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Protein

Transposable element Tc3 transposase

Gene

tc3a

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the terminal nucleotides of the TC3 inverted repeat. Its expression results in frequent excision and transposition of endogenous TC3 elements. TC3 transposase acts by making double strand breaks at the ends of TC3 element. The excised element would then be inserted into a target sequence.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi2 – 135Add BLAST134

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transposable element Tc3 transposase
Gene namesi
Name:tc3a
ORF Names:B0303.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724451 – 329Transposable element Tc3 transposaseAdd BLAST329

Proteomic databases

PRIDEiP34257.

Interactioni

Subunit structurei

Homodimer or homotetramer.Curated

Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 20Combined sources12
Helixi25 – 32Combined sources8
Helixi36 – 44Combined sources9
Turni47 – 50Combined sources4
Helixi63 – 75Combined sources13
Helixi80 – 86Combined sources7
Helixi93 – 102Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TC3X-ray2.45C2-52[»]
1U78X-ray2.69A1-135[»]
ProteinModelPortaliP34257.
SMRiP34257.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34257.

Family & Domainsi

Sequence similaritiesi

Belongs to the transposase 5 family.Curated

Phylogenomic databases

InParanoidiP34257.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR025898. Tc3_transposase_DNA-bd_dom.
IPR002492. Transposase_Tc1-like.
[Graphical view]
PfamiPF11427. HTH_Tnp_Tc3_1. 1 hit.
PF01498. HTH_Tnp_Tc3_2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.

Sequencei

Sequence statusi: Complete.

P34257-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGSALSDT ERAQLDVMKL LNVSLHEMSR KISRSRHCIR EYLKDPVSYG
60 70 80 90 100
TSKRAPRRKA LSVRDERNVI RAASNSCKTA RDIRNELQLS ASKRTILNVI
110 120 130 140 150
KRSGVIVRQK LRPAPLLSAD HKLKRLEFAK NNMGTNWSKV VFSDEKKFNL
160 170 180 190 200
DGPDGCRYYW RDLRKEPMVF SRRNFGGGTV MVWGAFTEKK KLEIQFVSSK
210 220 230 240 250
MNSTDYQNVL ELELSKYLRH YSRKDFRFQQ DNATIHVSNS TRDYFKLKKI
260 270 280 290 300
NLLDWPARSP DLNPIENLWG ILVRIVYAQN KTYPTVASLK QGILDAWKSI
310 320
PDNQLKSLVR SMEDRLIEII RTQGNPINY
Length:329
Mass (Da):38,253
Last modified:February 1, 1994 - v1
Checksum:iF7421854CE11C6DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080163 Genomic DNA. No translation available.
PIRiS27787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080163 Genomic DNA. No translation available.
PIRiS27787.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TC3X-ray2.45C2-52[»]
1U78X-ray2.69A1-135[»]
ProteinModelPortaliP34257.
SMRiP34257.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP34257.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiP34257.

Miscellaneous databases

EvolutionaryTraceiP34257.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR025898. Tc3_transposase_DNA-bd_dom.
IPR002492. Transposase_Tc1-like.
[Graphical view]
PfamiPF11427. HTH_Tnp_Tc3_1. 1 hit.
PF01498. HTH_Tnp_Tc3_2. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTC3A_CAEEL
AccessioniPrimary (citable) accession number: P34257
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome, Transposable element

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.