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P34227

- PRX1_YEAST

UniProt

P34227 - PRX1_YEAST

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Protein
Mitochondrial peroxiredoxin PRX1
Gene
PRX1, YBL064C, YBL0503, YBL0524
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has a thioredoxin peroxidase activity with a role in reduction of hydroperoxides.1 Publication

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

pH dependencei

Optimum pH is 6.5.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911 By similarity

GO - Molecular functioni

  1. thioredoxin peroxidase activity Source: SGD

GO - Biological processi

  1. cell redox homeostasis Source: SGD
  2. cellular response to oxidative stress Source: SGD
  3. response to cadmium ion Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1836-MONOMER.
YEAST:G3O-28961-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial peroxiredoxin PRX1 (EC:1.11.1.15)
Alternative name(s):
1-Cys PRX
Mitochondrial thiol peroxidase
Short name:
mTPx
Thioredoxin reductase
Gene namesi
Name:PRX1
Ordered Locus Names:YBL064C
ORF Names:YBL0503, YBL0524
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBL064c.
SGDiS000000160. PRX1.

Subcellular locationi

Mitochondrion 2 Publications

GO - Cellular componenti

  1. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi91 – 911C → S: No activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Mitochondrial peroxiredoxin PRX1
PRO_0000135151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34227.
PaxDbiP34227.
PeptideAtlasiP34227.

2D gel databases

UCD-2DPAGEP34227.

Expressioni

Gene expression databases

GenevestigatoriP34227.

Interactioni

Protein-protein interaction databases

BioGridi32635. 48 interactions.
DIPiDIP-6412N.
IntActiP34227. 11 interactions.
MINTiMINT-642862.
STRINGi4932.YBL064C.

Structurei

3D structure databases

ProteinModelPortaliP34227.
SMRiP34227. Positions 56-258.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 212164Thioredoxin
Add
BLAST

Sequence similaritiesi

Belongs to the AhpC/TSA family.
Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0450.
GeneTreeiENSGT00550000074794.
HOGENOMiHOG000022346.
KOiK03386.
OMAiKAMLVYP.
OrthoDBiEOG7RBZM1.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34227-1 [UniParc]FASTAAdd to Basket

« Hide

MFSRICSAQL KRTAWTLPKQ AHLQSQTIKT FATAPILCKQ FKQSDQPRLR    50
INSDAPNFDA DTTVGKINFY DYLGDSWGVL FSHPADFTPV CTTEVSAFAK 100
LKPEFDKRNV KLIGLSVEDV ESHEKWIQDI KEIAKVKNVG FPIIGDTFRN 150
VAFLYDMVDA EGFKNINDGS LKTVRSVFVI DPKKKIRLIF TYPSTVGRNT 200
SEVLRVIDAL QLTDKEGVVT PINWQPADDV IIPPSVSNDE AKAKFGQFNE 250
IKPYLRFTKS K 261
Length:261
Mass (Da):29,496
Last modified:February 1, 1994 - v1
Checksum:iF611A9ED85E4681A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23261 Genomic DNA. Translation: CAA80784.1.
Z35825 Genomic DNA. Translation: CAA84884.1.
BK006936 Genomic DNA. Translation: DAA07056.1.
PIRiS39825.
RefSeqiNP_009489.1. NM_001178304.1.

Genome annotation databases

EnsemblFungiiYBL064C; YBL064C; YBL064C.
GeneIDi852215.
KEGGisce:YBL064C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z23261 Genomic DNA. Translation: CAA80784.1 .
Z35825 Genomic DNA. Translation: CAA84884.1 .
BK006936 Genomic DNA. Translation: DAA07056.1 .
PIRi S39825.
RefSeqi NP_009489.1. NM_001178304.1.

3D structure databases

ProteinModelPortali P34227.
SMRi P34227. Positions 56-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32635. 48 interactions.
DIPi DIP-6412N.
IntActi P34227. 11 interactions.
MINTi MINT-642862.
STRINGi 4932.YBL064C.

2D gel databases

UCD-2DPAGE P34227.

Proteomic databases

MaxQBi P34227.
PaxDbi P34227.
PeptideAtlasi P34227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBL064C ; YBL064C ; YBL064C .
GeneIDi 852215.
KEGGi sce:YBL064C.

Organism-specific databases

CYGDi YBL064c.
SGDi S000000160. PRX1.

Phylogenomic databases

eggNOGi COG0450.
GeneTreei ENSGT00550000074794.
HOGENOMi HOG000022346.
KOi K03386.
OMAi KAMLVYP.
OrthoDBi EOG7RBZM1.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-1836-MONOMER.
YEAST:G3O-28961-MONOMER.

Miscellaneous databases

NextBioi 970724.
PROi P34227.

Gene expression databases

Genevestigatori P34227.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view ]
PIRSFi PIRSF000239. AHPC. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes."
    Scherens B., el Bakkoury M., Vierendeels F., Dubois E., Messenguy F.
    Yeast 9:1355-1371(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae."
    Park S.G., Cha M.-K., Jeong W., Kim I.-H.
    J. Biol. Chem. 275:5723-5732(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF CYS-91.
  5. "Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity."
    Pedrajas J.R., Miranda-Vizuete A., Javanmardy N., Gustafsson J.A., Spyrou G.
    J. Biol. Chem. 275:16296-16301(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.
  8. "Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase."
    Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B., van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.
    Mol. Cell. Proteomics 6:1896-1906(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ATCC 76625 / YPH499.

Entry informationi

Entry nameiPRX1_YEAST
AccessioniPrimary (citable) accession number: P34227
Secondary accession number(s): D6VPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4510 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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