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P34240

- ZRT3_YEAST

UniProt

P34240 - ZRT3_YEAST

Protein

Zinc-regulated transporter 3

Gene

ZRT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Transports zinc from storage in the vacuole to the cytoplasm.1 Publication

    GO - Molecular functioni

    1. zinc ion transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. cellular zinc ion homeostasis Source: SGD
    2. zinc ion transmembrane transport Source: GOC
    3. zinc ion transport Source: SGD

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31942-MONOMER.

    Protein family/group databases

    TCDBi2.A.5.5.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc-regulated transporter 3
    Alternative name(s):
    Vacuolar membrane zinc transporter
    Gene namesi
    Name:ZRT3
    Ordered Locus Names:YKL175W
    ORF Names:YKL640
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL175w.
    SGDiS000001658. ZRT3.

    Subcellular locationi

    Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. fungal-type vacuole membrane Source: SGD
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Zinc-regulated transporter 3PRO_0000203140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei178 – 1781Phosphoserine2 Publications
    Modified residuei188 – 1881Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP34240.
    PaxDbiP34240.
    PeptideAtlasiP34240.

    Expressioni

    Gene expression databases

    GenevestigatoriP34240.

    Interactioni

    Protein-protein interaction databases

    BioGridi33963. 13 interactions.
    DIPiDIP-5610N.
    IntActiP34240. 1 interaction.
    MINTiMINT-528697.
    STRINGi4932.YKL175W.

    Structurei

    3D structure databases

    ProteinModelPortaliP34240.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei398 – 41821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei482 – 50221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi102 – 13938His-richAdd
    BLAST
    Compositional biasi153 – 1586Poly-Ser
    Compositional biasi322 – 3254Poly-His
    Compositional biasi464 – 4674Poly-His

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    HOGENOMiHOG000142066.
    KOiK07238.
    OMAiPEGFIIF.
    OrthoDBiEOG7R5747.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34240-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKIPRWLLF SLISSVLCIL GALCVPLLSV AFDSKRNSQS KLVNYGLSLS    50
    AGSMITTSLY MLLPRIEKSN RFKVFPGLLL GICLSFFLNY LVHAFASESL 100
    VHCADSGDHA TGSHIHSKSH SHSHSHSHAD SHSNFSNDHD LENAPSEHGY 150
    ATSSSSVSEN DPLITKDSDR PQMKKKMSLI DLLTRRKSEG ECCDLNKCTP 200
    LLQSEQPEYI ACVPPVIKSS QSERNVPHGC EGSEDNGQSD DKDHRGLVCV 250
    ENNIGYDLEN LSLYRKNFLS SRHHHSSESP ENYGSNQLSH SFSSPLGNDV 300
    TENPAALADT QYHPENGSLY PHHHHLETPF SKLLSIGMQT CLVLALHKFP 350
    EGFIIFYTNR SDSSKSLGFS IFLSLTIHNF VEGFAMTLPF YTVFESKWVA 400
    ILITAVLGGG SQPLGALIGY FIFKGSTPRD HEPNMDFLLS VTAGFLLVIG 450
    LQMFQTGIGF SDGHHHHQGE GDEEMKQSHS SGTTCLKWCC TGVLLILASA 500
    LFT 503
    Length:503
    Mass (Da):55,403
    Last modified:June 1, 1994 - v2
    Checksum:iDBAD8CE2C2809082
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26878 Genomic DNA. Translation: CAA81511.1.
    X74151 Genomic DNA. Translation: CAA52263.1.
    Z28175 Genomic DNA. Translation: CAA82017.1.
    BK006944 Genomic DNA. Translation: DAA08991.1.
    PIRiS38005.
    RefSeqiNP_012746.1. NM_001179741.1.

    Genome annotation databases

    EnsemblFungiiYKL175W; YKL175W; YKL175W.
    GeneIDi853679.
    KEGGisce:YKL175W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26878 Genomic DNA. Translation: CAA81511.1 .
    X74151 Genomic DNA. Translation: CAA52263.1 .
    Z28175 Genomic DNA. Translation: CAA82017.1 .
    BK006944 Genomic DNA. Translation: DAA08991.1 .
    PIRi S38005.
    RefSeqi NP_012746.1. NM_001179741.1.

    3D structure databases

    ProteinModelPortali P34240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33963. 13 interactions.
    DIPi DIP-5610N.
    IntActi P34240. 1 interaction.
    MINTi MINT-528697.
    STRINGi 4932.YKL175W.

    Protein family/group databases

    TCDBi 2.A.5.5.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

    Proteomic databases

    MaxQBi P34240.
    PaxDbi P34240.
    PeptideAtlasi P34240.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL175W ; YKL175W ; YKL175W .
    GeneIDi 853679.
    KEGGi sce:YKL175W.

    Organism-specific databases

    CYGDi YKL175w.
    SGDi S000001658. ZRT3.

    Phylogenomic databases

    eggNOGi COG0428.
    HOGENOMi HOG000142066.
    KOi K07238.
    OMAi PEGFIIF.
    OrthoDBi EOG7R5747.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31942-MONOMER.

    Miscellaneous databases

    NextBioi 974637.

    Gene expression databases

    Genevestigatori P34240.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and analysis of a 20.5 kb DNA segment located on the left arm of yeast chromosome XI."
      Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.
      Yeast 10:S25-S33(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
      Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
      Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-233.
    5. "Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae."
      MacDiarmid C.W., Gaither L.A., Eide D.
      EMBO J. 19:2845-2855(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZRT3_YEAST
    AccessioniPrimary (citable) accession number: P34240
    Secondary accession number(s): D6VX25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3