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Protein

Probable serine/threonine-protein kinase HSL1

Gene

HSL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101ATPPROSITE-ProRule annotation
Active sitei239 – 2391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 959ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • cellular protein catabolic process Source: SGD
  • G2/M transition of mitotic cell cycle Source: SGD
  • intracellular signal transduction Source: GO_Central
  • morphogenesis checkpoint Source: SGD
  • peptidyl-serine phosphorylation Source: SGD
  • protein autophosphorylation Source: SGD
  • protein localization to septin ring Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of cell cycle Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31891-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase HSL1 (EC:2.7.11.1)
Gene namesi
Name:HSL1
Ordered Locus Names:YKL101W
ORF Names:YKL453
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL101W.
SGDiS000001584. HSL1.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud neck septin ring Source: SGD
  • nucleus Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15181518Probable serine/threonine-protein kinase HSL1PRO_0000086148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei511 – 5111PhosphoserineCombined sources
Modified residuei629 – 6291PhosphoserineCombined sources
Modified residuei685 – 6851PhosphoserineCombined sources
Modified residuei837 – 8371PhosphoserineCombined sources
Modified residuei866 – 8661PhosphoserineCombined sources
Modified residuei1220 – 12201PhosphoserineCombined sources
Modified residuei1250 – 12501PhosphoserineCombined sources
Modified residuei1284 – 12841PhosphoserineCombined sources
Modified residuei1287 – 12871PhosphoserineCombined sources
Modified residuei1325 – 13251PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34244.

PTM databases

iPTMnetiP34244.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HOG1P324852EBI-9771,EBI-8437

Protein-protein interaction databases

BioGridi34032. 271 interactions.
DIPiDIP-3022N.
IntActiP34244. 10 interactions.
MINTiMINT-672648.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5G04electron microscopy4.00S667-872[»]
ProteinModelPortaliP34244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 369289Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00840000129789.
HOGENOMiHOG000112964.
InParanoidiP34244.
KOiK02515.
OMAiAIHYFKQ.
OrthoDBiEOG092C0QJU.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGHVSKTSH VPKGRPSSLA KKAAKRAMAK VNSNPKRASG HLERVVQSVN
60 70 80 90 100
DATKRLSQPD STVSVATKSS KRKSRDTVGP WKLGKTLGKG SSGRVRLAKN
110 120 130 140 150
METGQLAAIK IVPKKKAFVH CSNNGTVPNS YSSSMVTSNV SSPSIASREH
160 170 180 190 200
SNHSQTNPYG IEREIVIMKL ISHTNVMALF EVWENKSELY LVLEYVDGGE
210 220 230 240 250
LFDYLVSKGK LPEREAIHYF KQIVEGVSYC HSFNICHRDL KPENLLLDKK
260 270 280 290 300
NRRIKIADFG MAALELPNKL LKTSCGSPHY ASPEIVMGRP YHGGPSDVWS
310 320 330 340 350
CGIVLFALLT GHLPFNDDNI KKLLLKVQSG KYQMPSNLSS EARDLISKIL
360 370 380 390 400
VIDPEKRITT QEILKHPLIK KYDDLPVNKV LRKMRKDNMA RGKSNSDLHL
410 420 430 440 450
LNNVSPSIVT LHSKGEIDES ILRSLQILWH GVSRELITAK LLQKPMSEEK
460 470 480 490 500
LFYSLLLQYK QRHSISLSSS SENKKSATES SVNEPRIEYA SKTANNTGLR
510 520 530 540 550
SENNDVKTLH SLEIHSEDTS TVNQNNAITG VNTEINAPVL AQKSQFSINT
560 570 580 590 600
LSQPESDKAE AEAVTLPPAI PIFNASSSRI FRNSYTSISS RSRRSLRLSN
610 620 630 640 650
SRLSLSASTS RETVHDNEMP LPQLPKSPSR YSLSRRAIHA SPSTKSIHKS
660 670 680 690 700
LSRKNIAATV AARRTLQNSA SKRSLYSLQS ISKRSLNLND LLVFDDPLPS
710 720 730 740 750
KKPASENVNK SEPHSLESDS DFEILCDQIL FGNALDRILE EEEDNEKERD
760 770 780 790 800
TQRQRQNDTK SSADTFTISG VSTNKENEGP EYPTKIEKNQ FNMSYKPSEN
810 820 830 840 850
MSGLSSFPIF EKENTLSSSY LEEQKPKRAA LSDITNSFNK MNKQEGMRIE
860 870 880 890 900
KKIQREQLQK KNDRPSPLKP IQHQELRVNS LPNDQGKPSL SLDPRRNISQ
910 920 930 940 950
PVNSKVESLL QGLKFKKEPA SHWTHERGSL FMSEHVEDEK PVKASDVSIE
960 970 980 990 1000
SSYVPLTTVA TSSRDPSVLA ESSTIQKPML SLPSSFLNTS MTFKNLSQIL
1010 1020 1030 1040 1050
ADDGDDKHLS VPQNQSRSVA MSHPLRKQSA KISLTPRSNL NANLSVKRNQ
1060 1070 1080 1090 1100
GSPGSYLSND LDGISDMTFA MEIPTNTFTA QAIQLMNNDT DNNKINTSPK
1110 1120 1130 1140 1150
ASSFTKEKVI KSAAYISKEK EPDNSDTNYI PDYTIPNTYD EKAINIFEDA
1160 1170 1180 1190 1200
PSDEGSLNTS SSESDSRASV HRKAVSIDTM ATTNVLTPAT NVRVSLYWNN
1210 1220 1230 1240 1250
NSSGIPRETT EEILSKLRLS PENPSNTHMQ KRFSSTRGSR DSNALGISQS
1260 1270 1280 1290 1300
LQSMFKDLEE DQDGHTSQAD ILESSMSYSK RRPSEESVNP KQRVTMLFDE
1310 1320 1330 1340 1350
EEEESKKVGG GKIKEEHTKL DNKISEESSQ LVLPVVEKKE NANNTENNYS
1360 1370 1380 1390 1400
KIPKPSTIKV TKDTAMESNT QTHTKKPILK SVQNVEVEEA PSSDKKNWFV
1410 1420 1430 1440 1450
KLFQNFSSHN NATKASKNHV TNISFDDAHM LTLNEFNKNS IDYQLKNLDH
1460 1470 1480 1490 1500
KFGRKVVEYD CKFVKGNFKF KIKITSTPNA STVITVKKRS KHSNTSSNKA
1510
FEKFNDDVER VIRNAGRS
Length:1,518
Mass (Da):169,607
Last modified:September 21, 2011 - v2
Checksum:i803F84F7574304CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1482 – 14821T → S in AAB07455 (PubMed:8647431).Curated
Sequence conflicti1482 – 14821T → S in CAA50456 (PubMed:8256524).Curated
Sequence conflicti1482 – 14821T → S in CAA81941 (PubMed:8196765).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65921 Genomic DNA. Translation: AAB07455.1.
X71133 Genomic DNA. Translation: CAA50456.1.
Z28101 Genomic DNA. Translation: CAA81941.1.
BK006944 Genomic DNA. Translation: DAA09056.2.
PIRiS37928.
RefSeqiNP_012821.2. NM_001179667.2.

Genome annotation databases

EnsemblFungiiYKL101W; YKL101W; YKL101W.
GeneIDi853760.
KEGGisce:YKL101W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65921 Genomic DNA. Translation: AAB07455.1.
X71133 Genomic DNA. Translation: CAA50456.1.
Z28101 Genomic DNA. Translation: CAA81941.1.
BK006944 Genomic DNA. Translation: DAA09056.2.
PIRiS37928.
RefSeqiNP_012821.2. NM_001179667.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5G04electron microscopy4.00S667-872[»]
ProteinModelPortaliP34244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34032. 271 interactions.
DIPiDIP-3022N.
IntActiP34244. 10 interactions.
MINTiMINT-672648.

PTM databases

iPTMnetiP34244.

Proteomic databases

MaxQBiP34244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL101W; YKL101W; YKL101W.
GeneIDi853760.
KEGGisce:YKL101W.

Organism-specific databases

EuPathDBiFungiDB:YKL101W.
SGDiS000001584. HSL1.

Phylogenomic databases

GeneTreeiENSGT00840000129789.
HOGENOMiHOG000112964.
InParanoidiP34244.
KOiK02515.
OMAiAIHYFKQ.
OrthoDBiEOG092C0QJU.

Enzyme and pathway databases

BioCyciYEAST:G3O-31891-MONOMER.

Miscellaneous databases

PROiP34244.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSL1_YEAST
AccessioniPrimary (citable) accession number: P34244
Secondary accession number(s): A2NP40, D6VXI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 21, 2011
Last modified: September 7, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.