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Protein

Protein CASP

Gene

COY1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intra-Golgi transport.1 Publication

GO - Biological processi

  • Golgi vesicle transport Source: SGD
  • intra-Golgi vesicle-mediated transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31945-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASP
Gene namesi
Name:COY1
Ordered Locus Names:YKL179C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL179C.
SGDiS000001662. COY1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 614614CytoplasmicSequence analysisAdd
BLAST
Transmembranei615 – 63521Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini636 – 67944LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi membrane Source: SGD
  • integral component of Golgi membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi619 – 6191Y → L: Retained in the endoplasmic reticulum. 1 Publication
Mutagenesisi624 – 6241H → L: No effect on subcellular location. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679Protein CASPPRO_0000071795Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei364 – 3641PhosphoserineCombined sources
Modified residuei450 – 4501PhosphoserineCombined sources
Modified residuei453 – 4531PhosphoserineCombined sources
Modified residuei555 – 5551PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34237.

PTM databases

iPTMnetiP34237.

Interactioni

Protein-protein interaction databases

BioGridi33960. 146 interactions.
DIPiDIP-2851N.
IntActiP34237. 2 interactions.
MINTiMINT-438873.

Structurei

3D structure databases

ProteinModelPortaliP34237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili14 – 9077Sequence analysisAdd
BLAST
Coiled coili178 – 341164Sequence analysisAdd
BLAST
Coiled coili385 – 44460Sequence analysisAdd
BLAST
Coiled coili492 – 54049Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CASP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063019.
HOGENOMiHOG000205115.
InParanoidiP34237.
KOiK09313.
OMAiNWEAKEK.
OrthoDBiEOG7G4QPR.

Family and domain databases

InterProiIPR012955. CASP_C.
[Graphical view]
PfamiPF08172. CASP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSVYSHAL DIWAKADLTN LQRELDADVI EIKDKETLSL NSRKSLATET
60 70 80 90 100
KKFKKLEPEE KLNNVNKIIK QYQREIDNLT QRSKFSEKVL FDVYEKLSEA
110 120 130 140 150
PDPQPLLQSS LEKLGKIDDS KELKEKISYL EDKLAKYADY ETLKSRLLDL
160 170 180 190 200
EQSSAKTLAK RLTAKTQEIN STWEEKGRNW KEREADLLKQ LTNVQEQNKA
210 220 230 240 250
LEAKISKNID IEGNGNEDGD QENNQKEVST RIAEYNLVTQ ELETTQARIY
260 270 280 290 300
QLEKRNEELS GALAKATSEA EKETELHAKE LKLNQLESEN ALLSASYEQE
310 320 330 340 350
RKSTSHAINE LKEQLNSVVA ESESYKSELE TVRRKLNNYS DYNKIKEELS
360 370 380 390 400
ALKKIEFGVN EDDSDNDIRS EDKNDNTFES SLLSANKKLQ ATLAEYRSKS
410 420 430 440 450
TAQEEERNEL KKSVDQLKQQ IATLKEANEK LETDLEKVEN VSPHFNETAS
460 470 480 490 500
MMSGVTRQMN NRTSHKMSPT SSIIGIPEDG ELSGNQSTIL PIVTKQRDRF
510 520 530 540 550
RSRNMDLEKQ LRQGNSEKGK LKLEISKLKG DNTKLYERIR YLQSYNNNNA
560 570 580 590 600
PVNQSTERID VESQYSRVYD ESLHPMANFR QNELNHYKNK KLSALEKLFS
610 620 630 640 650
SFAKVILQNK MTRMVFLFYC IGLHGLVFMM SMYVINISGY MTPEVGIVQS
660 670
AKSSSNLNGG LGGAEKVAAG VGSVHGINR
Length:679
Mass (Da):77,514
Last modified:June 1, 1994 - v2
Checksum:iCA849F6F4C88A4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74151 Genomic DNA. Translation: CAA52259.1.
Z28179 Genomic DNA. Translation: CAA82021.1.
BK006944 Genomic DNA. Translation: DAA08988.1.
PIRiS38011.
RefSeqiNP_012742.1. NM_001179745.1.

Genome annotation databases

EnsemblFungiiYKL179C; YKL179C; YKL179C.
GeneIDi853675.
KEGGisce:YKL179C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74151 Genomic DNA. Translation: CAA52259.1.
Z28179 Genomic DNA. Translation: CAA82021.1.
BK006944 Genomic DNA. Translation: DAA08988.1.
PIRiS38011.
RefSeqiNP_012742.1. NM_001179745.1.

3D structure databases

ProteinModelPortaliP34237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33960. 146 interactions.
DIPiDIP-2851N.
IntActiP34237. 2 interactions.
MINTiMINT-438873.

PTM databases

iPTMnetiP34237.

Proteomic databases

MaxQBiP34237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL179C; YKL179C; YKL179C.
GeneIDi853675.
KEGGisce:YKL179C.

Organism-specific databases

EuPathDBiFungiDB:YKL179C.
SGDiS000001662. COY1.

Phylogenomic databases

GeneTreeiENSGT00530000063019.
HOGENOMiHOG000205115.
InParanoidiP34237.
KOiK09313.
OMAiNWEAKEK.
OrthoDBiEOG7G4QPR.

Enzyme and pathway databases

BioCyciYEAST:G3O-31945-MONOMER.

Miscellaneous databases

PROiP34237.

Family and domain databases

InterProiIPR012955. CASP_C.
[Graphical view]
PfamiPF08172. CASP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
    Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
    Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro."
    Lievens P.M.-J., Tufarelli C., Donady J.J., Stagg A., Neufeld E.J.
    Gene 197:73-81(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin."
    Gillingham A.K., Pfeifer A.C., Munro S.
    Mol. Biol. Cell 13:3761-3774(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-619 AND HIS-624.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364 AND SER-450, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364; SER-450; SER-453 AND SER-555, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCASP_YEAST
AccessioniPrimary (citable) accession number: P34237
Secondary accession number(s): D6VX22, P34236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2650 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.