P34265 (KIN31_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tyrosine-protein kinase kin-31
EC=2.7.10.2

Gene names

Name:	kin-31
ORF Names:	B0523.1

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain. Contains 1 SH2 domain.

Ontologies

Keywords
Domain	SH2 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Probable tyrosine-protein kinase kin-31		PRO_0000088120
Regions
	Domain	20 – 118	99	SH2
	Domain	130 – 387	258	Protein kinase
	Nucleotide binding	136 – 144	9	ATP By similarity
Sites
	Active site	256	1	Proton acceptor By similarity
	Binding site	159	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P34265 [UniParc]. Last modified October 24, 2003. Version 4. Checksum: 603C1CBDBC1FAEC6	FASTA	437	49,394
	10 20 30 40 50 60 MSINSLSNET PTPTIEKEAY FHGLIQREDV FQLLDNNGDY VVRLSDPKPG EPRSYILSVM 70 80 90 100 110 120 FNNKLDENSS VKHFVINSVE NKYFVNNNMS FNTIQQMLSH YQKSRTEILE ACKILHPVRR 130 140 150 160 170 180 QFWELDHGNI VIEKKLGEGA FGEVSSGVMK FKRGGRLVKV AVKQVKTDGI GKDQIKDFLM 190 200 210 220 230 240 EARTMRNLGH PNIVRFLGIA VLQEPLFLVM ELATGGALDS YLKHNELLPI DKRHEMLLQA 250 260 270 280 290 300 AWGLEYIHGK PMLHRDIAAR NCLYGDGKVK ISDFGLTRRG TIYQLHPETK SPIRWLAVCS 310 320 330 340 350 360 QKTDVWAYGI LCWEIFNNGA EPYPGLTANE VAKQVTDGYR MPPHQLAAPE VQALMTRCCA 370 380 390 400 410 420 ENPNDRPTMS DVAQILQRVT GQGRPNFAAI AKKEAEELLI MNSRSARRTS RRKGSNKKSA 430 IPNGVLTPVN RAQEIKH

References

[1]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. , Gardner A., Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J., Wohldman P. Nature 368:32-38(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080165 Genomic DNA. Translation: CCD61728.1.
PIR	G88535.
RefSeq	NP_498912.3. NM_066511.5.
3D structure databases
ProteinModelPortal	P34265.
SMR	P34265. Positions 15-379.
ModBase	Search...
Protein-protein interaction databases
STRING	6239.B0523.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	B0523.1; B0523.1; B0523.1.
GeneID	176214.
KEGG	cel:CELE_B0523.1.
UCSC	B0523.1. c. elegans.
Organism-specific databases
CTD	176214.
WormBase	B0523.1; CE33023; WBGene00002212; kin-31.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00600000084126.
HOGENOM	HOG000233858.
InParanoid	P34265.
KO	K08253.
OMA	RCCAENP.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	891608.

Entry information

Entry name

KIN31_CAEEL

Accession

Primary (citable) accession number: P34265

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	October 24, 2003
Last modified:	May 1, 2013
This is version 109 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project