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P34247

- UTP11_YEAST

UniProt

P34247 - UTP11_YEAST

Protein

U3 small nucleolar RNA-associated protein 11

Gene

UTP11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

    GO - Biological processi

    1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    4. rRNA processing Source: UniProtKB
    5. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31889-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar RNA-associated protein 11
    Short name:
    U3 snoRNA-associated protein 11
    Alternative name(s):
    U three protein 11
    Gene namesi
    Name:UTP11
    Ordered Locus Names:YKL099C
    ORF Names:YKL449
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    SGDiS000001582. UTP11.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. small nucleolar ribonucleoprotein complex Source: UniProtKB
    3. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250U3 small nucleolar RNA-associated protein 11PRO_0000211052Add
    BLAST

    Proteomic databases

    MaxQBiP34247.
    PaxDbiP34247.

    Expressioni

    Gene expression databases

    GenevestigatoriP34247.

    Interactioni

    Subunit structurei

    Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with EBP2, FAF1, MPP10, RPS16A and RRP14.3 Publications

    Protein-protein interaction databases

    BioGridi34034. 26 interactions.
    DIPiDIP-6569N.
    IntActiP34247. 4 interactions.
    MINTiMINT-8285535.
    STRINGi4932.YKL099C.

    Structurei

    3D structure databases

    ProteinModelPortaliP34247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UTP11 family.Curated

    Phylogenomic databases

    eggNOGiCOG5223.
    GeneTreeiENSGT00390000005813.
    HOGENOMiHOG000231076.
    KOiK14769.
    OMAiRVFNRPT.
    OrthoDBiEOG7HB5P3.

    Family and domain databases

    InterProiIPR007144. SSU_processome_Utp11.
    [Graphical view]
    PANTHERiPTHR12838. PTHR12838. 1 hit.
    PfamiPF03998. Utp11. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015952. U3snoRNP11. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P34247-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLVHDVQK KQHRERSQLT SRSRYGFLEK HKDYVKRAQD FHRKQSTLKV    50
    LREKAKERNP DEYYHAMHSR KTDAKGLLIS SRHGDEEDES LSMDQVKLLK 100
    TQDSNYVRTL RQIELKKLEK GAKQLMFKSS GNHTIFVDSR EKMNEFTPEK 150
    FFNTTSEMVN RSENRLTKDQ LAQDISNNRN ASSIMPKESL DKKKLKKFKQ 200
    VKQHLQRETQ LKQVQQRMDA QRELLKKGSK KKIVDSSGKI SFKWKKQRKR 250
    Length:250
    Mass (Da):29,735
    Last modified:June 16, 2009 - v2
    Checksum:iAA013651708C4DB6
    GO

    Sequence cautioni

    The sequence CAA50458.1 differs from that shown. Reason: Frameshift at position 237.
    The sequence CAA81939.1 differs from that shown. Reason: Frameshift at position 237.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71133 Genomic DNA. Translation: CAA50458.1. Frameshift.
    Z28099 Genomic DNA. Translation: CAA81939.1. Frameshift.
    BK006944 Genomic DNA. Translation: DAA09058.1.
    PIRiS37926.
    RefSeqiNP_012823.2. NM_001179665.1.

    Genome annotation databases

    EnsemblFungiiYKL099C; YKL099C; YKL099C.
    GeneIDi853762.
    KEGGisce:YKL099C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71133 Genomic DNA. Translation: CAA50458.1 . Frameshift.
    Z28099 Genomic DNA. Translation: CAA81939.1 . Frameshift.
    BK006944 Genomic DNA. Translation: DAA09058.1 .
    PIRi S37926.
    RefSeqi NP_012823.2. NM_001179665.1.

    3D structure databases

    ProteinModelPortali P34247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34034. 26 interactions.
    DIPi DIP-6569N.
    IntActi P34247. 4 interactions.
    MINTi MINT-8285535.
    STRINGi 4932.YKL099C.

    Proteomic databases

    MaxQBi P34247.
    PaxDbi P34247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL099C ; YKL099C ; YKL099C .
    GeneIDi 853762.
    KEGGi sce:YKL099C.

    Organism-specific databases

    SGDi S000001582. UTP11.

    Phylogenomic databases

    eggNOGi COG5223.
    GeneTreei ENSGT00390000005813.
    HOGENOMi HOG000231076.
    KOi K14769.
    OMAi RVFNRPT.
    OrthoDBi EOG7HB5P3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31889-MONOMER.

    Miscellaneous databases

    NextBioi 974846.
    PROi P34247.

    Gene expression databases

    Genevestigatori P34247.

    Family and domain databases

    InterProi IPR007144. SSU_processome_Utp11.
    [Graphical view ]
    PANTHERi PTHR12838. PTHR12838. 1 hit.
    Pfami PF03998. Utp11. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015952. U3snoRNP11. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence analysis of a 17 kb fragment of yeast chromosome XI physically localizes the MRB1 gene and reveals eight new open reading frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases."
      Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F., Bolotin-Fukuhara M.
      Yeast 9:1149-1155(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
    6. "Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, interacts with factors of both the 60 S and the 40 s ribosomal subunit assembly."
      Shirai C., Takai T., Nariai M., Horigome C., Mizuta K.
      J. Biol. Chem. 279:25353-25358(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EBP2; FAF1 AND RPS16A.
    7. "Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity."
      Yamada H., Horigome C., Okada T., Shirai C., Mizuta K.
      RNA 13:1977-1987(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RRP14.

    Entry informationi

    Entry nameiUTP11_YEAST
    AccessioniPrimary (citable) accession number: P34247
    Secondary accession number(s): D6VXI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3