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P34240

- ZRT3_YEAST

UniProt

P34240 - ZRT3_YEAST

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Protein

Zinc-regulated transporter 3

Gene

ZRT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transports zinc from storage in the vacuole to the cytoplasm.1 Publication

GO - Molecular functioni

  1. zinc ion transmembrane transporter activity Source: SGD

GO - Biological processi

  1. cellular zinc ion homeostasis Source: SGD
  2. zinc ion transmembrane transport Source: GOC
  3. zinc ion transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-31942-MONOMER.

Protein family/group databases

TCDBi2.A.5.5.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-regulated transporter 3
Alternative name(s):
Vacuolar membrane zinc transporter
Gene namesi
Name:ZRT3
Ordered Locus Names:YKL175W
ORF Names:YKL640
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL175w.
SGDiS000001658. ZRT3.

Subcellular locationi

Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication

GO - Cellular componenti

  1. fungal-type vacuole membrane Source: SGD
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Zinc-regulated transporter 3PRO_0000203140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphoserine2 Publications
Modified residuei188 – 1881Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34240.
PaxDbiP34240.
PeptideAtlasiP34240.

Expressioni

Gene expression databases

GenevestigatoriP34240.

Interactioni

Protein-protein interaction databases

BioGridi33963. 13 interactions.
DIPiDIP-5610N.
IntActiP34240. 1 interaction.
MINTiMINT-528697.
STRINGi4932.YKL175W.

Structurei

3D structure databases

ProteinModelPortaliP34240.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence AnalysisAdd
BLAST
Transmembranei398 – 41821HelicalSequence AnalysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi102 – 13938His-richAdd
BLAST
Compositional biasi153 – 1586Poly-Ser
Compositional biasi322 – 3254Poly-His
Compositional biasi464 – 4674Poly-His

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
HOGENOMiHOG000142066.
InParanoidiP34240.
KOiK07238.
OMAiPEGFIIF.
OrthoDBiEOG7R5747.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34240-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKIPRWLLF SLISSVLCIL GALCVPLLSV AFDSKRNSQS KLVNYGLSLS
60 70 80 90 100
AGSMITTSLY MLLPRIEKSN RFKVFPGLLL GICLSFFLNY LVHAFASESL
110 120 130 140 150
VHCADSGDHA TGSHIHSKSH SHSHSHSHAD SHSNFSNDHD LENAPSEHGY
160 170 180 190 200
ATSSSSVSEN DPLITKDSDR PQMKKKMSLI DLLTRRKSEG ECCDLNKCTP
210 220 230 240 250
LLQSEQPEYI ACVPPVIKSS QSERNVPHGC EGSEDNGQSD DKDHRGLVCV
260 270 280 290 300
ENNIGYDLEN LSLYRKNFLS SRHHHSSESP ENYGSNQLSH SFSSPLGNDV
310 320 330 340 350
TENPAALADT QYHPENGSLY PHHHHLETPF SKLLSIGMQT CLVLALHKFP
360 370 380 390 400
EGFIIFYTNR SDSSKSLGFS IFLSLTIHNF VEGFAMTLPF YTVFESKWVA
410 420 430 440 450
ILITAVLGGG SQPLGALIGY FIFKGSTPRD HEPNMDFLLS VTAGFLLVIG
460 470 480 490 500
LQMFQTGIGF SDGHHHHQGE GDEEMKQSHS SGTTCLKWCC TGVLLILASA

LFT
Length:503
Mass (Da):55,403
Last modified:June 1, 1994 - v2
Checksum:iDBAD8CE2C2809082
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26878 Genomic DNA. Translation: CAA81511.1.
X74151 Genomic DNA. Translation: CAA52263.1.
Z28175 Genomic DNA. Translation: CAA82017.1.
BK006944 Genomic DNA. Translation: DAA08991.1.
PIRiS38005.
RefSeqiNP_012746.1. NM_001179741.1.

Genome annotation databases

EnsemblFungiiYKL175W; YKL175W; YKL175W.
GeneIDi853679.
KEGGisce:YKL175W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26878 Genomic DNA. Translation: CAA81511.1 .
X74151 Genomic DNA. Translation: CAA52263.1 .
Z28175 Genomic DNA. Translation: CAA82017.1 .
BK006944 Genomic DNA. Translation: DAA08991.1 .
PIRi S38005.
RefSeqi NP_012746.1. NM_001179741.1.

3D structure databases

ProteinModelPortali P34240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33963. 13 interactions.
DIPi DIP-5610N.
IntActi P34240. 1 interaction.
MINTi MINT-528697.
STRINGi 4932.YKL175W.

Protein family/group databases

TCDBi 2.A.5.5.3. the zinc (zn(2+))-iron (fe(2+)) permease (zip) family.

Proteomic databases

MaxQBi P34240.
PaxDbi P34240.
PeptideAtlasi P34240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL175W ; YKL175W ; YKL175W .
GeneIDi 853679.
KEGGi sce:YKL175W.

Organism-specific databases

CYGDi YKL175w.
SGDi S000001658. ZRT3.

Phylogenomic databases

eggNOGi COG0428.
HOGENOMi HOG000142066.
InParanoidi P34240.
KOi K07238.
OMAi PEGFIIF.
OrthoDBi EOG7R5747.

Enzyme and pathway databases

BioCyci YEAST:G3O-31942-MONOMER.

Miscellaneous databases

NextBioi 974637.

Gene expression databases

Genevestigatori P34240.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and analysis of a 20.5 kb DNA segment located on the left arm of yeast chromosome XI."
    Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.
    Yeast 10:S25-S33(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
    Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
    Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-233.
  5. "Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae."
    MacDiarmid C.W., Gaither L.A., Eide D.
    EMBO J. 19:2845-2855(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZRT3_YEAST
AccessioniPrimary (citable) accession number: P34240
Secondary accession number(s): D6VX25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3