Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P34265

- KIN31_CAEEL

UniProt

P34265 - KIN31_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable tyrosine-protein kinase kin-31

Gene

kin-31

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591ATPPROSITE-ProRule annotation
Active sitei256 – 2561Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi136 – 1449ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP34265.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tyrosine-protein kinase kin-31 (EC:2.7.10.2)
Gene namesi
Name:kin-31
ORF Names:B0523.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiB0523.1; CE33023; WBGene00002212; kin-31.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Probable tyrosine-protein kinase kin-31PRO_0000088120Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6239.B0523.1.

Structurei

3D structure databases

ProteinModelPortaliP34265.
SMRiP34265. Positions 15-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11899SH2PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 387258Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
HOGENOMiHOG000233858.
InParanoidiP34265.
KOiK08253.
OMAiRCCAENP.
OrthoDBiEOG708VXW.
PhylomeDBiP34265.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34265-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSINSLSNET PTPTIEKEAY FHGLIQREDV FQLLDNNGDY VVRLSDPKPG
60 70 80 90 100
EPRSYILSVM FNNKLDENSS VKHFVINSVE NKYFVNNNMS FNTIQQMLSH
110 120 130 140 150
YQKSRTEILE ACKILHPVRR QFWELDHGNI VIEKKLGEGA FGEVSSGVMK
160 170 180 190 200
FKRGGRLVKV AVKQVKTDGI GKDQIKDFLM EARTMRNLGH PNIVRFLGIA
210 220 230 240 250
VLQEPLFLVM ELATGGALDS YLKHNELLPI DKRHEMLLQA AWGLEYIHGK
260 270 280 290 300
PMLHRDIAAR NCLYGDGKVK ISDFGLTRRG TIYQLHPETK SPIRWLAVCS
310 320 330 340 350
QKTDVWAYGI LCWEIFNNGA EPYPGLTANE VAKQVTDGYR MPPHQLAAPE
360 370 380 390 400
VQALMTRCCA ENPNDRPTMS DVAQILQRVT GQGRPNFAAI AKKEAEELLI
410 420 430
MNSRSARRTS RRKGSNKKSA IPNGVLTPVN RAQEIKH
Length:437
Mass (Da):49,394
Last modified:October 24, 2003 - v4
Checksum:i603C1CBDBC1FAEC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080165 Genomic DNA. Translation: CCD61728.1.
PIRiG88535.
RefSeqiNP_498912.3. NM_066511.5.
UniGeneiCel.24327.

Genome annotation databases

EnsemblMetazoaiB0523.1; B0523.1; WBGene00002212.
GeneIDi176214.
KEGGicel:CELE_B0523.1.
UCSCiB0523.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080165 Genomic DNA. Translation: CCD61728.1 .
PIRi G88535.
RefSeqi NP_498912.3. NM_066511.5.
UniGenei Cel.24327.

3D structure databases

ProteinModelPortali P34265.
SMRi P34265. Positions 15-400.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.B0523.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai B0523.1 ; B0523.1 ; WBGene00002212 .
GeneIDi 176214.
KEGGi cel:CELE_B0523.1.
UCSCi B0523.1. c. elegans.

Organism-specific databases

CTDi 176214.
WormBasei B0523.1 ; CE33023 ; WBGene00002212 ; kin-31.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119011.
HOGENOMi HOG000233858.
InParanoidi P34265.
KOi K08253.
OMAi RCCAENP.
OrthoDBi EOG708VXW.
PhylomeDBi P34265.

Enzyme and pathway databases

SignaLinki P34265.

Miscellaneous databases

NextBioi 891608.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiKIN31_CAEEL
AccessioniPrimary (citable) accession number: P34265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 24, 2003
Last modified: October 29, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3