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Protein

Putative ATP-dependent RNA helicase rha-2

Gene

rha-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable ATP-binding RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi259 – 266ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase rha-2 (EC:3.6.4.13)
Gene namesi
Name:rha-2
ORF Names:C06E1.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC06E1.10; CE29563; WBGene00015525; rha-2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551941 – 1148Putative ATP-dependent RNA helicase rha-2Add BLAST1148

Proteomic databases

EPDiP34305.
PaxDbiP34305.
PeptideAtlasiP34305.
PRIDEiP34305.

PTM databases

iPTMnetiP34305.

Expressioni

Gene expression databases

BgeeiWBGene00015525.

Interactioni

Protein-protein interaction databases

BioGridi41411. 1 interactor.
IntActiP34305. 1 interactor.
STRINGi6239.C06E1.10.

Structurei

3D structure databases

ProteinModelPortaliP34305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 412Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST167
Domaini463 – 703Helicase C-terminalPROSITE-ProRule annotationAdd BLAST241

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi355 – 358DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 153Poly-Glu8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0926. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00550000074985.
HOGENOMiHOG000201240.
InParanoidiP34305.
KOiK14780.
OMAiKIHRMLP.
OrthoDBiEOG091G02IP.
PhylomeDBiP34305.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR002464. DNA/RNA_helicase_DEAH_CS.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00690. DEAH_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P34305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRKTKEDN ASEDYDANEL MIVPGEKRKK LEKSGEKSAT GGKKNRNFAK
60 70 80 90 100
EKEVAKLTKQ AKRKLAAVQS RKALKQTQEE LFAGLAEFQL DPSKLCQLSS
110 120 130 140 150
STKLSKEPEK APVFPEKLKV FSGKTKTEAK RTQQDYYPTD DESSSEEEEE
160 170 180 190 200
EEEGDNDIED AGNTVEVKIE PIDLDDVDEA IDGNPETNLD QIVVKREDDE
210 220 230 240 250
ESDNEDILAL PTTTVINRKK VIVERSKEIQ KSRAELPIFA EEMRIVEAIN
260 270 280 290 300
ENLVTVVCGE TGSGKTTQIP QFLYEAGYAS EGELIGITEP RRVAAIAMAQ
310 320 330 340 350
RVGVELAKPD EVSYQIRYEG TRSETTNILF MTDGVLMKEM EQDVMLKKYS
360 370 380 390 400
VILIDEAHER SMYSDVLIGM LSRIVPLRSK TARPLRLVIM SATLRLDDFT
410 420 430 440 450
HKKLFPLLTP KVIKVDARQF PVSVHFEKRT PDDYIASAFR KTCRIHETLP
460 470 480 490 500
PGAILVFVTG QHEVKQLITK LKKRYPVVYE TDKNGEVLVK GTKEWKEKKV
510 520 530 540 550
EAAKSIKLED FKEETPETED FEDVDDGLMD GDDMNERGAA EAFDDYEEFE
560 570 580 590 600
NGDGDLSDGK VENSIGAPPA DCEPLYCLPL YSLLSMGKQR RVFDETPAGM
610 620 630 640 650
RLCVISTNVA ETSLTIPGVK YVIDGGFEKR RLYDSITGVS RFAVCRISQA
660 670 680 690 700
SGDQRAGRAG RISAGHAYRL YSSAVYQDFV KFADPEILSK PADQLVLHLK
710 720 730 740 750
SMNIVKVVNF PFPSAPDEQM LESAEKRLCR LGALSESTKN GKTEARITKL
760 770 780 790 800
GKTLAVFPLA PSYAKFIAMA DQHNLMSHAI LLISLLSVRE PLIPVSSLRG
810 820 830 840 850
DTPEETKELM KNVLKERRRW CSHTGARRLG DLKVLMHAAS VAEQIKYNAR
860 870 880 890 900
ECEKVGLRVK ALVEARKLRQ QLTNIVNASC KKEHAAALDS DLPPPTDQQA
910 920 930 940 950
QLLRQMVVAS FSDRLARRVD RSVGQEEVQK GAYETTLIKG HVFIDPCSVV
960 970 980 990 1000
FTEEPEFVIY QELVQVNEKK LMTSVCAVDK EWLSRLAESY CNYGEQDKNQ
1010 1020 1030 1040 1050
EPIYDPVKDM VVKTVKVTFG PLNWELPNEN RSVPHDIMMY RYFALFLLDG
1060 1070 1080 1090 1100
LVFEKLKEYT PKLLAPPSTM VKSWAKLQKR TEMLLNKLIE KEVTTRSSLK
1110 1120 1130 1140
EQWLKNENWL LEEYLEWVPE SVHQQISLMW PPLEDHEKTI KMGRNKKY
Length:1,148
Mass (Da):129,963
Last modified:June 6, 2002 - v2
Checksum:i7BD99951D16D455A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080280 Genomic DNA. Translation: CCD62570.1.
PIRiH88533.
RefSeqiNP_498895.1. NM_066494.1.
UniGeneiCel.10874.

Genome annotation databases

EnsemblMetazoaiC06E1.10; C06E1.10; WBGene00015525.
GeneIDi176207.
KEGGicel:CELE_C06E1.10.
UCSCiC06E1.10. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiRHA2_CAEEL
AccessioniPrimary (citable) accession number: P34305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 6, 2002
Last modified: July 5, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families