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P34241

- URB1_YEAST

UniProt

P34241 - URB1_YEAST

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Protein

Nucleolar pre-ribosomal-associated protein 1

Gene
URB1, NPA1, YKL014C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for 60S ribosomal subunit formation and pre-rRNA processing. Required for normal accumulation of 25S and 5.8S rRNAs.3 Publications

GO - Biological processi

  1. maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-31823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar pre-ribosomal-associated protein 1
Alternative name(s):
Unhealthy ribosome biogenesis protein 1
Gene namesi
Name:URB1
Synonyms:NPA1
Ordered Locus Names:YKL014C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL014c.
SGDiS000001497. URB1.

Subcellular locationi

Nucleusnucleolus
Note: Accumulates in the immediate vicinity of the dense fibrillar component of the nucleolus.3 Publications

GO - Cellular componenti

  1. nucleolus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17641764Nucleolar pre-ribosomal-associated protein 1PRO_0000203190Add
BLAST

Proteomic databases

MaxQBiP34241.
PaxDbiP34241.
PeptideAtlasiP34241.

Expressioni

Gene expression databases

GenevestigatoriP34241.

Interactioni

Subunit structurei

Associates with pre-60S ribosomal particles. Predominantly associated with the 27SA2 pre-rRNA. Can associate with a subset of box H/ACA and box C/D small nucleolar RNPs (snoRNPs) required for peptidyl transferase center modification and with small RNAs snR37 and snR42. Interacts with URB2. Together with DBP6, NOP8, URB2 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.3 Publications

Protein-protein interaction databases

BioGridi34118. 99 interactions.
DIPiDIP-2701N.
IntActiP34241. 17 interactions.
MINTiMINT-668747.
STRINGi4932.YKL014C.

Structurei

3D structure databases

ProteinModelPortaliP34241.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG324825.
HOGENOMiHOG000141826.
KOiK14861.
OMAiPYKYVDM.
OrthoDBiEOG76DV31.

Family and domain databases

InterProiIPR021714. Npa1_N.
[Graphical view]
PfamiPF11707. Npa1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34241-1 [UniParc]FASTAAdd to Basket

« Hide

MSNHSEAYGS RDQRREKYTQ GKEFEDGTLE TLESIISAVE DETLSKDYQP     50
LIVFFQRGFG AQLVQTWSYY AQVNNHGKFS KTTSLLTKTL RVLSSDTSTV 100
TIGSGLIRLI LTDYTKVLYR GLNNMRAQLT NPILRLLKQI VNFNNGQHIE 150
ELVSYFDFSL PILPRLLVPS KSELANGNSS ADSSKHDSLR FTFIKFWLTL 200
ISNASPFVRK ELLTENFKIM SNLFKFMNKA DSDKLSEHIL SVFINDILKE 250
KSFKRTTKTK ILNELAASKI HHFYYSSNKN LVKKANEFFL TFGASRDFSV 300
AFPDNCVWFK NSVADGASHG APITVNQVEF QIHNKLLFNT LRLFKPWEDT 350
LQLGTLIKIL ENVPELVAPY SIFLTTNGNY DPKMTSYWFG ITLLINKIIN 400
LKIPQFMEKV DSNIPPATSL VIENILPSLL TKSSLVKSLQ FETPIIRQLA 450
CQSIVLALKK LEKVSTFYDQ KGWRNEKTIL LNEFHTRIPD LPIFVSTLSN 500
SLASNKDNRI LPLSISIIFN YYSKMFPNLF SINLPSSNIY TDIMQKSKIS 550
GIEFAILDNY LQFQEFNSTQ TRWWNPSSGG NSLFTLLLKL ASSKNASNVI 600
TTRISNLLDE LTRTNVIFNI SLISPVMALV NSLQGLSLQV SEIDNMEQVW 650
KWFDETISRV VKTPYKYVDM AKEYNYISPF IMCLSEQWKY VDKSGNPEFL 700
IKWLILFLRN MIFIGEDHIG IDKLVKNVFP EVSDHDVNIY LKLDSFEENI 750
KKTNSSNSLI SSMKSSSFFQ YISALPSKNL MNISRLPVNK LDAAGILFRV 800
QLLVEDDSVV YDNWFEATAC ELTGKIASYM VTDTEFPIIK VLERYINFAL 850
PKLAIEKRNA LLMKKSRFMC NLIGAVCFET GHQLVEFREI IQKVVFSGEN 900
VEEYANYNEL YQKEDVNAFL TSVSEYLSTS ALTSLLMCST KLESTRNILQ 950
KLFNEGKTIK ISLVKNILNK AANEDPASIK EVNISLAKFF EENKVCVDAS 1000
SDPMGKLSLS ETTSLINSFV SSDLNYLVLK AFYRWEHFSF PSFIPSIWRI 1050
KDSPLLSIVT TAALFKHMQD KDFSAFAHET ISKYGNEIAK STYTTSKSEI 1100
FDEILNMITT YIDFYDETKR NEILKCVLSQ SDHKYHAATV RYIAAHNNFT 1150
YPGVETWLHK TLLYLTKYLS ERKVISNSFF ELLRAMAELL KLEEVPNKLN 1200
VKIINSQLEA ILGSEWIKQI KVLEYVIVLI FCVSKKSIQS QRMVQLLLSN 1250
DSYSSIMIKD NDEDSSYRKF LSTMILFSLF SIDPVVNSTP IVQEKLLTFY 1300
SGTISSNDKL ILKILETIES HTATSWTNMI FSWEFIKDEE EEILEAIGDT 1350
RLITKEREGL ILTLQKNMIK KSIDRYVLER PQVPELYTDS NTNNYDATTR 1400
CDLVKKYYDD TERSGVDMYD PLFLLLLIIH NKELVKMVKD DEGNVTYRYE 1450
FENFLDCKIF QFIICSLSDC HTVANISYEH LSNLASSLEK KTAQMNLEKQ 1500
ITSKDNERKE SDSDLIKYNS IYQVLIKRIL YQRQQNQDPI NPLIWFSISR 1550
IVDLLGSPTA PLHEKAYRWV LSNSTIRSWD IPMVSDVMMS YNKRQQDDNK 1600
KEIDMEIYYG ELSWVLTTIC KGIKTDEDYK MLEKKGVFEW LLNLINMPYL 1650
KERLRELIYF IFYKVQRVAD DGGLNLISRN GIVSFFEVLN NNIKSRLPQD 1700
DILNNIGTLR NENRGTLNTT LRLAQEQNGI EKLLLGYNEL VKSQKRLILW 1750
TEGDSDNVVK RLRK 1764
Length:1,764
Mass (Da):203,287
Last modified:June 1, 1994 - v2
Checksum:iD4EC1FA19E051367
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74152 Genomic DNA. Translation: CAA52264.1.
Z28014 Genomic DNA. Translation: CAA81849.1.
BK006944 Genomic DNA. Translation: DAA09142.1.
PIRiS37827.
RefSeqiNP_012911.3. NM_001179580.3.

Genome annotation databases

EnsemblFungiiYKL014C; YKL014C; YKL014C.
GeneIDi853855.
KEGGisce:YKL014C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X74152 Genomic DNA. Translation: CAA52264.1 .
Z28014 Genomic DNA. Translation: CAA81849.1 .
BK006944 Genomic DNA. Translation: DAA09142.1 .
PIRi S37827.
RefSeqi NP_012911.3. NM_001179580.3.

3D structure databases

ProteinModelPortali P34241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34118. 99 interactions.
DIPi DIP-2701N.
IntActi P34241. 17 interactions.
MINTi MINT-668747.
STRINGi 4932.YKL014C.

Proteomic databases

MaxQBi P34241.
PaxDbi P34241.
PeptideAtlasi P34241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL014C ; YKL014C ; YKL014C .
GeneIDi 853855.
KEGGi sce:YKL014C.

Organism-specific databases

CYGDi YKL014c.
SGDi S000001497. URB1.

Phylogenomic databases

eggNOGi NOG324825.
HOGENOMi HOG000141826.
KOi K14861.
OMAi PYKYVDM.
OrthoDBi EOG76DV31.

Enzyme and pathway databases

BioCyci YEAST:G3O-31823-MONOMER.

Miscellaneous databases

NextBioi 975094.

Gene expression databases

Genevestigatori P34241.

Family and domain databases

InterProi IPR021714. Npa1_N.
[Graphical view ]
Pfami PF11707. Npa1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
    Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
    Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: FUNCTION, INTERACTION WITH URB2.
  7. "Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification."
    Dez C., Froment C., Noaillac-Depeyre J., Monsarrat B., Caizergues-Ferrer M., Henry Y.
    Mol. Cell. Biol. 24:6324-6337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH URB2, SUBCELLULAR LOCATION.
  8. "Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae."
    Rosado I.V., de la Cruz J.
    RNA 10:1073-1083(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH PRE-RIBOSOMAL PARTICLES, SUBCELLULAR LOCATION.
  9. "Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a Low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis."
    Rosado I.V., Dez C., Lebaron S., Caizergues-Ferrer M., Henry Y., de la Cruz J.
    Mol. Cell. Biol. 27:1207-1221(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH DBP6; NOP8; URB2 AND RSA3.

Entry informationi

Entry nameiURB1_YEAST
AccessioniPrimary (citable) accession number: P34241
Secondary accession number(s): D6VXS2, P34242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: May 14, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5890 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3

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