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P34286

- PSB1_CAEEL

UniProt

P34286 - PSB1_CAEEL

Protein

Proteasome subunit beta type-1

Gene

pbs-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.By similarity

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. threonine-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. proteolysis involved in cellular protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit beta type-1 (EC:3.4.25.1)
    Alternative name(s):
    Proteasome subunit beta 6
    Gene namesi
    Name:pbs-6
    ORF Names:C02F5.9
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC02F5.9; CE26745; WBGene00003952; pbs-6.

    Subcellular locationi

    Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. proteasome core complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Proteasome subunit beta type-1PRO_0000148035Add
    BLAST

    Proteomic databases

    PaxDbiP34286.

    Interactioni

    Subunit structurei

    The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    fbxa-166O172003EBI-313778,EBI-313801
    wve-1Q9XVK63EBI-313778,EBI-312105

    Protein-protein interaction databases

    BioGridi41365. 17 interactions.
    DIPiDIP-24619N.
    IntActiP34286. 14 interactions.
    MINTiMINT-210761.
    STRINGi6239.C02F5.9.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP34286.
    SMRiP34286. Positions 43-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1B family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    GeneTreeiENSGT00550000075035.
    HOGENOMiHOG000091081.
    InParanoidiP34286.
    KOiK02732.
    OMAiQCRAGGA.
    OrthoDBiEOG7WHHBB.
    PhylomeDBiP34286.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34286-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSFTGITAV ANATNEMAMF KQAMKEVAAH PEWMSSRQIE RQRWNPYSME    50
    GGSTCAISGE NFAIVASDTR MTQNDINILT RDAEKIQILN DNIILTTSGF 100
    YGDVLQLKKV LQSRLHKYRF DYRSDMSVDL CAELLSRNLY YRRFFPYYTG 150
    AILAGIDEHG KGAVFSYDPI GCIERLGYSA SGAAEPMIIP FLDCQIGHVT 200
    LSEGYERPEL TLDRAISLMK DSFRGAAERE ISTGDKIHLV IAEAGKPVVV 250
    KFLPLRED 258
    Length:258
    Mass (Da):28,930
    Last modified:July 11, 2002 - v2
    Checksum:i0ADDB88824AFD87D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080288 Genomic DNA. Translation: CCD62635.1.
    AF303265 mRNA. Translation: AAG50223.1.
    PIRiS44611.
    RefSeqiNP_498806.1. NM_066405.4.
    UniGeneiCel.23369.

    Genome annotation databases

    EnsemblMetazoaiC02F5.9; C02F5.9; WBGene00003952.
    GeneIDi176161.
    KEGGicel:CELE_C02F5.9.
    UCSCiC02F5.9.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080288 Genomic DNA. Translation: CCD62635.1 .
    AF303265 mRNA. Translation: AAG50223.1 .
    PIRi S44611.
    RefSeqi NP_498806.1. NM_066405.4.
    UniGenei Cel.23369.

    3D structure databases

    ProteinModelPortali P34286.
    SMRi P34286. Positions 43-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41365. 17 interactions.
    DIPi DIP-24619N.
    IntActi P34286. 14 interactions.
    MINTi MINT-210761.
    STRINGi 6239.C02F5.9.1.

    Proteomic databases

    PaxDbi P34286.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C02F5.9 ; C02F5.9 ; WBGene00003952 .
    GeneIDi 176161.
    KEGGi cel:CELE_C02F5.9.
    UCSCi C02F5.9.1. c. elegans.

    Organism-specific databases

    CTDi 176161.
    WormBasei C02F5.9 ; CE26745 ; WBGene00003952 ; pbs-6.

    Phylogenomic databases

    eggNOGi COG0638.
    GeneTreei ENSGT00550000075035.
    HOGENOMi HOG000091081.
    InParanoidi P34286.
    KOi K02732.
    OMAi QCRAGGA.
    OrthoDBi EOG7WHHBB.
    PhylomeDBi P34286.

    Enzyme and pathway databases

    Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
    REACT_183279. ER-Phagosome pathway.
    REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
    REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
    REACT_184635. Orc1 removal from chromatin.
    REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
    REACT_215136. Asymmetric localization of PCP proteins.

    Miscellaneous databases

    NextBioi 891386.
    PROi P34286.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR016050. Proteasome_bsu_CS.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
    PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    3. "The Caenorhabditis elegans transcriptome project, a complementary view of the genome."
      Kohara Y., Shin'i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPSB1_CAEEL
    AccessioniPrimary (citable) accession number: P34286
    Secondary accession number(s): Q9BMU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3