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Protein

Peptidyl-tRNA hydrolase 2

Gene

PTH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.By similarity2 Publications

Miscellaneous

Present with 2190 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.

GO - Molecular functioni

  • aminoacyl-tRNA hydrolase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:G3O-28955-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-tRNA hydrolase 2 (EC:3.1.1.29)
Short name:
PTH 2
Gene namesi
Name:PTH2
Ordered Locus Names:YBL057C
ORF Names:YBL0510, YBL0514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL057C
SGDiS000000153 PTH2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202841 – 208Peptidyl-tRNA hydrolase 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki152Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP34222
PaxDbiP34222
PRIDEiP34222

PTM databases

iPTMnetiP34222

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32642, 70 interactors
IntActiP34222, 3 interactors
MINTiP34222
STRINGi4932.YBL057C

Structurei

3D structure databases

ProteinModelPortaliP34222
SMRiP34222
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PTH2 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000015991
HOGENOMiHOG000227349
InParanoidiP34222
KOiK04794
OMAiKITLQVP
OrthoDBiEOG092C5K7L

Family and domain databases

CDDicd02430 PTH2, 1 hit
Gene3Di3.40.1490.10, 1 hit
InterProiView protein in InterPro
IPR023476 Pep_tRNA_hydro_II_dom_sf
IPR002833 PTH2
PfamiView protein in Pfam
PF01981 PTH2, 1 hit
SUPFAMiSSF102462 SSF102462, 1 hit
TIGRFAMsiTIGR00283 arch_pth2, 1 hit

Sequencei

Sequence statusi: Complete.

P34222-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKMTVSSNY TIALWATFTA ISFAVGYQLG TSNASSTKKS SATLLRSKEM
60 70 80 90 100
KEGKLHNDTD EEESESEDES DEDEDIESTS LNDIPGEVRM ALVIRQDLGM
110 120 130 140 150
TKGKIAAQCC HAALSCFRHI ATNPARASYN PIMTQRWLNA GQAKITLKCP
160 170 180 190 200
DKFTMDELYA KAISLGVNAA VIHDAGRTQI AAGSATVLGL GPAPKAVLDQ

ITGDLKLY
Length:208
Mass (Da):22,435
Last modified:July 27, 2011 - v2
Checksum:iA77F3A5BAC578943
GO

Sequence cautioni

The sequence AAT92782 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA80790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA84877 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA Translation: CAA80790.1 Different initiation.
Z35818 Genomic DNA Translation: CAA84877.1 Different initiation.
AY692763 Genomic DNA Translation: AAT92782.1 Different initiation.
BK006936 Genomic DNA Translation: DAA07063.2
PIRiS39831
RefSeqiNP_009496.2, NM_001178297.2

Genome annotation databases

EnsemblFungiiYBL057C; YBL057C; YBL057C
GeneIDi852223
KEGGisce:YBL057C

Similar proteinsi

Entry informationi

Entry nameiPTH2_YEAST
AccessioniPrimary (citable) accession number: P34222
Secondary accession number(s): D6VPU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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