U3 small nucleolar RNA-associated protein 11 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P34247 (UTP11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
U3 small nucleolar RNA-associated protein 11
Short name=U3 snoRNA-associated protein 11

Alternative name(s):
U three protein 11

Gene names

Name:	UTP11
Ordered Locus Names:	YKL099C
ORF Names:	YKL449

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in nucleolar processing of pre-18S ribosomal RNA. Ref.4
Subunit structure	Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with EBP2, FAF1, MPP10, RPS16A and RRP14. Ref.4 Ref.6 Ref.7
Subcellular location	Nucleus › nucleolus Ref.4.
Sequence similarities	Belongs to the UTP11 family.
Sequence caution	The sequence CAA50458.1 differs from that shown. Reason: Frameshift at position 237. The sequence CAA81939.1 differs from that shown. Reason: Frameshift at position 237.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Nucleus
Molecular function	Ribonucleoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from mutant phenotype PubMed 15489292. Source: SGD endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from mutant phenotype PubMed 15489292. Source: SGD endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from mutant phenotype PubMed 15489292. Source: SGD translation Inferred from mutant phenotype Ref.4. Source: UniProtKB
Cellular_component	nucleolus Inferred from direct assay Ref.4. Source: SGD small nucleolar ribonucleoprotein complex Non-traceable author statement Ref.4. Source: UniProtKB small-subunit processome Inferred from direct assay Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 250

250

U3 small nucleolar RNA-associated protein 11

PRO_0000211052

Sequences

Sequence

Length

Mass (Da)

Tools

P34247 [UniParc].

Last modified June 16, 2009. Version 2.
Checksum: AA013651708C4DB6
Show »

FASTA

250

29,735

        10         20         30         40         50         60 
MAKLVHDVQK KQHRERSQLT SRSRYGFLEK HKDYVKRAQD FHRKQSTLKV LREKAKERNP 

        70         80         90        100        110        120 
DEYYHAMHSR KTDAKGLLIS SRHGDEEDES LSMDQVKLLK TQDSNYVRTL RQIELKKLEK 

       130        140        150        160        170        180 
GAKQLMFKSS GNHTIFVDSR EKMNEFTPEK FFNTTSEMVN RSENRLTKDQ LAQDISNNRN 

       190        200        210        220        230        240 
ASSIMPKESL DKKKLKKFKQ VKQHLQRETQ LKQVQQRMDA QRELLKKGSK KKIVDSSGKI 

       250 
SFKWKKQRKR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DNA sequence analysis of a 17 kb fragment of yeast chromosome XI physically localizes the MRB1 gene and reveals eight new open reading frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases." Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F., Bolotin-Fukuhara M. Yeast 9:1149-1155(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis." Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J. Nature 417:967-970(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[5]	"Sequencing and comparison of yeast species to identify genes and regulatory elements." Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S. Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF FRAMESHIFT.
[6]	"Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, interacts with factors of both the 60 S and the 40 s ribosomal subunit assembly." Shirai C., Takai T., Nariai M., Horigome C., Mizuta K. J. Biol. Chem. 279:25353-25358(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EBP2; FAF1 AND RPS16A.
[7]	"Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity." Yamada H., Horigome C., Okada T., Shirai C., Mizuta K. RNA 13:1977-1987(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RRP14.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X71133 Genomic DNA. Translation: CAA50458.1. Frameshift. Z28099 Genomic DNA. Translation: CAA81939.1. Frameshift. BK006944 Genomic DNA. Translation: DAA09058.1.
PIR	S37926.
RefSeq	NP_012823.2. NM_001179665.1.
3D structure databases
ProteinModelPortal	P34247.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6569N.
IntAct	P34247. 4 interactions.
MINT	MINT-672597.
STRING	4932.YKL099C.
Proteomic databases
PaxDb	P34247.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YKL099C; YKL099C; YKL099C.
GeneID	853762.
KEGG	sce:YKL099C.
Organism-specific databases
SGD	S000001582. UTP11.
Phylogenomic databases
eggNOG	COG5223.
GeneTree	ENSGT00390000005813.
HOGENOM	HOG000231076.
KO	K14769.
OMA	ERQKQYN.
OrthoDB	EOG496326.
Gene expression databases
Genevestigator	P34247.
GermOnline	YKL099C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007144. SSU_processome_Utp11. [Graphical view]
PANTHER	PTHR12838. PTHR12838. 1 hit.
Pfam	PF03998. Utp11. 1 hit. [Graphical view]
PIRSF	PIRSF015952. U3snoRNP11. 1 hit.
ProtoNet	Search...
Other
NextBio	974846.

Entry information

Entry name

UTP11_YEAST

Accession

Primary (citable) accession number: P34247
Secondary accession number(s): D6VXI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	June 16, 2009
Last modified:	April 3, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents