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P34329

- PDIA4_CAEEL

UniProt

P34329 - PDIA4_CAEEL

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Protein

Probable protein disulfide-isomerase A4

Gene

C14B9.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: RefGenome

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. endoplasmic reticulum unfolded protein response Source: WormBase
  3. protein folding Source: RefGenome
  4. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein disulfide-isomerase A4 (EC:5.3.4.1)
Alternative name(s):
ERp-72 homolog
Gene namesi
ORF Names:C14B9.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC14B9.2; CE30601; WBGene00015752.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum lumen Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 618597Probable protein disulfide-isomerase A4PRO_0000034232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 68Redox-activePROSITE-ProRule annotation
Disulfide bondi176 ↔ 179Redox-activePROSITE-ProRule annotation
Disulfide bondi529 ↔ 532Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP34329.
PRIDEiP34329.

Interactioni

Protein-protein interaction databases

BioGridi41353. 1 interaction.
MINTiMINT-1112011.
STRINGi6239.C14B9.2.1.

Structurei

3D structure databases

ProteinModelPortaliP34329.
SMRiP34329. Positions 2-618.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 139118Thioredoxin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 254117Thioredoxin 2PROSITE-ProRule annotationAdd
BLAST
Domaini480 – 609130Thioredoxin 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi615 – 6184Prevents secretion from ER

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 3 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00760000119201.
HOGENOMiHOG000162459.
InParanoidiP34329.
KOiK09582.
OMAiIIGVFKG.
OrthoDBiEOG7VHSX1.
PhylomeDBiP34329.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR017068. Protein_diS-isomerase_A4.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
PIRSFiPIRSF036862. Disulphide_isom_A4. 1 hit.
SUPFAMiSSF52833. SSF52833. 5 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 3 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34329-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMFDRRFFAL VVLLCVSAVR STEDASDDEL NYEMDEGVVV LTDKNFDAFL
60 70 80 90 100
KKNPSVLVKF YAPWCGHCKH LAPEYEKASS KVSIPLAKVD ATVETELGKR
110 120 130 140 150
FEIQGYPTLK FWKDGKGPND YDGGRDEAGI VEWVESRVDP NYKPPPEEVV
160 170 180 190 200
TLTTENFDDF ISNNELVLVE FYAPWCGHCK KLAPEYEKAA QKLKAQGSKV
210 220 230 240 250
KLGKVDATIE KDLGTKYGVS GYPTMKIIRN GRRFDYNGPR EAAGIIKYMT
260 270 280 290 300
DQSKPAAKKL PKLKDVERFM SKDDVTIIGF FATEDSTAFE AFSDSAEMLR
310 320 330 340 350
EEFKTMGHTS DPAAFKKWDA KPNDIIIFYP SLFHSKFEPK SRTYNKAAAT
360 370 380 390 400
SEDLLAFFRE HSAPLVGKMT KKNAATRYTK KPLVVVYYNA DFSVQYREGS
410 420 430 440 450
EYWRSKVLNI AQKYQKDKYK FAVADEEEFA KELEELGLGD SGLEHNVVVF
460 470 480 490 500
GYDGKKYPMN PDEFDGELDE NLEAFMKQIS SGKAKAHVKS APAPKDDKGP
510 520 530 540 550
VKTVVGSNFD KIVNDESKDV LIEFYAPWCG HCKSFESKYV ELAQALKKTQ
560 570 580 590 600
PNVVLAKMDA TINDAPSQFA VEGFPTIYFA PAGKKSEPIK YSGNRDLEDL
610
KKFMTKHGVK SFQKKDEL
Length:618
Mass (Da):69,797
Last modified:February 21, 2001 - v2
Checksum:i1DC0207A71444220
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080531 Genomic DNA. Translation: CCD64436.1.
PIRiS44756.
RefSeqiNP_498775.2. NM_066374.7.
UniGeneiCel.17287.

Genome annotation databases

EnsemblMetazoaiC14B9.2; C14B9.2; WBGene00015752.
GeneIDi176147.
KEGGicel:CELE_C14B9.2.
UCSCiC14B9.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080531 Genomic DNA. Translation: CCD64436.1 .
PIRi S44756.
RefSeqi NP_498775.2. NM_066374.7.
UniGenei Cel.17287.

3D structure databases

ProteinModelPortali P34329.
SMRi P34329. Positions 2-618.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41353. 1 interaction.
MINTi MINT-1112011.
STRINGi 6239.C14B9.2.1.

Proteomic databases

PaxDbi P34329.
PRIDEi P34329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C14B9.2 ; C14B9.2 ; WBGene00015752 .
GeneIDi 176147.
KEGGi cel:CELE_C14B9.2.
UCSCi C14B9.2.1. c. elegans.

Organism-specific databases

CTDi 176147.
WormBasei C14B9.2 ; CE30601 ; WBGene00015752 .

Phylogenomic databases

eggNOGi COG0526.
GeneTreei ENSGT00760000119201.
HOGENOMi HOG000162459.
InParanoidi P34329.
KOi K09582.
OMAi IIGVFKG.
OrthoDBi EOG7VHSX1.
PhylomeDBi P34329.

Miscellaneous databases

NextBioi 891332.
PROi P34329.

Family and domain databases

Gene3Di 3.40.30.10. 4 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR017068. Protein_diS-isomerase_A4.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 3 hits.
[Graphical view ]
PIRSFi PIRSF036862. Disulphide_isom_A4. 1 hit.
SUPFAMi SSF52833. SSF52833. 5 hits.
TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 3 hits.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPDIA4_CAEEL
AccessioniPrimary (citable) accession number: P34329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 21, 2001
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3