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Protein

Mitochondrial peroxiredoxin PRX1

Gene

PRX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a thioredoxin peroxidase activity with a role in reduction of hydroperoxides.1 Publication

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

pH dependencei

Optimum pH is 6.5.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91By similarity1

GO - Molecular functioni

  • thioredoxin peroxidase activity Source: SGD

GO - Biological processi

  • cell redox homeostasis Source: SGD
  • cellular response to oxidative stress Source: SGD
  • response to cadmium ion Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciYEAST:G3O-28961-MONOMER.
ReactomeiR-SCE-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial peroxiredoxin PRX1 (EC:1.11.1.15)
Alternative name(s):
1-Cys PRX
Mitochondrial thiol peroxidase
Short name:
mTPx
Thioredoxin reductase
Gene namesi
Name:PRX1
Ordered Locus Names:YBL064C
ORF Names:YBL0503, YBL0524
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL064C.
SGDiS000000160. PRX1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi91C → S: No activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001351511 – 261Mitochondrial peroxiredoxin PRX1Add BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34227.
PRIDEiP34227.
TopDownProteomicsiP34227.

2D gel databases

UCD-2DPAGEP34227.

PTM databases

iPTMnetiP34227.

Interactioni

Protein-protein interaction databases

BioGridi32635. 51 interactors.
DIPiDIP-6412N.
IntActiP34227. 11 interactors.
MINTiMINT-642862.

Structurei

3D structure databases

ProteinModelPortaliP34227.
SMRiP34227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 212ThioredoxinPROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the AhpC/TSA family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

GeneTreeiENSGT00550000074794.
HOGENOMiHOG000022346.
InParanoidiP34227.
KOiK03386.
OMAiANTIESH.
OrthoDBiEOG092C3W08.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34227-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRICSAQL KRTAWTLPKQ AHLQSQTIKT FATAPILCKQ FKQSDQPRLR
60 70 80 90 100
INSDAPNFDA DTTVGKINFY DYLGDSWGVL FSHPADFTPV CTTEVSAFAK
110 120 130 140 150
LKPEFDKRNV KLIGLSVEDV ESHEKWIQDI KEIAKVKNVG FPIIGDTFRN
160 170 180 190 200
VAFLYDMVDA EGFKNINDGS LKTVRSVFVI DPKKKIRLIF TYPSTVGRNT
210 220 230 240 250
SEVLRVIDAL QLTDKEGVVT PINWQPADDV IIPPSVSNDE AKAKFGQFNE
260
IKPYLRFTKS K
Length:261
Mass (Da):29,496
Last modified:February 1, 1994 - v1
Checksum:iF611A9ED85E4681A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA. Translation: CAA80784.1.
Z35825 Genomic DNA. Translation: CAA84884.1.
BK006936 Genomic DNA. Translation: DAA07056.1.
PIRiS39825.
RefSeqiNP_009489.1. NM_001178304.1.

Genome annotation databases

EnsemblFungiiYBL064C; YBL064C; YBL064C.
GeneIDi852215.
KEGGisce:YBL064C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA. Translation: CAA80784.1.
Z35825 Genomic DNA. Translation: CAA84884.1.
BK006936 Genomic DNA. Translation: DAA07056.1.
PIRiS39825.
RefSeqiNP_009489.1. NM_001178304.1.

3D structure databases

ProteinModelPortaliP34227.
SMRiP34227.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32635. 51 interactors.
DIPiDIP-6412N.
IntActiP34227. 11 interactors.
MINTiMINT-642862.

PTM databases

iPTMnetiP34227.

2D gel databases

UCD-2DPAGEP34227.

Proteomic databases

MaxQBiP34227.
PRIDEiP34227.
TopDownProteomicsiP34227.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL064C; YBL064C; YBL064C.
GeneIDi852215.
KEGGisce:YBL064C.

Organism-specific databases

EuPathDBiFungiDB:YBL064C.
SGDiS000000160. PRX1.

Phylogenomic databases

GeneTreeiENSGT00550000074794.
HOGENOMiHOG000022346.
InParanoidiP34227.
KOiK03386.
OMAiANTIESH.
OrthoDBiEOG092C3W08.

Enzyme and pathway databases

BioCyciYEAST:G3O-28961-MONOMER.
ReactomeiR-SCE-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP34227.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000866. AhpC/TSA.
IPR024706. Peroxiredoxin_AhpC-typ.
IPR019479. Peroxiredoxin_C.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PIRSFiPIRSF000239. AHPC. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRX1_YEAST
AccessioniPrimary (citable) accession number: P34227
Secondary accession number(s): D6VPT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4510 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.