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Protein

Zinc-regulated transporter 3

Gene

ZRT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transports zinc from storage in the vacuole to the cytoplasm.1 Publication

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • cellular zinc ion homeostasis Source: SGD
  • zinc II ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31942-MONOMER.

Protein family/group databases

TCDBi2.A.5.5.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-regulated transporter 3
Alternative name(s):
Vacuolar membrane zinc transporter
Gene namesi
Name:ZRT3
Ordered Locus Names:YKL175W
ORF Names:YKL640
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL175W.
SGDiS000001658. ZRT3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002031401 – 503Zinc-regulated transporter 3Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34240.
PRIDEiP34240.
TopDownProteomicsiP34240.

PTM databases

iPTMnetiP34240.

Interactioni

Protein-protein interaction databases

BioGridi33963. 13 interactors.
DIPiDIP-5610N.
IntActiP34240. 1 interactor.
MINTiMINT-528697.

Structurei

3D structure databases

ProteinModelPortaliP34240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 139His-richAdd BLAST38
Compositional biasi153 – 158Poly-Ser6
Compositional biasi322 – 325Poly-His4
Compositional biasi464 – 467Poly-His4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000142066.
InParanoidiP34240.
KOiK07238.
OMAiGTTCLKW.
OrthoDBiEOG092C33H7.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIPRWLLF SLISSVLCIL GALCVPLLSV AFDSKRNSQS KLVNYGLSLS
60 70 80 90 100
AGSMITTSLY MLLPRIEKSN RFKVFPGLLL GICLSFFLNY LVHAFASESL
110 120 130 140 150
VHCADSGDHA TGSHIHSKSH SHSHSHSHAD SHSNFSNDHD LENAPSEHGY
160 170 180 190 200
ATSSSSVSEN DPLITKDSDR PQMKKKMSLI DLLTRRKSEG ECCDLNKCTP
210 220 230 240 250
LLQSEQPEYI ACVPPVIKSS QSERNVPHGC EGSEDNGQSD DKDHRGLVCV
260 270 280 290 300
ENNIGYDLEN LSLYRKNFLS SRHHHSSESP ENYGSNQLSH SFSSPLGNDV
310 320 330 340 350
TENPAALADT QYHPENGSLY PHHHHLETPF SKLLSIGMQT CLVLALHKFP
360 370 380 390 400
EGFIIFYTNR SDSSKSLGFS IFLSLTIHNF VEGFAMTLPF YTVFESKWVA
410 420 430 440 450
ILITAVLGGG SQPLGALIGY FIFKGSTPRD HEPNMDFLLS VTAGFLLVIG
460 470 480 490 500
LQMFQTGIGF SDGHHHHQGE GDEEMKQSHS SGTTCLKWCC TGVLLILASA

LFT
Length:503
Mass (Da):55,403
Last modified:June 1, 1994 - v2
Checksum:iDBAD8CE2C2809082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26878 Genomic DNA. Translation: CAA81511.1.
X74151 Genomic DNA. Translation: CAA52263.1.
Z28175 Genomic DNA. Translation: CAA82017.1.
BK006944 Genomic DNA. Translation: DAA08991.1.
PIRiS38005.
RefSeqiNP_012746.1. NM_001179741.1.

Genome annotation databases

EnsemblFungiiYKL175W; YKL175W; YKL175W.
GeneIDi853679.
KEGGisce:YKL175W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26878 Genomic DNA. Translation: CAA81511.1.
X74151 Genomic DNA. Translation: CAA52263.1.
Z28175 Genomic DNA. Translation: CAA82017.1.
BK006944 Genomic DNA. Translation: DAA08991.1.
PIRiS38005.
RefSeqiNP_012746.1. NM_001179741.1.

3D structure databases

ProteinModelPortaliP34240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33963. 13 interactors.
DIPiDIP-5610N.
IntActiP34240. 1 interactor.
MINTiMINT-528697.

Protein family/group databases

TCDBi2.A.5.5.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

PTM databases

iPTMnetiP34240.

Proteomic databases

MaxQBiP34240.
PRIDEiP34240.
TopDownProteomicsiP34240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL175W; YKL175W; YKL175W.
GeneIDi853679.
KEGGisce:YKL175W.

Organism-specific databases

EuPathDBiFungiDB:YKL175W.
SGDiS000001658. ZRT3.

Phylogenomic databases

HOGENOMiHOG000142066.
InParanoidiP34240.
KOiK07238.
OMAiGTTCLKW.
OrthoDBiEOG092C33H7.

Enzyme and pathway databases

BioCyciYEAST:G3O-31942-MONOMER.

Miscellaneous databases

PROiP34240.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZRT3_YEAST
AccessioniPrimary (citable) accession number: P34240
Secondary accession number(s): D6VX25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.