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Protein

Probable protein disulfide-isomerase A4

Gene

C14B9.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein disulfide-isomerase A4 (EC:5.3.4.1)
Alternative name(s):
ERp-72 homolog
Gene namesi
ORF Names:C14B9.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC14B9.2; CE30601; WBGene00015752.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003423222 – 618Probable protein disulfide-isomerase A4Add BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 68Redox-activePROSITE-ProRule annotation
Disulfide bondi176 ↔ 179Redox-activePROSITE-ProRule annotation
Disulfide bondi529 ↔ 532Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP34329.
PaxDbiP34329.
PeptideAtlasiP34329.
PRIDEiP34329.

Expressioni

Gene expression databases

BgeeiWBGene00015752.

Interactioni

Protein-protein interaction databases

BioGridi41353. 1 interactor.
MINTiMINT-1112011.
STRINGi6239.C14B9.2.

Structurei

3D structure databases

ProteinModelPortaliP34329.
SMRiP34329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 139Thioredoxin 1PROSITE-ProRule annotationAdd BLAST118
Domaini138 – 254Thioredoxin 2PROSITE-ProRule annotationAdd BLAST117
Domaini480 – 609Thioredoxin 3PROSITE-ProRule annotationAdd BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi615 – 618Prevents secretion from ER4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 3 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000162459.
InParanoidiP34329.
KOiK09582.
OMAiREGSEYW.
OrthoDBiEOG091G05J9.
PhylomeDBiP34329.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR017068. Protein_diS-isomerase_A4.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
PIRSFiPIRSF036862. Disulphide_isom_A4. 1 hit.
SUPFAMiSSF52833. SSF52833. 5 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 3 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFDRRFFAL VVLLCVSAVR STEDASDDEL NYEMDEGVVV LTDKNFDAFL
60 70 80 90 100
KKNPSVLVKF YAPWCGHCKH LAPEYEKASS KVSIPLAKVD ATVETELGKR
110 120 130 140 150
FEIQGYPTLK FWKDGKGPND YDGGRDEAGI VEWVESRVDP NYKPPPEEVV
160 170 180 190 200
TLTTENFDDF ISNNELVLVE FYAPWCGHCK KLAPEYEKAA QKLKAQGSKV
210 220 230 240 250
KLGKVDATIE KDLGTKYGVS GYPTMKIIRN GRRFDYNGPR EAAGIIKYMT
260 270 280 290 300
DQSKPAAKKL PKLKDVERFM SKDDVTIIGF FATEDSTAFE AFSDSAEMLR
310 320 330 340 350
EEFKTMGHTS DPAAFKKWDA KPNDIIIFYP SLFHSKFEPK SRTYNKAAAT
360 370 380 390 400
SEDLLAFFRE HSAPLVGKMT KKNAATRYTK KPLVVVYYNA DFSVQYREGS
410 420 430 440 450
EYWRSKVLNI AQKYQKDKYK FAVADEEEFA KELEELGLGD SGLEHNVVVF
460 470 480 490 500
GYDGKKYPMN PDEFDGELDE NLEAFMKQIS SGKAKAHVKS APAPKDDKGP
510 520 530 540 550
VKTVVGSNFD KIVNDESKDV LIEFYAPWCG HCKSFESKYV ELAQALKKTQ
560 570 580 590 600
PNVVLAKMDA TINDAPSQFA VEGFPTIYFA PAGKKSEPIK YSGNRDLEDL
610
KKFMTKHGVK SFQKKDEL
Length:618
Mass (Da):69,797
Last modified:February 21, 2001 - v2
Checksum:i1DC0207A71444220
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080531 Genomic DNA. Translation: CCD64436.1.
PIRiS44756.
RefSeqiNP_498775.2. NM_066374.7.
UniGeneiCel.17287.

Genome annotation databases

EnsemblMetazoaiC14B9.2; C14B9.2; WBGene00015752.
GeneIDi176147.
KEGGicel:CELE_C14B9.2.
UCSCiC14B9.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080531 Genomic DNA. Translation: CCD64436.1.
PIRiS44756.
RefSeqiNP_498775.2. NM_066374.7.
UniGeneiCel.17287.

3D structure databases

ProteinModelPortaliP34329.
SMRiP34329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41353. 1 interactor.
MINTiMINT-1112011.
STRINGi6239.C14B9.2.

Proteomic databases

EPDiP34329.
PaxDbiP34329.
PeptideAtlasiP34329.
PRIDEiP34329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC14B9.2; C14B9.2; WBGene00015752.
GeneIDi176147.
KEGGicel:CELE_C14B9.2.
UCSCiC14B9.2.1. c. elegans.

Organism-specific databases

CTDi176147.
WormBaseiC14B9.2; CE30601; WBGene00015752.

Phylogenomic databases

eggNOGiKOG0190. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133691.
HOGENOMiHOG000162459.
InParanoidiP34329.
KOiK09582.
OMAiREGSEYW.
OrthoDBiEOG091G05J9.
PhylomeDBiP34329.

Miscellaneous databases

PROiP34329.

Gene expression databases

BgeeiWBGene00015752.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR017068. Protein_diS-isomerase_A4.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
PIRSFiPIRSF036862. Disulphide_isom_A4. 1 hit.
SUPFAMiSSF52833. SSF52833. 5 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 3 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDIA4_CAEEL
AccessioniPrimary (citable) accession number: P34329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 21, 2001
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.