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Protein

Transcriptional regulatory protein TOD6

Gene

TOD6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. TOD6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi97 – 120H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • sequence-specific DNA binding Source: SGD

GO - Biological processi

  • regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein TOD6
Alternative name(s):
PAC-binding factor 1
Twin of DOT6
Gene namesi
Name:TOD6
Synonyms:PBF1
Ordered Locus Names:YBL054W
ORF Names:YBL0509, YBL0513
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL054W.
SGDiS000000150. TOD6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971461 – 525Transcriptional regulatory protein TOD6Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei280PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34219.
PRIDEiP34219.
TopDownProteomicsiP34219.

PTM databases

iPTMnetiP34219.

Interactioni

Subunit structurei

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, DOT6, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, TOD6; UME1 and UME6.1 Publication

Protein-protein interaction databases

BioGridi32645. 36 interactors.
DIPiDIP-2636N.
IntActiP34219. 3 interactors.
MINTiMINT-427067.

Structurei

3D structure databases

ProteinModelPortaliP34219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 124HTH myb-typePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the DOT6 family.Curated
Contains 1 HTH myb-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000068139.
InParanoidiP34219.
OrthoDBiEOG092C51OF.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P34219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPKLSSVS VSSGHVSANS HGFSILSKHP HPNNLVHSHS LSHTNAKSHL
60 70 80 90 100
PISSTSTKEN STNKEEAESL KKNNPSSWDP SDDIKLRHLK EIKNLGWKEI
110 120 130 140 150
AHHFPNRTPN ACQFRWRRLK SGNLKSNKTA VIDINKLFGV YATGDATPSA
160 170 180 190 200
GTPSAEEAVK EEAVEDEDIT AGSSAIEDSP PDFKPLVKPK YMDRKLITQR
210 220 230 240 250
STSTFSDHEP QHTKPRKLFV KPRSFSHSIT TNTPNVKTAQ QTNLSLYNTT
260 270 280 290 300
SAKTNKAVNS NDYENIGLVP KIIIRSRRNS FIPSTQIPHS TTKTRKNSHS
310 320 330 340 350
VISSRRSSFN MMHSRRSSFN SHAPTEPISR RASLVVSPYM SPRRLSTSQS
360 370 380 390 400
VHYHPQHQYY LNPIASPNCK TDHANDKITH TRTFLDMQKF ANKHPWSRED
410 420 430 440 450
DEVLLNNTKD KQNHLSPLEI SIVLPNNRSE LEIQQRMDYL KRKGRVSGFH
460 470 480 490 500
TNEGCKDEEE EDDIDPLHKE NGINTPSQQS QNYGMLEAKH DNPKSSELSS
510 520
MTSANDIRNE QDELPGINSI FKNIF
Length:525
Mass (Da):59,226
Last modified:February 1, 1994 - v1
Checksum:i8663DFE2641AA72E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA. Translation: CAA80793.1.
Z35815 Genomic DNA. Translation: CAA84874.1.
AY692625 Genomic DNA. Translation: AAT92644.1.
BK006936 Genomic DNA. Translation: DAA07066.1.
PIRiS39834.
RefSeqiNP_009499.1. NM_001178294.1.

Genome annotation databases

EnsemblFungiiYBL054W; YBL054W; YBL054W.
GeneIDi852226.
KEGGisce:YBL054W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA. Translation: CAA80793.1.
Z35815 Genomic DNA. Translation: CAA84874.1.
AY692625 Genomic DNA. Translation: AAT92644.1.
BK006936 Genomic DNA. Translation: DAA07066.1.
PIRiS39834.
RefSeqiNP_009499.1. NM_001178294.1.

3D structure databases

ProteinModelPortaliP34219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32645. 36 interactors.
DIPiDIP-2636N.
IntActiP34219. 3 interactors.
MINTiMINT-427067.

PTM databases

iPTMnetiP34219.

Proteomic databases

MaxQBiP34219.
PRIDEiP34219.
TopDownProteomicsiP34219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL054W; YBL054W; YBL054W.
GeneIDi852226.
KEGGisce:YBL054W.

Organism-specific databases

EuPathDBiFungiDB:YBL054W.
SGDiS000000150. TOD6.

Phylogenomic databases

GeneTreeiENSGT00530000068139.
InParanoidiP34219.
OrthoDBiEOG092C51OF.

Enzyme and pathway databases

BioCyciYEAST:G3O-28952-MONOMER.

Miscellaneous databases

PROiP34219.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOD6_YEAST
AccessioniPrimary (citable) accession number: P34219
Secondary accession number(s): D6VPU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 830 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.