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P34265

- KIN31_CAEEL

UniProt

P34265 - KIN31_CAEEL

Protein

Probable tyrosine-protein kinase kin-31

Gene

kin-31

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 4 (24 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei159 – 1591ATPPROSITE-ProRule annotation
    Active sitei256 – 2561Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi136 – 1449ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiP34265.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable tyrosine-protein kinase kin-31 (EC:2.7.10.2)
    Gene namesi
    Name:kin-31
    ORF Names:B0523.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiB0523.1; CE33023; WBGene00002212; kin-31.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Probable tyrosine-protein kinase kin-31PRO_0000088120Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.B0523.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP34265.
    SMRiP34265. Positions 15-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 11899SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 387258Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117264.
    HOGENOMiHOG000233858.
    InParanoidiP34265.
    KOiK08253.
    OMAiRCCAENP.
    OrthoDBiEOG708VXW.
    PhylomeDBiP34265.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34265-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSINSLSNET PTPTIEKEAY FHGLIQREDV FQLLDNNGDY VVRLSDPKPG    50
    EPRSYILSVM FNNKLDENSS VKHFVINSVE NKYFVNNNMS FNTIQQMLSH 100
    YQKSRTEILE ACKILHPVRR QFWELDHGNI VIEKKLGEGA FGEVSSGVMK 150
    FKRGGRLVKV AVKQVKTDGI GKDQIKDFLM EARTMRNLGH PNIVRFLGIA 200
    VLQEPLFLVM ELATGGALDS YLKHNELLPI DKRHEMLLQA AWGLEYIHGK 250
    PMLHRDIAAR NCLYGDGKVK ISDFGLTRRG TIYQLHPETK SPIRWLAVCS 300
    QKTDVWAYGI LCWEIFNNGA EPYPGLTANE VAKQVTDGYR MPPHQLAAPE 350
    VQALMTRCCA ENPNDRPTMS DVAQILQRVT GQGRPNFAAI AKKEAEELLI 400
    MNSRSARRTS RRKGSNKKSA IPNGVLTPVN RAQEIKH 437
    Length:437
    Mass (Da):49,394
    Last modified:October 24, 2003 - v4
    Checksum:i603C1CBDBC1FAEC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080165 Genomic DNA. Translation: CCD61728.1.
    PIRiG88535.
    RefSeqiNP_498912.3. NM_066511.5.
    UniGeneiCel.24327.

    Genome annotation databases

    EnsemblMetazoaiB0523.1; B0523.1; WBGene00002212.
    GeneIDi176214.
    KEGGicel:CELE_B0523.1.
    UCSCiB0523.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080165 Genomic DNA. Translation: CCD61728.1 .
    PIRi G88535.
    RefSeqi NP_498912.3. NM_066511.5.
    UniGenei Cel.24327.

    3D structure databases

    ProteinModelPortali P34265.
    SMRi P34265. Positions 15-400.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.B0523.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai B0523.1 ; B0523.1 ; WBGene00002212 .
    GeneIDi 176214.
    KEGGi cel:CELE_B0523.1.
    UCSCi B0523.1. c. elegans.

    Organism-specific databases

    CTDi 176214.
    WormBasei B0523.1 ; CE33023 ; WBGene00002212 ; kin-31.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117264.
    HOGENOMi HOG000233858.
    InParanoidi P34265.
    KOi K08253.
    OMAi RCCAENP.
    OrthoDBi EOG708VXW.
    PhylomeDBi P34265.

    Enzyme and pathway databases

    SignaLinki P34265.

    Miscellaneous databases

    NextBioi 891608.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiKIN31_CAEEL
    AccessioniPrimary (citable) accession number: P34265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: October 24, 2003
    Last modified: October 1, 2014
    This is version 119 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3