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P34277 (GSTO2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione transferase omega-2

EC=2.5.1.18
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase
EC=1.8.5.1
Monomethylarsonic acid reductase
Short name=MMA(V) reductase
EC=1.20.4.2
Gene names
Name:gsto-2
ORF Names:C02D5.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.

Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sequence similarities

Belongs to the GST superfamily. Omega family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Probable glutathione transferase omega-2
PRO_0000185890

Regions

Domain25 – 10581GST N-terminal
Domain110 – 239130GST C-terminal
Region89 – 902Glutathione binding By similarity

Sites

Active site351Nucleophile By similarity
Binding site621Glutathione By similarity
Binding site751Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P34277 [UniParc].

Last modified February 8, 2011. Version 5.
Checksum: C648FE7E6889CCB5

FASTA25428,799
        10         20         30         40         50         60 
MSVLSGLNTK VVKNGDPAPA PPASGTIRIY NMRYCPWAQR ALIFASLKKI PTEVINIHLD 

        70         80         90        100        110        120 
QKPDWFFTKH YKGQVPALEH DEGKKIVIES AVIPEYLDDI YPEPRIIPTD HYEKVQQKLL 

       130        140        150        160        170        180 
LDRISGQLSS AFYGVVQAAK ISDLLKEKLV ELAKAYDTAE ELLTGDFYSG TSKPGFVDYL 

       190        200        210        220        230        240 
IYPNIQRAFW TSHIIKDFPL KVESFPGPNY PKLSKWYKRL DSIPEVIATS QPTETAVEFF 

       250 
KSWIIGAPNF DYGL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080279 Genomic DNA. Translation: CCD62560.1.
PIRS44745.
RefSeqNP_871705.3. NM_181976.3.
UniGeneCel.39460.

3D structure databases

ProteinModelPortalP34277.
SMRP34277. Positions 6-254.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP34277.
PRIDEP34277.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaC02D5.3; C02D5.3; C02D5.3.
GeneID353420.
KEGGcel:CELE_C02D5.3.

Organism-specific databases

CTD353420.
WormBaseC02D5.3; CE39555; WBGene00015337; gsto-2.

Phylogenomic databases

eggNOGNOG288793.
InParanoidP34277.
KOK00799.
OMAIPSLKYT.
OrthoDBEOG71CFNG.
PhylomeDBP34277.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSPR01625. GSTRNSFRASEO.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio953629.

Entry information

Entry nameGSTO2_CAEEL
AccessionPrimary (citable) accession number: P34277
Secondary accession number(s): Q2L6Y9 expand/collapse secondary AC list , Q304F1, Q304F2, Q8I7N0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 101 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase