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Protein

Glutamate receptor 1

Gene

glr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor (PubMed:7477293). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (PubMed:7477293). The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists (PubMed:7477293). May contribute to a sensory discrimination between mechanical and chemical stimuli (PubMed:7477293). Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response (PubMed:27223098). In AIB interneurons, promotes omega turns, a movement that frequently follows backwards locomotion or "reversals" in response to environmental cues while possibly playing an inhibitory role in alternative neurons to inhibit omega turns (PubMed:27223098).2 Publications

GO - Molecular functioni

  • AMPA glutamate receptor activity Source: WormBase
  • enzyme binding Source: WormBase
  • extracellular-glutamate-gated ion channel activity Source: InterPro
  • ionotropic glutamate receptor activity Source: WormBase

GO - Biological processi

  • adult locomotory behavior Source: UniProtKB
  • associative learning Source: WormBase
  • feeding behavior Source: WormBase
  • forward locomotion Source: UniProtKB
  • habituation Source: WormBase
  • hyperosmotic response Source: WormBase
  • ionotropic glutamate receptor signaling pathway Source: WormBase
  • regulation of backward locomotion Source: WormBase
  • response to mechanical stimulus Source: WormBase
  • sensory perception of bitter taste Source: WormBase
  • short-term memory Source: WormBase
  • synaptic transmission, glutamatergic Source: WormBase
  • thigmotaxis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-CEL-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-CEL-399710. Activation of AMPA receptors.
R-CEL-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-CEL-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor 1Imported
Gene namesi
Name:glr-1Imported
ORF Names:C06E1.4Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC06E1.4; CE31407; WBGene00001612; glr-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 591ExtracellularSequence analysisAdd BLAST566
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Topological domaini613 – 668CytoplasmicSequence analysisAdd BLAST56
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21
Topological domaini690 – 855ExtracellularSequence analysisAdd BLAST166
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Topological domaini877 – 962CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cell surface Source: UniProtKB
  • dendrite Source: UniProtKB
  • ionotropic glutamate receptor complex Source: WormBase
  • neuronal cell body Source: UniProtKB
  • neuron projection Source: WormBase
  • neuron projection membrane Source: WormBase
  • perinuclear endoplasmic reticulum Source: UniProtKB
  • plasma membrane Source: WormBase
  • postsynaptic density Source: WormBase
  • postsynaptic membrane Source: UniProtKB
  • recycling endosome Source: UniProtKB-SubCell
  • synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Endosome, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Decreased frequency of reversals, suppression of hyperreversal phenotype of cni-1 mutants, decreased tactile response and increased osmotic avoidance (PubMed:24094107). Overall, display increased omega turn frequency following reversals, however deletion in AIB interneurons specifically results in decreased omega turn frequency (PubMed:27223098). Decreased nose touch responses (PubMed:27223098).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi888K → R: Increased levels of glr-1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001159026 – 962Glutamate receptor 1Add BLAST937

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi482N-linked (GlcNAc...)Sequence analysis1
Glycosylationi852N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Ubiquitinated. Deubiquitinated by usp-46 which prevents its degradation.2 Publications
Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP34299.

Expressioni

Tissue specificityi

Command interneurons of the locomotory control circuit (AIB, AVA, AVB, AVD, AVE and PVC) and motor neurons (RMD, RIM, SMD, AVG, PVQ and URY).2 Publications

Gene expression databases

BgeeiWBGene00001612.

Interactioni

Subunit structurei

Interacts with sol-1 (PubMed:14749834). Interacts with cni-1; the interaction negatively regulates export of glr-1 from the endoplasmic reticulum to synapses (PubMed:24094107). Interacts with usp-46; the interaction results in deubiquitination of glr-1 (PubMed:24356955).3 Publications

GO - Molecular functioni

  • enzyme binding Source: WormBase

Protein-protein interaction databases

BioGridi41408. 3 interactors.
STRINGi6239.C06E1.4.

Structurei

3D structure databases

ProteinModelPortaliP34299.
SMRiP34299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234372.
InParanoidiP34299.
KOiK05313.
OMAiLINIRSA.
OrthoDBiEOG091G11CB.
PhylomeDBiP34299.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00062. PBPb. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSFSFLNM FGVLFTVFNL TVVQPYPSHI IIKSFGNNEE VSRVALKAME
60 70 80 90 100
YTSDHINSRD DVPFKLAFDH RVVEEGAAVS WNMVNAVCDE LKEGAMALLS
110 120 130 140 150
SVDGKGREGI RGVSDALEMP LVSLTALSND DHQQQQFGNL FEVSVRPPIS
160 170 180 190 200
ELLADFIVHK GWGEVLVLID PVHASLHLPS LWRHLRTRTN TSVKASMFDL
210 220 230 240 250
PADEKQFEAY LMQFNMMRNN ETNRILIDCA SPKRLKKLLI NIRSAQFNQA
260 270 280 290 300
NYHYVLANYD FLPYDQEMFQ NGNINISGFN IINKDGREYW SLKKHLKTSS
310 320 330 340 350
SLGGGDDVSV EAAVGHDAML VTWHGFAKCL QANDSLFHGT FRHRRFFNRG
360 370 380 390 400
FPGIYCDPLS DRSHPNRPFS SFEHGKTIGV AFRNMKIGHK EGTLTGNIEF
410 420 430 440 450
DRFGNRKNFD VSIVDLVSNT KATFNSKEVL AWRQGVGFFS NRTVAQHSRK
460 470 480 490 500
SQNDHKDNQV IVLTNLVAPF VMIKRECLEM ANLTECQGNN KFEGFCIDLL
510 520 530 540 550
KLLADKIEEF NYEIKLGTKA GSKQADGSWD GMIGELLSGR AHAVVASLTI
560 570 580 590 600
NQERERVVDF SKPFMTTGIS IMIKKPDKQE FSVFSFMQPL STEIWMYIIF
610 620 630 640 650
AYIGVSVVIF LVSRFSPYEW RVEETSRGGF TISNDFSVYN CLWFTLAAFM
660 670 680 690 700
QQGTDILPRS ISGRIASSAW WFFTMIIVSS YTANLAAFLT LEKMQAPIES
710 720 730 740 750
VEDLAKQSKI KYGIQGGGST ASFFKYSSVQ IYQRMWRYME SQVPPVFVAS
760 770 780 790 800
YAEGIERVRS HKGRYAFLLE ATANEYENTR KPCDTMKVGA NLNSIGYGIA
810 820 830 840 850
TPFGSDWKDH INLAILALQE RGELKKLENK WWYDRGQCDA GITVDGSSAS
860 870 880 890 900
LNLSKVAGIF YILMGGMVIS MLAALGEFLY RSRIEARKSN SNSMVANFAK
910 920 930 940 950
NLKSALSSQL RLSVEGGAVA QPGSQSHNAI RRQQVAAFLP ANEKEAFNNV
960
DRPANTLYNT AV
Length:962
Mass (Da):108,142
Last modified:March 28, 2003 - v2
Checksum:i25488406566A5583
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34661 mRNA. Translation: AAA92006.1.
FO080280 Genomic DNA. Translation: CCD62564.1.
PIRiB88533.
S60225.
RefSeqiNP_498887.2. NM_066486.6.
UniGeneiCel.6005.

Genome annotation databases

EnsemblMetazoaiC06E1.4; C06E1.4; WBGene00001612.
GeneIDi176204.
KEGGicel:CELE_C06E1.4.
UCSCiC06E1.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34661 mRNA. Translation: AAA92006.1.
FO080280 Genomic DNA. Translation: CCD62564.1.
PIRiB88533.
S60225.
RefSeqiNP_498887.2. NM_066486.6.
UniGeneiCel.6005.

3D structure databases

ProteinModelPortaliP34299.
SMRiP34299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41408. 3 interactors.
STRINGi6239.C06E1.4.

Proteomic databases

PaxDbiP34299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC06E1.4; C06E1.4; WBGene00001612.
GeneIDi176204.
KEGGicel:CELE_C06E1.4.
UCSCiC06E1.4. c. elegans.

Organism-specific databases

CTDi176204.
WormBaseiC06E1.4; CE31407; WBGene00001612; glr-1.

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234372.
InParanoidiP34299.
KOiK05313.
OMAiLINIRSA.
OrthoDBiEOG091G11CB.
PhylomeDBiP34299.

Enzyme and pathway databases

ReactomeiR-CEL-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-CEL-399710. Activation of AMPA receptors.
R-CEL-438066. Unblocking of NMDA receptor, glutamate binding and activation.
R-CEL-5694530. Cargo concentration in the ER.

Miscellaneous databases

PROiP34299.

Gene expression databases

BgeeiWBGene00001612.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. Solute-binding_3/MltF_N.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00062. PBPb. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGLR1_CAEEL
AccessioniPrimary (citable) accession number: P34299
Secondary accession number(s): Q17363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: March 28, 2003
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.