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Protein

Protein CASP

Gene

COY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intra-Golgi transport.1 Publication

Miscellaneous

Present with 2650 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • Golgi vesicle transport Source: SGD
  • intra-Golgi vesicle-mediated transport Source: InterPro

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-31945-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASP
Gene namesi
Name:COY1
Ordered Locus Names:YKL179C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL179C
SGDiS000001662 COY1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 614CytoplasmicSequence analysisAdd BLAST614
Transmembranei615 – 635Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini636 – 679LumenalSequence analysisAdd BLAST44

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi619Y → L: Retained in the endoplasmic reticulum. 1 Publication1
Mutagenesisi624H → L: No effect on subcellular location. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717951 – 679Protein CASPAdd BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei364PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34237
PaxDbiP34237
PRIDEiP34237

PTM databases

iPTMnetiP34237

Interactioni

Protein-protein interaction databases

BioGridi33960, 157 interactors
DIPiDIP-2851N
IntActiP34237, 5 interactors
MINTiP34237
STRINGi4932.YKL179C

Structurei

3D structure databases

ProteinModelPortaliP34237
SMRiP34237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili14 – 90Sequence analysisAdd BLAST77
Coiled coili178 – 341Sequence analysisAdd BLAST164
Coiled coili385 – 444Sequence analysisAdd BLAST60
Coiled coili492 – 540Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the CASP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00910000144709
HOGENOMiHOG000205115
InParanoidiP34237
KOiK09313
OMAiNLFAGYC
OrthoDBiEOG092C1PWK

Family and domain databases

InterProiView protein in InterPro
IPR012955 CASP_C
PfamiView protein in Pfam
PF08172 CASP_C, 1 hit

Sequencei

Sequence statusi: Complete.

P34237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSVYSHAL DIWAKADLTN LQRELDADVI EIKDKETLSL NSRKSLATET
60 70 80 90 100
KKFKKLEPEE KLNNVNKIIK QYQREIDNLT QRSKFSEKVL FDVYEKLSEA
110 120 130 140 150
PDPQPLLQSS LEKLGKIDDS KELKEKISYL EDKLAKYADY ETLKSRLLDL
160 170 180 190 200
EQSSAKTLAK RLTAKTQEIN STWEEKGRNW KEREADLLKQ LTNVQEQNKA
210 220 230 240 250
LEAKISKNID IEGNGNEDGD QENNQKEVST RIAEYNLVTQ ELETTQARIY
260 270 280 290 300
QLEKRNEELS GALAKATSEA EKETELHAKE LKLNQLESEN ALLSASYEQE
310 320 330 340 350
RKSTSHAINE LKEQLNSVVA ESESYKSELE TVRRKLNNYS DYNKIKEELS
360 370 380 390 400
ALKKIEFGVN EDDSDNDIRS EDKNDNTFES SLLSANKKLQ ATLAEYRSKS
410 420 430 440 450
TAQEEERNEL KKSVDQLKQQ IATLKEANEK LETDLEKVEN VSPHFNETAS
460 470 480 490 500
MMSGVTRQMN NRTSHKMSPT SSIIGIPEDG ELSGNQSTIL PIVTKQRDRF
510 520 530 540 550
RSRNMDLEKQ LRQGNSEKGK LKLEISKLKG DNTKLYERIR YLQSYNNNNA
560 570 580 590 600
PVNQSTERID VESQYSRVYD ESLHPMANFR QNELNHYKNK KLSALEKLFS
610 620 630 640 650
SFAKVILQNK MTRMVFLFYC IGLHGLVFMM SMYVINISGY MTPEVGIVQS
660 670
AKSSSNLNGG LGGAEKVAAG VGSVHGINR
Length:679
Mass (Da):77,514
Last modified:June 1, 1994 - v2
Checksum:iCA849F6F4C88A4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74151 Genomic DNA Translation: CAA52259.1
Z28179 Genomic DNA Translation: CAA82021.1
BK006944 Genomic DNA Translation: DAA08988.1
PIRiS38011
RefSeqiNP_012742.1, NM_001179745.1

Genome annotation databases

EnsemblFungiiYKL179C; YKL179C; YKL179C
GeneIDi853675
KEGGisce:YKL179C

Similar proteinsi

Entry informationi

Entry nameiCASP_YEAST
AccessioniPrimary (citable) accession number: P34237
Secondary accession number(s): D6VX22, P34236
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health