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P34219

- TOD6_YEAST

UniProt

P34219 - TOD6_YEAST

Protein

Transcriptional regulatory protein TOD6

Gene

TOD6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. TOD6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi97 – 12024H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. sequence-specific DNA binding Source: SGD

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: SGD

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28952-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional regulatory protein TOD6
    Alternative name(s):
    PAC-binding factor 1
    Twin of DOT6
    Gene namesi
    Name:TOD6
    Synonyms:PBF1
    Ordered Locus Names:YBL054W
    ORF Names:YBL0509, YBL0513
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBL054w.
    SGDiS000000150. TOD6.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Transcriptional regulatory protein TOD6PRO_0000197146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei280 – 2801Phosphoserine1 Publication
    Modified residuei333 – 3331Phosphoserine1 Publication
    Modified residuei341 – 3411Phosphoserine1 Publication
    Modified residuei366 – 3661Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP34219.
    PaxDbiP34219.
    PeptideAtlasiP34219.

    Expressioni

    Gene expression databases

    GenevestigatoriP34219.

    Interactioni

    Subunit structurei

    Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, DOT6, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, TOD6; UME1 and UME6.1 Publication

    Protein-protein interaction databases

    BioGridi32645. 34 interactions.
    DIPiDIP-2636N.
    IntActiP34219. 3 interactions.
    MINTiMINT-427067.
    STRINGi4932.YBL054W.

    Structurei

    3D structure databases

    ProteinModelPortaliP34219.
    SMRiP34219. Positions 76-123, 392-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 12458HTH myb-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DOT6 family.Curated
    Contains 1 HTH myb-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG244012.
    GeneTreeiENSGT00530000068139.
    OMAiANDKITH.
    OrthoDBiEOG7Q8CX9.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR001005. SANT/Myb.
    [Graphical view]
    PfamiPF00249. Myb_DNA-binding. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51294. HTH_MYB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P34219-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLPKLSSVS VSSGHVSANS HGFSILSKHP HPNNLVHSHS LSHTNAKSHL    50
    PISSTSTKEN STNKEEAESL KKNNPSSWDP SDDIKLRHLK EIKNLGWKEI 100
    AHHFPNRTPN ACQFRWRRLK SGNLKSNKTA VIDINKLFGV YATGDATPSA 150
    GTPSAEEAVK EEAVEDEDIT AGSSAIEDSP PDFKPLVKPK YMDRKLITQR 200
    STSTFSDHEP QHTKPRKLFV KPRSFSHSIT TNTPNVKTAQ QTNLSLYNTT 250
    SAKTNKAVNS NDYENIGLVP KIIIRSRRNS FIPSTQIPHS TTKTRKNSHS 300
    VISSRRSSFN MMHSRRSSFN SHAPTEPISR RASLVVSPYM SPRRLSTSQS 350
    VHYHPQHQYY LNPIASPNCK TDHANDKITH TRTFLDMQKF ANKHPWSRED 400
    DEVLLNNTKD KQNHLSPLEI SIVLPNNRSE LEIQQRMDYL KRKGRVSGFH 450
    TNEGCKDEEE EDDIDPLHKE NGINTPSQQS QNYGMLEAKH DNPKSSELSS 500
    MTSANDIRNE QDELPGINSI FKNIF 525
    Length:525
    Mass (Da):59,226
    Last modified:February 1, 1994 - v1
    Checksum:i8663DFE2641AA72E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z23261 Genomic DNA. Translation: CAA80793.1.
    Z35815 Genomic DNA. Translation: CAA84874.1.
    AY692625 Genomic DNA. Translation: AAT92644.1.
    BK006936 Genomic DNA. Translation: DAA07066.1.
    PIRiS39834.
    RefSeqiNP_009499.1. NM_001178294.1.

    Genome annotation databases

    EnsemblFungiiYBL054W; YBL054W; YBL054W.
    GeneIDi852226.
    KEGGisce:YBL054W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z23261 Genomic DNA. Translation: CAA80793.1 .
    Z35815 Genomic DNA. Translation: CAA84874.1 .
    AY692625 Genomic DNA. Translation: AAT92644.1 .
    BK006936 Genomic DNA. Translation: DAA07066.1 .
    PIRi S39834.
    RefSeqi NP_009499.1. NM_001178294.1.

    3D structure databases

    ProteinModelPortali P34219.
    SMRi P34219. Positions 76-123, 392-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32645. 34 interactions.
    DIPi DIP-2636N.
    IntActi P34219. 3 interactions.
    MINTi MINT-427067.
    STRINGi 4932.YBL054W.

    Proteomic databases

    MaxQBi P34219.
    PaxDbi P34219.
    PeptideAtlasi P34219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBL054W ; YBL054W ; YBL054W .
    GeneIDi 852226.
    KEGGi sce:YBL054W.

    Organism-specific databases

    CYGDi YBL054w.
    SGDi S000000150. TOD6.

    Phylogenomic databases

    eggNOGi NOG244012.
    GeneTreei ENSGT00530000068139.
    OMAi ANDKITH.
    OrthoDBi EOG7Q8CX9.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28952-MONOMER.

    Miscellaneous databases

    NextBioi 970754.

    Gene expression databases

    Genevestigatori P34219.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR017930. Myb_dom.
    IPR001005. SANT/Myb.
    [Graphical view ]
    Pfami PF00249. Myb_DNA-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51294. HTH_MYB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes."
      Scherens B., el Bakkoury M., Vierendeels F., Dubois E., Messenguy F.
      Yeast 9:1355-1371(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genes."
      Wade C.H., Umbarger M.A., McAlear M.A.
      Yeast 23:293-306(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    9. "Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment."
      Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C., Thomas H., Krogan N.J., Shevchenko A., Stewart A.F.
      Genome Biol. 9:R167.1-R167.22(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RPD3(L) COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    10. Cited for: DNA-BINDING.
    11. Cited for: FUNCTION.
    12. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; SER-333 AND SER-341, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTOD6_YEAST
    AccessioniPrimary (citable) accession number: P34219
    Secondary accession number(s): D6VPU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 830 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3