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P34232

- MTR2_YEAST

UniProt

P34232 - MTR2_YEAST

Protein

mRNA transport regulator MTR2

Gene

MTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Affects mRNA transport from the nucleus to the cytoplasm.

    GO - Molecular functioni

    1. protein binding Source: SGD

    GO - Biological processi

    1. poly(A)+ mRNA export from nucleus Source: SGD
    2. ribosomal large subunit export from nucleus Source: SGD
    3. ribosomal small subunit export from nucleus Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-31949-MONOMER.

    Protein family/group databases

    TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    mRNA transport regulator MTR2
    Gene namesi
    Name:MTR2
    Ordered Locus Names:YKL186C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XI

    Organism-specific databases

    CYGDiYKL186c1.
    SGDiS000001669. MTR2.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear RNA export factor complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 184184mRNA transport regulator MTR2PRO_0000096634Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei125 – 1251Phosphothreonine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP34232.
    PaxDbiP34232.
    PeptideAtlasiP34232.

    Expressioni

    Gene expression databases

    GenevestigatoriP34232.

    Interactioni

    Subunit structurei

    Interacts with MEX67.1 Publication

    Protein-protein interaction databases

    BioGridi33936. 36 interactions.
    DIPiDIP-4856N.
    IntActiP34232. 7 interactions.
    MINTiMINT-496382.
    STRINGi4932.YKL186C.

    Structurei

    Secondary structure

    1
    184
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi15 – 3117
    Helixi39 – 424
    Beta strandi52 – 543
    Beta strandi57 – 604
    Helixi62 – 7211
    Beta strandi77 – 8812
    Turni89 – 924
    Beta strandi93 – 10311
    Beta strandi145 – 15410
    Helixi155 – 1595
    Beta strandi166 – 17510

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OF5X-ray2.80B1-184[»]
    ProteinModelPortaliP34232.
    SMRiP34232. Positions 14-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP34232.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG40097.
    HOGENOMiHOG000248726.
    KOiK14543.
    OMAiSEYIENS.
    OrthoDBiEOG7FJHBN.

    Family and domain databases

    InterProiIPR019488. Nucl_pore_RNA_shuttling_Mtr2.
    [Graphical view]
    PfamiPF10429. Mtr2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34232-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTNSNTMVM NDANQAQITA TFTKKILAHL DDPDSNKLAQ FVQLFNPNNC    50
    RIIFNATPFA QATVFLQMWQ NQVVQTQHAL TGVDYHAIPG SGTLICNVNC 100
    KVRFDESGRD KMGQDATVPI QPNNTGNRNR PNDMNKPRPL WGPYFGISLQ 150
    LIIDDRIFRN DFNGVISGFN YNMVYKPEDS LLKI 184
    Length:184
    Mass (Da):20,784
    Last modified:February 1, 1994 - v1
    Checksum:iD3AE487A11FA2750
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S77467 Genomic DNA. Translation: AAB33484.1.
    X74151 Genomic DNA. Translation: CAA52252.1.
    Z28186 Genomic DNA. Translation: CAA82029.1.
    AY558555 Genomic DNA. Translation: AAS56881.1.
    BK006944 Genomic DNA. Translation: DAA08980.1.
    PIRiS34684.
    RefSeqiNP_012735.1. NM_001179752.1.

    Genome annotation databases

    EnsemblFungiiYKL186C; YKL186C; YKL186C.
    GeneIDi853649.
    KEGGisce:YKL186C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S77467 Genomic DNA. Translation: AAB33484.1 .
    X74151 Genomic DNA. Translation: CAA52252.1 .
    Z28186 Genomic DNA. Translation: CAA82029.1 .
    AY558555 Genomic DNA. Translation: AAS56881.1 .
    BK006944 Genomic DNA. Translation: DAA08980.1 .
    PIRi S34684.
    RefSeqi NP_012735.1. NM_001179752.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OF5 X-ray 2.80 B 1-184 [» ]
    ProteinModelPortali P34232.
    SMRi P34232. Positions 14-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33936. 36 interactions.
    DIPi DIP-4856N.
    IntActi P34232. 7 interactions.
    MINTi MINT-496382.
    STRINGi 4932.YKL186C.

    Protein family/group databases

    TCDBi 1.I.1.1.1. the nuclear pore complex (npc) family.

    Proteomic databases

    MaxQBi P34232.
    PaxDbi P34232.
    PeptideAtlasi P34232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YKL186C ; YKL186C ; YKL186C .
    GeneIDi 853649.
    KEGGi sce:YKL186C.

    Organism-specific databases

    CYGDi YKL186c1.
    SGDi S000001669. MTR2.

    Phylogenomic databases

    eggNOGi NOG40097.
    HOGENOMi HOG000248726.
    KOi K14543.
    OMAi SEYIENS.
    OrthoDBi EOG7FJHBN.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-31949-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P34232.
    NextBioi 974557.

    Gene expression databases

    Genevestigatori P34232.

    Family and domain databases

    InterProi IPR019488. Nucl_pore_RNA_shuttling_Mtr2.
    [Graphical view ]
    Pfami PF10429. Mtr2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant."
      Kadowaki T., Hitomi M., Chen S., Tartakoff A.M.
      Mol. Biol. Cell 5:1253-1263(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
      Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
      Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete DNA sequence of yeast chromosome XI."
      Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
      , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
      Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15."
      Fribourg S., Conti E.
      EMBO Rep. 4:699-703(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 14-178 IN COMPLEX WITH MEX67.

    Entry informationi

    Entry nameiMTR2_YEAST
    AccessioniPrimary (citable) accession number: P34232
    Secondary accession number(s): D6VX14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XI
      Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

    External Data

    Dasty 3