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Protein

U3 small nucleolar RNA-associated protein 11

Gene

UTP11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

GO - Biological processi

  1. endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  3. endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  4. rRNA processing Source: UniProtKB
  5. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31889-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 11
Short name:
U3 snoRNA-associated protein 11
Alternative name(s):
U three protein 11
Gene namesi
Name:UTP11
Ordered Locus Names:YKL099C
ORF Names:YKL449
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

SGDiS000001582. UTP11.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. small nucleolar ribonucleoprotein complex Source: UniProtKB
  3. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250U3 small nucleolar RNA-associated protein 11PRO_0000211052Add
BLAST

Proteomic databases

MaxQBiP34247.
PaxDbiP34247.

Expressioni

Gene expression databases

GenevestigatoriP34247.

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with EBP2, FAF1, MPP10, RPS16A and RRP14.3 Publications

Protein-protein interaction databases

BioGridi34034. 27 interactions.
DIPiDIP-6569N.
IntActiP34247. 4 interactions.
MINTiMINT-8285535.
STRINGi4932.YKL099C.

Structurei

3D structure databases

ProteinModelPortaliP34247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UTP11 family.Curated

Phylogenomic databases

eggNOGiCOG5223.
GeneTreeiENSGT00390000005813.
HOGENOMiHOG000231076.
InParanoidiP34247.
KOiK14769.
OMAiERQKQYN.
OrthoDBiEOG7HB5P3.

Family and domain databases

InterProiIPR007144. SSU_processome_Utp11.
[Graphical view]
PANTHERiPTHR12838. PTHR12838. 1 hit.
PfamiPF03998. Utp11. 1 hit.
[Graphical view]
PIRSFiPIRSF015952. U3snoRNP11. 1 hit.

Sequencei

Sequence statusi: Complete.

P34247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLVHDVQK KQHRERSQLT SRSRYGFLEK HKDYVKRAQD FHRKQSTLKV
60 70 80 90 100
LREKAKERNP DEYYHAMHSR KTDAKGLLIS SRHGDEEDES LSMDQVKLLK
110 120 130 140 150
TQDSNYVRTL RQIELKKLEK GAKQLMFKSS GNHTIFVDSR EKMNEFTPEK
160 170 180 190 200
FFNTTSEMVN RSENRLTKDQ LAQDISNNRN ASSIMPKESL DKKKLKKFKQ
210 220 230 240 250
VKQHLQRETQ LKQVQQRMDA QRELLKKGSK KKIVDSSGKI SFKWKKQRKR
Length:250
Mass (Da):29,735
Last modified:June 16, 2009 - v2
Checksum:iAA013651708C4DB6
GO

Sequence cautioni

The sequence CAA50458.1 differs from that shown. Reason: Frameshift at position 237. Curated
The sequence CAA81939.1 differs from that shown. Reason: Frameshift at position 237. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71133 Genomic DNA. Translation: CAA50458.1. Frameshift.
Z28099 Genomic DNA. Translation: CAA81939.1. Frameshift.
BK006944 Genomic DNA. Translation: DAA09058.1.
PIRiS37926.
RefSeqiNP_012823.2. NM_001179665.1.

Genome annotation databases

EnsemblFungiiYKL099C; YKL099C; YKL099C.
GeneIDi853762.
KEGGisce:YKL099C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71133 Genomic DNA. Translation: CAA50458.1. Frameshift.
Z28099 Genomic DNA. Translation: CAA81939.1. Frameshift.
BK006944 Genomic DNA. Translation: DAA09058.1.
PIRiS37926.
RefSeqiNP_012823.2. NM_001179665.1.

3D structure databases

ProteinModelPortaliP34247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34034. 27 interactions.
DIPiDIP-6569N.
IntActiP34247. 4 interactions.
MINTiMINT-8285535.
STRINGi4932.YKL099C.

Proteomic databases

MaxQBiP34247.
PaxDbiP34247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL099C; YKL099C; YKL099C.
GeneIDi853762.
KEGGisce:YKL099C.

Organism-specific databases

SGDiS000001582. UTP11.

Phylogenomic databases

eggNOGiCOG5223.
GeneTreeiENSGT00390000005813.
HOGENOMiHOG000231076.
InParanoidiP34247.
KOiK14769.
OMAiERQKQYN.
OrthoDBiEOG7HB5P3.

Enzyme and pathway databases

BioCyciYEAST:G3O-31889-MONOMER.

Miscellaneous databases

NextBioi974846.
PROiP34247.

Gene expression databases

GenevestigatoriP34247.

Family and domain databases

InterProiIPR007144. SSU_processome_Utp11.
[Graphical view]
PANTHERiPTHR12838. PTHR12838. 1 hit.
PfamiPF03998. Utp11. 1 hit.
[Graphical view]
PIRSFiPIRSF015952. U3snoRNP11. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence analysis of a 17 kb fragment of yeast chromosome XI physically localizes the MRB1 gene and reveals eight new open reading frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases."
    Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F., Bolotin-Fukuhara M.
    Yeast 9:1149-1155(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  6. "Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, interacts with factors of both the 60 S and the 40 s ribosomal subunit assembly."
    Shirai C., Takai T., Nariai M., Horigome C., Mizuta K.
    J. Biol. Chem. 279:25353-25358(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EBP2; FAF1 AND RPS16A.
  7. "Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity."
    Yamada H., Horigome C., Okada T., Shirai C., Mizuta K.
    RNA 13:1977-1987(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RRP14.

Entry informationi

Entry nameiUTP11_YEAST
AccessioniPrimary (citable) accession number: P34247
Secondary accession number(s): D6VXI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 16, 2009
Last modified: January 7, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.