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P34232

- MTR2_YEAST

UniProt

P34232 - MTR2_YEAST

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Protein

mRNA transport regulator MTR2

Gene

MTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Affects mRNA transport from the nucleus to the cytoplasm.

GO - Biological processi

  1. poly(A)+ mRNA export from nucleus Source: SGD
  2. ribosomal large subunit export from nucleus Source: SGD
  3. ribosomal small subunit export from nucleus Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31949-MONOMER.

Protein family/group databases

TCDBi1.I.1.1.1. the nuclear pore complex (npc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA transport regulator MTR2
Gene namesi
Name:MTR2
Ordered Locus Names:YKL186C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XI

Organism-specific databases

CYGDiYKL186c1.
SGDiS000001669. MTR2.

Subcellular locationi

GO - Cellular componenti

  1. nuclear RNA export factor complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184mRNA transport regulator MTR2PRO_0000096634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei125 – 1251Phosphothreonine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34232.
PaxDbiP34232.
PeptideAtlasiP34232.

Expressioni

Gene expression databases

GenevestigatoriP34232.

Interactioni

Subunit structurei

Interacts with MEX67.1 Publication

Protein-protein interaction databases

BioGridi33936. 36 interactions.
DIPiDIP-4856N.
IntActiP34232. 7 interactions.
MINTiMINT-496382.
STRINGi4932.YKL186C.

Structurei

Secondary structure

1
184
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 3117Combined sources
Helixi39 – 424Combined sources
Beta strandi52 – 543Combined sources
Beta strandi57 – 604Combined sources
Helixi62 – 7211Combined sources
Beta strandi77 – 8812Combined sources
Turni89 – 924Combined sources
Beta strandi93 – 10311Combined sources
Beta strandi145 – 15410Combined sources
Helixi155 – 1595Combined sources
Beta strandi166 – 17510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OF5X-ray2.80B1-184[»]
ProteinModelPortaliP34232.
SMRiP34232. Positions 14-178.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34232.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG40097.
HOGENOMiHOG000248726.
InParanoidiP34232.
KOiK14543.
OMAiSEYIENS.
OrthoDBiEOG7FJHBN.

Family and domain databases

InterProiIPR019488. Nucl_pore_RNA_shuttling_Mtr2.
[Graphical view]
PfamiPF10429. Mtr2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34232-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTNSNTMVM NDANQAQITA TFTKKILAHL DDPDSNKLAQ FVQLFNPNNC
60 70 80 90 100
RIIFNATPFA QATVFLQMWQ NQVVQTQHAL TGVDYHAIPG SGTLICNVNC
110 120 130 140 150
KVRFDESGRD KMGQDATVPI QPNNTGNRNR PNDMNKPRPL WGPYFGISLQ
160 170 180
LIIDDRIFRN DFNGVISGFN YNMVYKPEDS LLKI
Length:184
Mass (Da):20,784
Last modified:February 1, 1994 - v1
Checksum:iD3AE487A11FA2750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77467 Genomic DNA. Translation: AAB33484.1.
X74151 Genomic DNA. Translation: CAA52252.1.
Z28186 Genomic DNA. Translation: CAA82029.1.
AY558555 Genomic DNA. Translation: AAS56881.1.
BK006944 Genomic DNA. Translation: DAA08980.1.
PIRiS34684.
RefSeqiNP_012735.1. NM_001179752.1.

Genome annotation databases

EnsemblFungiiYKL186C; YKL186C; YKL186C.
GeneIDi853649.
KEGGisce:YKL186C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77467 Genomic DNA. Translation: AAB33484.1 .
X74151 Genomic DNA. Translation: CAA52252.1 .
Z28186 Genomic DNA. Translation: CAA82029.1 .
AY558555 Genomic DNA. Translation: AAS56881.1 .
BK006944 Genomic DNA. Translation: DAA08980.1 .
PIRi S34684.
RefSeqi NP_012735.1. NM_001179752.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OF5 X-ray 2.80 B 1-184 [» ]
ProteinModelPortali P34232.
SMRi P34232. Positions 14-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33936. 36 interactions.
DIPi DIP-4856N.
IntActi P34232. 7 interactions.
MINTi MINT-496382.
STRINGi 4932.YKL186C.

Protein family/group databases

TCDBi 1.I.1.1.1. the nuclear pore complex (npc) family.

Proteomic databases

MaxQBi P34232.
PaxDbi P34232.
PeptideAtlasi P34232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YKL186C ; YKL186C ; YKL186C .
GeneIDi 853649.
KEGGi sce:YKL186C.

Organism-specific databases

CYGDi YKL186c1.
SGDi S000001669. MTR2.

Phylogenomic databases

eggNOGi NOG40097.
HOGENOMi HOG000248726.
InParanoidi P34232.
KOi K14543.
OMAi SEYIENS.
OrthoDBi EOG7FJHBN.

Enzyme and pathway databases

BioCyci YEAST:G3O-31949-MONOMER.

Miscellaneous databases

EvolutionaryTracei P34232.
NextBioi 974557.

Gene expression databases

Genevestigatori P34232.

Family and domain databases

InterProi IPR019488. Nucl_pore_RNA_shuttling_Mtr2.
[Graphical view ]
Pfami PF10429. Mtr2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant."
    Kadowaki T., Hitomi M., Chen S., Tartakoff A.M.
    Mol. Biol. Cell 5:1253-1263(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene."
    Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W.
    Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete DNA sequence of yeast chromosome XI."
    Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C.
    , Domdey H., Duesterhoeft A., Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H., Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L., Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M., Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H., Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J., Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H., Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J., Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S., Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F., Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R., Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W., Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M., Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C., Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H., Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L., van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S., von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M., Becker I., Mewes H.-W.
    Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-125, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15."
    Fribourg S., Conti E.
    EMBO Rep. 4:699-703(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 14-178 IN COMPLEX WITH MEX67.

Entry informationi

Entry nameiMTR2_YEAST
AccessioniPrimary (citable) accession number: P34232
Secondary accession number(s): D6VX14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

External Data

Dasty 3