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P34329

- PDIA4_CAEEL

UniProt

P34329 - PDIA4_CAEEL

Protein

Probable protein disulfide-isomerase A4

Gene

C14B9.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Catalyzes the rearrangement of -S-S- bonds in proteins.

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: RefGenome

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. endoplasmic reticulum unfolded protein response Source: WormBase
    3. protein folding Source: RefGenome
    4. response to endoplasmic reticulum stress Source: RefGenome

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein disulfide-isomerase A4 (EC:5.3.4.1)
    Alternative name(s):
    ERp-72 homolog
    Gene namesi
    ORF Names:C14B9.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC14B9.2; CE30601; WBGene00015752.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 618597Probable protein disulfide-isomerase A4PRO_0000034232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi65 ↔ 68Redox-activePROSITE-ProRule annotation
    Disulfide bondi176 ↔ 179Redox-activePROSITE-ProRule annotation
    Disulfide bondi529 ↔ 532Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP34329.
    PRIDEiP34329.

    Interactioni

    Protein-protein interaction databases

    BioGridi41353. 1 interaction.
    MINTiMINT-1112011.
    STRINGi6239.C14B9.2.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP34329.
    SMRiP34329. Positions 2-618.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 139118Thioredoxin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 254117Thioredoxin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini480 – 609130Thioredoxin 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi615 – 6184Prevents secretion from ER

    Sequence similaritiesi

    Belongs to the protein disulfide isomerase family.Curated
    Contains 3 thioredoxin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    GeneTreeiENSGT00740000115037.
    HOGENOMiHOG000162459.
    InParanoidiP34329.
    KOiK09582.
    OMAiIIGVFKG.
    OrthoDBiEOG7VHSX1.
    PhylomeDBiP34329.

    Family and domain databases

    Gene3Di3.40.30.10. 4 hits.
    InterProiIPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR017068. Protein_diS-isomerase_A4.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF00085. Thioredoxin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF036862. Disulphide_isom_A4. 1 hit.
    SUPFAMiSSF52833. SSF52833. 5 hits.
    TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 3 hits.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 3 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P34329-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMFDRRFFAL VVLLCVSAVR STEDASDDEL NYEMDEGVVV LTDKNFDAFL    50
    KKNPSVLVKF YAPWCGHCKH LAPEYEKASS KVSIPLAKVD ATVETELGKR 100
    FEIQGYPTLK FWKDGKGPND YDGGRDEAGI VEWVESRVDP NYKPPPEEVV 150
    TLTTENFDDF ISNNELVLVE FYAPWCGHCK KLAPEYEKAA QKLKAQGSKV 200
    KLGKVDATIE KDLGTKYGVS GYPTMKIIRN GRRFDYNGPR EAAGIIKYMT 250
    DQSKPAAKKL PKLKDVERFM SKDDVTIIGF FATEDSTAFE AFSDSAEMLR 300
    EEFKTMGHTS DPAAFKKWDA KPNDIIIFYP SLFHSKFEPK SRTYNKAAAT 350
    SEDLLAFFRE HSAPLVGKMT KKNAATRYTK KPLVVVYYNA DFSVQYREGS 400
    EYWRSKVLNI AQKYQKDKYK FAVADEEEFA KELEELGLGD SGLEHNVVVF 450
    GYDGKKYPMN PDEFDGELDE NLEAFMKQIS SGKAKAHVKS APAPKDDKGP 500
    VKTVVGSNFD KIVNDESKDV LIEFYAPWCG HCKSFESKYV ELAQALKKTQ 550
    PNVVLAKMDA TINDAPSQFA VEGFPTIYFA PAGKKSEPIK YSGNRDLEDL 600
    KKFMTKHGVK SFQKKDEL 618
    Length:618
    Mass (Da):69,797
    Last modified:February 21, 2001 - v2
    Checksum:i1DC0207A71444220
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080531 Genomic DNA. Translation: CCD64436.1.
    PIRiS44756.
    RefSeqiNP_498775.2. NM_066374.7.
    UniGeneiCel.17287.

    Genome annotation databases

    EnsemblMetazoaiC14B9.2; C14B9.2; WBGene00015752.
    GeneIDi176147.
    KEGGicel:CELE_C14B9.2.
    UCSCiC14B9.2.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080531 Genomic DNA. Translation: CCD64436.1 .
    PIRi S44756.
    RefSeqi NP_498775.2. NM_066374.7.
    UniGenei Cel.17287.

    3D structure databases

    ProteinModelPortali P34329.
    SMRi P34329. Positions 2-618.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41353. 1 interaction.
    MINTi MINT-1112011.
    STRINGi 6239.C14B9.2.1.

    Proteomic databases

    PaxDbi P34329.
    PRIDEi P34329.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C14B9.2 ; C14B9.2 ; WBGene00015752 .
    GeneIDi 176147.
    KEGGi cel:CELE_C14B9.2.
    UCSCi C14B9.2.1. c. elegans.

    Organism-specific databases

    CTDi 176147.
    WormBasei C14B9.2 ; CE30601 ; WBGene00015752 .

    Phylogenomic databases

    eggNOGi COG0526.
    GeneTreei ENSGT00740000115037.
    HOGENOMi HOG000162459.
    InParanoidi P34329.
    KOi K09582.
    OMAi IIGVFKG.
    OrthoDBi EOG7VHSX1.
    PhylomeDBi P34329.

    Miscellaneous databases

    NextBioi 891332.
    PROi P34329.

    Family and domain databases

    Gene3Di 3.40.30.10. 4 hits.
    InterProi IPR005788. Disulphide_isomerase.
    IPR005792. Prot_disulphide_isomerase.
    IPR017068. Protein_diS-isomerase_A4.
    IPR012336. Thioredoxin-like_fold.
    IPR017937. Thioredoxin_CS.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF00085. Thioredoxin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF036862. Disulphide_isom_A4. 1 hit.
    SUPFAMi SSF52833. SSF52833. 5 hits.
    TIGRFAMsi TIGR01130. ER_PDI_fam. 1 hit.
    TIGR01126. pdi_dom. 3 hits.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00194. THIOREDOXIN_1. 3 hits.
    PS51352. THIOREDOXIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPDIA4_CAEEL
    AccessioniPrimary (citable) accession number: P34329
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3