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P34268 (FLII_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein flightless-1 homolog
Gene names
Name:fli-1
ORF Names:B0523.5
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length1257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components By similarity.

Sequence similarities

Belongs to the villin/gelsolin family.

Contains 4 gelsolin-like repeats.

Contains 16 LRR (leucine-rich) repeats.

Ontologies

Keywords
   DomainLeucine-rich repeat
Repeat
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 18485202. Source: WormBase

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12571257Protein flightless-1 homolog
PRO_0000218752

Regions

Repeat6 – 3126LRR 1
Repeat32 – 5423LRR 2
Repeat56 – 7722LRR 3
Repeat78 – 10225LRR 4
Repeat103 – 12624LRR 5
Repeat128 – 14821LRR 6
Repeat149 – 17224LRR 7
Repeat174 – 19522LRR 8
Repeat197 – 22125LRR 9
Repeat222 – 24423LRR 10
Repeat246 – 26722LRR 11
Repeat268 – 29023LRR 12
Repeat292 – 31524LRR 13
Repeat316 – 33823LRR 14
Repeat339 – 36123LRR 15
Repeat363 – 38422LRR 16
Repeat510 – 56859Gelsolin-like 1
Repeat641 – 68141Gelsolin-like 2
Repeat755 – 79844Gelsolin-like 3
Repeat1166 – 120641Gelsolin-like 4

Sequences

Sequence LengthMass (Da)Tools
P34268 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: F3EFD79FACB07493

FASTA1,257144,815
        10         20         30         40         50         60 
MSTGVLQFVK GIDFSGNDFS GDRFPHDVEQ MTQMTWLKLN DSKLEQVPDE LSRCANLEHL 

        70         80         90        100        110        120 
QMAHNQLISV HGELSDLPRL RSVIVRDNNL KTAGIPTDIF RMKDLTIIDL SRNQLREVPT 

       130        140        150        160        170        180 
NLEYAKGSIV LNLSYNNIET IPNSVCANLI DLLFLDLSNN KLDMLPPQIR RLSMLQSLKL 

       190        200        210        220        230        240 
SNNPLNHFQL KQLPSMTSLS VLHMSNTNRT LDNIPPTLDD MHNLRDVDFS ENNLPIVPEA 

       250        260        270        280        290        300 
LFKLRNLRKL NLSGNKIEKL NMTEGEWENL ETLNMSHNQL TVLPDCVVKL TRLTKLYAAN 

       310        320        330        340        350        360 
NQLTFEGIPS GIGKLIQLTV LHLSYNKLEL VPEGISRCVK LQKLKLDHNR LITLPEGIHL 

       370        380        390        400        410        420 
LPDLKVLDLH ENENLVMPPK PNDARKKLAF YNIDFSLEHQ RKIAGQMTSP SSSISSVHSG 

       430        440        450        460        470        480 
GARQDALARR KEFIRRRKQQ ADQQSADKVI QGMSKIAGVG AALTEKQQEE EERQLEAKSA 

       490        500        510        520        530        540 
VNWKKNIEKN RRHIDYSDIF DEDVGSDEGM WVWEIENFYP SIMDEAFHGQ FYDADAYLVL 

       550        560        570        580        590        600 
KTTREASGQL RHAIFYWLGE HASLDKGMCS AVHAVGLRNH LNATCRTQRE EMNDETEEFL 

       610        620        630        640        650        660 
TLFGEEIVYI EGGRTISGFY TTEKPAHLTR LYRAGVNGTA VEMEPVPLSV ESLDPRFCFL 

       670        680        690        700        710        720 
LDAGETIWIW SGYKSRITVS NKARLFAERL NKRDRKGKSE IETCRQARCP PEFWQALTGN 

       730        740        750        760        770        780 
PDKPQGAIVE HVPEGFVAER KKLYKVNIGM GFLELPQVEL PKGIAKQDML GSKGVFVLDS 

       790        800        810        820        830        840 
NSDIFLWIGK KANRLLKMAG QKLVVELHQM IDRPDYAQVY RETEGEESMM FRSKFAGWDE 

       850        860        870        880        890        900 
IVPVDYTRTS DSVQRVPDLK VIVKKDNMMR ADLAALFLER QPSMSYEESE ELMEDCNYDL 

       910        920        930        940        950        960 
ELMESFVLEG KKFVKLPQKE FGIFYTMDCY VFLCRYAVMP EEDEEGEDEH DEDDKPEMDF 

       970        980        990       1000       1010       1020 
KCVVYFWQGR DASNMGWLNF TFQLQPNFEE IFKDKLEVVR MYQQQENHKF LSHFKRKFLI 

      1030       1040       1050       1060       1070       1080 
KRGRRGLTKN LGGKWPELFQ MRANGSSVCN RTIQVDCQAN QLCSAFCHML RIPFKEIEED 

      1090       1100       1110       1120       1130       1140 
GHRGVVYVWM GKDSDPREHE FARQVASDLV VRDDDNDFRI VEVQEGEENE EFWKVLGGKK 

      1150       1160       1170       1180       1190       1200 
KYETDSSFVK HTRLFRCTNE KGYFAISEKT VDFCQDDLDD DDIMILDNGD AVFLWIGARS 

      1210       1220       1230       1240       1250 
SDIEAKLSYQ AAQVYHASMR MKANEKPRKF MLAVRGRESC RFRKCFHAWS KMKEPMG

« Hide

References

« Hide 'large scale' references
[1]"The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans."
Campbell H.D., Schimansky T., Claudianos C., Ozsarac N., Kasprzak A.B., Cotsell J.N., Young I.G., de Couet H.G., Miklos G.L.G.
Proc. Natl. Acad. Sci. U.S.A. 90:11386-11390(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans."
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. expand/collapse author list , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P.
Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[3]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U01183 mRNA. Translation: AAC03567.1.
FO080165 Genomic DNA. Translation: CCD61730.1.
PIRA88536.
S27783.
RefSeqNP_498913.2. NM_066512.5.
UniGeneCel.5659.

3D structure databases

ProteinModelPortalP34268.
SMRP34268. Positions 9-399, 505-838, 903-1253.
ModBaseSearch...

Proteomic databases

PaxDbP34268.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaB0523.5; B0523.5; B0523.5.
GeneID176215.
KEGGcel:CELE_B0523.5.
UCSCB0523.5. c. elegans.

Organism-specific databases

CTD176215.
WormBaseB0523.5; CE36522; WBGene00001443; fli-1.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00660000095502.
HOGENOMHOG000016110.
InParanoidP34268.
OMAMEEWNED.

Family and domain databases

InterProIPR007123. Gelsolin_dom.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERPTHR11977. PTHR11977. 1 hit.
PfamPF00626. Gelsolin. 4 hits.
PF00560. LRR_1. 1 hit.
[Graphical view]
PRINTSPR00597. GELSOLIN.
SMARTSM00262. GEL. 6 hits.
SM00369. LRR_TYP. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio891612.

Entry information

Entry nameFLII_CAEEL
AccessionPrimary (citable) accession number: P34268
Secondary accession number(s): P90739, Q17331
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 15, 1998
Last modified: May 1, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents