Reviewed, UniProtKB/Swiss-Prot P34317 (UGT60_CAEEL)

Names and origin

Protein names

Recommended name:
    Putative UDP-glucuronosyltransferase ugt-60
      Short name=UDPGT 60
    EC=2.4.1.17

Gene names

Name:	ugt-60
ORF Names:	C07A9.6

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 507	492	Putative UDP-glucuronosyltransferase ugt-60		PRO_0000036067
Regions
	Transmembrane	379 – 399	21	Potential
Amino acid modifications
	Glycosylation	312	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P34317-1 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: BE91C2F305B4FAE6	FASTA	507	57,727
	10 20 30 40 50 60 MYLPIFCIFL SVVDSLRILQ IVPGFTNSHV LFNYRLAETL RFLGHDVKMW TQMEMAMLDT 70 80 90 100 110 120 GNNKLPEGVS EYRIPIHFTD TLKTEGLKVF QSMMFESGDA HDLWWTGQEF KDMRVEACEQ 130 140 150 160 170 180 MLRHDESVYE DFRKDGFDVA IAHFHDLCPL AIAKKMNVKR VIWITHGTSI YEFSAVQLGL 190 200 210 220 230 240 RTIPSTIPHP LSSAGFSQLF LDRVQNTLWH LSLLDFVNLP QNLLVDENLF YREFVGADQD 250 260 270 280 290 300 DLWDLAKTTV PSLLINGDRM LDFPRPLPIH IAFSGELGVS KGKKLVMEKW LEDIIEKPSD 310 320 330 340 350 360 GLIVFSLGTV SNTTNMPAQM INSFLGAFGK LKTYTILWRM EKSVAGAEKY ENLHLVKWLP 370 380 390 400 410 420 QKDIMRHPKM KLMIAHGGYN SFLEAAQAGI PAVLMPLFAD QKINAKRAQR YGMATVLDKL 430 440 450 460 470 480 DLTINNVYGA IKEALKPEYS TNAKKLSAML SDQVARKPYS ALRYSLKLAT SPKPSLFTLK 490 500 SQHLSFLEFH NLDIFSIVLL TAFIVCF

References

[1]

"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

[2]

"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z29094 Genomic DNA. Translation: CAA82344.2.
PIR	S40710.
RefSeq	NP_001021158.1.
UniGene	Cel.10865
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	C07A9.6. Caenorhabditis elegans. [Contig view]
GeneID	176366.
KEGG	cel:C07A9.6.
Organism-specific databases
WormBase	WBGene00007402. ugt-60.
WormPep	C07A9.6. CE33970. [WorfDB]
Phylogenomic databases
OMA	P34317. RVEACEQ.
Enzyme and pathway databases
BRENDA	2.4.1.17. 672.
Gene expression databases
ArrayExpress	P34317.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	892266.

Entry information

Entry name

UGT60_CAEEL

Accession

Primary (citable) accession number: P34317

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	March 1, 2004
Last modified:	May 5, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project