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P34286 (PSB1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-1

EC=3.4.25.1
Alternative name(s):
Proteasome subunit beta 6
Gene names
Name:pbs-6
ORF Names:C02F5.9
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

fbxa-166O172003EBI-313778,EBI-313801
wve-1Q9XVK63EBI-313778,EBI-312105

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Proteasome subunit beta type-1
PRO_0000148035

Sequences

Sequence LengthMass (Da)Tools
P34286 [UniParc].

Last modified July 11, 2002. Version 2.
Checksum: 0ADDB88824AFD87D

FASTA25828,930
        10         20         30         40         50         60 
MTSFTGITAV ANATNEMAMF KQAMKEVAAH PEWMSSRQIE RQRWNPYSME GGSTCAISGE 

        70         80         90        100        110        120 
NFAIVASDTR MTQNDINILT RDAEKIQILN DNIILTTSGF YGDVLQLKKV LQSRLHKYRF 

       130        140        150        160        170        180 
DYRSDMSVDL CAELLSRNLY YRRFFPYYTG AILAGIDEHG KGAVFSYDPI GCIERLGYSA 

       190        200        210        220        230        240 
SGAAEPMIIP FLDCQIGHVT LSEGYERPEL TLDRAISLMK DSFRGAAERE ISTGDKIHLV 

       250 
IAEAGKPVVV KFLPLRED 

« Hide

References

[1]"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. expand/collapse author list , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.
Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"The Caenorhabditis elegans transcriptome project, a complementary view of the genome."
Kohara Y., Shin'i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080288 Genomic DNA. Translation: CCD62635.1.
AF303265 mRNA. Translation: AAG50223.1.
PIRS44611.
RefSeqNP_498806.1. NM_066405.4.
UniGeneCel.23369.

3D structure databases

ProteinModelPortalP34286.
SMRP34286. Positions 43-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid41365. 17 interactions.
DIPDIP-24619N.
IntActP34286. 14 interactions.
MINTMINT-210761.
STRING6239.C02F5.9.1.

Proteomic databases

PaxDbP34286.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC02F5.9; C02F5.9; WBGene00003952.
GeneID176161.
KEGGcel:CELE_C02F5.9.
UCSCC02F5.9.1. c. elegans.

Organism-specific databases

CTD176161.
WormBaseC02F5.9; CE26745; WBGene00003952; pbs-6.

Phylogenomic databases

eggNOGCOG0638.
GeneTreeENSGT00550000075035.
HOGENOMHOG000091081.
InParanoidP34286.
KOK02732.
OMAQCRAGGA.
OrthoDBEOG7WHHBB.
PhylomeDBP34286.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio891386.
PROP34286.

Entry information

Entry namePSB1_CAEEL
AccessionPrimary (citable) accession number: P34286
Secondary accession number(s): Q9BMU3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2002
Last modified: June 11, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase