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P34286

- PSB1_CAEEL

UniProt

P34286 - PSB1_CAEEL

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Protein

Proteasome subunit beta type-1

Gene

pbs-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.
REACT_243979. CDK-mediated phosphorylation and removal of Cdc6.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_255237. degradation of DVL.
REACT_261912. Ubiquitin-dependent degradation of Cyclin D1.
REACT_263250. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-1 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit beta 6
Gene namesi
Name:pbs-6
ORF Names:C02F5.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC02F5.9; CE26745; WBGene00003952; pbs-6.

Subcellular locationi

Cytoplasm PROSITE-ProRule annotation. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Proteasome subunit beta type-1PRO_0000148035Add
BLAST

Proteomic databases

PaxDbiP34286.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
fbxa-166O172003EBI-313778,EBI-313801
wve-1Q9XVK63EBI-313778,EBI-312105

Protein-protein interaction databases

BioGridi41365. 17 interactions.
DIPiDIP-24619N.
IntActiP34286. 14 interactions.
MINTiMINT-210761.
STRINGi6239.C02F5.9.1.

Structurei

3D structure databases

ProteinModelPortaliP34286.
SMRiP34286. Positions 43-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0638.
GeneTreeiENSGT00550000075035.
HOGENOMiHOG000091081.
InParanoidiP34286.
KOiK02732.
OMAiQCRAGGA.
OrthoDBiEOG7WHHBB.
PhylomeDBiP34286.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34286-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSFTGITAV ANATNEMAMF KQAMKEVAAH PEWMSSRQIE RQRWNPYSME
60 70 80 90 100
GGSTCAISGE NFAIVASDTR MTQNDINILT RDAEKIQILN DNIILTTSGF
110 120 130 140 150
YGDVLQLKKV LQSRLHKYRF DYRSDMSVDL CAELLSRNLY YRRFFPYYTG
160 170 180 190 200
AILAGIDEHG KGAVFSYDPI GCIERLGYSA SGAAEPMIIP FLDCQIGHVT
210 220 230 240 250
LSEGYERPEL TLDRAISLMK DSFRGAAERE ISTGDKIHLV IAEAGKPVVV

KFLPLRED
Length:258
Mass (Da):28,930
Last modified:July 11, 2002 - v2
Checksum:i0ADDB88824AFD87D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080288 Genomic DNA. Translation: CCD62635.1.
AF303265 mRNA. Translation: AAG50223.1.
PIRiS44611.
RefSeqiNP_498806.1. NM_066405.4.
UniGeneiCel.23369.

Genome annotation databases

EnsemblMetazoaiC02F5.9; C02F5.9; WBGene00003952.
GeneIDi176161.
KEGGicel:CELE_C02F5.9.
UCSCiC02F5.9.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080288 Genomic DNA. Translation: CCD62635.1 .
AF303265 mRNA. Translation: AAG50223.1 .
PIRi S44611.
RefSeqi NP_498806.1. NM_066405.4.
UniGenei Cel.23369.

3D structure databases

ProteinModelPortali P34286.
SMRi P34286. Positions 43-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41365. 17 interactions.
DIPi DIP-24619N.
IntActi P34286. 14 interactions.
MINTi MINT-210761.
STRINGi 6239.C02F5.9.1.

Proteomic databases

PaxDbi P34286.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C02F5.9 ; C02F5.9 ; WBGene00003952 .
GeneIDi 176161.
KEGGi cel:CELE_C02F5.9.
UCSCi C02F5.9.1. c. elegans.

Organism-specific databases

CTDi 176161.
WormBasei C02F5.9 ; CE26745 ; WBGene00003952 ; pbs-6.

Phylogenomic databases

eggNOGi COG0638.
GeneTreei ENSGT00550000075035.
HOGENOMi HOG000091081.
InParanoidi P34286.
KOi K02732.
OMAi QCRAGGA.
OrthoDBi EOG7WHHBB.
PhylomeDBi P34286.

Enzyme and pathway databases

Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.
REACT_243979. CDK-mediated phosphorylation and removal of Cdc6.
REACT_249811. Degradation of beta-catenin by the destruction complex.
REACT_254516. SCF(Skp2)-mediated degradation of p27/p21.
REACT_255237. degradation of DVL.
REACT_261912. Ubiquitin-dependent degradation of Cyclin D1.
REACT_263250. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_263687. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.

Miscellaneous databases

NextBioi 891386.
PROi P34286.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The Caenorhabditis elegans transcriptome project, a complementary view of the genome."
    Kohara Y., Shin'i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPSB1_CAEEL
AccessioniPrimary (citable) accession number: P34286
Secondary accession number(s): Q9BMU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2002
Last modified: November 26, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3