Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glutathione transferase omega-2

Gene

gsto-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351NucleophileBy similarity
Binding sitei62 – 621GlutathioneBy similarity
Binding sitei75 – 751Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiREACT_271650. Vitamin C (ascorbate) metabolism.
REACT_326456. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione transferase omega-2 (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Gene namesi
Name:gsto-2
ORF Names:C02D5.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC02D5.3; CE39555; WBGene00015337; gsto-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Probable glutathione transferase omega-2PRO_0000185890Add
BLAST

Proteomic databases

PaxDbiP34277.
PRIDEiP34277.

Interactioni

Protein-protein interaction databases

STRINGi6239.C02D5.3.

Structurei

3D structure databases

ProteinModelPortaliP34277.
SMRiP34277. Positions 6-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10581GST N-terminalAdd
BLAST
Domaini110 – 239130GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 902Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG288793.
GeneTreeiENSGT00390000005479.
InParanoidiP34277.
KOiK00799.
OMAiADYNMLY.
OrthoDBiEOG71CFNG.
PhylomeDBiP34277.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLSGLNTK VVKNGDPAPA PPASGTIRIY NMRYCPWAQR ALIFASLKKI
60 70 80 90 100
PTEVINIHLD QKPDWFFTKH YKGQVPALEH DEGKKIVIES AVIPEYLDDI
110 120 130 140 150
YPEPRIIPTD HYEKVQQKLL LDRISGQLSS AFYGVVQAAK ISDLLKEKLV
160 170 180 190 200
ELAKAYDTAE ELLTGDFYSG TSKPGFVDYL IYPNIQRAFW TSHIIKDFPL
210 220 230 240 250
KVESFPGPNY PKLSKWYKRL DSIPEVIATS QPTETAVEFF KSWIIGAPNF

DYGL
Length:254
Mass (Da):28,799
Last modified:February 8, 2011 - v5
Checksum:iC648FE7E6889CCB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080279 Genomic DNA. Translation: CCD62560.1.
PIRiS44745.
RefSeqiNP_871705.3. NM_181976.3.
UniGeneiCel.39460.

Genome annotation databases

EnsemblMetazoaiC02D5.3; C02D5.3; WBGene00015337.
GeneIDi353420.
KEGGicel:CELE_C02D5.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080279 Genomic DNA. Translation: CCD62560.1.
PIRiS44745.
RefSeqiNP_871705.3. NM_181976.3.
UniGeneiCel.39460.

3D structure databases

ProteinModelPortaliP34277.
SMRiP34277. Positions 6-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C02D5.3.

Proteomic databases

PaxDbiP34277.
PRIDEiP34277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC02D5.3; C02D5.3; WBGene00015337.
GeneIDi353420.
KEGGicel:CELE_C02D5.3.

Organism-specific databases

CTDi353420.
WormBaseiC02D5.3; CE39555; WBGene00015337; gsto-2.

Phylogenomic databases

eggNOGiNOG288793.
GeneTreeiENSGT00390000005479.
InParanoidiP34277.
KOiK00799.
OMAiADYNMLY.
OrthoDBiEOG71CFNG.
PhylomeDBiP34277.

Enzyme and pathway databases

ReactomeiREACT_271650. Vitamin C (ascorbate) metabolism.
REACT_326456. Glutathione conjugation.

Miscellaneous databases

NextBioi953629.
PROiP34277.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGSTO2_CAEEL
AccessioniPrimary (citable) accession number: P34277
Secondary accession number(s): Q2L6Y9
, Q304F1, Q304F2, Q8I7N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 8, 2011
Last modified: June 24, 2015
This is version 109 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.