domain databases

Gene3D3.40.30.10. 4 hits.
InterProIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR017068. Protein_diS-isomerase_A4.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 3 hits.
[Graphical view]
PIRSFPIRSF036862. Disulphide_isom_A4. 1 hit.
SUPFAMSSF52833. SSF52833. 5 hits.
TIGRFAMsTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 3 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio891332.
PROP34329.

Entry information

Entry namePDIA4_CAEEL
AccessionPrimary (citable) accession number: P34329
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 21, 2001
Last modified: June 11, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase