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P34277

- GSTO2_CAEEL

UniProt

P34277 - GSTO2_CAEEL

Protein

Probable glutathione transferase omega-2

Gene

gsto-2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 5 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) By similarity.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.
    2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
    Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei35 – 351NucleophileBy similarity
    Binding sitei62 – 621GlutathioneBy similarity
    Binding sitei75 – 751Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. glutathione dehydrogenase (ascorbate) activity Source: UniProtKB-EC
    2. glutathione transferase activity Source: UniProtKB-EC
    3. methylarsonate reductase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione transferase omega-2 (EC:2.5.1.18)
    Alternative name(s):
    Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
    Monomethylarsonic acid reductase (EC:1.20.4.2)
    Short name:
    MMA(V) reductase
    Gene namesi
    Name:gsto-2
    ORF Names:C02D5.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiC02D5.3; CE39555; WBGene00015337; gsto-2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Probable glutathione transferase omega-2PRO_0000185890Add
    BLAST

    Proteomic databases

    PaxDbiP34277.
    PRIDEiP34277.

    Structurei

    3D structure databases

    ProteinModelPortaliP34277.
    SMRiP34277. Positions 6-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 10581GST N-terminalAdd
    BLAST
    Domaini110 – 239130GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni89 – 902Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Omega family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG288793.
    GeneTreeiENSGT00390000005479.
    InParanoidiP34277.
    KOiK00799.
    OMAiRIEMALK.
    OrthoDBiEOG71CFNG.
    PhylomeDBiP34277.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005442. GST_omega.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    PRINTSiPR01625. GSTRNSFRASEO.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34277-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVLSGLNTK VVKNGDPAPA PPASGTIRIY NMRYCPWAQR ALIFASLKKI    50
    PTEVINIHLD QKPDWFFTKH YKGQVPALEH DEGKKIVIES AVIPEYLDDI 100
    YPEPRIIPTD HYEKVQQKLL LDRISGQLSS AFYGVVQAAK ISDLLKEKLV 150
    ELAKAYDTAE ELLTGDFYSG TSKPGFVDYL IYPNIQRAFW TSHIIKDFPL 200
    KVESFPGPNY PKLSKWYKRL DSIPEVIATS QPTETAVEFF KSWIIGAPNF 250
    DYGL 254
    Length:254
    Mass (Da):28,799
    Last modified:February 8, 2011 - v5
    Checksum:iC648FE7E6889CCB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080279 Genomic DNA. Translation: CCD62560.1.
    PIRiS44745.
    RefSeqiNP_871705.3. NM_181976.3.
    UniGeneiCel.39460.

    Genome annotation databases

    EnsemblMetazoaiC02D5.3; C02D5.3; WBGene00015337.
    GeneIDi353420.
    KEGGicel:CELE_C02D5.3.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080279 Genomic DNA. Translation: CCD62560.1 .
    PIRi S44745.
    RefSeqi NP_871705.3. NM_181976.3.
    UniGenei Cel.39460.

    3D structure databases

    ProteinModelPortali P34277.
    SMRi P34277. Positions 6-254.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P34277.
    PRIDEi P34277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai C02D5.3 ; C02D5.3 ; WBGene00015337 .
    GeneIDi 353420.
    KEGGi cel:CELE_C02D5.3.

    Organism-specific databases

    CTDi 353420.
    WormBasei C02D5.3 ; CE39555 ; WBGene00015337 ; gsto-2.

    Phylogenomic databases

    eggNOGi NOG288793.
    GeneTreei ENSGT00390000005479.
    InParanoidi P34277.
    KOi K00799.
    OMAi RIEMALK.
    OrthoDBi EOG71CFNG.
    PhylomeDBi P34277.

    Miscellaneous databases

    NextBioi 953629.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR005442. GST_omega.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    PRINTSi PR01625. GSTRNSFRASEO.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGSTO2_CAEEL
    AccessioniPrimary (citable) accession number: P34277
    Secondary accession number(s): Q2L6Y9
    , Q304F1, Q304F2, Q8I7N0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 104 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3