Reviewed, UniProtKB/Swiss-Prot P34275 (IVD_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable isovaleryl-CoA dehydrogenase
      Short name=IVD
    EC=1.3.99.10

Gene names

ORF Names:

C02D5.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor.
Cofactor	FAD.
Pathway	Amino-acid degradation; L-leucine degradation; HMG-CoA from 3-isovaleryl-CoA: step 1/3.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro isovaleryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Probable isovaleryl-CoA dehydrogenase		PRO_0000201191
Sites
	Active site	265	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P34275-1 [UniParc]. Last modified December 19, 2001. Version 2. Checksum: A6351C6DCDCA962D	FASTA	408	45,326
	10 20 30 40 50 60 MAFLARKTSS LLPATTSSTV KHMIYDEPHF AMQNSLAKLI KEKINPNVAQ WEKSGRYPAH 70 80 90 100 110 120 FVFKMLGQLG VFAVNKPVDY GGTGRDFAMS IAIAEQIGAV DCGSIPMSVM VQSDMSTPAL 130 140 150 160 170 180 AQFGSDSLRN RFLRPSINGD LVSSIAVSEP HAGSDVSAIR THARRYGSDL IINGSKMWIT 190 200 210 220 230 240 NGDQADWACV LVNTSNAKNL HKNKSLVCIP LDSIGVHRST PLDKLGMRSS DTVQLFFEDV 250 260 270 280 290 300 RVPSSYIIGE EGRGFAYQMN QFNDERLVTV AVGLLPLQKC INETIEYARE RLIFGKTLLD 310 320 330 340 350 360 QQYVQFRLAE LEAELEATRS LLYRTVLARC QGEDVSMLTA MAKLKIGRLA RKVTDQCLQI 370 380 390 400 WGGAGYLNDN GISRAFRDFR IFSIGAGCDE VMMQIIHKTQ SKRQQKRI

References

[1]

"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

[2]

"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L16622 Genomic DNA. Translation: AAA27913.2.
PIR	S44743.
RefSeq	NP_498885.1.
UniGene	Cel.10914
3D structure databases
HSSP	HSSP built from PDB template 1JQI based on UniProtKB P15651.
ModBase	Search...
Genome annotation databases
Ensembl	C02D5.1. Caenorhabditis elegans. [Contig view]
GeneID	182112.
KEGG	cel:C02D5.1.
NMPDR	fig|6239.3.peg.10888.
Organism-specific databases
WormBase	WBGene00015335. C02D5.1.
WormPep	C02D5.1. CE24778. [WorfDB]
Phylogenomic databases
OMA	P34275. LLCNTSD.
Enzyme and pathway databases
BRENDA	1.3.99.10. 672.
Gene expression databases
ArrayExpress	P34275.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	916428.

Entry information

Entry name

IVD_CAEEL

Accession

Primary (citable) accession number: P34275

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	December 19, 2001
Last modified:	June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project