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Protein

Probable tyrosine-protein kinase kin-31

Gene

kin-31

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591ATPPROSITE-ProRule annotation
Active sitei256 – 2561Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi136 – 1449ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  3. receptor binding Source: GO_Central

GO - Biological processi

  1. cell differentiation Source: GO_Central
  2. cell migration Source: GO_Central
  3. innate immune response Source: GO_Central
  4. peptidyl-tyrosine autophosphorylation Source: GO_Central
  5. regulation of apoptotic process Source: GO_Central
  6. regulation of cell proliferation Source: GO_Central
  7. transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_309370. Sema3A PAK dependent Axon repulsion.
REACT_337268. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_351918. CRMPs in Sema3A signaling.
SignaLinkiP34265.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein kinase kin-31 (EC:2.7.10.2)
Gene namesi
Name:kin-31
ORF Names:B0523.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiB0523.1; CE33023; WBGene00002212; kin-31.

Subcellular locationi

GO - Cellular componenti

  1. extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Probable tyrosine-protein kinase kin-31PRO_0000088120Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.B0523.1.

Structurei

3D structure databases

ProteinModelPortaliP34265.
SMRiP34265. Positions 15-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11899SH2PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 387258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiP34265.
KOiK08253.
OMAiRCCAENP.
OrthoDBiEOG708VXW.
PhylomeDBiP34265.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34265-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSINSLSNET PTPTIEKEAY FHGLIQREDV FQLLDNNGDY VVRLSDPKPG
60 70 80 90 100
EPRSYILSVM FNNKLDENSS VKHFVINSVE NKYFVNNNMS FNTIQQMLSH
110 120 130 140 150
YQKSRTEILE ACKILHPVRR QFWELDHGNI VIEKKLGEGA FGEVSSGVMK
160 170 180 190 200
FKRGGRLVKV AVKQVKTDGI GKDQIKDFLM EARTMRNLGH PNIVRFLGIA
210 220 230 240 250
VLQEPLFLVM ELATGGALDS YLKHNELLPI DKRHEMLLQA AWGLEYIHGK
260 270 280 290 300
PMLHRDIAAR NCLYGDGKVK ISDFGLTRRG TIYQLHPETK SPIRWLAVCS
310 320 330 340 350
QKTDVWAYGI LCWEIFNNGA EPYPGLTANE VAKQVTDGYR MPPHQLAAPE
360 370 380 390 400
VQALMTRCCA ENPNDRPTMS DVAQILQRVT GQGRPNFAAI AKKEAEELLI
410 420 430
MNSRSARRTS RRKGSNKKSA IPNGVLTPVN RAQEIKH
Length:437
Mass (Da):49,394
Last modified:October 24, 2003 - v4
Checksum:i603C1CBDBC1FAEC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080165 Genomic DNA. Translation: CCD61728.1.
PIRiG88535.
RefSeqiNP_498912.3. NM_066511.5.
UniGeneiCel.24327.

Genome annotation databases

EnsemblMetazoaiB0523.1; B0523.1; WBGene00002212.
GeneIDi176214.
KEGGicel:CELE_B0523.1.
UCSCiB0523.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080165 Genomic DNA. Translation: CCD61728.1.
PIRiG88535.
RefSeqiNP_498912.3. NM_066511.5.
UniGeneiCel.24327.

3D structure databases

ProteinModelPortaliP34265.
SMRiP34265. Positions 15-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0523.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0523.1; B0523.1; WBGene00002212.
GeneIDi176214.
KEGGicel:CELE_B0523.1.
UCSCiB0523.1. c. elegans.

Organism-specific databases

CTDi176214.
WormBaseiB0523.1; CE33023; WBGene00002212; kin-31.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiP34265.
KOiK08253.
OMAiRCCAENP.
OrthoDBiEOG708VXW.
PhylomeDBiP34265.

Enzyme and pathway databases

ReactomeiREACT_309370. Sema3A PAK dependent Axon repulsion.
REACT_337268. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_351918. CRMPs in Sema3A signaling.
SignaLinkiP34265.

Miscellaneous databases

NextBioi891608.
PROiP34265.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiKIN31_CAEEL
AccessioniPrimary (citable) accession number: P34265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 24, 2003
Last modified: April 29, 2015
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.