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Protein

mRNA transport regulator MTR2

Gene

MTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Affects mRNA transport from the nucleus to the cytoplasm.

GO - Biological processi

  • poly(A)+ mRNA export from nucleus Source: SGD
  • ribosomal large subunit export from nucleus Source: SGD
  • ribosomal small subunit export from nucleus Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-31949-MONOMER

Protein family/group databases

TCDBi1.I.1.1.1 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA transport regulator MTR2
Gene namesi
Name:MTR2
Ordered Locus Names:YKL186C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL186C
SGDiS000001669 MTR2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966341 – 184mRNA transport regulator MTR2Add BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei125PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34232
PaxDbiP34232
PRIDEiP34232

PTM databases

iPTMnetiP34232

Interactioni

Subunit structurei

Interacts with MEX67.1 Publication

Protein-protein interaction databases

BioGridi33936, 151 interactors
DIPiDIP-4856N
IntActiP34232, 7 interactors
MINTiP34232
STRINGi4932.YKL186C

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 31Combined sources17
Helixi39 – 42Combined sources4
Beta strandi47 – 49Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi57 – 60Combined sources4
Helixi62 – 72Combined sources11
Beta strandi77 – 88Combined sources12
Turni89 – 92Combined sources4
Beta strandi93 – 103Combined sources11
Beta strandi115 – 117Combined sources3
Beta strandi145 – 154Combined sources10
Helixi155 – 159Combined sources5
Beta strandi166 – 175Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OF5X-ray2.80B1-184[»]
4WWUX-ray3.30C/F/I/L1-184[»]
ProteinModelPortaliP34232
SMRiP34232
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34232

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000248726
InParanoidiP34232
KOiK14543
OMAiVNCKVRF
OrthoDBiEOG092C58Z7

Family and domain databases

InterProiView protein in InterPro
IPR032710 NTF2-like_dom_sf
IPR019488 Nucl_pore_RNA_shuttling_Mtr2
PfamiView protein in Pfam
PF10429 Mtr2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit

Sequencei

Sequence statusi: Complete.

P34232-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTNSNTMVM NDANQAQITA TFTKKILAHL DDPDSNKLAQ FVQLFNPNNC
60 70 80 90 100
RIIFNATPFA QATVFLQMWQ NQVVQTQHAL TGVDYHAIPG SGTLICNVNC
110 120 130 140 150
KVRFDESGRD KMGQDATVPI QPNNTGNRNR PNDMNKPRPL WGPYFGISLQ
160 170 180
LIIDDRIFRN DFNGVISGFN YNMVYKPEDS LLKI
Length:184
Mass (Da):20,784
Last modified:February 1, 1994 - v1
Checksum:iD3AE487A11FA2750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77467 Genomic DNA Translation: AAB33484.1
X74151 Genomic DNA Translation: CAA52252.1
Z28186 Genomic DNA Translation: CAA82029.1
AY558555 Genomic DNA Translation: AAS56881.1
BK006944 Genomic DNA Translation: DAA08980.1
PIRiS34684
RefSeqiNP_012735.1, NM_001179752.1

Genome annotation databases

EnsemblFungiiYKL186C; YKL186C; YKL186C
GeneIDi853649
KEGGisce:YKL186C

Similar proteinsi

Entry informationi

Entry nameiMTR2_YEAST
AccessioniPrimary (citable) accession number: P34232
Secondary accession number(s): D6VX14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health