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Protein

Iodotyrosine dehalogenase 1 homolog

Gene

sup-18

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to coordination of muscle contraction as regulatory subunit of the nonessential sup-9 potassium channel complex. May act downstream of sup-10.1 Publication

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei315 – 3151FMNBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi135 – 1395FMNBy similarity
Nucleotide bindingi162 – 1643FMNBy similarity
Nucleotide bindingi272 – 2754FMNBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Flavoprotein, FMN, Potassium

Enzyme and pathway databases

ReactomeiREACT_279327. Thyroxine biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Iodotyrosine dehalogenase 1 homolog1 Publication (EC:1.22.-.-1 Publication)
Short name:
IYD-11 Publication
Gene namesi
Name:sup-18Imported
ORF Names:C02C2.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC02C2.5; CE34519; WBGene00015334; sup-18.

Subcellular locationi

  • Membrane 1 Publication; Single-pass membrane protein 1 Publication

  • Note: In body-wall muscle cells, localizes to dense body-like structures which connect the myofibril lattice to the cell membrane. Colocalizes with sup-10. Membrane localization is not essential for its activity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Topological domaini63 – 325263Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Fully suppresses the rubber band uncoordinated phenotype in gain of function (gf) mutants of sup-10 but only slightly in gf mutants of sup-9 and unc-93.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi137 – 1371S → N in n1010; loss of function. 1 Publication
Mutagenesisi258 – 2581G → D in n1554; loss of function. 1 Publication
Mutagenesisi258 – 2581G → S in n1471; loss of function. 1 Publication
Mutagenesisi271 – 2711T → I in n1556; loss of function. 1 Publication
Mutagenesisi280 – 2801G → R in n1014; loss of function. 1 Publication
Mutagenesisi288 – 2881R → K in n1022; loss of function. 1 Publication
Mutagenesisi322 – 3221T → P in n528; loss of function. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Iodotyrosine dehalogenase 1 homologPRO_0000065104Add
BLAST

Expressioni

Tissue specificityi

Expressed in body-wall, anal depressor and vulval muscles.1 Publication

Gene expression databases

ExpressionAtlasiP34273. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliP34273.
SMRiP34273. Positions 125-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nitroreductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0778.
GeneTreeiENSGT00390000004348.
HOGENOMiHOG000146731.
InParanoidiP34273.
OrthoDBiEOG7HMS24.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.

Sequencei

Sequence statusi: Complete.

P34273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKHTHHKAY GDSTGKEPLI DLQSIKLWLN SFGNQGHSSE AVLNVLFTLG
60 70 80 90 100
VILFVIYQVA SLLHRMNKRV EKQLESRTKQ RKVEVADKHV GDEMVFTDLH
110 120 130 140 150
ENVIRERMIP YRMPVINDDI TLRNSQIFYE EMKMRRSCRQ FSSRDVPLKV
160 170 180 190 200
IQNLLKTAGT SPSVGNLQPW TFCVVSSDSI KTMIRKILEA DERDNYVSRK
210 220 230 240 250
KGASWVVDVS QLQDTWRRPY ITDAPYLLIV CHEIFRDVHS KTERVFHYNQ
260 270 280 290 300
ISTSIAVGIL LAAIQNVGLS TVVTSPLNAG PDISRILRRP ENESILLLLP
310 320
LGYASEDVLV PDLKRKPVEH ITKLY
Length:325
Mass (Da):37,261
Last modified:February 4, 2015 - v3
Checksum:i973CECAAE4A3BA58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX978835 mRNA. Translation: AGC39147.1.
FO080276 Genomic DNA. Translation: CCD62530.2.
PIRiS44738.
RefSeqiNP_498712.3. NM_066311.4.
UniGeneiCel.10915.

Genome annotation databases

EnsemblMetazoaiC02C2.5; C02C2.5; WBGene00015334.
GeneIDi182108.
UCSCiC02C2.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX978835 mRNA. Translation: AGC39147.1.
FO080276 Genomic DNA. Translation: CCD62530.2.
PIRiS44738.
RefSeqiNP_498712.3. NM_066311.4.
UniGeneiCel.10915.

3D structure databases

ProteinModelPortaliP34273.
SMRiP34273. Positions 125-321.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC02C2.5; C02C2.5; WBGene00015334.
GeneIDi182108.
UCSCiC02C2.5. c. elegans.

Organism-specific databases

WormBaseiC02C2.5; CE34519; WBGene00015334; sup-18.

Phylogenomic databases

eggNOGiCOG0778.
GeneTreeiENSGT00390000004348.
HOGENOMiHOG000146731.
InParanoidiP34273.
OrthoDBiEOG7HMS24.

Enzyme and pathway databases

ReactomeiREACT_279327. Thyroxine biosynthesis.

Miscellaneous databases

NextBioi916404.
PROiP34273.

Gene expression databases

ExpressionAtlasiP34273. baseline and differential.

Family and domain databases

Gene3Di3.40.109.10. 1 hit.
InterProiIPR029479. Nitroreductase.
IPR000415. Nitroreductase-like.
[Graphical view]
PfamiPF00881. Nitroreductase. 1 hit.
[Graphical view]
SUPFAMiSSF55469. SSF55469. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9."
    de la Cruz I.P., Ma L., Horvitz H.R.
    PLoS Genet. 10:E1004175-E1004175(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, TOPOLOGY, DISRUPTION PHENOTYPE, MUTAGENESIS OF SER-137; GLY-258; THR-271; GLY-280; ARG-288 AND THR-322.
    Strain: Bristol N2Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiIYD1H_CAEEL
AccessioniPrimary (citable) accession number: P34273
Secondary accession number(s): L7TUZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 4, 2015
Last modified: July 22, 2015
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.