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Protein

Probable glutathione transferase omega-2

Gene

gsto-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35NucleophileBy similarity1
Binding sitei62GlutathioneBy similarity1
Binding sitei75Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-156590. Glutathione conjugation.
R-CEL-196836. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione transferase omega-2 (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Gene namesi
Name:gsto-2
ORF Names:C02D5.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC02D5.3; CE39555; WBGene00015337; gsto-2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858901 – 254Probable glutathione transferase omega-2Add BLAST254

Proteomic databases

PaxDbiP34277.
PeptideAtlasiP34277.

Expressioni

Gene expression databases

BgeeiWBGene00015337.

Interactioni

Protein-protein interaction databases

STRINGi6239.C02D5.3.

Structurei

3D structure databases

ProteinModelPortaliP34277.
SMRiP34277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 105GST N-terminalAdd BLAST81
Domaini110 – 239GST C-terminalAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 90Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
GeneTreeiENSGT00390000005479.
InParanoidiP34277.
KOiK00799.
OMAiTEVINIH.
OrthoDBiEOG091G0IEA.
PhylomeDBiP34277.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLSGLNTK VVKNGDPAPA PPASGTIRIY NMRYCPWAQR ALIFASLKKI
60 70 80 90 100
PTEVINIHLD QKPDWFFTKH YKGQVPALEH DEGKKIVIES AVIPEYLDDI
110 120 130 140 150
YPEPRIIPTD HYEKVQQKLL LDRISGQLSS AFYGVVQAAK ISDLLKEKLV
160 170 180 190 200
ELAKAYDTAE ELLTGDFYSG TSKPGFVDYL IYPNIQRAFW TSHIIKDFPL
210 220 230 240 250
KVESFPGPNY PKLSKWYKRL DSIPEVIATS QPTETAVEFF KSWIIGAPNF

DYGL
Length:254
Mass (Da):28,799
Last modified:February 8, 2011 - v5
Checksum:iC648FE7E6889CCB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080279 Genomic DNA. Translation: CCD62560.1.
PIRiS44745.
RefSeqiNP_871705.3. NM_181976.3.
UniGeneiCel.39460.

Genome annotation databases

EnsemblMetazoaiC02D5.3; C02D5.3; WBGene00015337.
GeneIDi353420.
KEGGicel:CELE_C02D5.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080279 Genomic DNA. Translation: CCD62560.1.
PIRiS44745.
RefSeqiNP_871705.3. NM_181976.3.
UniGeneiCel.39460.

3D structure databases

ProteinModelPortaliP34277.
SMRiP34277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C02D5.3.

Proteomic databases

PaxDbiP34277.
PeptideAtlasiP34277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC02D5.3; C02D5.3; WBGene00015337.
GeneIDi353420.
KEGGicel:CELE_C02D5.3.

Organism-specific databases

CTDi353420.
WormBaseiC02D5.3; CE39555; WBGene00015337; gsto-2.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
GeneTreeiENSGT00390000005479.
InParanoidiP34277.
KOiK00799.
OMAiTEVINIH.
OrthoDBiEOG091G0IEA.
PhylomeDBiP34277.

Enzyme and pathway databases

ReactomeiR-CEL-156581. Methylation.
R-CEL-156590. Glutathione conjugation.
R-CEL-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

PROiP34277.

Gene expression databases

BgeeiWBGene00015337.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR005442. GST_omega.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01625. GSTRNSFRASEO.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTO2_CAEEL
AccessioniPrimary (citable) accession number: P34277
Secondary accession number(s): Q2L6Y9
, Q304F1, Q304F2, Q8I7N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 8, 2011
Last modified: November 2, 2016
This is version 122 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.