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P34277

- GSTO2_CAEEL

UniProt

P34277 - GSTO2_CAEEL

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Protein

Probable glutathione transferase omega-2

Gene

gsto-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351NucleophileBy similarity
Binding sitei62 – 621GlutathioneBy similarity
Binding sitei75 – 751Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB-EC
  2. glutathione transferase activity Source: UniProtKB-EC
  3. methylarsonate reductase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione transferase omega-2 (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Gene namesi
Name:gsto-2
ORF Names:C02D5.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiC02D5.3; CE39555; WBGene00015337; gsto-2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Probable glutathione transferase omega-2PRO_0000185890Add
BLAST

Proteomic databases

PaxDbiP34277.
PRIDEiP34277.

Structurei

3D structure databases

ProteinModelPortaliP34277.
SMRiP34277. Positions 6-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10581GST N-terminalAdd
BLAST
Domaini110 – 239130GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 902Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG288793.
GeneTreeiENSGT00390000005479.
InParanoidiP34277.
KOiK00799.
OMAiRIEMALK.
OrthoDBiEOG71CFNG.
PhylomeDBiP34277.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34277 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVLSGLNTK VVKNGDPAPA PPASGTIRIY NMRYCPWAQR ALIFASLKKI
60 70 80 90 100
PTEVINIHLD QKPDWFFTKH YKGQVPALEH DEGKKIVIES AVIPEYLDDI
110 120 130 140 150
YPEPRIIPTD HYEKVQQKLL LDRISGQLSS AFYGVVQAAK ISDLLKEKLV
160 170 180 190 200
ELAKAYDTAE ELLTGDFYSG TSKPGFVDYL IYPNIQRAFW TSHIIKDFPL
210 220 230 240 250
KVESFPGPNY PKLSKWYKRL DSIPEVIATS QPTETAVEFF KSWIIGAPNF

DYGL
Length:254
Mass (Da):28,799
Last modified:February 8, 2011 - v5
Checksum:iC648FE7E6889CCB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080279 Genomic DNA. Translation: CCD62560.1.
PIRiS44745.
RefSeqiNP_871705.3. NM_181976.3.
UniGeneiCel.39460.

Genome annotation databases

EnsemblMetazoaiC02D5.3; C02D5.3; WBGene00015337.
GeneIDi353420.
KEGGicel:CELE_C02D5.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080279 Genomic DNA. Translation: CCD62560.1 .
PIRi S44745.
RefSeqi NP_871705.3. NM_181976.3.
UniGenei Cel.39460.

3D structure databases

ProteinModelPortali P34277.
SMRi P34277. Positions 6-254.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P34277.
PRIDEi P34277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai C02D5.3 ; C02D5.3 ; WBGene00015337 .
GeneIDi 353420.
KEGGi cel:CELE_C02D5.3.

Organism-specific databases

CTDi 353420.
WormBasei C02D5.3 ; CE39555 ; WBGene00015337 ; gsto-2.

Phylogenomic databases

eggNOGi NOG288793.
GeneTreei ENSGT00390000005479.
InParanoidi P34277.
KOi K00799.
OMAi RIEMALK.
OrthoDBi EOG71CFNG.
PhylomeDBi P34277.

Miscellaneous databases

NextBioi 953629.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
PRINTSi PR01625. GSTRNSFRASEO.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGSTO2_CAEEL
AccessioniPrimary (citable) accession number: P34277
Secondary accession number(s): Q2L6Y9
, Q304F1, Q304F2, Q8I7N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 8, 2011
Last modified: October 1, 2014
This is version 104 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3