Reviewed,
UniProtKB/Swiss-Prot P34232 (MTR2_YEAST)
Last modified
November 24, 2009.
Version 70.
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50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: mRNA transport regulator MTR2 | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4932 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 184 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Affects mRNA transport from the nucleus to the cytoplasm. |
| Subunit structure | Interacts with MEX67. |
| Subcellular location |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Nucleus |
| PTM | Phosphoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | poly(A)+ mRNA export from nucleus Ref.1 Inferred from mutant phenotype. Source: SGD ribosomal large subunit export from nucleusInferred from genetic interaction. Source: SGD |
| Cellular component | nuclear RNA export factor complex Inferred from physical interaction. Source: SGD nuclear poreInferred from direct assay. Source: SGD |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 184 | 184 | mRNA transport regulator MTR2 | PRO_0000096634 | ||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||
| Modified residue | 125 | 1 | Phosphothreonine Ref.5 | |||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||
| Helix | 15 – 31 | 17 | ||||||||||||||||||||||||||||||
| Helix | 39 – 42 | 4 | ||||||||||||||||||||||||||||||
| Turn | 43 – 44 | 2 | ||||||||||||||||||||||||||||||
| Beta strand | 52 – 54 | 3 | ||||||||||||||||||||||||||||||
| Turn | 55 – 56 | 2 | ||||||||||||||||||||||||||||||
| Beta strand | 57 – 60 | 4 | ||||||||||||||||||||||||||||||
| Helix | 62 – 72 | 11 | ||||||||||||||||||||||||||||||
| Beta strand | 77 – 88 | 12 | ||||||||||||||||||||||||||||||
| Turn | 89 – 92 | 4 | ||||||||||||||||||||||||||||||
| Beta strand | 93 – 103 | 11 | ||||||||||||||||||||||||||||||
| Beta strand | 145 – 154 | 10 | ||||||||||||||||||||||||||||||
| Helix | 155 – 159 | 5 | ||||||||||||||||||||||||||||||
| Turn | 160 | 1 | ||||||||||||||||||||||||||||||
| Turn | 163 – 164 | 2 | ||||||||||||||||||||||||||||||
| Beta strand | 166 – 175 | 10 | ||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant." Kadowaki T., Hitomi M., Chen S., Tartakoff A.M. Mol. Biol. Cell 5:1253-1263(1994) [PubMed: 7865887] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene." Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W. Yeast 9:1343-1348(1993) [PubMed: 8154185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W.Nature 369:371-378(1994) [PubMed: 8196765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [4] | "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J.Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [5] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-125, MASS SPECTROMETRY. |
| [6] | "Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15." Fribourg S., Conti E. EMBO Rep. 4:699-703(2003) [PubMed: 12835756] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 14-178 IN COMPLEX WITH MEX67. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S77467 Genomic DNA. Translation: AAB33484.1. X74151 Genomic DNA. Translation: CAA52252.1. Z28186 Genomic DNA. Translation: CAA82029.1. AY558555 Genomic DNA. Translation: AAS56881.1. | |||||||||||||
| PIR | S34684. | ||||||||||||
| RefSeq | NP_012735.1. | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP:4856N. | ||||||||||||
| IntAct | P34232. 6 interactions. | ||||||||||||
| STRING | P34232. | ||||||||||||
Protein family/group databases | |||||||||||||
| TCDB | 9.A.14.1.1. nuclear pore complex (NPC) family. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P34232. | ||||||||||||
| PRIDE | P34232. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | YKL186C; YKL186C; YKL186C; Saccharomyces cerevisiae. [Genome view] | ||||||||||||
| GeneID | 853649. | ||||||||||||
| KEGG | sce:YKL186C. | ||||||||||||
| NMPDR | fig|4932.3.peg.3712. | ||||||||||||
Organism-specific databases | |||||||||||||
| CYGD | YKL186c. | ||||||||||||
| SGD | S000001669. MTR2. | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P34232. | ||||||||||||
| OMA | VNCKVRF | ||||||||||||
| OrthoDB | EOG9R259X | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P34232. | ||||||||||||
| Genevestigator | P34232. | ||||||||||||
| GermOnline | YKL186C. Saccharomyces cerevisiae. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR019488. Nucl_pore_RNA_shuttling_Mtr2. [Graphical view] | ||||||||||||
| Pfam | PF10429. Mtr2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 974557. | ||||||||||||
Entry information
| Entry name | MTR2_YEAST | ||||||||
| Accession | Primary (citable) accession number: P34232 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XI Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names |

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